The orthogonal time frequency space(OTFS)modulation is a novel modulation scheme that can effectively cope with the high Doppler expansion caused by high mobility.Since it modulates data on delay-Doppler(DD)domain and...The orthogonal time frequency space(OTFS)modulation is a novel modulation scheme that can effectively cope with the high Doppler expansion caused by high mobility.Since it modulates data on delay-Doppler(DD)domain and makes full use of the sparse characteristics of DD domain,it has been widely studied to design efficient channel estimation and signal detection schemes.In this paper,we design a novel superimposed pilot pattern with transition band,which replaces the traditional embedded pilot(EP)guard zero-symbols,and perform a two-stage channel estimation.In the first stage,we fully utilize the dispersion characteristics of OTFS signal in DD domain,and use threshold decision to make coarse channel estimation.In the second stage,we use the results of the coarse estimation for iterative signal detection and accurate channel estimation.During the second stage,we make full use of the sparsity of the channel in DD domain,remodel the received signal into the form of sparse channel vector multiplied by channel coefficient matrix,and introduce Doppler index segmentation factor(DISF)to subdivide the Doppler index to solve the problem of fractional Doppler.Simulations reveal that,the scheme proposed in this paper has higher spectral efficiency compared with traditional EP scheme and lower peak-to-average power ratio(PAPR)compared with traditional superimposed pilot scheme.展开更多
Natural gas methane and hydrates are a chemical compound of water molecules formed under low temperature and high pressure. The decomposition of 1 m^3 of natural gas hydrates can release about 0.8 m^3 of water and 164...Natural gas methane and hydrates are a chemical compound of water molecules formed under low temperature and high pressure. The decomposition of 1 m^3 of natural gas hydrates can release about 0.8 m^3 of water and 164 m3 of natural gas. Thus, natural gas hydrates are characterized by their high-energy density and huge resource potential. It is estimated that the world＇s total natural gas hydrates resource amount is equivalent to twice the total carbon amount of the global proven conventional fuels and can meet the human energy requirement in the future for 1000 years. They are thus the first choice to replace conventional energy of petroleum and coal.展开更多
Recently the pilot moving-bed unit for manufacturing aromatics from methanol and toluene with co-production of low-carbon olefins designed by the Sinopec Engineering Incorporation(SEC)has been put on stream successful...Recently the pilot moving-bed unit for manufacturing aromatics from methanol and toluene with co-production of low-carbon olefins designed by the Sinopec Engineering Incorporation(SEC)has been put on stream successfully.In the course of commissioning,the pilot unit ran smoothly,leading to high conversion rate in the moving-bed reactor,high yield of xylene product,easy lift of catalyst,and good coke burnout results,with all indicators complying with the expected operating requirements.展开更多
Objective： To explore the fundamental theory, methods and data of the quality of life （QOL） of soldiers and its influence factors in the first response army. Methods： Totally 215 soldiers in the first response arm...Objective： To explore the fundamental theory, methods and data of the quality of life （QOL） of soldiers and its influence factors in the first response army. Methods： Totally 215 soldiers in the first response army of a military area in China were inquired by using self-regulating questionnaire and WHOQOL-BREF （Chinese Edition）. Resalts： WHOQOL-BREF had good acceptability, reliability and validity in the first response army. QOL of soldiers in the first response army was middling. The influencing factors of QOL of the soldiers in first army includes self-report health, different areas where the army men come from, different arms of services, whether only child in family. And the difference was statistically significant. Conclusion： WHOQOL-BREF is fit for evaluating the quality of life of soldiers in the first response army. There are differences of the quality of life among the soldiers in the first response army. So we should take appropriate measures to improve the soldiers＇ quality of life.展开更多
