Widespread use of green hydrogen is a critical route to achieving a carbon-neutral society,but it cannot be accomplished without extensive hydrogen distribution.Hydrogen pipelines are the most energy-efficient approac...Widespread use of green hydrogen is a critical route to achieving a carbon-neutral society,but it cannot be accomplished without extensive hydrogen distribution.Hydrogen pipelines are the most energy-efficient approach to transporting hydrogen in areas with high,long-term demand for hydrogen.A well-known fact is that the properties of hydrogen differ from those of natural gas,which leads to significant variations in the pipeline transportation process.In addition,hydrogen can degrade the mechanical properties of steels,thereby affecting pipeline integrity.This situation has led to two inevitable key challenges in the current development of hydrogen-pipeline technology:economic viability and safety.Based on a review of the current state of hydrogen pipelines,including material compatibility with hydrogen,design methods,process operations,safety monitoring,and standards,this paper highlights key knowledge gaps in gaseous hydrogen pipelines.These gaps include the utilisation of high-strength materials for hydrogen pipelines,design of high-quality hydrogen pipelines,determination of hydrogen velocity,and repurposing of existing natural-gas pipelines.This review aims to identify the challenges in current hydrogen pipelines development and provide valuable suggestions for future research.展开更多
Deep-sea mineral resource transportation predominantly utilizes hydraulic pipeline methodology.Environmental factors induce vibrations in flexible pipelines,thereby affecting the internal flow characteristics.Therefor...Deep-sea mineral resource transportation predominantly utilizes hydraulic pipeline methodology.Environmental factors induce vibrations in flexible pipelines,thereby affecting the internal flow characteristics.Therefore,real-time monitoring of solid–liquid two-phase flow in pipelines is crucial for system maintenance.This study develops an autoencoder-based deep learning framework to reconstruct three-dimensional solid–liquid two-phase flow within flexible vibrating pipelines utilizing sparse wall information from sensors.Within this framework,separate X-model and F-model with distinct hidden-layer structures are established to reconstruct the coordinates and flow field information on the computational domain grid of the pipeline under traveling wave vibration.Following hyperparameter optimization,the models achieved high reconstruction accuracy,demonstrating R^(2)values of 0.990 and 0.945,respectively.The models’robustness is evaluated across three aspects:vibration parameters,physical fields,and vibration modes,demonstrating good reconstruction performance.Results concerning sensors show that 20 sensors(0.06%of total grids)achieve a balance between accuracy and cost,with superior accuracy obtained when arranged along the full length of the pipe compared to a dense arrangement at the front end.The models exhibited a signal-to-noise ratio tolerance of approximately 27 dB,with reconstruction accuracy being more affected by sensor failures at both ends of the pipeline.展开更多
This paper experimentally investigates the wave pressure and pore pressure within a sandy seabed around two pipelines under the action of random waves(currents).The experiments revealed that when the random wave plus ...This paper experimentally investigates the wave pressure and pore pressure within a sandy seabed around two pipelines under the action of random waves(currents).The experiments revealed that when the random wave plus current cases are compared with the random wave-only case,the forward current promotes wave propagation,whereas the reversed backward current inhibits wave propagation.Furthermore,the wave pressure on the downstream pipeline decreases as the relative spacing ratio increases and increases as the diameter increases.However,alterations in the relative spacing ratio or dimensions of the downstream pipeline exert a negligible influence on the wave pressure of the upstream pipeline.Moreover,the relative spacing ratio between the pipelines and the dimensions of the pipelines considerably influence the pore pressure in the sand bed.When the relative spacing ratio remains constant,increasing the downstream pipeline diameter will increase the pore-water pressure of the soil below the downstream pipeline.展开更多
This paper analyses the impact of oil and gas pipelines on the environment and settlements from the perspective of environmental justice,using a case study of the oil-producing communities in the Niger Delta region of...This paper analyses the impact of oil and gas pipelines on the environment and settlements from the perspective of environmental justice,using a case study of the oil-producing communities in the Niger Delta region of Nigeria.The paper mobilises theories of environmental justice to support an in-depth empirical analysis of the development and management of oil and gas pipelines in the region.The empirical evidence equally suggests that the lack of community involvement and appropriate recognition of some groups of stakeholders in the management of the oil and gas pipeline project is strongly related to the incidence of pipeline impacts on the communities[1].The paper advocates a new approach,based on the core principles of environmental justice that promotes inclusion of the necessary stakeholders,including the physical planners,and would incorporate local knowledge and experience into the environmental management of the region in a way to protect the environment and people from the impacts of the pipeline[2].展开更多
Sound speed is essential for leakage detection in liquid pipelines when using acoustic methods,which can be significantly influenced by gas bubbles generated from leakage.The propagation characteristics and mechanism ...Sound speed is essential for leakage detection in liquid pipelines when using acoustic methods,which can be significantly influenced by gas bubbles generated from leakage.The propagation characteristics and mechanism of acoustic waves in horizontal liquid pipelines containing gas bubbles are studied in detail in the present paper.The effect of sound wave frequency,bubble size and bubble distribution pattern on sound speed is studied through numerical simulations.The results show that the acoustic wave generated by leakage of liquid pipelines containing gas bubbles is a multi-frequency signal,and the energy of the signal is mainly concentrated within 200 Hz.In the low-frequency range,the propagation of sound waves has almost no dispersion in bubbly liquid.Sound speed at a certain void fraction is not constant,which is related to the bubble size and distribution pattern.The bubble size affects the gasliquid heat transfer equilibrium,during which sound speed is affected.For this reason,a thermodynamic correction factor is proposed,which enables the accuracy of the sound speed calculation to reach98.2%.What's more,sound speed increases non-linearly with the reduction of the bubble distribution space in the pipeline axial direction.This paper establishes a theoretical calculation model of sound speed based on the bubble distribution pattern in the pipeline axial direction,which is in good agreement with the numerical calculation results.The results of this paper provide the basis for applying acoustic leak detection technology in liquid pipelines containing gas bubbles.展开更多
