This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health care.Design co...This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health care.Design considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human tissues.In addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and hemocompatibility.The wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease diagnosis.Lastly,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.展开更多
Real-time physiological information monitoring can predict and prevent disease, or improve treatment by early diagnosis. A comprehensive and continuous monitoring of human health requires highly integrated wearable an...Real-time physiological information monitoring can predict and prevent disease, or improve treatment by early diagnosis. A comprehensive and continuous monitoring of human health requires highly integrated wearable and comfortable sensing devices. To address this need, we propose a low-cost electronic fabric-enabled multifunctional flexible sensing integration platform that includes a flexible pressure sensor for monitoring postural pressure, a humidity sensor for monitoring the humidity of the skin surface, and a flexible temperature sensor for visualizing the ambient temperature around the human body. Thanks to the unique rough surface texture, hierarchical structure, and robust electromechanical features of the MXene-modified nonwoven fabrics, the flexible pressure sensor can achieve a monitoring sensitivity of 1529.1 kPa~(-1) and a pressure range of 150 kPa, which meets the demand for human pressure detection. In addition, the unique porous structure of the fabric and the stacked multilayer structure of MXene enable the humidity sensor to exhibit extremely high monitoring sensitivity, even through clothing, and still be able to detect the humidity on the skin surface.Temperature sensors based on screen-printed thermochromic liquid crystals enable visual monitoring in the range of 0℃–65℃. Through further integration with flexible printed circuit board circuits, we demonstrate a proof-of-concept device that enables real-time monitoring of human physiological information such as physical pressure, humidity, and ambient temperature environment, suggesting that the device provides an excellent platform for the development of commercially viable wearable healthcare monitors.展开更多
With the aging of society and the increase in people’s concern for personal health,long-term physiological signal monitoring in daily life is in demand.In recent years,electronic skin(e-skin)for daily health monitori...With the aging of society and the increase in people’s concern for personal health,long-term physiological signal monitoring in daily life is in demand.In recent years,electronic skin(e-skin)for daily health monitoring applications has achieved rapid development due to its advantages in high-quality physiological signals monitoring and suitability for system integrations.Among them,the breathable e-skin has developed rapidly in recent years because it adapts to the long-term and high-comfort wear requirements of monitoring physiological signals in daily life.In this review,the recent achievements of breathable e-skins for daily physiological monitoring are systematically introduced and discussed.By dividing them into breathable e-skin electrodes,breathable e-skin sensors,and breathable e-skin systems,we sort out their design ideas,manufacturing processes,performances,and applications and show their advantages in long-term physiological signal monitoring in daily life.In addition,the development directions and challenges of the breathable e-skin are discussed and prospected.展开更多
Technological advancements have profoundly transformed the sports domain,ushering it into the digital era.Services leveraging big data in intelligent sports-encompassing performance analytics,train-ing statistical eva...Technological advancements have profoundly transformed the sports domain,ushering it into the digital era.Services leveraging big data in intelligent sports-encompassing performance analytics,train-ing statistical evaluations and metrics-have become indispensable.These tools are vital in aiding athletes with their daily training regimens and in devising sophisticated competition strategies,proving crucial in the pursuit of victory.Despite their potential,wearable electronic devices used for motion monitoring are subject to several limitations,including prohibitive cost,extensive energy usage,incompatibility with individual spatial structures,and flawed data analysis methodologies.Triboelectric nanogenerators(TENGs)have become instrumental in the development of self-powered devices/systems owing to their remarkable capacity to harnessing ambient high-entropy energy from the environment.This paper provides a thorough review of the advancements and emerging trends in TENG-based intelligent sports,focusing on physiological data monitoring,sports training performance,event refereeing assistance,and sports injury prevention and rehabilitation.Excluding the potential influence of sports psychological factors,this review provides a detailed discourse on present challenges and prospects for boosting smart sports with energy autonomy and digital intelligence.This study presents innovative insights and motivations for propelling the evolution of intelligent sports toward a more sustainable and efficient future for humanity.展开更多