Coal dependence and inefficient decentralized heating have significantly increased China’s energy consumption for winter heating,increasing air pollution and exacerbating the greenhouse effect.In 2017,China implement...Coal dependence and inefficient decentralized heating have significantly increased China’s energy consumption for winter heating,increasing air pollution and exacerbating the greenhouse effect.In 2017,China implemented the Pilot Policy on Clean Winter Heating in Northern China,aiming to achieve high central heating coverage and cleaner energy consumption.Studying the effects of this policy can help promote its implementation and serve as a reference for effective adjustment of the contents in the future.However,few studies have investigated this policy and its carbon reduction effects,and most focus on the provincial or city levels.Therefore,this paper considers the policy’s influence on air pollution and carbon emissions at the county level to provide a precise and comprehensive assessment of the policy effects.We use panel data from 1290 counties in 15 provinces in Northern China from 2014 to 2021,applying a multiperiod difference-in-differences model to quantify the impact of the policy on carbon emissions and air quality in the pilot area.We then conduct a series of tests to demonstrate the robustness of the results and analyze the mechanisms of the policy effects from two perspectives,namely,central heating and natural gas use,through a mediating effect model.Finally,we examine the heterogeneity of policy effects between counties based on geographic location and per capita income levels of rural residents through a moderating effect model.The results reveal that the policy significantly reduces air pollution and carbon emissions in the pilot area by increasing the central heating area and natural gas use.Compared with the central and western regions in the north and areas with low-income rural residents,the policy effects in the eastern regions in the north and areas with high-income rural residents are more pronounced.展开更多
The world’s first demonstration device for producing 1,000 tons/year gasoline from carbon dioxide(CO_(2))hydrogenation in Zoucheng Industrial Park,Shandong province,China,completed its trial operation and technology ...The world’s first demonstration device for producing 1,000 tons/year gasoline from carbon dioxide(CO_(2))hydrogenation in Zoucheng Industrial Park,Shandong province,China,completed its trial operation and technology assessment on March 4.The project was jointly developed by the Dalian Institute of Chemical Physics(DICP)of the Chinese Academy of Sciences(CAS)and Zhuhai Futian Energy Technology Co.,Ltd.展开更多
Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcom...Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.展开更多
Background: The objective of this pilot study was to describe clinical profile, electric, echocardiographic and angiographic caracteristics with procedural outcome of congolease patients undergoing coronarography in t...Background: The objective of this pilot study was to describe clinical profile, electric, echocardiographic and angiographic caracteristics with procedural outcome of congolease patients undergoing coronarography in the first and only one cardiac catheterization center opened in Kinshasa. Methods: An analytical cross-sectional study was carried out over a period from October 2019 (date of establishment of the first coronary angiography unit in DR Congo) to March 2021. We proceeded to a serial sampling of the consecutive cases of all the patients who have an angiographic exploration of coronary arteries. Clinical, ECG and cardiac ultrasound data were collected in all patients. The indications for the coronary angiography examination were set by differents cardiologists on the basis of repolarization troubles in the electrocardiogram, cinetic troubles in echocardiography, positive stress test and chest pain in patients with cardiovascular risq factors. Results: The serie (47 patients) was predominantly male with a sex ratio M/W of 2.6. The average age was 59.8 ± 10.5 years. Arterial hypertension (HBP) was the main risk factor (89.4%);followed by diabetes mellitus (14.9%). Chest pain was the main functional sign with an atypical character in 44.7%. The ECG showed ST segment depression (17%) and T wave inversion (17%), the anterior region being the most affected. Hypokinesia was the most common echocardiographic abnormality (34%), followed by akinesia (10.6%). The anteroseptal and apical territories were affected in 12.8%. Dilated myocardiopathy (DMC) was significantly predominant in the male sex (29.4% vs 7.7%;p = 0.011). With radial puncture as the main approach, coronary angiography was pathological in 44% revealing mono-truncal lesions. The left coronary network was the most affected: the middle inter ventricular artery (12.8%), the proximal interventricular artery (10.6%) and the proximal circonflex artery (10.6%). In multivariate logistic regression analysis, age (for age > 50 years for men and >60 years for women), arterial hypertension and dilated cardiomyopathy emerged as independent determinants of pathological coronary angiography. Transluminal angioplasty was performed in 27.7% of patients. The bypass indication was retained in 4.3% of cases and medical treatment in 68%. Conclusion: Coronary angiography was used to diagnose lesions responsible for ischemic heart disease and to treat 27.7% of patients locally. The young age of patients and limited financial resources encourage the strengthening of preventive measures against cardio vascular risq factors.展开更多
After more than half a year of preparatory work, the CAS announced its initiation of 12 pilot projects on October 14, 1998 as the first step for starting the National Program of Knowledge Innovation (NPKI).