A piggyback pipeline is a special configuration of offshore pipelines for offshore oil and gas exploration and is characterized by the coupling of a large-diameter pipe with a small-diameter pipe. This study conducts ...A piggyback pipeline is a special configuration of offshore pipelines for offshore oil and gas exploration and is characterized by the coupling of a large-diameter pipe with a small-diameter pipe. This study conducts a numerical investigation of the transverse VIV characteristics of a piggyback pipeline at low Reynolds numbers, as the vortex shedding modes and vibration characteristics can be accurately represented under laminar flow conditions with minimal computational expense. The effects of influential factors, such as the mass ratio, position angle of the small pipe relative to the main pipe, and Reynolds number, on the VIV amplitude, frequency, vibration center, and mean lift coefficient are specifically examined. The results indicate that the mass ratio has a limited effect on the maximum VIV amplitude. However, as the mass ratio decreases, the lock-in region expands, and the vibration center of the piggyback pipeline deviates further from its original position. The VIV amplitude is minimized, and the lock-in region is the narrowest at a position angle of 45°, whereas the vibration center reaches its maximum displacement at a position angle of 135°. As the Reynolds number increases, the VIV amplitude slightly increases, accompanied by convergence of the vibration center toward its initial position. The mean lift coefficient and wake vortices are also analyzed to establish a connection with the vibration characteristics of the piggyback pipeline. The optimal configuration of the piggyback pipeline is also proposed on the basis of the present numerical results.展开更多
This work presents a study on the use of cathodic protection as a measure against corrosion in pipelines.The cathodic protection,compliant with the API 5L standard,is implemented here by applying an impressed current,...This work presents a study on the use of cathodic protection as a measure against corrosion in pipelines.The cathodic protection,compliant with the API 5L standard,is implemented here by applying an impressed current,while carefully considering several essential variables,such as soil characteristics,the type and color of the pipeline material,as well as the placement and size of the anode.Therefore,it is crucial to optimize the location and values of anodic overflows or ground resistances to ensure a uniform distribution of potential across the entire structure.In this method,impressed current protection uses an auxiliary anode and an external direct current source to induce a current through the electrolyte and the pipeline,thus countering the resistance of the steel.This approach is advantageous as it allows for the adjustment of electrical characteristics,particularly current levels,to meet specific needs.The factors essential to the effectiveness of cathodic protection systems,which optimize the distribution of protection potential across the structure,largely depend on the precise management of ground resistances during anodic discharge,particularly the attenuation coefficient(α).These factors were studied,and the results obtained were presented and discussed based on their influence.展开更多
Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crac...Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire wrapping.The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied.The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum value.The analysis of the influence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire broke.The increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the influence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline cross-section.The analysis of the temperature effect on the pipeline material,within a range from-40℃to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length decreased.Within such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline significantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of prestressing.This work integrated the existing methods for crack localization along steel gas pipelines.展开更多
A numerical simulation analysis is conducted to examine the unsteady hydrodynamic characteristics of vortex-induced vibration(VIV)and the suppression effect of helical strakes on VIV in subsea pipelines.The analysis u...A numerical simulation analysis is conducted to examine the unsteady hydrodynamic characteristics of vortex-induced vibration(VIV)and the suppression effect of helical strakes on VIV in subsea pipelines.The analysis uses the standard k−εturbulence model for 4.5-and 12.75-inch pipes,and its accuracy is verified by comparing the results with large-scale hydrodynamic experiments.These experiments are designed to evaluate the suppression efficiency of VIV with and without helical strakes,focusing on displacement and drag coefficients under different flow conditions.Furthermore,the influence of important geometric parameters of the helical strakes on drag coefficients and VIV suppression efficiency at different flow rates is compared and discussed.Numerical results agree well with experimental data for drag coefficient and vortex shedding frequency.Spring-pipe self-excited vibration experimental tests reveal that the installation of helical strakes substantially reduces the drag coefficient of VIV within a certain flow rate range,achieving suppression efficiencies exceeding 90%with strake heights larger than 0.15D.Notably,the optimized parameter combination of helical strakes,with a pitch of 15D,a fin height of 0.2D,and 45°edge slopes,maintains high suppression efficiency,thereby exhibiting superior performance.This study provides a valuable reference for the design and application of helical strakes and VIV suppression in subsea engineering.展开更多
Strong surface impact will produce strong vibration,which will pose a threat to the safety of nearby buried pipelines and other important lifeline projects.Based on the verified numerical method,a comprehensive numeri...Strong surface impact will produce strong vibration,which will pose a threat to the safety of nearby buried pipelines and other important lifeline projects.Based on the verified numerical method,a comprehensive numerical parameter analysis is conducted on the key influencing factors of the vibration isolation hole(VIH),which include hole diameter,hole net spacing,hole depth,hole number,hole arrangement,and soil parameters.The results indicate that a smaller ratio of net spacing to hole diameter,the deeper the hole,the multi-row hole,the hole adoption of staggered arrangements,and better site soil conditions can enhance the efficiency of the VIH barrier.The average maximum vibration reduction efficiency within the vibration isolation area can reach 42.2%.The vibration safety of adjacent oil pipelines during a dynamic compaction projection was evaluated according to existing standards,and the measurement of the VIH was recommended to reduce excessive vibration.The single-row vibration isolation scheme and three-row staggered arrangement with the same hole parameters are suggested according to different cases.The research findings can serve as a reference for the vibration safety analysis,assessment,and control of adjacent underground facilities under the influence of strong surface impact loads.展开更多