Due to the development of the novel materials,the past two decades have witnessed the rapid advances of soft electronics.The soft electronics have huge potential in the physical sign monitoring and health care.One of ...Due to the development of the novel materials,the past two decades have witnessed the rapid advances of soft electronics.The soft electronics have huge potential in the physical sign monitoring and health care.One of the important advantages of soft electronics is forming good interface with skin,which can increase the user scale and improve the signal quality.Therefore,it is easy to build the specific dataset,which is important to improve the performance of machine learning algorithm.At the same time,with the assistance of machine learning algorithm,the soft electronics have become more and more intelligent to realize real-time analysis and diagnosis.The soft electronics and machining learning algorithms complement each other very well.It is indubitable that the soft electronics will bring us to a healthier and more intelligent world in the near future.Therefore,in this review,we will give a careful introduction about the new soft material,physiological signal detected by soft devices,and the soft devices assisted by machine learning algorithm.Some soft materials will be discussed such as two-dimensional material,carbon nanotube,nanowire,nanomesh,and hydrogel.Then,soft sensors will be discussed according to the physiological signal types(pulse,respiration,human motion,intraocular pressure,phonation,etc.).After that,the soft electronics assisted by various algorithms will be reviewed,including some classical algorithms and powerful neural network algorithms.Especially,the soft device assisted by neural network will be introduced carefully.Finally,the outlook,challenge,and conclusion of soft system powered by machine learning algorithm will be discussed.展开更多
INTRODUCTIONBirth asphyxia may lead to disturbances of gastroenteric motility of newborn infants[1.2] . The change of gut pressure and reflux are the major manifestations of the motor disturbance [3-9] . To evaluate t...INTRODUCTIONBirth asphyxia may lead to disturbances of gastroenteric motility of newborn infants[1.2] . The change of gut pressure and reflux are the major manifestations of the motor disturbance [3-9] . To evaluate the effects of perinatal asphyxia on the gastroenteric motility, gastric and esophageal pressure and double pH were measured in a group of asphyxiated newborns. And. their pathophysiological and anatomical effects on gastroenteric function were discussed.展开更多
Improvements to body-surface physiological monitoring ability including real-time,accuracy and integration,are essential to meet the expansive demands for personal healthcare.As part of this,simultaneous monitoring of...Improvements to body-surface physiological monitoring ability including real-time,accuracy and integration,are essential to meet the expansive demands for personal healthcare.As part of this,simultaneous monitoring of sweat metabolites and body temperature offers an exciting path to maximizing diagnostic precision and minimizing morbidity rates.Herein,we report a high-performance biomarker-temperature sensor made of a single As_(3)Se_(5)Te_(2)chalcogenide glass fiber to monitor physiology evolution on body-surface.The sensor integrates efficient thermal resistance and fiber evanescent wave effects,permitting the independent sensing of temperature and biomarkers with an ultrahigh temperature coefficient of resistance(−5.84%K^(–1)),rapid temperature response(0.3 s)and excellent IR sensing sensitivity.Moreover,by attaching a fiber to the wrist,we demonstrate simultaneous observation of both sweat metabolite(urea and lactate)and temperature changes during exercise.This illuminating sensing method will provide crucial capabilities in physiological monitoring and pave the way for advanced personalized diagnostic.展开更多
The research on flexible pressure sensors has drawn widespread attention in recent years,especially in the fields of health care and intelligent robots.In practical applications,the sensitivity of sensors directly aff...The research on flexible pressure sensors has drawn widespread attention in recent years,especially in the fields of health care and intelligent robots.In practical applications,the sensitivity of sensors directly affects the precision and integrity of weak pressure signals.Here,a pressure sensor with high sensitivity and a wide measurement range composed of porous fiber paper and 3D patterned electrodes is proposed.Multi-walled carbon nanotubes with excellent conductivity were evenly sprayed on the fiber paper to form the natural spatial conducting networks,while the copper-deposited polydimethylsiloxane films with micropyramids array were used as electrodes and flexible substrates.Increased conducting paths between electrodes and fibers can be obtained when high-density micro-pyramids fall into the porous structures of the fiber paper under external pressure,thereby promoting the pressure sensor to show an ultra-high sensitivity of 17.65 kPa^(-1)in the pressure range of 0–2 kPa,16 times that of the device without patterned electrodes.Besides,the sensor retains a high sensitivity of 2.06 kPa^(-1)in an ultra-wide measurement range of 150 kPa.Moreover,the sensor can detect various physiological signals,including pulse and voice,while attached to the human skin.This work provides a novel strategy to significantly improve the sensitivity and measurement range of flexible pressure sensors,as well as demonstrates attractive applications in physiological signal monitoring.展开更多