After the examination and approval by a nine-member panel headed by two members of CAS (The Chinese Academy of Sciences) and one member of CAE (The Chinese Academy of Engineering), successful pilot test on the cultiva...After the examination and approval by a nine-member panel headed by two members of CAS (The Chinese Academy of Sciences) and one member of CAE (The Chinese Academy of Engineering), successful pilot test on the cultivation of a new strain of transgenic Yellow River carp was announced on October 17 at the Wuhan-based CAS Institute of Hydrobiology. Scientists believe the success would lay a solid foundation for the industrialization of展开更多
Addressing the environmental issues of traditional vanadium extraction methods from vanadium-bearing shale,a highly efficient and clean suspension oxidation roasting-curing-leaching process was proposed and semi-indus...Addressing the environmental issues of traditional vanadium extraction methods from vanadium-bearing shale,a highly efficient and clean suspension oxidation roasting-curing-leaching process was proposed and semi-industrial trials were conducted.Vanadium in raw ore mainly exists in sericite,roscoelite,and limonite,predominantly in the forms of V(Ⅲ)and V(Ⅳ).Under the conditions of a feed rate of 30 kg/h,an air flow rate of 28.0 m^(3)/h,an O_(2) flow rate of 4.0 m^(3)/h,and a temperature of 900℃ in both the suspension furnace and fluidized reactor,the vanadium-bearing mica underwent dehydroxylation and transformed into illite-montmorillonite.These changes disrupted the crystal structure of mica,facilitating vanadium extraction.Compared to direct acid leaching,curing-leaching demonstrates better performance in vanadium extraction.Under the conditions of curing temperature of 130℃,acid dosage of 40 wt.%,curing time of 6 h,and leaching time of 3 h,a V_(2)O_(5) leaching efficiency of 83.92% was achieved.展开更多
In this paper,an interference cancellation based neural receiver for superimposed pilot(SIP)in multi-layer transmission is proposed,where the data and pilot are non-orthogonally superimposed in the same time-frequency...In this paper,an interference cancellation based neural receiver for superimposed pilot(SIP)in multi-layer transmission is proposed,where the data and pilot are non-orthogonally superimposed in the same time-frequency resource.Specifically,to deal with the intra-layer and inter-layer interference of SIP under multi-layer transmission,the interference cancellation with superimposed symbol aided channel estimation is leveraged in the neural receiver,accompanied by the pre-design of pilot code-division orthogonal mechanism at transmitter.In addition,to address the complexity issue for inter-vendor collaboration and the generalization problem in practical deployments,respectively,this paper also provides a fixed SIP(F-SIP)design based on constant pilot power ratio and scalable mechanisms for different modulation and coding schemes(MCSs)and transmission layers.Simulation results demonstrate the superiority of the proposed schemes on the performance of block error rate and throughput compared with existing counterparts.展开更多
Sewage sludge in cities of Yangzi River Belt,China,generally exhibits a lower organic content and higher silt contentdue to leakage of drainage system,which caused low bioenergy recovery and carbon emission benefits i...Sewage sludge in cities of Yangzi River Belt,China,generally exhibits a lower organic content and higher silt contentdue to leakage of drainage system,which caused low bioenergy recovery and carbon emission benefits in conventional anaerobic digestion(CAD).Therefore,this paper is on a pilot scale,a bio-thermophilic pretreatment anaerobic digestion(BTPAD)for low organic sludge(volatile solids(VS)of 4%)was operated with a long-term continuous flow of 200 days.The VS degradation rate and CH_(4) yield of BTPAD increased by 19.93%and 53.33%,respectively,compared to those of CAD.The analysis of organic compositions in sludge revealed that BTPAD mainly improved the hydrolysis of proteins in sludge.Further analysis of microbial community proportions by high-throughput sequencing revealed that the short-term bio-thermophilic pretreatment was enriched in Clostridiales,Coprothermobacter and Gelria,was capable of hydrolyzing acidified proteins,and provided more volatile fatty acid(VFA)for the subsequent reaction.Biome combined with fluorescence quantitative polymerase chain reaction(PCR)analysis showed that the number of bacteria with high methanogenic capacity in BTPAD was much higher than that in CAD during the medium temperature digestion stage,indicating that short-term bio-thermophilic pretreatment could provide better methanogenic conditions for BTPAD.Furthermore,the greenhouse gas emission footprint analysis showed that short-term bio-thermophilic pretreatment could reduce the carbon emission of sludge anaerobic digestion system by 19.18%.展开更多
Before nationwide implementation of waste classification programs in rural areas,identifying suitable pilot regions is crucial.This study develops a comprehensive framework for assessing and selecting these pilot regi...Before nationwide implementation of waste classification programs in rural areas,identifying suitable pilot regions is crucial.This study develops a comprehensive framework for assessing and selecting these pilot regions.Data were collected through 654 valid questionnaires and interviews with respondents from rural areas in six provinces across China.Primary assessment criteria included disposal methods for kitchen waste,recyclables,hazardous waste,and residual waste,as well as farmers’willingness to separate hazardous waste when offered compensation and the impact of centralized waste treatment in villages.Secondary criteria focused on disposal methods for agrochemical packages and other hazardous waste.Using the weighted sum of squares method,the study evaluated the suitability of six regions as pilot areas for waste classification.The results identified villages in Jiangsu province and Hebei province as the most suitable pilot regions.Based on the findings,the study provides recommendations to address weaknesses in these regions to enhance the effectiveness of future trials and offers tailored suggestions for other regions to improve their waste classification initiatives.展开更多