The relative stiffness between underground structures and surrounding soil may significantly influence the dynamic response of such structures.In this study,two underground pipelines were fabricated using rubber joint...The relative stiffness between underground structures and surrounding soil may significantly influence the dynamic response of such structures.In this study,two underground pipelines were fabricated using rubber joints with varying stiffness,and the corresponding dynamic response was evaluated.Model soils were prepared based on similarity ratios.Next,reduced-scale shaking table tests were conducted to investigate the impact of circular underground structures with varying stiffness joints on the amplification of ground acceleration,dynamic response,and deformation patterns of the underground pipelines.The comparative analysis showed that structures with lower stiffness exert less constraint on the surrounding soil,resulting in a higher amplification factor of ground acceleration.The seismic response of less stiff structures is generally 1.1 to 1.3 times the response of the stiffer structures.Therefore,the seismic response of the variable stiffness pipeline exhibits pronounced characteristics.Rubber joints effectively reduce the seismic response of underground structures,demonstrating favorable isolation effects.Consequently,relative stiffness plays a crucial role in the seismic design of underground structures,and the use of rubber materials in underground structures is advantageous.展开更多
Corrosion poses a major threat to the safety of transportation pipelines.Therefore,it is crucial to have an in-depth understanding of corrosion mechanisms in pipeline steels for the effective management of pipeline in...Corrosion poses a major threat to the safety of transportation pipelines.Therefore,it is crucial to have an in-depth understanding of corrosion mechanisms in pipeline steels for the effective management of pipeline integrity.Conducting research on corrosion mechanisms relies on the use of efficient and reliable corrosion monitoring and analysis techniques.The advancements in corrosion monitoring techniques specifically designed for the localized corrosion monitoring were aimed to be introduced,and a comprehensive overview of recent progress in understanding the localized corrosion mechanisms in pipeline steels was provided.Based on the different corrosive environments encountered,the localized corrosion issues inside pipelines are classified into two categories:localized corrosion primarily influenced by electrochemical processes and localized corrosion controlled by both electrochemical and mechanical factors.Additionally,a thorough analysis of the synergistic effects between micro-cell and macro-cell currents,as well as the interplay of mechanics and electrochemistry is presented.Finally,recommendations for future research on the mechanisms of internal localized corrosion in pipelines are provided.展开更多
Vibration of flexible pipelines in the marine environment affects the flow characteristics of the transported materials inside the pipelines,which is related to transportation efficiency and energy consumption,thereby...Vibration of flexible pipelines in the marine environment affects the flow characteristics of the transported materials inside the pipelines,which is related to transportation efficiency and energy consumption,thereby necessitating further investigation.In this study,the flow characteristics of particle-liquid two-phase flow transported upward in flexible pipelines are investigated based on the computational fluid dynamics-discrete element method(CFD-DEM).Typical forms of vibration including standing wave vibration and traveling wave vibration are employed and compared with a stationary pipeline.Results reveal that particles in the upward-traveling-wave vibrating pipeline still mainly distribute in the middle of the pipeline,while particles in the standing-wave vibrating pipeline exhibit periodic transverse aggregation near the pipe wall,and the fluctuations of particle concentration and particle z-direction velocity over time in each cross section of the pipeline are more obviously suppressed.When the propagation direction of the vibration wave changes from the same direction as the particle transport to static and then to the opposite direction,its hindering and regulating effect on the particles gradually increases,and the pipeline pressure drop gradually decreases.展开更多
This research extends ongoing efforts to develop methods for reinforcing damaged main gas pipelines to prevent catastrophic failure.This study establishes the use of scaled-down experimental models for assessing the d...This research extends ongoing efforts to develop methods for reinforcing damaged main gas pipelines to prevent catastrophic failure.This study establishes the use of scaled-down experimental models for assessing the dynamic strength of damaged pipeline sections reinforced with wire wrapping or composite sleeves.A generalized dynamic model is introduced for numerical simulation to evaluate the effectiveness of reinforcement techniques.The model incorporates the elastoplastic behavior of pipe and wire materials,the influence of temperature on mechanical properties,the contact interaction between the pipe and the reinforcement components(including pretensioning),and local material failure under transient internal pressure.Based on these parameters,a finite element model was developed using ANSYS 19.2 to enable parametric studies.The accuracy of the proposed model was verified by comparing the simulation results with the experimental findings.Pipeline section samples containing non-penetrating longitudinal crackswere subjected to comparative analyses and transient pressure until critical failure.The unreinforced and steel wire-wrapped sections were investigated.The results confirm the feasibility of applying the computational model to study the dynamic strength of reinforced damaged pipe sections.Furthermore,pipelines with longitudinal cracks reinforced using circular composite overlays with orthotropic mechanical properties were examined,and recommendations are provided for selecting the geometric parameters of such overlays.展开更多
With the development of offshore oil and gas resources,hydrates pose a significant challenge to flow assurance.Hydrates can form,accumulate,and settle in pipelines,causing blockages,reducing transport capacity,and lea...With the development of offshore oil and gas resources,hydrates pose a significant challenge to flow assurance.Hydrates can form,accumulate,and settle in pipelines,causing blockages,reducing transport capacity,and leading to significant economic losses and fatalities.As oil and gas exploration moves deeper into the ocean,the issue of hydrate blockages has become more severe.It is essential to take adequate measures promptly to mitigate the hazards of hydrate blockages after they form.However,a prerequisite for effective mitigation is accurately detecting the location and amount of hydrate formation.This article summarizes the temperature–pressure,acoustic,electrical,instrumental–response,and flow characteristics of hydrate formation and blocking under various conditions.It also analyzes the principles,limitations,and applicability of various blockage detection methods,including acoustic,transient,and fiber-optic-based methods.Finally,it lists the results of field experiments and commercially used products.Given their advantages of accuracy and a wide detection range,acoustic pulse reflectometry and transient-based methods are considered effective for detecting hydrate blockages in future underwater pipelines.Using strict backpressure warnings combined with accurate detection via acoustic pulse reflectometry or transient-based methods,efficient and timely diagnosis of hydrate blockages can be achieved.The use of a hydrate model combined with fiber optics could prove to be an effective method for detecting blockages in newly laid pipelines in the future.展开更多