Objective: To study the effect of vascularized fibular graft on large defects of long bones and the monitoring method for the vascular status of the grafted fibula. Methods: From March 1988 to February 1998, 30 patien...Objective: To study the effect of vascularized fibular graft on large defects of long bones and the monitoring method for the vascular status of the grafted fibula. Methods: From March 1988 to February 1998, 30 patients with long bone defects over 6 cm in length received vascularized fibular graft including a monitoring island flap in our department to monitor the blood circulation of the fibulae. Results: Monitoring island abnormalities were indicated in 6 flaps, which accurately gave the alarm of the circulation crisis of the fibular graft. Surgical exploration was performed timely and the blood supply was recovered instantaneously. All the bone defects were healed at 6 months postoperatively. After 4 years of follow up, all the grafted fibulae were thickened and were just like tibiae. Conclusions: A monitoring island flap is a satisfactory method for repairing large defects of the long bones and a reliable method for assessing the vascular status of the grafted fibulae.展开更多
Cell culture encompasses procedures for extracting cells from their natural tissue and cultivating them under controlled artificial conditions. During this process, various factors, including cell physiological/morpho...Cell culture encompasses procedures for extracting cells from their natural tissue and cultivating them under controlled artificial conditions. During this process, various factors, including cell physiological/morphological properties, culture environments, metabolites, and contaminants, have to be precisely controlled and monitored for the survival of cells and the pursuit of the desired properties of the cells. This review summarizes recent advances in sensor technologies and manufacturing strategies for various cell culture platforms using traditional plastics, microfluidic chips, and scalable bioreactors. We share the details of newly developed biological sensors, chemical sensors, optical sensors, electronic chip technologies, and material integration methods. The precise control of parameters based on the feedback by these sensors and electronics enhances cell culture quality and throughput.展开更多
With the prevalence of cardiovascular disease,it is imperative that medical monitoring and treatment become more instantaneous and comfortable for patients.Recently,wearable and implantable optoelectronic devices can ...With the prevalence of cardiovascular disease,it is imperative that medical monitoring and treatment become more instantaneous and comfortable for patients.Recently,wearable and implantable optoelectronic devices can be seamlessly integrated into human body to enable physiological monitoring and treatment in an imperceptible and spatiotemporally unconstrained manner,opening countless possibilities for the intelligent healthcare paradigm.To achieve biointegrated cardiac healthcare,researchers have focused on novel strategies for the construction of flexible/stretchable optoelectronic devices and systems.Here,we overview the progress of biointegrated flexible and stretchable optoelectronics for wearable and implantable cardiac healthcare devices.Firstly,the device design is addressed,including the mechanical design,interface adhesion,and encapsulation strategies.Next,the practical applications of optoelectronic devices for cardiac physiological monitoring,cardiac optogenetics,and nongenetic stimulation are presented.Finally,an outlook on biointegrated flexible and stretchable optoelectronic devices and systems for intelligent cardiac healthcare is discussed.展开更多
A versatile sensing platform employing inorganic MoS_(2) nanoflowers and organic poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)has been investigated to develop the resistive and capacitive force-...A versatile sensing platform employing inorganic MoS_(2) nanoflowers and organic poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)has been investigated to develop the resistive and capacitive force-sensitive devices.The microstructure of the sensing layer heightens the sensitivity and response time of the dual-mode pressure sensors by augmenting electron pathways and inner stress in response to mechanical stimuli.Consequently,the capacitive and resistive sensors exhibit sensitivities of 0.37 and 0.12 kPa^(-1),respectively,while demonstrating a remarkable response time of approximately 100 ms.Furthermore,it is noteworthy that the PEDOT:PSS layer exhibits excellent adhesion to polydimethylsiloxane(PDMS)substrates,which contributes to the development of highly robust force-sensitive sensors capable of enduring more than 10000loading/unloading cycles.The combination of MoS_(2)/PEDOT:PSS layers in these dual-mode sensors has shown promising results in detecting human joint movements and subtle physiological signals.Notably,the sensors have achieved a remarkable precision rate of 98%in identifying target objects.These outcomes underscore the significant potential of these sensors for integration into applications such as electronic skin and human-machine interaction.展开更多