A pilot plant integrating pervaporation membrane bioreactor and mechanical vapor compression for bioethanol production was designed and constructed in the study,with a bioethanol production of 300 t·a^(-1).Key eq...A pilot plant integrating pervaporation membrane bioreactor and mechanical vapor compression for bioethanol production was designed and constructed in the study,with a bioethanol production of 300 t·a^(-1).Key equipment in the process were designed based on bench test data.A pilot-scale fermenter with 20 m^(3) in volume,4 m in height and 2.5 m in diameter was designed based on geometric similarity criterion and power equality criterion.An integrated plate-frame membrane module with 105 plates was newly developed.Compared with conventional batch fermentation,the improvement of equipment utilization efficiency and the cell utilization efficiency can be expected as 1.5-2.0 times and 2-10 times,respectively,with waste water reduced by 70% to 85%.The high-exergy energy requirement for pilot plant was 57.5 k W,of which the broth preheater occupied 85.7%,following by the compressor 1.1%,pump1.9% and fermenter agitator 0.3%.The total energy requirement including distillation for producing 1 kg ethanol(95%(mass)) achieved an energy surplus of 15.6 MJ.展开更多
The clinical application of solid lipid particles(SLPs)is hampered due to the need for advanced nano/micro-suspension production technology.This research aims to establish a pilot-scale production line employing high-...The clinical application of solid lipid particles(SLPs)is hampered due to the need for advanced nano/micro-suspension production technology.This research aims to establish a pilot-scale production line employing high-speed shears as emulsification equipment.The primary purpose is to manufacture nano/micro-suspensions using solid lipid particles(SLPs).The study also exhaustively introduces and analyzes the regulatory schemes for process parameters and formulations at various stages of production.The process and formulation endured optimization through orthog-onal or single-factor tests at various production steps:laboratory research,small-scale trial production,and pilot production.Quality standards for the product were determined,and key parameters were obtained at each stage.The laboratory research demonstrated that the optimal SLPs comprised 15 mL 3%polyvinyl alcohol(PVA)per 1.0 g tilmicosin and 2.5 g carnauba wax(WAX).During small-scale production,modifications were made to the volume of the aqueous phase,emulsifier concentration,and emulsification strength,setting them to 16 mL,5%,and 2200 r/min,respectively.In the pilot production stage,the shear time was considered optimal at eight min.The impurity,content,polydispersion coefficient(PDI),and size of the pilot product were<3%,5%,0385 and 2.64μm,respectively.Among the several parameters studied,heating temperature,drug-lipid ratio,and emulsifier concentration were identified as the main factors affecting product quality,and they were regulated at 100℃,1:3,and 5%,respectively.A novel hot melt emulsification shear method aided the development of a new solid lipid-based suspension from its preliminary stages in the laboratory to pilot production.This innovation is expected to enhance solid lipid-based suspensions'industrial evolution extensively.展开更多
Dear Editor,In recent years,there has been a significant upward trend in the detection rate of thyroid diseases among military flight personnel[1].Thyroid diseases not only pose a serious threat to the health of fligh...Dear Editor,In recent years,there has been a significant upward trend in the detection rate of thyroid diseases among military flight personnel[1].Thyroid diseases not only pose a serious threat to the health of flight personnel but also have negative impacts on the aviation safety and combat effectiveness of troops.It has been confirmed that the occurrence and progression of thyroid diseases are closely linked to dietary iodine intake.Studies have manifested that long-term excessive or insufficient iodine intake can lead to thyroid diseases[2,3].展开更多
Cross-border e-commerce has emerged as a new growth point in foreign trade.While the Dalian comprehensive pilot zone has made some progress,its development is constrained by issues such as the global economic slowdown...Cross-border e-commerce has emerged as a new growth point in foreign trade.While the Dalian comprehensive pilot zone has made some progress,its development is constrained by issues such as the global economic slowdown,the relatively small scale of cross-border e-commerce,a high concentration of export commodities,imperfect information mechanisms,and high overall costs.To address these challenges,this paper explores the importance of the construction of the Dalian comprehensive pilot zone for cross-border e-commerce to the transformation and upgrading of exports.Based on my research project,“Research on Path Optimization of Financial Support for the Development of Advanced Manufacturing Clusters in Dalian,”this paper analyzes the current challenges and limiting factors and proposes corresponding countermeasures and suggestions.展开更多
Background:Atopic eczema is the most common type of skin disorder in both children and adults.It is characterized by erythema,pruritus,papules,xeransis,and lichenification.The KangminⅠdecoction,a Chinese herbal medic...Background:Atopic eczema is the most common type of skin disorder in both children and adults.It is characterized by erythema,pruritus,papules,xeransis,and lichenification.The KangminⅠdecoction,a Chinese herbal medicine prepared with several ingredients and used to treat eczema,was formulated according to traditional Chinese medicine theory.Objectives:To investigate the efficacy and safety of KangminⅠdecoction for treating atopic eczema compared to that of loratadine.Methods:90 patients were enrolled at the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine and randomly divided into the KangminⅠdecoction treatment group(n=45)and loratadine control group(n=45).Clinical efficacy was evaluated using the Eczema Area and Severity Index(EASI),Dermatology Life Quality Index(DLQI),adverse events(AEs),and recurrence rates,which were compared between the groups.Results:Compared to the loratadine control group(51.16%,18.60%),the KangminⅠdecoction group(7.72%,4.55%)displayed a significantly reduced effective rate(x^(2)=8.324,P=0.040)and recurrence rate(x^(2)=4.225,P=0.040).The incidence of AEs was similar between the groups(P=0.502).Conclusions:These results support further development of KangminⅠdecoction for the treatment of eczema.The KangminⅠdecoction showed good efficacy with a low recurrence rate and tolerable AEs.The main limitations of this study include the small sample size and the short treatment and follow-up periods.Larger controlled studies are needed to more adequately evaluate both safety and efficacy.展开更多
基金supported by National Natural Science Foundation(NNSF)of China under Grant 62001351the Foundation of National Key Laboratory of Electromagnetic Environment(6142403220202)the Stability Support Fund for Basic Military Industrial Research Institutes(A240104130).