In recent years,scholars around the world have shown increasing interest in elastic support structures,leading to significant progress in dynamic modeling techniques for pipeline systems.Although multiple analytical a...In recent years,scholars around the world have shown increasing interest in elastic support structures,leading to significant progress in dynamic modeling techniques for pipeline systems.Although multiple analytical approaches exist,engineers increasingly prioritize computationally efficient,precise low-order models for practical implementation.In order to address this need,this study develops an innovative nonlinear dynamic formulation for pipelines accounting for both foundation and boundary nonlinearities.The proposed solution methodology initiates with global mode extraction using the global mode technique,followed by a detailed implementation procedure.Model validation is conducted through a cantilever pipeline case study featuring nonlinear support conditions,where strong agreement between the proposed model's predictions and finiteelement benchmark solutions demonstrates its reliability.Subsequently,a comprehensive parametric study investigates the combined effects of foundation stiffness,boundary constraints,excitation intensity,and nonlinear interaction terms on the vibrational response of the cantilever pipe.This systematic approach yields critical insights for practical engineering designs and applications.展开更多
This study presents a comprehensive investigation of residual strength in corroded pipelines within the Yichang-Qianjiang section of the Sichuan-East Gas Pipeline,integrating advanced numerical simulation with experim...This study presents a comprehensive investigation of residual strength in corroded pipelines within the Yichang-Qianjiang section of the Sichuan-East Gas Pipeline,integrating advanced numerical simulation with experimental validation.The research methodology incorporates three distinct parameter grouping approaches:a random group based on statistical analysis of 389 actual corrosion defects detected during 2023 MFL inspection,a deviation group representing historically documented failure scenarios,and a structural group examining systematic parameter variations.Using ABAQUS finite element software,we developed a dynamic implicit analysis model incorporating geometric nonlinearity and validated it through 1:12.7 scaled model testing,achieving prediction deviations consistently within 5%for standard cases.Our analysis revealed distinct failure mechanisms between large and small defects,with large defects exhibiting stress concentration at circumferential edges and small defects concentrating stress centrally.Quantitative analysis identified defect depth as themost significant factor,with every 1mmincrease reducing strength by 0.054MPa,while defect length showed moderate influence at 0.0018MPa reduction per mm.Comparative analysis demonstrated that circumferential defects exhibited 15%higher burst failure pressure compared to axial defects,though this advantage diminished significantly at depths exceeding 40%wall thickness.These findings,validated through experimental testing with deviations within 5%,provide valuable insights for pipeline integrity management,particularly emphasizing the importance of defect depth monitoring and the need for orientation-specific assessment criteria in corrosion evaluation protocols.展开更多
Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect...Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect detection in urban underground pipelines,this study developed an improved defect detection method for urban underground pipelines based on fully convolutional one-stage object detector(FCOS),called spatial pyramid pooling-fast(SPPF)feature fusion and dual detection heads based on FCOS(SDH-FCOS)model.This study improved the feature fusion component of the model network based on FCOS,introduced an SPPF network structure behind the last output feature layer of the backbone network,fused the local and global features,added a top-down path to accelerate the circulation of shallowinformation,and enriched the semantic information acquired by shallow features.The ability of the model to detect objects with multiple morphologies was strengthened by introducing dual detection heads.The experimental results using an open dataset of underground pipes show that the proposed SDH-FCOS model can recognize underground pipe defects more accurately;the average accuracy was improved by 2.7% compared with the original FCOS model,reducing the leakage rate to a large extent and achieving real-time detection.Also,our model achieved a good trade-off between accuracy and speed compared with other mainstream methods.This proved the effectiveness of the proposed model.展开更多
Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil aroun...Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil around submarine pipelines is prone to local scour,severely affecting their operational safety.With the Yellow River Delta as the research area and based on the renormalized group(RNG)k-εturbulence model and Stokes fifth-order wave theory,this study solves the Navier-Stokes(N-S)equation using the finite difference method.The volume of fluid(VOF)method is used to describe the fluid-free surface,and a threedimensional numerical model of currents and waves-submarine pipeline-silty sandy seabed is established.The rationality of the numerical model is verified using a self-built waveflow flume.On this basis,in this study,the local scour development and characteristics of submarine pipelines in the Yellow River Delta silty sandy seabed in the prototype environment are explored and the influence of the presence of pipelines on hydrodynamic features such as surrounding flow field,shear stress,and turbulence intensity is analyzed.The results indicate that(1)local scour around submarine pipelines can be divided into three stages:rapid scour,slow scour,and stable scour.The maximum scour depth occurs directly below the pipeline,and the shape of the scour pits is asymmetric.(2)As the water depth decreases and the pipeline suspension height increases,the scour becomes more intense.(3)When currents go through a pipeline,a clear stagnation point is formed in front of the pipeline,and the flow velocity is positively correlated with the depth of scour.This study can provide a valuable reference for the protection of submarine pipelines in this area.展开更多
Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being dis...Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.展开更多
基金supported by the National Key Research and Development Program of China(No.2022YFB4003400)the Key Research and Development Program of Zhejiang Province of China(No.2023C01225)the State Key Laboratory of Clean Energy Utilization,China。
文摘Widespread use of green hydrogen is a critical route to achieving a carbon-neutral society,but it cannot be accomplished without extensive hydrogen distribution.Hydrogen pipelines are the most energy-efficient approach to transporting hydrogen in areas with high,long-term demand for hydrogen.A well-known fact is that the properties of hydrogen differ from those of natural gas,which leads to significant variations in the pipeline transportation process.In addition,hydrogen can degrade the mechanical properties of steels,thereby affecting pipeline integrity.This situation has led to two inevitable key challenges in the current development of hydrogen-pipeline technology:economic viability and safety.Based on a review of the current state of hydrogen pipelines,including material compatibility with hydrogen,design methods,process operations,safety monitoring,and standards,this paper highlights key knowledge gaps in gaseous hydrogen pipelines.These gaps include the utilisation of high-strength materials for hydrogen pipelines,design of high-quality hydrogen pipelines,determination of hydrogen velocity,and repurposing of existing natural-gas pipelines.This review aims to identify the challenges in current hydrogen pipelines development and provide valuable suggestions for future research.