Metabolism,transpiration,and invasion of pathogens during the storage and transportation of fruits can lead to significant waste and even food safety issues.Therefore,real-time,rapid,and accurate non-destructive monit...Metabolism,transpiration,and invasion of pathogens during the storage and transportation of fruits can lead to significant waste and even food safety issues.Therefore,real-time,rapid,and accurate non-destructive monitoring of physiological information during the storage of fruits and vegetables to assess fruit freshness is crucial.Herein,we engineered a degradable and multifunctional humidity sensing film for monitoring fruit freshness.The film is fabricated through the co-assembly of bagasse cellulose nanocrystals(CNC),okra polysaccharides(OPs),silver nanowires(Ag NWs),and phytic acid(PA),utilizing dynamic hydrogen and phosphate bonds.This innovative design endows the CNC/OPs/PA/Ag NWs(COPA)composite film with outstanding mechanical properties,water resistance,low water vapor permeability,antibacterial,degradability,and moisture-sensing ability.Notably,the proposed COPA humidity sensor exhibits high linearity(R^(2)=0.994),ultralow hysteresis(1.24%),and 32 days of operational stability across a 35%–98%relative humidity(RH)range,enabling precise freshness monitoring during fruit storage.Significantly,the COPA film prolonged the shelf-life of packaged fruit when compared to conventional PE film packaging.This research establishes a foundational framework for next-generation smart sensors in food quality management and biomedical monitoring applications.展开更多
Background：After cardiac surgery,central venous oxygen saturation （ScvO2） and serum lactate concentration are often used to guide resuscitation;however,neither are completely reliable indicators of global tissue hy...Background：After cardiac surgery,central venous oxygen saturation （ScvO2） and serum lactate concentration are often used to guide resuscitation;however,neither are completely reliable indicators of global tissue hypoxia.This observational study aimed to establish whether the ratio between the veno-arterial carbon dioxide and the arterial-venous oxygen differences （P（v-a）CO2/C（a-v）O2） could predict whether patients would respond to resuscitation by increasing oxygen delivery （DO2）.Methods：We selected 72 patients from a cohort of 290 who had undergone cardiac surgery in our institution between January 2012 and August 2014.The selected patients were managed postoperatively on the Intensive Care Unit,had a normal ScvO2,elevated serum lactate concentration,and responded to resuscitation by increasing DO2 by 〉10%.As a consequence,48 patients responded with an increase in oxygen consumption （VO2） while VO2 was static or fell in 24.Results：At baseline and before resuscitative intervention in postoperative cardiac surgery patients,a P（v-a）CO2/C（a-v）O2 ratio ≥1.6 mmHg/ml predicted a positive VO2 response to an increase in DO2 of〉1 0% with a sensitivity of 68.8% and a specificity of 87.5%.Conclusions：P（v-a）CO2/C（a-v）O2 ratio appears to be a reliable marker of global anaerobic metabolism and predicts response to DO2 challenge.Thus,patients likely to benefit from resuscitation can be identified promptly,the P（v-a）CO2/C（a-v）O2 ratio may,therefore,be a useful resuscitation target.展开更多
Flexible pressure sensors capable of monitoring diverse physiological signals and body movements have garnered tremendous attention in wearable electronic devices.Thereinto,high constant sensitivity over a wide pressu...Flexible pressure sensors capable of monitoring diverse physiological signals and body movements have garnered tremendous attention in wearable electronic devices.Thereinto,high constant sensitivity over a wide pressure range combined with breathability,biocompatibility,biodegradability is pivotal for manufacturing of reliable pressure sensors in practical sensing applications.In this work,inspired by the multilayered structure of skin epidermis,we propose and demonstrate a multi-attribute wearable piezoresistive pressure sensor consisting of multilayered gradient conductive poly(ε-caprolactone)nanofiber membranes composites.In response to externally applied pressure,a layer-by-layer current path is activated inside the multilayered membranes composites,leading to the most salient sensing performance of high constant sensitivity of 33.955 kPa^(−1) within the pressure range of 0–80 kPa.The proposed pressure sensor also exhibits a fast response–relaxation time,a low detection limit,excellent stability,which can be successfully used to measure human physiological signals.Lastly,an integrated sensor array system that can locate objects’positions is constructed and applied to simulate sitting posture monitoring.These results indicate that the proposed pressure sensor holds great potential in health monitoring and wearable electronic devices.展开更多
基金the NSF CCSS-2152638 and the IEN Center Grant from the Institute for Electronics and Nanotechnology at Georgia Tech.
文摘This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health care.Design considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human tissues.In addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and hemocompatibility.The wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease diagnosis.Lastly,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.