文摘The orthogonal time frequency space(OTFS)modulation is a novel modulation scheme that can effectively cope with the high Doppler expansion caused by high mobility.Since it modulates data on delay-Doppler(DD)domain and makes full use of the sparse characteristics of DD domain,it has been widely studied to design efficient channel estimation and signal detection schemes.In this paper,we design a novel superimposed pilot pattern with transition band,which replaces the traditional embedded pilot(EP)guard zero-symbols,and perform a two-stage channel estimation.In the first stage,we fully utilize the dispersion characteristics of OTFS signal in DD domain,and use threshold decision to make coarse channel estimation.In the second stage,we use the results of the coarse estimation for iterative signal detection and accurate channel estimation.During the second stage,we make full use of the sparsity of the channel in DD domain,remodel the received signal into the form of sparse channel vector multiplied by channel coefficient matrix,and introduce Doppler index segmentation factor(DISF)to subdivide the Doppler index to solve the problem of fractional Doppler.Simulations reveal that,the scheme proposed in this paper has higher spectral efficiency compared with traditional EP scheme and lower peak-to-average power ratio(PAPR)compared with traditional superimposed pilot scheme.
文摘Natural gas methane and hydrates are a chemical compound of water molecules formed under low temperature and high pressure. The decomposition of 1 m^3 of natural gas hydrates can release about 0.8 m^3 of water and 164 m3 of natural gas. Thus, natural gas hydrates are characterized by their high-energy density and huge resource potential. It is estimated that the world＇s total natural gas hydrates resource amount is equivalent to twice the total carbon amount of the global proven conventional fuels and can meet the human energy requirement in the future for 1000 years. They are thus the first choice to replace conventional energy of petroleum and coal.
文摘Recently the pilot moving-bed unit for manufacturing aromatics from methanol and toluene with co-production of low-carbon olefins designed by the Sinopec Engineering Incorporation(SEC)has been put on stream successfully.In the course of commissioning,the pilot unit ran smoothly,leading to high conversion rate in the moving-bed reactor,high yield of xylene product,easy lift of catalyst,and good coke burnout results,with all indicators complying with the expected operating requirements.
基金Supported by Youth Startup Fund of Second Military Medical University(05QN21)
文摘Objective： To explore the fundamental theory, methods and data of the quality of life （QOL） of soldiers and its influence factors in the first response army. Methods： Totally 215 soldiers in the first response army of a military area in China were inquired by using self-regulating questionnaire and WHOQOL-BREF （Chinese Edition）. Resalts： WHOQOL-BREF had good acceptability, reliability and validity in the first response army. QOL of soldiers in the first response army was middling. The influencing factors of QOL of the soldiers in first army includes self-report health, different areas where the army men come from, different arms of services, whether only child in family. And the difference was statistically significant. Conclusion： WHOQOL-BREF is fit for evaluating the quality of life of soldiers in the first response army. There are differences of the quality of life among the soldiers in the first response army. So we should take appropriate measures to improve the soldiers＇ quality of life.
基金supported by the National Social Science Fund of China[Grant No.21BGL181]to Yan Chen.
文摘Coal dependence and inefficient decentralized heating have significantly increased China’s energy consumption for winter heating,increasing air pollution and exacerbating the greenhouse effect.In 2017,China implemented the Pilot Policy on Clean Winter Heating in Northern China,aiming to achieve high central heating coverage and cleaner energy consumption.Studying the effects of this policy can help promote its implementation and serve as a reference for effective adjustment of the contents in the future.However,few studies have investigated this policy and its carbon reduction effects,and most focus on the provincial or city levels.Therefore,this paper considers the policy’s influence on air pollution and carbon emissions at the county level to provide a precise and comprehensive assessment of the policy effects.We use panel data from 1290 counties in 15 provinces in Northern China from 2014 to 2021,applying a multiperiod difference-in-differences model to quantify the impact of the policy on carbon emissions and air quality in the pilot area.We then conduct a series of tests to demonstrate the robustness of the results and analyze the mechanisms of the policy effects from two perspectives,namely,central heating and natural gas use,through a mediating effect model.Finally,we examine the heterogeneity of policy effects between counties based on geographic location and per capita income levels of rural residents through a moderating effect model.The results reveal that the policy significantly reduces air pollution and carbon emissions in the pilot area by increasing the central heating area and natural gas use.Compared with the central and western regions in the north and areas with low-income rural residents,the policy effects in the eastern regions in the north and areas with high-income rural residents are more pronounced.