基金financial support by the National Natural Science Foundation of China(Nos.52471293 and 12372270)the National Youth Science Foundation of China(Nos.52101322 and 52108375)+3 种基金the Program for Intergovernmental International S&T Cooperation Projects of Shanghai Municipality,China(Nos.24510711100 and 22160710200)The Oceanic Interdisciplinary Program of Shanghai Jiao Tong University(No.SL2022PT101)is also gratefully acknowledgedfunded by the Open Fund of the State Key Laboratory of Coastal and Offshore Engineering of Dalian University of Technology(No.LP2415)the National Key R&D Program of China(No.2023YFC2811600)is gratefully acknowledged.
文摘Deep-sea mineral resource transportation predominantly utilizes hydraulic pipeline methodology.Environmental factors induce vibrations in flexible pipelines,thereby affecting the internal flow characteristics.Therefore,real-time monitoring of solid–liquid two-phase flow in pipelines is crucial for system maintenance.This study develops an autoencoder-based deep learning framework to reconstruct three-dimensional solid–liquid two-phase flow within flexible vibrating pipelines utilizing sparse wall information from sensors.Within this framework,separate X-model and F-model with distinct hidden-layer structures are established to reconstruct the coordinates and flow field information on the computational domain grid of the pipeline under traveling wave vibration.Following hyperparameter optimization,the models achieved high reconstruction accuracy,demonstrating R^(2)values of 0.990 and 0.945,respectively.The models’robustness is evaluated across three aspects:vibration parameters,physical fields,and vibration modes,demonstrating good reconstruction performance.Results concerning sensors show that 20 sensors(0.06%of total grids)achieve a balance between accuracy and cost,with superior accuracy obtained when arranged along the full length of the pipe compared to a dense arrangement at the front end.The models exhibited a signal-to-noise ratio tolerance of approximately 27 dB,with reconstruction accuracy being more affected by sensor failures at both ends of the pipeline.
基金supported by the National Natural Science Foundation of China(Grant No.52271281)Shandong Provincial High-Level Talent Workstation,Shandong Province Natural Science Foundation Youth project(Grant No.ZR2023QE190)an Open funding project from the Key Laboratory of Ministry of Education for Coastal Disaster and Protection,Hohai University,China(Grant No.202206).
文摘This paper experimentally investigates the wave pressure and pore pressure within a sandy seabed around two pipelines under the action of random waves(currents).The experiments revealed that when the random wave plus current cases are compared with the random wave-only case,the forward current promotes wave propagation,whereas the reversed backward current inhibits wave propagation.Furthermore,the wave pressure on the downstream pipeline decreases as the relative spacing ratio increases and increases as the diameter increases.However,alterations in the relative spacing ratio or dimensions of the downstream pipeline exert a negligible influence on the wave pressure of the upstream pipeline.Moreover,the relative spacing ratio between the pipelines and the dimensions of the pipelines considerably influence the pore pressure in the sand bed.When the relative spacing ratio remains constant,increasing the downstream pipeline diameter will increase the pore-water pressure of the soil below the downstream pipeline.
文摘This paper analyses the impact of oil and gas pipelines on the environment and settlements from the perspective of environmental justice,using a case study of the oil-producing communities in the Niger Delta region of Nigeria.The paper mobilises theories of environmental justice to support an in-depth empirical analysis of the development and management of oil and gas pipelines in the region.The empirical evidence equally suggests that the lack of community involvement and appropriate recognition of some groups of stakeholders in the management of the oil and gas pipeline project is strongly related to the incidence of pipeline impacts on the communities[1].The paper advocates a new approach,based on the core principles of environmental justice that promotes inclusion of the necessary stakeholders,including the physical planners,and would incorporate local knowledge and experience into the environmental management of the region in a way to protect the environment and people from the impacts of the pipeline[2].
基金supported by the National Natural Science Foundation of China[grant number 52274066]。
文摘Sound speed is essential for leakage detection in liquid pipelines when using acoustic methods,which can be significantly influenced by gas bubbles generated from leakage.The propagation characteristics and mechanism of acoustic waves in horizontal liquid pipelines containing gas bubbles are studied in detail in the present paper.The effect of sound wave frequency,bubble size and bubble distribution pattern on sound speed is studied through numerical simulations.The results show that the acoustic wave generated by leakage of liquid pipelines containing gas bubbles is a multi-frequency signal,and the energy of the signal is mainly concentrated within 200 Hz.In the low-frequency range,the propagation of sound waves has almost no dispersion in bubbly liquid.Sound speed at a certain void fraction is not constant,which is related to the bubble size and distribution pattern.The bubble size affects the gasliquid heat transfer equilibrium,during which sound speed is affected.For this reason,a thermodynamic correction factor is proposed,which enables the accuracy of the sound speed calculation to reach98.2%.What's more,sound speed increases non-linearly with the reduction of the bubble distribution space in the pipeline axial direction.This paper establishes a theoretical calculation model of sound speed based on the bubble distribution pattern in the pipeline axial direction,which is in good agreement with the numerical calculation results.The results of this paper provide the basis for applying acoustic leak detection technology in liquid pipelines containing gas bubbles.
基金financially supported by the National Natural Science Foundation of China (Grant Nos. 52371289 and 51979192)。
文摘A piggyback pipeline is a special configuration of offshore pipelines for offshore oil and gas exploration and is characterized by the coupling of a large-diameter pipe with a small-diameter pipe. This study conducts a numerical investigation of the transverse VIV characteristics of a piggyback pipeline at low Reynolds numbers, as the vortex shedding modes and vibration characteristics can be accurately represented under laminar flow conditions with minimal computational expense. The effects of influential factors, such as the mass ratio, position angle of the small pipe relative to the main pipe, and Reynolds number, on the VIV amplitude, frequency, vibration center, and mean lift coefficient are specifically examined. The results indicate that the mass ratio has a limited effect on the maximum VIV amplitude. However, as the mass ratio decreases, the lock-in region expands, and the vibration center of the piggyback pipeline deviates further from its original position. The VIV amplitude is minimized, and the lock-in region is the narrowest at a position angle of 45°, whereas the vibration center reaches its maximum displacement at a position angle of 135°. As the Reynolds number increases, the VIV amplitude slightly increases, accompanied by convergence of the vibration center toward its initial position. The mean lift coefficient and wake vortices are also analyzed to establish a connection with the vibration characteristics of the piggyback pipeline. The optimal configuration of the piggyback pipeline is also proposed on the basis of the present numerical results.
