Background:Medical imaging advancements are constrained by fundamental trade-offs between acquisition speed,radiation dose,and image quality,forcing clinicians to work with noisy,incomplete data.Existing reconstructio...Background:Medical imaging advancements are constrained by fundamental trade-offs between acquisition speed,radiation dose,and image quality,forcing clinicians to work with noisy,incomplete data.Existing reconstruction methods either compromise on accuracy with iterative algorithms or suffer from limited generalizability with task-specific deep learning approaches.Methods:We present LDM-PIR,a lightweight physics-conditioned diffusion multi-model for medical image reconstruction that addresses key challenges in magnetic resonance imaging(MRI),CT,and low-photon imaging.Unlike traditional iterative methods,which are computationally expensive,or task-specific deep learning approaches lacking generalizability,integrates three innovations.A physics-conditioned diffusion framework that embeds acquisition operators(Fourier/Radon transforms)and noise models directly into the reconstruction process.A multi-model architecture that unifies denoising,inpainting,and super-resolution via shared weight conditioning.A lightweight design(2.1M parameters)enabling rapid inference(0.8s/image on GPU).Through self-supervised fine-tuning with measurement consistency losses adapts to new imaging modalities using fewer annotated samples.Results:Achieves state-of-the-art performance on fastMRI(peak signal-to-noise ratio(PSNR):34.04 for single-coil/31.50 for multi-coil)and Lung Image Database Consortium and Image Database Resource Initiative(28.83 PSNR under Poisson noise).Clinical evaluations demonstrate superior preservation of anatomical structures,with SSIM improvements of 8.8%for single-coil and 4.36%for multi-coil MRI over uDPIR.Conclusion:It offers a flexible,efficient,and scalable solution for medical image reconstruction,addressing the challenges of noise,undersampling,and modality generalization.The model’s lightweight design allows for rapid inference,while its self-supervised fine-tuning capability minimizes reliance on large annotated datasets,making it suitable for real-world clinical applications.展开更多
文摘Background:Medical imaging advancements are constrained by fundamental trade-offs between acquisition speed,radiation dose,and image quality,forcing clinicians to work with noisy,incomplete data.Existing reconstruction methods either compromise on accuracy with iterative algorithms or suffer from limited generalizability with task-specific deep learning approaches.Methods:We present LDM-PIR,a lightweight physics-conditioned diffusion multi-model for medical image reconstruction that addresses key challenges in magnetic resonance imaging(MRI),CT,and low-photon imaging.Unlike traditional iterative methods,which are computationally expensive,or task-specific deep learning approaches lacking generalizability,integrates three innovations.A physics-conditioned diffusion framework that embeds acquisition operators(Fourier/Radon transforms)and noise models directly into the reconstruction process.A multi-model architecture that unifies denoising,inpainting,and super-resolution via shared weight conditioning.A lightweight design(2.1M parameters)enabling rapid inference(0.8s/image on GPU).Through self-supervised fine-tuning with measurement consistency losses adapts to new imaging modalities using fewer annotated samples.Results:Achieves state-of-the-art performance on fastMRI(peak signal-to-noise ratio(PSNR):34.04 for single-coil/31.50 for multi-coil)and Lung Image Database Consortium and Image Database Resource Initiative(28.83 PSNR under Poisson noise).Clinical evaluations demonstrate superior preservation of anatomical structures,with SSIM improvements of 8.8%for single-coil and 4.36%for multi-coil MRI over uDPIR.Conclusion:It offers a flexible,efficient,and scalable solution for medical image reconstruction,addressing the challenges of noise,undersampling,and modality generalization.The model’s lightweight design allows for rapid inference,while its self-supervised fine-tuning capability minimizes reliance on large annotated datasets,making it suitable for real-world clinical applications.
