In this study,fucoidan(Fuc)extracted from kelp by water(WFu)and acid(AFu)was combined with zein to prepare nanoparticles.Its potential application as a curcumin(Cur)delivery system was also investigated.The results of...In this study,fucoidan(Fuc)extracted from kelp by water(WFu)and acid(AFu)was combined with zein to prepare nanoparticles.Its potential application as a curcumin(Cur)delivery system was also investigated.The results of chemical composition analysis showed that the sulfate content of AFu(26.44%)was significantly higher than that of WFu(19.65%).The molecular weight(Mw)and monosaccharide composition of WFu and AFu were also different.The anti-solvent precipitation method was used to prepare the nanoparticles.The analysis of nanoparticles with different mass ratios showed that the nanoparticles with a mass ratio of Fuc/zein of 1.5:1 had uniform particle distribution,good stability and the best encapsulation effect.Fourier transform infrared spectroscopy(FT-IR),differential scanning calorimetry(DSC),and fluorescence spectroscopy showed that hydrogen bonds and electrostatic interaction were the main forces responsible for the formation of the nanoparticles.Moreover,Fuc enhanced the thermal and storage stability of zein nanoparticles(ZNP).An in vitro digestion experiment using nanoparticles revealed that Fuc-ZNP had strong tolerance to the gastrointestinal tract and could be used for colon-specific Cur delivery.In addition,antioxidant experiments showed that Fuc significantly increased the antioxidant activity of ZNP(P<0.05).In conclusion,Fuc-ZNP have potential as a Cur delivery system.展开更多
In this study, the physicochemical compatibility and stability of four drug mixtures were evaluated, and the common drug mixtures used in the treatment of severe malaria in children were simulated by gravity perfusion...In this study, the physicochemical compatibility and stability of four drug mixtures were evaluated, and the common drug mixtures used in the treatment of severe malaria in children were simulated by gravity perfusion dynamic simulation experiment. The results showed that under experimental conditions, all drug mixtures exhibited clear transparency, stable density and refractive index, and pH values changed by no more than one unit, demonstrating compatibility and stability during the study period.展开更多
Objectives:Tiger nut(Cyperus esculentus L.)oil is a promising edible oil that is rich in oleic acid.This study aimed to clarify the impact of different degumming methods on the chemical composition and physicochemical...Objectives:Tiger nut(Cyperus esculentus L.)oil is a promising edible oil that is rich in oleic acid.This study aimed to clarify the impact of different degumming methods on the chemical composition and physicochemical properties of crude tiger nut oil(CTO).Materials and Methods:Five degummed tiger nut oils were prepared by high-temperature water(HWDO),medium-temperature water(MWDO),sodium chloride solution(SDO),acidic solution(ADO),and enzymatic method(EDO),respectively.Results:Compared to that of CTO,the phospholipid contents of HWDO,MWDO,SDO,ADO,and EDO were reduced by 99.39%,97.18%,69.95%,63.77%,and 65.60%,respectively.For CTO and all degummed oils,the fatty acid and endogenous antioxidant(i.e.tocopherols,sterols,flavonoids,total phenolics,and carotenoids)contents showed only small differences,but showed significant differences in quality parameters.Both the oxidative stability index and ferric ion-reducing antioxidant power decreased significantly after degumming;the former decreased from 52.26 to 15.55-19.80 h,and the latter decreased from 5818.91 to 4348.73-4524.34μmol Trolox(TE)/kg.Conclusions:These changes are highly related to the removal of hydratable phospholipids.In short,EDO exhibited the lowest turbidity,whereas MWDO showed the best oxidative stability(19.80 h)and highest smoke point(230.0℃).This information can be utilized to improve the industrial production of tigernutoil.展开更多
基金supported by the National Natural Science Foundation of China(No.31701611)the Education Department of Jilin Province of China(No.JJKH20200579KJ)the Young Scholars Climbing Project of Changchun University(No.ZKP202032).
文摘In this study,fucoidan(Fuc)extracted from kelp by water(WFu)and acid(AFu)was combined with zein to prepare nanoparticles.Its potential application as a curcumin(Cur)delivery system was also investigated.The results of chemical composition analysis showed that the sulfate content of AFu(26.44%)was significantly higher than that of WFu(19.65%).The molecular weight(Mw)and monosaccharide composition of WFu and AFu were also different.The anti-solvent precipitation method was used to prepare the nanoparticles.The analysis of nanoparticles with different mass ratios showed that the nanoparticles with a mass ratio of Fuc/zein of 1.5:1 had uniform particle distribution,good stability and the best encapsulation effect.Fourier transform infrared spectroscopy(FT-IR),differential scanning calorimetry(DSC),and fluorescence spectroscopy showed that hydrogen bonds and electrostatic interaction were the main forces responsible for the formation of the nanoparticles.Moreover,Fuc enhanced the thermal and storage stability of zein nanoparticles(ZNP).An in vitro digestion experiment using nanoparticles revealed that Fuc-ZNP had strong tolerance to the gastrointestinal tract and could be used for colon-specific Cur delivery.In addition,antioxidant experiments showed that Fuc significantly increased the antioxidant activity of ZNP(P<0.05).In conclusion,Fuc-ZNP have potential as a Cur delivery system.
文摘In this study, the physicochemical compatibility and stability of four drug mixtures were evaluated, and the common drug mixtures used in the treatment of severe malaria in children were simulated by gravity perfusion dynamic simulation experiment. The results showed that under experimental conditions, all drug mixtures exhibited clear transparency, stable density and refractive index, and pH values changed by no more than one unit, demonstrating compatibility and stability during the study period.
基金supported by the National Key Research and Development Plan of China(No.2019YFD1002605)the National Key Research and Development Plan for Science and Technology Innovation of China(No.SQ2019YFD100114)the‘Double First-Class’Project for Postgraduate Academic Innovation Enhancement Programme of Henan University of Technology(No.HAUTSYL2023TS08),China.
文摘Objectives:Tiger nut(Cyperus esculentus L.)oil is a promising edible oil that is rich in oleic acid.This study aimed to clarify the impact of different degumming methods on the chemical composition and physicochemical properties of crude tiger nut oil(CTO).Materials and Methods:Five degummed tiger nut oils were prepared by high-temperature water(HWDO),medium-temperature water(MWDO),sodium chloride solution(SDO),acidic solution(ADO),and enzymatic method(EDO),respectively.Results:Compared to that of CTO,the phospholipid contents of HWDO,MWDO,SDO,ADO,and EDO were reduced by 99.39%,97.18%,69.95%,63.77%,and 65.60%,respectively.For CTO and all degummed oils,the fatty acid and endogenous antioxidant(i.e.tocopherols,sterols,flavonoids,total phenolics,and carotenoids)contents showed only small differences,but showed significant differences in quality parameters.Both the oxidative stability index and ferric ion-reducing antioxidant power decreased significantly after degumming;the former decreased from 52.26 to 15.55-19.80 h,and the latter decreased from 5818.91 to 4348.73-4524.34μmol Trolox(TE)/kg.Conclusions:These changes are highly related to the removal of hydratable phospholipids.In short,EDO exhibited the lowest turbidity,whereas MWDO showed the best oxidative stability(19.80 h)and highest smoke point(230.0℃).This information can be utilized to improve the industrial production of tigernutoil.