基金financially National Natural Science Foundation of China (No. 62274140)Fundamental Research Funds for the Central Universities (No. 20720230030)+3 种基金Xiaomi Young Talents Program/Xiaomi Foundation, Shenzhen Science and Technology Program (No. JCYJ20230807091401003)National Key Research and Development Program of China (No. 2023YFB3208600)National Key Laboratory of Materials Behaviors and Evaluation Technology in Space Environments (No. WDZC-HGD-2022-08)Science and Technology on Vacuum Technology and Physics Laboratory Fund (No. HTKJ2023KL510008)。
文摘Real-time physiological information monitoring can predict and prevent disease, or improve treatment by early diagnosis. A comprehensive and continuous monitoring of human health requires highly integrated wearable and comfortable sensing devices. To address this need, we propose a low-cost electronic fabric-enabled multifunctional flexible sensing integration platform that includes a flexible pressure sensor for monitoring postural pressure, a humidity sensor for monitoring the humidity of the skin surface, and a flexible temperature sensor for visualizing the ambient temperature around the human body. Thanks to the unique rough surface texture, hierarchical structure, and robust electromechanical features of the MXene-modified nonwoven fabrics, the flexible pressure sensor can achieve a monitoring sensitivity of 1529.1 kPa~(-1) and a pressure range of 150 kPa, which meets the demand for human pressure detection. In addition, the unique porous structure of the fabric and the stacked multilayer structure of MXene enable the humidity sensor to exhibit extremely high monitoring sensitivity, even through clothing, and still be able to detect the humidity on the skin surface.Temperature sensors based on screen-printed thermochromic liquid crystals enable visual monitoring in the range of 0℃–65℃. Through further integration with flexible printed circuit board circuits, we demonstrate a proof-of-concept device that enables real-time monitoring of human physiological information such as physical pressure, humidity, and ambient temperature environment, suggesting that the device provides an excellent platform for the development of commercially viable wearable healthcare monitors.
基金supported by the National Key R&D Program 2021YFC3002201 of Chinathe National Natural Science Foundation(U20A20168,61874065,51861145202)of ChinaThe authors are also thankful for the support of the Research Fund from the Beijing Innovation Center for Future Chip,the Independent Research Program of Tsinghua University(20193080047).
文摘With the aging of society and the increase in people’s concern for personal health,long-term physiological signal monitoring in daily life is in demand.In recent years,electronic skin(e-skin)for daily health monitoring applications has achieved rapid development due to its advantages in high-quality physiological signals monitoring and suitability for system integrations.Among them,the breathable e-skin has developed rapidly in recent years because it adapts to the long-term and high-comfort wear requirements of monitoring physiological signals in daily life.In this review,the recent achievements of breathable e-skins for daily physiological monitoring are systematically introduced and discussed.By dividing them into breathable e-skin electrodes,breathable e-skin sensors,and breathable e-skin systems,we sort out their design ideas,manufacturing processes,performances,and applications and show their advantages in long-term physiological signal monitoring in daily life.In addition,the development directions and challenges of the breathable e-skin are discussed and prospected.
基金sponsored by the Liaoning Sports Science Society Planning Project(2024LTXH013)the National Key Research and Development Program of China(2023YFB3208102)the National Natural Science Foundation of China(52073031).
文摘Technological advancements have profoundly transformed the sports domain,ushering it into the digital era.Services leveraging big data in intelligent sports-encompassing performance analytics,train-ing statistical evaluations and metrics-have become indispensable.These tools are vital in aiding athletes with their daily training regimens and in devising sophisticated competition strategies,proving crucial in the pursuit of victory.Despite their potential,wearable electronic devices used for motion monitoring are subject to several limitations,including prohibitive cost,extensive energy usage,incompatibility with individual spatial structures,and flawed data analysis methodologies.Triboelectric nanogenerators(TENGs)have become instrumental in the development of self-powered devices/systems owing to their remarkable capacity to harnessing ambient high-entropy energy from the environment.This paper provides a thorough review of the advancements and emerging trends in TENG-based intelligent sports,focusing on physiological data monitoring,sports training performance,event refereeing assistance,and sports injury prevention and rehabilitation.Excluding the potential influence of sports psychological factors,this review provides a detailed discourse on present challenges and prospects for boosting smart sports with energy autonomy and digital intelligence.This study presents innovative insights and motivations for propelling the evolution of intelligent sports toward a more sustainable and efficient future for humanity.