文摘This work presents a study on the use of cathodic protection as a measure against corrosion in pipelines.The cathodic protection,compliant with the API 5L standard,is implemented here by applying an impressed current,while carefully considering several essential variables,such as soil characteristics,the type and color of the pipeline material,as well as the placement and size of the anode.Therefore,it is crucial to optimize the location and values of anodic overflows or ground resistances to ensure a uniform distribution of potential across the entire structure.In this method,impressed current protection uses an auxiliary anode and an external direct current source to induce a current through the electrolyte and the pipeline,thus countering the resistance of the steel.This approach is advantageous as it allows for the adjustment of electrical characteristics,particularly current levels,to meet specific needs.The factors essential to the effectiveness of cathodic protection systems,which optimize the distribution of protection potential across the structure,largely depend on the precise management of ground resistances during anodic discharge,particularly the attenuation coefficient(α).These factors were studied,and the results obtained were presented and discussed based on their influence.
基金funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan(Grant No.AP19680589).
文摘Using the software ANSYS-19.2/Explicit Dynamics,this study performedfinite-element modeling of the large-diameter steel pipeline cross-section for the Beineu-Bozoy-Shymkent gas pipeline with a non-through straight crack,strengthened by steel wire wrapping.The effects of the thread tensile force of the steel winding in the form of single rings at the crack edges and the wires with different winding diameters and pitches were also studied.The results showed that the strengthening was preferably executed at a minimum value of the thread tensile force,which was 6.4%more effective than that at its maximum value.The analysis of the influence of the winding dia-meters showed that the equivalent stresses increased by 32%from the beginning of the crack growth until the wire broke.The increment in winding diameter decelerated the disclosure of the edge crack and reduced its length by 8.2%.The analysis of the influence of the winding pitch showed that decreasing the distance between the winding turns also led to a 33.6%reduction in the length of the straight crack and a 7.9%reduction in the maximum stres-ses on the strengthened pipeline cross-section.The analysis of the temperature effect on the pipeline material,within a range from-40℃to+50℃,resulted in a crack length change of up to 5.8%.As the temperature dropped,the crack length decreased.Within such a temperature range,the maximum stresses were observed along the cen-tral area of the crack,which were equal to 413 MPa at+50℃and 440 MPa at-40℃.The results also showed that the presence of the steel winding in the pipeline significantly reduced the length of crack propagation up to 8.4 times,depending on the temperature effect and design parameters of prestressing.This work integrated the existing methods for crack localization along steel gas pipelines.
基金Supported by the National Natural Science Foundation of China (Grant No. 52222111)the National Science and Technology Major Project of China “Key Technologies and Equipment for Deepwater Dry Oil and Gas Production and Processing Platforms”(No. 2024ZD1403300)+1 种基金Subproject 5 “Research on Safety Risk Assessment Technology System for Deepwater Dry Oil and Gas Production and Processing Platforms”(No. 2024ZD1403305)the China Scholarship Council (202306440019)。
文摘A numerical simulation analysis is conducted to examine the unsteady hydrodynamic characteristics of vortex-induced vibration(VIV)and the suppression effect of helical strakes on VIV in subsea pipelines.The analysis uses the standard k−εturbulence model for 4.5-and 12.75-inch pipes,and its accuracy is verified by comparing the results with large-scale hydrodynamic experiments.These experiments are designed to evaluate the suppression efficiency of VIV with and without helical strakes,focusing on displacement and drag coefficients under different flow conditions.Furthermore,the influence of important geometric parameters of the helical strakes on drag coefficients and VIV suppression efficiency at different flow rates is compared and discussed.Numerical results agree well with experimental data for drag coefficient and vortex shedding frequency.Spring-pipe self-excited vibration experimental tests reveal that the installation of helical strakes substantially reduces the drag coefficient of VIV within a certain flow rate range,achieving suppression efficiencies exceeding 90%with strake heights larger than 0.15D.Notably,the optimized parameter combination of helical strakes,with a pitch of 15D,a fin height of 0.2D,and 45°edge slopes,maintains high suppression efficiency,thereby exhibiting superior performance.This study provides a valuable reference for the design and application of helical strakes and VIV suppression in subsea engineering.
基金National Natural Science Foundation of China under Grant Nos.52078386 and 52308496SINOMACH Youth Science and Technology Fund under Grant No.QNJJ-PY-2022-02+2 种基金Young Elite Scientists Sponsorship Program under Grant No.BYESS2023432Fund of State Key Laboratory of Precision Blasting and Hubei Key Laboratory of Blasting Engineering,Jianghan University under Grant No.PBSKL2023A9Fund of China Railway Construction Group Co.,Ltd.under Grant No.LX19-04b。
文摘Strong surface impact will produce strong vibration,which will pose a threat to the safety of nearby buried pipelines and other important lifeline projects.Based on the verified numerical method,a comprehensive numerical parameter analysis is conducted on the key influencing factors of the vibration isolation hole(VIH),which include hole diameter,hole net spacing,hole depth,hole number,hole arrangement,and soil parameters.The results indicate that a smaller ratio of net spacing to hole diameter,the deeper the hole,the multi-row hole,the hole adoption of staggered arrangements,and better site soil conditions can enhance the efficiency of the VIH barrier.The average maximum vibration reduction efficiency within the vibration isolation area can reach 42.2%.The vibration safety of adjacent oil pipelines during a dynamic compaction projection was evaluated according to existing standards,and the measurement of the VIH was recommended to reduce excessive vibration.The single-row vibration isolation scheme and three-row staggered arrangement with the same hole parameters are suggested according to different cases.The research findings can serve as a reference for the vibration safety analysis,assessment,and control of adjacent underground facilities under the influence of strong surface impact loads.