文摘The world’s first demonstration device for producing 1,000 tons/year gasoline from carbon dioxide(CO_(2))hydrogenation in Zoucheng Industrial Park,Shandong province,China,completed its trial operation and technology assessment on March 4.The project was jointly developed by the Dalian Institute of Chemical Physics(DICP)of the Chinese Academy of Sciences(CAS)and Zhuhai Futian Energy Technology Co.,Ltd.
文摘Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.
文摘Background: The objective of this pilot study was to describe clinical profile, electric, echocardiographic and angiographic caracteristics with procedural outcome of congolease patients undergoing coronarography in the first and only one cardiac catheterization center opened in Kinshasa. Methods: An analytical cross-sectional study was carried out over a period from October 2019 (date of establishment of the first coronary angiography unit in DR Congo) to March 2021. We proceeded to a serial sampling of the consecutive cases of all the patients who have an angiographic exploration of coronary arteries. Clinical, ECG and cardiac ultrasound data were collected in all patients. The indications for the coronary angiography examination were set by differents cardiologists on the basis of repolarization troubles in the electrocardiogram, cinetic troubles in echocardiography, positive stress test and chest pain in patients with cardiovascular risq factors. Results: The serie (47 patients) was predominantly male with a sex ratio M/W of 2.6. The average age was 59.8 ± 10.5 years. Arterial hypertension (HBP) was the main risk factor (89.4%);followed by diabetes mellitus (14.9%). Chest pain was the main functional sign with an atypical character in 44.7%. The ECG showed ST segment depression (17%) and T wave inversion (17%), the anterior region being the most affected. Hypokinesia was the most common echocardiographic abnormality (34%), followed by akinesia (10.6%). The anteroseptal and apical territories were affected in 12.8%. Dilated myocardiopathy (DMC) was significantly predominant in the male sex (29.4% vs 7.7%;p = 0.011). With radial puncture as the main approach, coronary angiography was pathological in 44% revealing mono-truncal lesions. The left coronary network was the most affected: the middle inter ventricular artery (12.8%), the proximal interventricular artery (10.6%) and the proximal circonflex artery (10.6%). In multivariate logistic regression analysis, age (for age > 50 years for men and >60 years for women), arterial hypertension and dilated cardiomyopathy emerged as independent determinants of pathological coronary angiography. Transluminal angioplasty was performed in 27.7% of patients. The bypass indication was retained in 4.3% of cases and medical treatment in 68%. Conclusion: Coronary angiography was used to diagnose lesions responsible for ischemic heart disease and to treat 27.7% of patients locally. The young age of patients and limited financial resources encourage the strengthening of preventive measures against cardio vascular risq factors.
文摘After more than half a year of preparatory work, the CAS announced its initiation of 12 pilot projects on October 14, 1998 as the first step for starting the National Program of Knowledge Innovation (NPKI).
文摘After the examination and approval by a nine-member panel headed by two members of CAS (The Chinese Academy of Sciences) and one member of CAE (The Chinese Academy of Engineering), successful pilot test on the cultivation of a new strain of transgenic Yellow River carp was announced on October 17 at the Wuhan-based CAS Institute of Hydrobiology. Scientists believe the success would lay a solid foundation for the industrialization of
基金funded by the National Key Research and Development Program of China(No.2020YFC1909704)the Fundamental Research Funds for the Central Universities,China(Nos.N2301026,N2301017).
文摘Addressing the environmental issues of traditional vanadium extraction methods from vanadium-bearing shale,a highly efficient and clean suspension oxidation roasting-curing-leaching process was proposed and semi-industrial trials were conducted.Vanadium in raw ore mainly exists in sericite,roscoelite,and limonite,predominantly in the forms of V(Ⅲ)and V(Ⅳ).Under the conditions of a feed rate of 30 kg/h,an air flow rate of 28.0 m^(3)/h,an O_(2) flow rate of 4.0 m^(3)/h,and a temperature of 900℃ in both the suspension furnace and fluidized reactor,the vanadium-bearing mica underwent dehydroxylation and transformed into illite-montmorillonite.These changes disrupted the crystal structure of mica,facilitating vanadium extraction.Compared to direct acid leaching,curing-leaching demonstrates better performance in vanadium extraction.Under the conditions of curing temperature of 130℃,acid dosage of 40 wt.%,curing time of 6 h,and leaching time of 3 h,a V_(2)O_(5) leaching efficiency of 83.92% was achieved.