基金supported by National Natural Science Foundation of China(No.62201624,32000939,21775168,22174167,51861145202,U20A20168)the Guangdong Basic and Applied Basic Research Foundation(2019A1515111183)+3 种基金Shenzhen Research Funding Program(JCYJ20190807160401657,JCYJ201908073000608,JCYJ20150831192224146)the National Key R&D Program(2018YFC2001202)the support of the Research Fund from Tsinghua University Initiative Scientific Research Programthe support from Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province(No.2020B1212060077)。
文摘Due to the development of the novel materials,the past two decades have witnessed the rapid advances of soft electronics.The soft electronics have huge potential in the physical sign monitoring and health care.One of the important advantages of soft electronics is forming good interface with skin,which can increase the user scale and improve the signal quality.Therefore,it is easy to build the specific dataset,which is important to improve the performance of machine learning algorithm.At the same time,with the assistance of machine learning algorithm,the soft electronics have become more and more intelligent to realize real-time analysis and diagnosis.The soft electronics and machining learning algorithms complement each other very well.It is indubitable that the soft electronics will bring us to a healthier and more intelligent world in the near future.Therefore,in this review,we will give a careful introduction about the new soft material,physiological signal detected by soft devices,and the soft devices assisted by machine learning algorithm.Some soft materials will be discussed such as two-dimensional material,carbon nanotube,nanowire,nanomesh,and hydrogel.Then,soft sensors will be discussed according to the physiological signal types(pulse,respiration,human motion,intraocular pressure,phonation,etc.).After that,the soft electronics assisted by various algorithms will be reviewed,including some classical algorithms and powerful neural network algorithms.Especially,the soft device assisted by neural network will be introduced carefully.Finally,the outlook,challenge,and conclusion of soft system powered by machine learning algorithm will be discussed.
基金Project supported ty the Research Fund of the Ministry of Healty of China,No.96-2-170(1996)
文摘INTRODUCTIONBirth asphyxia may lead to disturbances of gastroenteric motility of newborn infants[1.2] . The change of gut pressure and reflux are the major manifestations of the motor disturbance [3-9] . To evaluate the effects of perinatal asphyxia on the gastroenteric motility, gastric and esophageal pressure and double pH were measured in a group of asphyxiated newborns. And. their pathophysiological and anatomical effects on gastroenteric function were discussed.
基金supported by the“Pioneer”and“Leading Goose”R&D Program of Zhejiang(Grant No.2025C01166)National Natural Science Foundation of China(Grant Nos.62105168,62122039)+2 种基金Zhejiang Provincial Natural Science Foundation of China(Grant No.LY23F050006)Ningbo Natural Science Foundation(Grant No.2024J460)sponsored by K.C.Wong Magna Fund in Ningbo University.
文摘Improvements to body-surface physiological monitoring ability including real-time,accuracy and integration,are essential to meet the expansive demands for personal healthcare.As part of this,simultaneous monitoring of sweat metabolites and body temperature offers an exciting path to maximizing diagnostic precision and minimizing morbidity rates.Herein,we report a high-performance biomarker-temperature sensor made of a single As_(3)Se_(5)Te_(2)chalcogenide glass fiber to monitor physiology evolution on body-surface.The sensor integrates efficient thermal resistance and fiber evanescent wave effects,permitting the independent sensing of temperature and biomarkers with an ultrahigh temperature coefficient of resistance(−5.84%K^(–1)),rapid temperature response(0.3 s)and excellent IR sensing sensitivity.Moreover,by attaching a fiber to the wrist,we demonstrate simultaneous observation of both sweat metabolite(urea and lactate)and temperature changes during exercise.This illuminating sensing method will provide crucial capabilities in physiological monitoring and pave the way for advanced personalized diagnostic.
基金supported by the National Key R&D Program of China(Grant Nos.2019YFE0120300,2019YFF0301802)National Natural Science Foundation of China(Grant Nos.52175554,62101513,51975542)+3 种基金Natural Science Foundation of Shanxi Province(Grant No.201801D121152)Shanxi“1331 Project”Key Subject Construction(Grant No.1331KSC)National Defense Fundamental Research ProjectResearch Project Supported by Shan Xi Scholarship Council of China(Grant No.2020-109)。
文摘The research on flexible pressure sensors has drawn widespread attention in recent years,especially in the fields of health care and intelligent robots.In practical applications,the sensitivity of sensors directly affects the precision and integrity of weak pressure signals.Here,a pressure sensor with high sensitivity and a wide measurement range composed of porous fiber paper and 3D patterned electrodes is proposed.Multi-walled carbon nanotubes with excellent conductivity were evenly sprayed on the fiber paper to form the natural spatial conducting networks,while the copper-deposited polydimethylsiloxane films with micropyramids array were used as electrodes and flexible substrates.Increased conducting paths between electrodes and fibers can be obtained when high-density micro-pyramids fall into the porous structures of the fiber paper under external pressure,thereby promoting the pressure sensor to show an ultra-high sensitivity of 17.65 kPa^(-1)in the pressure range of 0–2 kPa,16 times that of the device without patterned electrodes.Besides,the sensor retains a high sensitivity of 2.06 kPa^(-1)in an ultra-wide measurement range of 150 kPa.Moreover,the sensor can detect various physiological signals,including pulse and voice,while attached to the human skin.This work provides a novel strategy to significantly improve the sensitivity and measurement range of flexible pressure sensors,as well as demonstrates attractive applications in physiological signal monitoring.