基金Key International(Regional)Joint Research Project under Grant No.52020105002National Natural Science Foundation of China under Grant No.51991393。
文摘The relative stiffness between underground structures and surrounding soil may significantly influence the dynamic response of such structures.In this study,two underground pipelines were fabricated using rubber joints with varying stiffness,and the corresponding dynamic response was evaluated.Model soils were prepared based on similarity ratios.Next,reduced-scale shaking table tests were conducted to investigate the impact of circular underground structures with varying stiffness joints on the amplification of ground acceleration,dynamic response,and deformation patterns of the underground pipelines.The comparative analysis showed that structures with lower stiffness exert less constraint on the surrounding soil,resulting in a higher amplification factor of ground acceleration.The seismic response of less stiff structures is generally 1.1 to 1.3 times the response of the stiffer structures.Therefore,the seismic response of the variable stiffness pipeline exhibits pronounced characteristics.Rubber joints effectively reduce the seismic response of underground structures,demonstrating favorable isolation effects.Consequently,relative stiffness plays a crucial role in the seismic design of underground structures,and the use of rubber materials in underground structures is advantageous.
基金sponsored by the National Key R&D Program of China(No.2022YFC2806200)the National Natural Science Foundation of China(No.52001055)the Open Foundation of State Key Laboratory of Structural Analysis for Industrial Equipment(GZ22118).
文摘Corrosion poses a major threat to the safety of transportation pipelines.Therefore,it is crucial to have an in-depth understanding of corrosion mechanisms in pipeline steels for the effective management of pipeline integrity.Conducting research on corrosion mechanisms relies on the use of efficient and reliable corrosion monitoring and analysis techniques.The advancements in corrosion monitoring techniques specifically designed for the localized corrosion monitoring were aimed to be introduced,and a comprehensive overview of recent progress in understanding the localized corrosion mechanisms in pipeline steels was provided.Based on the different corrosive environments encountered,the localized corrosion issues inside pipelines are classified into two categories:localized corrosion primarily influenced by electrochemical processes and localized corrosion controlled by both electrochemical and mechanical factors.Additionally,a thorough analysis of the synergistic effects between micro-cell and macro-cell currents,as well as the interplay of mechanics and electrochemistry is presented.Finally,recommendations for future research on the mechanisms of internal localized corrosion in pipelines are provided.
基金supported by the National Natural Science Foundation of China(Grant Nos.52471293,12372270)the National Youth Science Foundation of China(Grant Nos.52101322,52108375)+3 种基金the National Key Research and Development Program of China(Grant No.2023YFC2811600)supported by the Program for Intergovernmental International S&T Cooperation Projects of Shanghai Municipality(Grant No.22160710200)the Oceanic Interdisciplinary Program of Shanghai Jiao Tong University(Grant No.SL2022PT101)the Open Fund of the State Key Laboratory of Coastal and Offshore Engineering,Dalian University of Technology(Grant No.LP2415).
文摘Vibration of flexible pipelines in the marine environment affects the flow characteristics of the transported materials inside the pipelines,which is related to transportation efficiency and energy consumption,thereby necessitating further investigation.In this study,the flow characteristics of particle-liquid two-phase flow transported upward in flexible pipelines are investigated based on the computational fluid dynamics-discrete element method(CFD-DEM).Typical forms of vibration including standing wave vibration and traveling wave vibration are employed and compared with a stationary pipeline.Results reveal that particles in the upward-traveling-wave vibrating pipeline still mainly distribute in the middle of the pipeline,while particles in the standing-wave vibrating pipeline exhibit periodic transverse aggregation near the pipe wall,and the fluctuations of particle concentration and particle z-direction velocity over time in each cross section of the pipeline are more obviously suppressed.When the propagation direction of the vibration wave changes from the same direction as the particle transport to static and then to the opposite direction,its hindering and regulating effect on the particles gradually increases,and the pipeline pressure drop gradually decreases.
基金funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan(Grant No.AP19680589).
文摘This research extends ongoing efforts to develop methods for reinforcing damaged main gas pipelines to prevent catastrophic failure.This study establishes the use of scaled-down experimental models for assessing the dynamic strength of damaged pipeline sections reinforced with wire wrapping or composite sleeves.A generalized dynamic model is introduced for numerical simulation to evaluate the effectiveness of reinforcement techniques.The model incorporates the elastoplastic behavior of pipe and wire materials,the influence of temperature on mechanical properties,the contact interaction between the pipe and the reinforcement components(including pretensioning),and local material failure under transient internal pressure.Based on these parameters,a finite element model was developed using ANSYS 19.2 to enable parametric studies.The accuracy of the proposed model was verified by comparing the simulation results with the experimental findings.Pipeline section samples containing non-penetrating longitudinal crackswere subjected to comparative analyses and transient pressure until critical failure.The unreinforced and steel wire-wrapped sections were investigated.The results confirm the feasibility of applying the computational model to study the dynamic strength of reinforced damaged pipe sections.Furthermore,pipelines with longitudinal cracks reinforced using circular composite overlays with orthotropic mechanical properties were examined,and recommendations are provided for selecting the geometric parameters of such overlays.
基金supported by the National Natural Science Foundation of China(52476058,U21B2065,52006024,and 52306188)the National Key Research and Development(2022YFC2806200).
文摘With the development of offshore oil and gas resources,hydrates pose a significant challenge to flow assurance.Hydrates can form,accumulate,and settle in pipelines,causing blockages,reducing transport capacity,and leading to significant economic losses and fatalities.As oil and gas exploration moves deeper into the ocean,the issue of hydrate blockages has become more severe.It is essential to take adequate measures promptly to mitigate the hazards of hydrate blockages after they form.However,a prerequisite for effective mitigation is accurately detecting the location and amount of hydrate formation.This article summarizes the temperature–pressure,acoustic,electrical,instrumental–response,and flow characteristics of hydrate formation and blocking under various conditions.It also analyzes the principles,limitations,and applicability of various blockage detection methods,including acoustic,transient,and fiber-optic-based methods.Finally,it lists the results of field experiments and commercially used products.Given their advantages of accuracy and a wide detection range,acoustic pulse reflectometry and transient-based methods are considered effective for detecting hydrate blockages in future underwater pipelines.Using strict backpressure warnings combined with accurate detection via acoustic pulse reflectometry or transient-based methods,efficient and timely diagnosis of hydrate blockages can be achieved.The use of a hydrate model combined with fiber optics could prove to be an effective method for detecting blockages in newly laid pipelines in the future.