文摘In this paper,an interference cancellation based neural receiver for superimposed pilot(SIP)in multi-layer transmission is proposed,where the data and pilot are non-orthogonally superimposed in the same time-frequency resource.Specifically,to deal with the intra-layer and inter-layer interference of SIP under multi-layer transmission,the interference cancellation with superimposed symbol aided channel estimation is leveraged in the neural receiver,accompanied by the pre-design of pilot code-division orthogonal mechanism at transmitter.In addition,to address the complexity issue for inter-vendor collaboration and the generalization problem in practical deployments,respectively,this paper also provides a fixed SIP(F-SIP)design based on constant pilot power ratio and scalable mechanisms for different modulation and coding schemes(MCSs)and transmission layers.Simulation results demonstrate the superiority of the proposed schemes on the performance of block error rate and throughput compared with existing counterparts.
基金supported by the National Key Research and Development Project (Nos.2020YFC1908702 and 2021YFC3200700)the National Natural Science Foundation of China (Nos.52192684 and 52192680).
文摘Sewage sludge in cities of Yangzi River Belt,China,generally exhibits a lower organic content and higher silt contentdue to leakage of drainage system,which caused low bioenergy recovery and carbon emission benefits in conventional anaerobic digestion(CAD).Therefore,this paper is on a pilot scale,a bio-thermophilic pretreatment anaerobic digestion(BTPAD)for low organic sludge(volatile solids(VS)of 4%)was operated with a long-term continuous flow of 200 days.The VS degradation rate and CH_(4) yield of BTPAD increased by 19.93%and 53.33%,respectively,compared to those of CAD.The analysis of organic compositions in sludge revealed that BTPAD mainly improved the hydrolysis of proteins in sludge.Further analysis of microbial community proportions by high-throughput sequencing revealed that the short-term bio-thermophilic pretreatment was enriched in Clostridiales,Coprothermobacter and Gelria,was capable of hydrolyzing acidified proteins,and provided more volatile fatty acid(VFA)for the subsequent reaction.Biome combined with fluorescence quantitative polymerase chain reaction(PCR)analysis showed that the number of bacteria with high methanogenic capacity in BTPAD was much higher than that in CAD during the medium temperature digestion stage,indicating that short-term bio-thermophilic pretreatment could provide better methanogenic conditions for BTPAD.Furthermore,the greenhouse gas emission footprint analysis showed that short-term bio-thermophilic pretreatment could reduce the carbon emission of sludge anaerobic digestion system by 19.18%.
基金supported by the Yunnan Provincial Education Department Scientific Research Fund Project(Grant No.2022J0525).
文摘Before nationwide implementation of waste classification programs in rural areas,identifying suitable pilot regions is crucial.This study develops a comprehensive framework for assessing and selecting these pilot regions.Data were collected through 654 valid questionnaires and interviews with respondents from rural areas in six provinces across China.Primary assessment criteria included disposal methods for kitchen waste,recyclables,hazardous waste,and residual waste,as well as farmers’willingness to separate hazardous waste when offered compensation and the impact of centralized waste treatment in villages.Secondary criteria focused on disposal methods for agrochemical packages and other hazardous waste.Using the weighted sum of squares method,the study evaluated the suitability of six regions as pilot areas for waste classification.The results identified villages in Jiangsu province and Hebei province as the most suitable pilot regions.Based on the findings,the study provides recommendations to address weaknesses in these regions to enhance the effectiveness of future trials and offers tailored suggestions for other regions to improve their waste classification initiatives.
基金supported by the National Key Research and Development Program of China(2021YFC2101204)the Natural Science Foundation of Sichuan Province(2025ZNSFSC0926)the Fundamental Research Funds for the Central Universities(2023SCU12080 and 20822041B4013)。
文摘A pilot plant integrating pervaporation membrane bioreactor and mechanical vapor compression for bioethanol production was designed and constructed in the study,with a bioethanol production of 300 t·a^(-1).Key equipment in the process were designed based on bench test data.A pilot-scale fermenter with 20 m^(3) in volume,4 m in height and 2.5 m in diameter was designed based on geometric similarity criterion and power equality criterion.An integrated plate-frame membrane module with 105 plates was newly developed.Compared with conventional batch fermentation,the improvement of equipment utilization efficiency and the cell utilization efficiency can be expected as 1.5-2.0 times and 2-10 times,respectively,with waste water reduced by 70% to 85%.The high-exergy energy requirement for pilot plant was 57.5 k W,of which the broth preheater occupied 85.7%,following by the compressor 1.1%,pump1.9% and fermenter agitator 0.3%.The total energy requirement including distillation for producing 1 kg ethanol(95%(mass)) achieved an energy surplus of 15.6 MJ.