基金MajorPlanningProjectsofScienceandTechnologyofGuangzhouCity (No .96 Z 70 2 )
文摘Objective: To study the effect of vascularized fibular graft on large defects of long bones and the monitoring method for the vascular status of the grafted fibula. Methods: From March 1988 to February 1998, 30 patients with long bone defects over 6 cm in length received vascularized fibular graft including a monitoring island flap in our department to monitor the blood circulation of the fibulae. Results: Monitoring island abnormalities were indicated in 6 flaps, which accurately gave the alarm of the circulation crisis of the fibular graft. Surgical exploration was performed timely and the blood supply was recovered instantaneously. All the bone defects were healed at 6 months postoperatively. After 4 years of follow up, all the grafted fibulae were thickened and were just like tibiae. Conclusions: A monitoring island flap is a satisfactory method for repairing large defects of the long bones and a reliable method for assessing the vascular status of the grafted fibulae.
基金NSF Engineering Research Center for Cell Manufacturing Technologies,Grant/Award Number:EEC 1648035。
文摘Cell culture encompasses procedures for extracting cells from their natural tissue and cultivating them under controlled artificial conditions. During this process, various factors, including cell physiological/morphological properties, culture environments, metabolites, and contaminants, have to be precisely controlled and monitored for the survival of cells and the pursuit of the desired properties of the cells. This review summarizes recent advances in sensor technologies and manufacturing strategies for various cell culture platforms using traditional plastics, microfluidic chips, and scalable bioreactors. We share the details of newly developed biological sensors, chemical sensors, optical sensors, electronic chip technologies, and material integration methods. The precise control of parameters based on the feedback by these sensors and electronics enhances cell culture quality and throughput.
基金financially supported by the National Key R&D Program of China(2023YFB3609000)the Strategic Priority Research Program of CAS(XDB0520101)+3 种基金the National Natural Science Foundation of China(U22A6002 and 22173109)the CAS Project for Young Scientists in Basic Research(YSBR-053)the CAS-Croucher Scheme for Joint Laboratoriesthe CAS Cooperation Project(121111KYSB20200036).
文摘With the prevalence of cardiovascular disease,it is imperative that medical monitoring and treatment become more instantaneous and comfortable for patients.Recently,wearable and implantable optoelectronic devices can be seamlessly integrated into human body to enable physiological monitoring and treatment in an imperceptible and spatiotemporally unconstrained manner,opening countless possibilities for the intelligent healthcare paradigm.To achieve biointegrated cardiac healthcare,researchers have focused on novel strategies for the construction of flexible/stretchable optoelectronic devices and systems.Here,we overview the progress of biointegrated flexible and stretchable optoelectronics for wearable and implantable cardiac healthcare devices.Firstly,the device design is addressed,including the mechanical design,interface adhesion,and encapsulation strategies.Next,the practical applications of optoelectronic devices for cardiac physiological monitoring,cardiac optogenetics,and nongenetic stimulation are presented.Finally,an outlook on biointegrated flexible and stretchable optoelectronic devices and systems for intelligent cardiac healthcare is discussed.
基金supported by the Natural Science Foundation of Guangdong Province(Grant No.2021A1515010691)the College Innovation Team Project of Guangdong Province(Grant No.2021KCXTD042)Wuyi University-Hong Kong-Macao Joint Research and Development Fund(Grant No.2019WGALH06)。
文摘A versatile sensing platform employing inorganic MoS_(2) nanoflowers and organic poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)has been investigated to develop the resistive and capacitive force-sensitive devices.The microstructure of the sensing layer heightens the sensitivity and response time of the dual-mode pressure sensors by augmenting electron pathways and inner stress in response to mechanical stimuli.Consequently,the capacitive and resistive sensors exhibit sensitivities of 0.37 and 0.12 kPa^(-1),respectively,while demonstrating a remarkable response time of approximately 100 ms.Furthermore,it is noteworthy that the PEDOT:PSS layer exhibits excellent adhesion to polydimethylsiloxane(PDMS)substrates,which contributes to the development of highly robust force-sensitive sensors capable of enduring more than 10000loading/unloading cycles.The combination of MoS_(2)/PEDOT:PSS layers in these dual-mode sensors has shown promising results in detecting human joint movements and subtle physiological signals.Notably,the sensors have achieved a remarkable precision rate of 98%in identifying target objects.These outcomes underscore the significant potential of these sensors for integration into applications such as electronic skin and human-machine interaction.
