Conventional agrochemical plant biostimulants have been used to increase crop yield and stress resistance,andthis strategy continues to be integral to today's farming.While effective,the large-scale implantations ...Conventional agrochemical plant biostimulants have been used to increase crop yield and stress resistance,andthis strategy continues to be integral to today's farming.While effective,the large-scale implantations of theseproducts are not without environmental,ecological,and cost concerns and the associated climate-change challenges.To alleviate this long-standing pressure on agriculture,designing and developing more biocompatible andsustainable plant stimulants are among the primary focuses of agricultural management.Over the recent decades,the field has witnessed significant progress in emerging naturally derived or nature-inspired nano-biostimulantswith large-active-surface areas,including bio-compounds,biopolymers,and nanocarbons.However,the extraction/preparation of these products may apply additional costs or require specific equipment.More recently,thefield's attention has shifted to the sustainable application of chemical-additive-free biostimulants towards practicalapplications in nano-agriculture.Herein,we rationally designed and reported the first evidence and elucidationon biostimulant impacts of plant-self-derived nano-extracts from donor Arabidopsis thaliana as a model forinducing mirror biostimulant activities in conspecific host seeds,seedlings,and plants.Moreover,we assessed theeffect of donor plants'age on short,mid-,and long-term biocompatibility,growth,and development/maturationof the recipient plants for up to around 30 days.As a proof-of-concept,we found these autologous bio-extractscould effectively promote seed sprouting,seedling germination,and the development of soil-drenched plantsof the same types.Our transmission-electron microscopy characterization of root/shoot pieces shows the presenceof multiple phyto-compounds,including microtubules/actin filaments,cell vacuoles,Golgi stacks/endoplasmicreticulum,cell wall polysaccharide-based cellulose fibers,and organic amorphous nanoparticles and clusters ofcarbon quantum dots in the structure of these extracts.This personalized plant stimulation may induce furthergrowth/defense-related mechanisms,setting new paradigms toward reducing the agrochemical inputs.展开更多
Molecular mechanism behind the therapeutic potential of pigeon pea over the human diseases such as rheumatoid arthritis,breast cancer,type II diabetes,malaria,measles and sickle cell disease were revealed through dock...Molecular mechanism behind the therapeutic potential of pigeon pea over the human diseases such as rheumatoid arthritis,breast cancer,type II diabetes,malaria,measles and sickle cell disease were revealed through docking of GC–MS identified phyto-compound ligands with candidate disease proteins.Of the 242 ligands,three dimensional structures of 47 compounds had to be drawn using ChemSketch and the remaining structures were retrieved from PubChem and docked with the active sites of candidate proteins.The molecules identified through docking were further subjected to ADMET analysis and promising drug candidates were identified for each disease.This paper presents a precise account of the chemoprofile of pigeon pea leaves,stems and seeds,interaction of these molecules with target proteins and suggests 26 highly potential molecules which are drug candidates for multiple human diseases.Pigeon pea seeds are especially proven as invaluable source for therapeutic molecules.展开更多
基金Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)grant number 525793193Prof.Stefan Eimer and Ms.Marion Basoglu at Goethe University for their assistance in TEM characterization+1 种基金Mr.Holger Schranz for his help in plant cultivation and maintenanceProf.Bruno M.Moerschbacher from the Institute of Plant Biology and Biotechnology at the Münster University。
文摘Conventional agrochemical plant biostimulants have been used to increase crop yield and stress resistance,andthis strategy continues to be integral to today's farming.While effective,the large-scale implantations of theseproducts are not without environmental,ecological,and cost concerns and the associated climate-change challenges.To alleviate this long-standing pressure on agriculture,designing and developing more biocompatible andsustainable plant stimulants are among the primary focuses of agricultural management.Over the recent decades,the field has witnessed significant progress in emerging naturally derived or nature-inspired nano-biostimulantswith large-active-surface areas,including bio-compounds,biopolymers,and nanocarbons.However,the extraction/preparation of these products may apply additional costs or require specific equipment.More recently,thefield's attention has shifted to the sustainable application of chemical-additive-free biostimulants towards practicalapplications in nano-agriculture.Herein,we rationally designed and reported the first evidence and elucidationon biostimulant impacts of plant-self-derived nano-extracts from donor Arabidopsis thaliana as a model forinducing mirror biostimulant activities in conspecific host seeds,seedlings,and plants.Moreover,we assessed theeffect of donor plants'age on short,mid-,and long-term biocompatibility,growth,and development/maturationof the recipient plants for up to around 30 days.As a proof-of-concept,we found these autologous bio-extractscould effectively promote seed sprouting,seedling germination,and the development of soil-drenched plantsof the same types.Our transmission-electron microscopy characterization of root/shoot pieces shows the presenceof multiple phyto-compounds,including microtubules/actin filaments,cell vacuoles,Golgi stacks/endoplasmicreticulum,cell wall polysaccharide-based cellulose fibers,and organic amorphous nanoparticles and clusters ofcarbon quantum dots in the structure of these extracts.This personalized plant stimulation may induce furthergrowth/defense-related mechanisms,setting new paradigms toward reducing the agrochemical inputs.
文摘Molecular mechanism behind the therapeutic potential of pigeon pea over the human diseases such as rheumatoid arthritis,breast cancer,type II diabetes,malaria,measles and sickle cell disease were revealed through docking of GC–MS identified phyto-compound ligands with candidate disease proteins.Of the 242 ligands,three dimensional structures of 47 compounds had to be drawn using ChemSketch and the remaining structures were retrieved from PubChem and docked with the active sites of candidate proteins.The molecules identified through docking were further subjected to ADMET analysis and promising drug candidates were identified for each disease.This paper presents a precise account of the chemoprofile of pigeon pea leaves,stems and seeds,interaction of these molecules with target proteins and suggests 26 highly potential molecules which are drug candidates for multiple human diseases.Pigeon pea seeds are especially proven as invaluable source for therapeutic molecules.