基金supported by the Fundamental Research Funds for the Central Universities(2662020DKPY008)the National Natural Science Foundation of China(grant No.31772797)。
文摘The clinical application of solid lipid particles(SLPs)is hampered due to the need for advanced nano/micro-suspension production technology.This research aims to establish a pilot-scale production line employing high-speed shears as emulsification equipment.The primary purpose is to manufacture nano/micro-suspensions using solid lipid particles(SLPs).The study also exhaustively introduces and analyzes the regulatory schemes for process parameters and formulations at various stages of production.The process and formulation endured optimization through orthog-onal or single-factor tests at various production steps:laboratory research,small-scale trial production,and pilot production.Quality standards for the product were determined,and key parameters were obtained at each stage.The laboratory research demonstrated that the optimal SLPs comprised 15 mL 3%polyvinyl alcohol(PVA)per 1.0 g tilmicosin and 2.5 g carnauba wax(WAX).During small-scale production,modifications were made to the volume of the aqueous phase,emulsifier concentration,and emulsification strength,setting them to 16 mL,5%,and 2200 r/min,respectively.In the pilot production stage,the shear time was considered optimal at eight min.The impurity,content,polydispersion coefficient(PDI),and size of the pilot product were<3%,5%,0385 and 2.64μm,respectively.Among the several parameters studied,heating temperature,drug-lipid ratio,and emulsifier concentration were identified as the main factors affecting product quality,and they were regulated at 100℃,1:3,and 5%,respectively.A novel hot melt emulsification shear method aided the development of a new solid lipid-based suspension from its preliminary stages in the laboratory to pilot production.This innovation is expected to enhance solid lipid-based suspensions'industrial evolution extensively.
基金supported by the Military Medical Science and Technology Youth Cultivation Program of the Chinese PLA(17QNP023)the Key Projects of Medical Service Scientific Research of the Navy Medical Center(20M2302)the Military Logistics National Military Standard General Project of Chinese PLA(BHJ22B002).
文摘Dear Editor,In recent years,there has been a significant upward trend in the detection rate of thyroid diseases among military flight personnel[1].Thyroid diseases not only pose a serious threat to the health of flight personnel but also have negative impacts on the aviation safety and combat effectiveness of troops.It has been confirmed that the occurrence and progression of thyroid diseases are closely linked to dietary iodine intake.Studies have manifested that long-term excessive or insufficient iodine intake can lead to thyroid diseases[2,3].
文摘Cross-border e-commerce has emerged as a new growth point in foreign trade.While the Dalian comprehensive pilot zone has made some progress,its development is constrained by issues such as the global economic slowdown,the relatively small scale of cross-border e-commerce,a high concentration of export commodities,imperfect information mechanisms,and high overall costs.To address these challenges,this paper explores the importance of the construction of the Dalian comprehensive pilot zone for cross-border e-commerce to the transformation and upgrading of exports.Based on my research project,“Research on Path Optimization of Financial Support for the Development of Advanced Manufacturing Clusters in Dalian,”this paper analyzes the current challenges and limiting factors and proposes corresponding countermeasures and suggestions.
基金sponsored by the National Key Research and Development Program(No.2024YFC3500314)the National Natural Science Foundation of China(No.82405403)+3 种基金the Shanghai 2022‘Science and Technology Innovation Action Plan’Medical Innovation Research Special Project(No.22Y11922200)the Key Discipline Construction Project of Shanghai’s Three Year Action Plan for Strengthening the Construction of Public Health System(No.GWVI-11.1-24)the Clinical Research plan of Shanghai Shenkang HospitalDevelopment Center(No.SHDC22022302)the High-level Chinese Medicine Key Discipline Construction Project(Integrative Chinese and Western Medicine Clinic)of National Administration of TCM(No.zyyzdxk-2023065).
文摘Background:Atopic eczema is the most common type of skin disorder in both children and adults.It is characterized by erythema,pruritus,papules,xeransis,and lichenification.The KangminⅠdecoction,a Chinese herbal medicine prepared with several ingredients and used to treat eczema,was formulated according to traditional Chinese medicine theory.Objectives:To investigate the efficacy and safety of KangminⅠdecoction for treating atopic eczema compared to that of loratadine.Methods:90 patients were enrolled at the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine and randomly divided into the KangminⅠdecoction treatment group(n=45)and loratadine control group(n=45).Clinical efficacy was evaluated using the Eczema Area and Severity Index(EASI),Dermatology Life Quality Index(DLQI),adverse events(AEs),and recurrence rates,which were compared between the groups.Results:Compared to the loratadine control group(51.16%,18.60%),the KangminⅠdecoction group(7.72%,4.55%)displayed a significantly reduced effective rate(x^(2)=8.324,P=0.040)and recurrence rate(x^(2)=4.225,P=0.040).The incidence of AEs was similar between the groups(P=0.502).Conclusions:These results support further development of KangminⅠdecoction for the treatment of eczema.The KangminⅠdecoction showed good efficacy with a low recurrence rate and tolerable AEs.The main limitations of this study include the small sample size and the short treatment and follow-up periods.Larger controlled studies are needed to more adequately evaluate both safety and efficacy.