基金financial support provided by the National Natural Science Foundation of China(Nos.52363014 and 22405179)the Science and Technology Project of Guangxi(GK AB23026136)the Open Fund Funding of Key Laboratory of New Processing Technology for Nonferrous Metal&Materials,Ministry of Education/Guangxi Key Laboratory of Optical and Electronic Materials and Devics(22AA-7).
文摘Metabolism,transpiration,and invasion of pathogens during the storage and transportation of fruits can lead to significant waste and even food safety issues.Therefore,real-time,rapid,and accurate non-destructive monitoring of physiological information during the storage of fruits and vegetables to assess fruit freshness is crucial.Herein,we engineered a degradable and multifunctional humidity sensing film for monitoring fruit freshness.The film is fabricated through the co-assembly of bagasse cellulose nanocrystals(CNC),okra polysaccharides(OPs),silver nanowires(Ag NWs),and phytic acid(PA),utilizing dynamic hydrogen and phosphate bonds.This innovative design endows the CNC/OPs/PA/Ag NWs(COPA)composite film with outstanding mechanical properties,water resistance,low water vapor permeability,antibacterial,degradability,and moisture-sensing ability.Notably,the proposed COPA humidity sensor exhibits high linearity(R^(2)=0.994),ultralow hysteresis(1.24%),and 32 days of operational stability across a 35%–98%relative humidity(RH)range,enabling precise freshness monitoring during fruit storage.Significantly,the COPA film prolonged the shelf-life of packaged fruit when compared to conventional PE film packaging.This research establishes a foundational framework for next-generation smart sensors in food quality management and biomedical monitoring applications.
文摘Background：After cardiac surgery,central venous oxygen saturation （ScvO2） and serum lactate concentration are often used to guide resuscitation;however,neither are completely reliable indicators of global tissue hypoxia.This observational study aimed to establish whether the ratio between the veno-arterial carbon dioxide and the arterial-venous oxygen differences （P（v-a）CO2/C（a-v）O2） could predict whether patients would respond to resuscitation by increasing oxygen delivery （DO2）.Methods：We selected 72 patients from a cohort of 290 who had undergone cardiac surgery in our institution between January 2012 and August 2014.The selected patients were managed postoperatively on the Intensive Care Unit,had a normal ScvO2,elevated serum lactate concentration,and responded to resuscitation by increasing DO2 by 〉10%.As a consequence,48 patients responded with an increase in oxygen consumption （VO2） while VO2 was static or fell in 24.Results：At baseline and before resuscitative intervention in postoperative cardiac surgery patients,a P（v-a）CO2/C（a-v）O2 ratio ≥1.6 mmHg/ml predicted a positive VO2 response to an increase in DO2 of〉1 0% with a sensitivity of 68.8% and a specificity of 87.5%.Conclusions：P（v-a）CO2/C（a-v）O2 ratio appears to be a reliable marker of global anaerobic metabolism and predicts response to DO2 challenge.Thus,patients likely to benefit from resuscitation can be identified promptly,the P（v-a）CO2/C（a-v）O2 ratio may,therefore,be a useful resuscitation target.
基金the National Natural Science Foundation of China(Nos.62174068 and 61888102)Rizhao City Key Research and Development Program(No.2021ZDYF010102).
文摘Flexible pressure sensors capable of monitoring diverse physiological signals and body movements have garnered tremendous attention in wearable electronic devices.Thereinto,high constant sensitivity over a wide pressure range combined with breathability,biocompatibility,biodegradability is pivotal for manufacturing of reliable pressure sensors in practical sensing applications.In this work,inspired by the multilayered structure of skin epidermis,we propose and demonstrate a multi-attribute wearable piezoresistive pressure sensor consisting of multilayered gradient conductive poly(ε-caprolactone)nanofiber membranes composites.In response to externally applied pressure,a layer-by-layer current path is activated inside the multilayered membranes composites,leading to the most salient sensing performance of high constant sensitivity of 33.955 kPa^(−1) within the pressure range of 0–80 kPa.The proposed pressure sensor also exhibits a fast response–relaxation time,a low detection limit,excellent stability,which can be successfully used to measure human physiological signals.Lastly,an integrated sensor array system that can locate objects’positions is constructed and applied to simulate sitting posture monitoring.These results indicate that the proposed pressure sensor holds great potential in health monitoring and wearable electronic devices.
