It has been reported that overweight Japanese males have poorly organised dermis and their skin may be fragile to external forces because of decreased dermal echogenicity. However, it is unknown whether the changes in...It has been reported that overweight Japanese males have poorly organised dermis and their skin may be fragile to external forces because of decreased dermal echogenicity. However, it is unknown whether the changes in the dermal structure actually affect the dermal function. The objective of this study was to clarify the relationship between dermal structural parameters and dermal functional parameters in overweight and obese Japanese males. A cross-sectional, observational study was conducted on Japanese male volunteers. Two ultrasound scanners, a 20-MHz Dermascan C<sup>®</sup> and an 18-MHz Mylab<sup>TM</sup> five<sup>®</sup> were used to evaluate dermal structure. Echogenicity of the lower dermis and dermal thickness of the participants’ abdomens and thighs were measured. A Cutometer<sup>®</sup> MPA580 was used to evaluate skin viscoelasticity, skin deformation (R0) and elasticity (R2, R7). The correlation between dermal structural parameters and skin viscoelasticity were validated using Pearson’s correlation coefficient or Spearman’s correlation coefficient by rank test. A total of 79 male volunteers were recruited of which 43 were control subjects with BMI <25 (age, 22 - 63 years), 25 were overweight subjects with BMI ≥ 25 to <30 (age, 23 - 64 years) and the 11 obese subjects had a BMI ≥ 30 (age, 26 - 47 years). There was no correlation between dermal structural parameters and skin viscoelasticity in the abdomens or thighs of all 79 participants. On the other hand, in the 36 overweight and obese participants, thigh dermal echogenicity was significantly and negatively correlated with R0 (r = -0.456, p < 0.01) and dermal thickness in the abdomen was significantly and positively correlated with R0 (r = 0.464, p < 0.01). The dermal functional parameter was significantly correlated with dermal structural parameters in overweight and obese males;in other words, a decrease in dermal function may be caused by structural changes in the dermis during obesity.展开更多
OBJECTIVE: Baby skin differs significantly from adult skin and requires special care. The Cussons Baby Sensicare Range (Sensicare) of products has been specifically formulated for baby skin and a range of standard cos...OBJECTIVE: Baby skin differs significantly from adult skin and requires special care. The Cussons Baby Sensicare Range (Sensicare) of products has been specifically formulated for baby skin and a range of standard cosmetic clinical tests were conducted in adult females with dry skin to evaluate the effectiveness of the range on skin moisturization and barrier function. METHODS: The studies were within subject, controlled, single blind studies. For the Sensicare Body Wash skin moisturization (Corneometer) was measured before application and after 7 and 14 days of twice daily use. For the Sensicare Moisturizing Lotion and Sensicare Soothing Cream skin moisturization was measured before application and at 2, 4, 6, 8 and 24 hours after a single application;skin elasticity (Cutometer) and transepidermal water loss (TEWL, Tewameter) were assessed before and after 14 days of twice daily use;and skin erythema (Mexameter) before induction with sodium lauryl sulphate (SLS), and at 30 mins, 24 and 48 hours after patch removal. Changes from baseline and changes versus control were evaluated. RESULTS: Thirty to thirty-five subjects completed each study. Skin moisture content was significantly increased from baseline for all Cussons Baby Sensicare Products (p < 0.05 for Hair & Body Wash;and p < 0.001 for Cream & Lotion). Changes from baseline in skin elasticity were significantly superior to control (unperfumed liquid soap) after 14 days twice daily use of the Lotion, and Cream (p < 0.05). There were no significant changes from baseline or significant differences from control in TEWL for the Lotion, or Cream. The increases in the average skin erythema index were significantly smaller for the Lotion, and Cream 30 minutes following SLS patch removal (p < 0.05 v sterile water, p < 0.001 v no treatment for both products). All the Sensicare products were well tolerated. CONCLUSION: These studies support the use of the Cussons Baby Sensicare range of products for new born, sensitive and eczema prone skin.展开更多
文摘It has been reported that overweight Japanese males have poorly organised dermis and their skin may be fragile to external forces because of decreased dermal echogenicity. However, it is unknown whether the changes in the dermal structure actually affect the dermal function. The objective of this study was to clarify the relationship between dermal structural parameters and dermal functional parameters in overweight and obese Japanese males. A cross-sectional, observational study was conducted on Japanese male volunteers. Two ultrasound scanners, a 20-MHz Dermascan C<sup>®</sup> and an 18-MHz Mylab<sup>TM</sup> five<sup>®</sup> were used to evaluate dermal structure. Echogenicity of the lower dermis and dermal thickness of the participants’ abdomens and thighs were measured. A Cutometer<sup>®</sup> MPA580 was used to evaluate skin viscoelasticity, skin deformation (R0) and elasticity (R2, R7). The correlation between dermal structural parameters and skin viscoelasticity were validated using Pearson’s correlation coefficient or Spearman’s correlation coefficient by rank test. A total of 79 male volunteers were recruited of which 43 were control subjects with BMI <25 (age, 22 - 63 years), 25 were overweight subjects with BMI ≥ 25 to <30 (age, 23 - 64 years) and the 11 obese subjects had a BMI ≥ 30 (age, 26 - 47 years). There was no correlation between dermal structural parameters and skin viscoelasticity in the abdomens or thighs of all 79 participants. On the other hand, in the 36 overweight and obese participants, thigh dermal echogenicity was significantly and negatively correlated with R0 (r = -0.456, p < 0.01) and dermal thickness in the abdomen was significantly and positively correlated with R0 (r = 0.464, p < 0.01). The dermal functional parameter was significantly correlated with dermal structural parameters in overweight and obese males;in other words, a decrease in dermal function may be caused by structural changes in the dermis during obesity.
文摘OBJECTIVE: Baby skin differs significantly from adult skin and requires special care. The Cussons Baby Sensicare Range (Sensicare) of products has been specifically formulated for baby skin and a range of standard cosmetic clinical tests were conducted in adult females with dry skin to evaluate the effectiveness of the range on skin moisturization and barrier function. METHODS: The studies were within subject, controlled, single blind studies. For the Sensicare Body Wash skin moisturization (Corneometer) was measured before application and after 7 and 14 days of twice daily use. For the Sensicare Moisturizing Lotion and Sensicare Soothing Cream skin moisturization was measured before application and at 2, 4, 6, 8 and 24 hours after a single application;skin elasticity (Cutometer) and transepidermal water loss (TEWL, Tewameter) were assessed before and after 14 days of twice daily use;and skin erythema (Mexameter) before induction with sodium lauryl sulphate (SLS), and at 30 mins, 24 and 48 hours after patch removal. Changes from baseline and changes versus control were evaluated. RESULTS: Thirty to thirty-five subjects completed each study. Skin moisture content was significantly increased from baseline for all Cussons Baby Sensicare Products (p < 0.05 for Hair & Body Wash;and p < 0.001 for Cream & Lotion). Changes from baseline in skin elasticity were significantly superior to control (unperfumed liquid soap) after 14 days twice daily use of the Lotion, and Cream (p < 0.05). There were no significant changes from baseline or significant differences from control in TEWL for the Lotion, or Cream. The increases in the average skin erythema index were significantly smaller for the Lotion, and Cream 30 minutes following SLS patch removal (p < 0.05 v sterile water, p < 0.001 v no treatment for both products). All the Sensicare products were well tolerated. CONCLUSION: These studies support the use of the Cussons Baby Sensicare range of products for new born, sensitive and eczema prone skin.