基金supported by the National Natural Science Foundation of China(Nos.52401342 and 12572025)the Fundamental Research Funds for the Central Universities of China(Nos.D5000240076 and G2025KY05171)+1 种基金the Natural Science Basic Research Program of Shaanxi Province(No.2025JCYBMS-026)the Basic Research Programs of Taicang(No.TC2024JC36)。
文摘In recent years,scholars around the world have shown increasing interest in elastic support structures,leading to significant progress in dynamic modeling techniques for pipeline systems.Although multiple analytical approaches exist,engineers increasingly prioritize computationally efficient,precise low-order models for practical implementation.In order to address this need,this study develops an innovative nonlinear dynamic formulation for pipelines accounting for both foundation and boundary nonlinearities.The proposed solution methodology initiates with global mode extraction using the global mode technique,followed by a detailed implementation procedure.Model validation is conducted through a cantilever pipeline case study featuring nonlinear support conditions,where strong agreement between the proposed model's predictions and finiteelement benchmark solutions demonstrates its reliability.Subsequently,a comprehensive parametric study investigates the combined effects of foundation stiffness,boundary constraints,excitation intensity,and nonlinear interaction terms on the vibrational response of the cantilever pipe.This systematic approach yields critical insights for practical engineering designs and applications.
文摘This study presents a comprehensive investigation of residual strength in corroded pipelines within the Yichang-Qianjiang section of the Sichuan-East Gas Pipeline,integrating advanced numerical simulation with experimental validation.The research methodology incorporates three distinct parameter grouping approaches:a random group based on statistical analysis of 389 actual corrosion defects detected during 2023 MFL inspection,a deviation group representing historically documented failure scenarios,and a structural group examining systematic parameter variations.Using ABAQUS finite element software,we developed a dynamic implicit analysis model incorporating geometric nonlinearity and validated it through 1:12.7 scaled model testing,achieving prediction deviations consistently within 5%for standard cases.Our analysis revealed distinct failure mechanisms between large and small defects,with large defects exhibiting stress concentration at circumferential edges and small defects concentrating stress centrally.Quantitative analysis identified defect depth as themost significant factor,with every 1mmincrease reducing strength by 0.054MPa,while defect length showed moderate influence at 0.0018MPa reduction per mm.Comparative analysis demonstrated that circumferential defects exhibited 15%higher burst failure pressure compared to axial defects,though this advantage diminished significantly at depths exceeding 40%wall thickness.These findings,validated through experimental testing with deviations within 5%,provide valuable insights for pipeline integrity management,particularly emphasizing the importance of defect depth monitoring and the need for orientation-specific assessment criteria in corrosion evaluation protocols.
基金supported by the National Natural Science Foundation of China under Grant No.61976226the Research and Academic Team of South-CentralMinzu University under Grant No.KTZ20050.
文摘Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect detection in urban underground pipelines,this study developed an improved defect detection method for urban underground pipelines based on fully convolutional one-stage object detector(FCOS),called spatial pyramid pooling-fast(SPPF)feature fusion and dual detection heads based on FCOS(SDH-FCOS)model.This study improved the feature fusion component of the model network based on FCOS,introduced an SPPF network structure behind the last output feature layer of the backbone network,fused the local and global features,added a top-down path to accelerate the circulation of shallowinformation,and enriched the semantic information acquired by shallow features.The ability of the model to detect objects with multiple morphologies was strengthened by introducing dual detection heads.The experimental results using an open dataset of underground pipes show that the proposed SDH-FCOS model can recognize underground pipe defects more accurately;the average accuracy was improved by 2.7% compared with the original FCOS model,reducing the leakage rate to a large extent and achieving real-time detection.Also,our model achieved a good trade-off between accuracy and speed compared with other mainstream methods.This proved the effectiveness of the proposed model.
基金China Postdoctoral Science Foundation,Grant/Award Number:2023M731999National Natural Science Foundation of China,Grant/Award Number:52301326。
文摘Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil around submarine pipelines is prone to local scour,severely affecting their operational safety.With the Yellow River Delta as the research area and based on the renormalized group(RNG)k-εturbulence model and Stokes fifth-order wave theory,this study solves the Navier-Stokes(N-S)equation using the finite difference method.The volume of fluid(VOF)method is used to describe the fluid-free surface,and a threedimensional numerical model of currents and waves-submarine pipeline-silty sandy seabed is established.The rationality of the numerical model is verified using a self-built waveflow flume.On this basis,in this study,the local scour development and characteristics of submarine pipelines in the Yellow River Delta silty sandy seabed in the prototype environment are explored and the influence of the presence of pipelines on hydrodynamic features such as surrounding flow field,shear stress,and turbulence intensity is analyzed.The results indicate that(1)local scour around submarine pipelines can be divided into three stages:rapid scour,slow scour,and stable scour.The maximum scour depth occurs directly below the pipeline,and the shape of the scour pits is asymmetric.(2)As the water depth decreases and the pipeline suspension height increases,the scour becomes more intense.(3)When currents go through a pipeline,a clear stagnation point is formed in front of the pipeline,and the flow velocity is positively correlated with the depth of scour.This study can provide a valuable reference for the protection of submarine pipelines in this area.
基金supported by the National Natural Science Foundation of China(32141003 and 82330110)the CAMS Innovation Fund for Medical Sciences(CIFMS+2 种基金2021-I2M-1-039)the National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32)the Fundamental Research Funds for the Central Universities(2021-PT350-001).
文摘Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.
