In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases.Currently,...In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases.Currently,implantable electrochemical microsensors have emerged as a prominent area of research.These microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for integration.They have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner,characterized by their bloodless,painless features,and exceptional performance.The development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated efforts.This review commenced with a comprehensive discussion of the construction of microsensors,including the materials utilized and the methods employed for fabrication.Following this,we proceeded to explore the various implantation technologies employed for electrochemical microsensors.In addition,a comprehensive overview was provided of the various applications of implantable electrochemical microsensors,specifically in the monitoring of diseases and the investigation of disease mechanisms.Lastly,a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors.展开更多
Solar-induced chlorophyll fluorescence(SiF)is a promising new proxy for global carbon cycle monitoring.Although many studies consider SIF to be linearly correlated with gross primary production(GPP),the relationship b...Solar-induced chlorophyll fluorescence(SiF)is a promising new proxy for global carbon cycle monitoring.Although many studies consider SIF to be linearly correlated with gross primary production(GPP),the relationship between SIF and GPP is jointly influenced by instantaneous radiation,canopy structure,and plant physiological factors,and their complex interactions lead to intricate SIF-GPP dynamics.Current research on SIF and GPP in subtropical evergreen mixed forests remains limited,primarily due to the lack of observational data from forest flux sites.Based on observations from the Dabie Mountain subtropical evergreen forest flux station from 2023 to 2024,we investigated the relative contributions of the radiative,structural,and physiological components of SiF to the SIF-GPP relationship at different temporal scales.The results revealed that:(1)At both seasonal and diurnal scales,SIF effectively tracks the changes in GPP;(2)The radiative component of SIF dominates the SIF-GPP linear relationship,with canopy structural variations driving its seasonal-scale dynamics while physiological response mechanisms reduce the correlation at hourly scales;and(3)During the growing season,as the time scale increased from half-hourly to daily,the SIF-GPP correlation strengthened(R2 rising from 0.36 to 0.44),while the radiative component contribution decreased slightly and the physiological component contribution weakened.Understanding the influences of these different factors on the SIF-GPP relationship can contribute to the development of more accurate models for GPP estimation using SIF.展开更多
Wearable sweat sensors that enable non-invasive sampling,efficient and rapid detection,and real-time monitoring capabilities have become an integral and critical component of human health management,with the potential...Wearable sweat sensors that enable non-invasive sampling,efficient and rapid detection,and real-time monitoring capabilities have become an integral and critical component of human health management,with the potential to provide meaningful clinical information related to physiologic diseases in the healthcare field.Here,a flexible nanoplasmonic paper-based sensor based on surface-enhanced Raman scattering(SERS)was developed,in which silver nanoparticles were loaded in the cellulose paper to enhance the Raman signals of targets via the generation of SERS“hotspots.”By incorporating the filter paper channel with a natural core absorbing liquid,the multifunctional chip is formed,which integrates the collection,transmission,and detection of trace sweat.This paperbased chip is soft and stretchable,and fits perfectly onto the human skin surface without causing any damage or irritation.Combined with a hand-held Raman spectrometer,quantitative detection of multiple sweat components can be achieved with the limit of detection of 17 and 1μmol/L for uric acid and glucose,respectively,and the measurable range is 4–7.5 for pH,enabling wearable and in-situ optical sensing for sweat markers under the condition of human physiology and pathology,within only 5 min for uric acid and glucose detection.This wearable biosensor would provide,to our knowledge,a new way for continuously monitoring the health status by collection and analysis of multiple components in human sweat,contributing to point-of-care testing and personalized medicine applications.展开更多
基金the Fundamental Research Funds for the Central Universities,National Natural Science Foundation of China(No.82302345).
文摘In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases.Currently,implantable electrochemical microsensors have emerged as a prominent area of research.These microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for integration.They have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner,characterized by their bloodless,painless features,and exceptional performance.The development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated efforts.This review commenced with a comprehensive discussion of the construction of microsensors,including the materials utilized and the methods employed for fabrication.Following this,we proceeded to explore the various implantation technologies employed for electrochemical microsensors.In addition,a comprehensive overview was provided of the various applications of implantable electrochemical microsensors,specifically in the monitoring of diseases and the investigation of disease mechanisms.Lastly,a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors.
基金The National Natural Science Foundation of China(42250205)The‘CUG Scholar’Scientific Research Funds at China University of Geosciences(2019004)。
文摘Solar-induced chlorophyll fluorescence(SiF)is a promising new proxy for global carbon cycle monitoring.Although many studies consider SIF to be linearly correlated with gross primary production(GPP),the relationship between SIF and GPP is jointly influenced by instantaneous radiation,canopy structure,and plant physiological factors,and their complex interactions lead to intricate SIF-GPP dynamics.Current research on SIF and GPP in subtropical evergreen mixed forests remains limited,primarily due to the lack of observational data from forest flux sites.Based on observations from the Dabie Mountain subtropical evergreen forest flux station from 2023 to 2024,we investigated the relative contributions of the radiative,structural,and physiological components of SiF to the SIF-GPP relationship at different temporal scales.The results revealed that:(1)At both seasonal and diurnal scales,SIF effectively tracks the changes in GPP;(2)The radiative component of SIF dominates the SIF-GPP linear relationship,with canopy structural variations driving its seasonal-scale dynamics while physiological response mechanisms reduce the correlation at hourly scales;and(3)During the growing season,as the time scale increased from half-hourly to daily,the SIF-GPP correlation strengthened(R2 rising from 0.36 to 0.44),while the radiative component contribution decreased slightly and the physiological component contribution weakened.Understanding the influences of these different factors on the SIF-GPP relationship can contribute to the development of more accurate models for GPP estimation using SIF.
基金National Natural Science Foundation of China(12374405)Provincial Science Foundation for Distinguished Young Scholars of Fujian(2024J010024)+3 种基金Fuzhou Science and Technology Major Project(2023-ZD-004)Natural Science Foundation of Fujian Province(2023J011267)Joint Funds for the Innovation of Science and Technology,Fujian(2021Y9196)Major Research Projects for Young and Middle-Aged Researchers of Fujian Provincial Health Commission(2021ZQNZD010)。
文摘Wearable sweat sensors that enable non-invasive sampling,efficient and rapid detection,and real-time monitoring capabilities have become an integral and critical component of human health management,with the potential to provide meaningful clinical information related to physiologic diseases in the healthcare field.Here,a flexible nanoplasmonic paper-based sensor based on surface-enhanced Raman scattering(SERS)was developed,in which silver nanoparticles were loaded in the cellulose paper to enhance the Raman signals of targets via the generation of SERS“hotspots.”By incorporating the filter paper channel with a natural core absorbing liquid,the multifunctional chip is formed,which integrates the collection,transmission,and detection of trace sweat.This paperbased chip is soft and stretchable,and fits perfectly onto the human skin surface without causing any damage or irritation.Combined with a hand-held Raman spectrometer,quantitative detection of multiple sweat components can be achieved with the limit of detection of 17 and 1μmol/L for uric acid and glucose,respectively,and the measurable range is 4–7.5 for pH,enabling wearable and in-situ optical sensing for sweat markers under the condition of human physiology and pathology,within only 5 min for uric acid and glucose detection.This wearable biosensor would provide,to our knowledge,a new way for continuously monitoring the health status by collection and analysis of multiple components in human sweat,contributing to point-of-care testing and personalized medicine applications.
