In response to the capabilities presented by the High-Intensity Heavy Ion Accelerator Facility(HIAF) and the Accelerator-Driven Subcritical System(Ci ADS), as well as the proposed Chinese Advanced Nuclear Physics Rese...In response to the capabilities presented by the High-Intensity Heavy Ion Accelerator Facility(HIAF) and the Accelerator-Driven Subcritical System(Ci ADS), as well as the proposed Chinese Advanced Nuclear Physics Research Facility(CNUF), we are assembling a consortium of experts in relevant disciplines, both domestically and internationally,to delineate high-precision physics experiments that leverage the state-of-the-art research environment afforded by CNUF.Our focus encompasses six primary domains of inquiry: hadron physics—including endeavors such as the super eta factory and investigations into light hadron structures;muon physics;neutrino physics;neutron physics;the testing of fundamental symmetries;and the exploration of quantum effects within nuclear physics, along with the utilization of vortex accelerators.We aim to foster a well-rounded portfolio of large, medium, and small-scale projects, thus unlocking new scientific avenues and optimizing the potential of the Huizhou large scientific facility. The aspiration for international leadership in scientific research will be a guiding principle in our strategic planning. This initiative will serve as a foundational reference for the Institute of Modern Physics in its strategic planning and goal-setting, ensuring alignment with its developmental objectives while striving to secure a competitive edge in technological advancement. Our ambition is to engage in substantive research within these realms of high-precision physics, to pursue groundbreaking discoveries, and to stimulate progress in China's nuclear physics landscape, positioning Huizhou as a preeminent global hub for advanced nuclear physics research.展开更多
Lithium–sulfur(Li–S)batteries are promisingcandidates for next-generation energy storagegiven their high energy density and potential low cost.Chemically activated carbon(CAC)is often used fortheir cathodes,because ...Lithium–sulfur(Li–S)batteries are promisingcandidates for next-generation energy storagegiven their high energy density and potential low cost.Chemically activated carbon(CAC)is often used fortheir cathodes,because it has a high specific surfacearea for sulfur loading.We have developed a pressurizedphysical activation(PPA)method that producedan activated carbon(PPAC)with a high specific surfacearea comparable to that of CAC.The pore structure of PPAC could be changed and its use as a cathode material for Li–Sbatteries was investigated.Battery tests at different capacity rates(C-rates)showed that it had a much improved high-rate performancewith a discharge capacity of 900 mAh/(g of sulfur)at 1 C,in contrast to only 600 mAh/(g of sulfur)for CAC.Porestructure analyses showed that PPAC prepared at a high activation temperature(1000℃)had unusual channel-like mesoporesbetween the microdomains that are the basic structural units of artificial carbon materials.These are connected to microporesdeveloped in each microdomain,and deliver ions from the surroundings to the internal pores and vice versa.The well-developedmicropores and mesopores of PPAC respectively ensured the high adsorption of lithium polysulfides and a high rate ofion diffusion.Compared to CAC,PPAC is a high-performance,low-cost cathode material that is promising for use in futureLi–S batteries.展开更多
To maintain soil quality under long-term saline water irrigation,the influence of manure on soil physical properties was examined.Long-term saline irrigation has been conducted from 2015 to 2024 at the Nanpi Eco-Agric...To maintain soil quality under long-term saline water irrigation,the influence of manure on soil physical properties was examined.Long-term saline irrigation has been conducted from 2015 to 2024 at the Nanpi Eco-Agricultural Experimental Station of Chinese Academy Sciences in the Low Plain of the North China Plain,comprising four irrigation treatments:irrigation once at the jointing stage for winter wheat with irrigation water containing salt at fresh water,3,4 and 5 g·L^(–1),and maize irrigation at sowing using fresh water.Manure application was conducted under all irrigation treatments,with treatments without manure application used as controls.The results showed that under long-term irrigation with saline water,the application of manure increased the soil organic matter content,exchangeable potassium,available phosphorus,and total nitrogen content in the 0–20 cm soil layer by 46.8%,117.0%,75.7%,and 45.5%,respectively,compared to treatments without manure application.The application of manure reduced soil bulk density.It also increased the proportion of water-stable aggregates and the abundance of bacteria,fungi,and actinomycetes in the tillage soil layer compared to the controls.Because of the salt contained in the manure,the application of manure had dual effects on soil salt content.During the winter wheat season,manure application increased soil salt content.The salt content was significantly reduced during the summer maize season,owing to the strong salt-leaching effects under manure application,resulting in a smaller difference in salt content between the manure and non-manure treatments.During the summer rainfall season,improvements in soil structure under manure application increased the soil desalination rate for the 1 m top soil layer.The desalination rate for 0–40 cm and 40–100 cm was averagely by 39.1%and 18.9%higher,respectively,under manure application as compared with that under the nomanure treatments.The yield of winter wheat under manure application was 0.12%lower than that of the control,owing to the higher salt content during the winter wheat season.In contrast,the yield of summer maize improved by 3.9%under manure application,owing to the increased soil nutrient content and effective salt leaching.The results of this study indicated that manure application helped maintain the soil physical structure,which is important for the long-term use of saline water.In practice,using manure with a low salt content is suggested to reduce the adverse effects of saline water irrigation on soil properties and achieve sustainable saline water use.展开更多
Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss...Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss to reduce the associated health burden.Physical activity is an important lifestyle behavior associated with enhanced health.Evidence supports that many of the benefits of physical activity are realized independent of initial weight status or whether weight loss is achieved,with some benefits additive to what is achieved with weight loss alone.These benefits include enhanced cardiometabolic,brain,cognitive and psychological health,and others.Moreover,in adults with overweight or obesity,physical activity has independent effects on cardiorespiratory fitness,muscular strength,physical function,and mobility.There are also benefits to body composition,with physical activity improving the quality of key tissues,such as skeletal muscle,which may not occur with diet-induced weight loss.Therefore,physical activity is an important public health target for adults with overweight or obesity to provide a wide range of health benefits that extend beyond those of weight loss alone.However,physical activity recommendations and programming efforts should consider the unique characteristics of adults with overweight or obesity to be most effective,and should support a focus on mobility,physical function,and other health outcomes.展开更多
Objective:We assessed the risk for physical inactivity due to inadequate health literacy using multivariable analysis in a large middleaged population.Methods:This cross-sectional mail survey using a self-administered...Objective:We assessed the risk for physical inactivity due to inadequate health literacy using multivariable analysis in a large middleaged population.Methods:This cross-sectional mail survey using a self-administered questionnaire was conducted in 2020 and included 33,902 community residents aged 40-64 years from 5 cities in Osaka Prefecture,Japan.Of these,12,446(36.7%)agreed to participate in the survey.After exclusion of those with regular visits to medical institutions and those with missing data,the analysis included 3742 participants.Health literacy was measured by the communicative and critical health literacy(CCHL)scale,and participants were classified into 3 groups(low,medium,and high health literacy groups)by the tertiles of the CCHL scale score.Physical inactivity was defined as not completing at least 150 min of moderate-intensity physical activity throughout the week.Results:After adjustment for age,gender,education level,occupation,economic status,living alone,and stages of health behavior change,the multivariable-adjusted odds ratios(ORs)for physical inactivity were 1.36(95% confidence interval[CI]:1.16-1.59,P<0.001)in the medium health literacy group and 1.70(95%CI:1.36-2.11,P<0.001)in the low health literacy group compared with the high health literacy group.Conclusions:This large-scale study provides compelling evidence that those with inadequate health literacy are at higher risk for physical inactivity among middle-aged adults.展开更多
The increasing complexity of intelligent sensing environments,driven by the growth of Internet of Things technologies,has created a strong demand for neuromorphic systems capable of real-time,low-power multisensory pe...The increasing complexity of intelligent sensing environments,driven by the growth of Internet of Things technologies,has created a strong demand for neuromorphic systems capable of real-time,low-power multisensory perception.Traditional sensory architectures,constrained by single-modal processing and centralized computing,struggle to meet the requirements of diverse and dynamic input conditions.Multisensory neuromorphic devices offer a promising solution by mimicking the distributed,event-driven processing of biological systems.Recent efforts have explored synaptic devices and material systems that respond to various input modalities,including visual,tactile,thermal,and chemical stimuli.However,challenges remain in signal conversion,encoding compatibility,and the fusion of heterogeneous inputs without loss of unisensory information.This review provides a comprehensive overview of the physical mechanisms,device behaviors,and integration strategies that underpin signal processing in neuromorphic hardware.We highlight synaptic mechanisms conducive to cross-modal interaction,analyze representative signal fusion approaches at the device level,and discuss future directions for constructing efficient,scalable,and biologically inspired multisensory neuromorphic systems.展开更多
Alzheimer's disease is the primary cause of dementia and imposes a significant socioeconomic burden globally.Physical exercise,as an effective strategy for improving general health,has been largely reported for it...Alzheimer's disease is the primary cause of dementia and imposes a significant socioeconomic burden globally.Physical exercise,as an effective strategy for improving general health,has been largely reported for its effectiveness in slowing neurodegeneration and increasing brain functional plasticity,particularly in aging brains.However,the underlying mechanisms of exercise in cognitive aging remain largely unclear.Adiponectin,a cell-secreted protein hormone,has recently been found to regulate synaptic plasticity and mediate the antidepressant effects of physical exercise.Studies on the neuroprotective effects of adiponectin have revealed potential innovative treatments for Alzheimer's disease.Here,we reviewed the functions of adiponectin and its receptor in the brains of human and animal models of cognitive impairment.We summarized the role of adiponectin in Alzheimer's disease,focusing on its impact on energy metabolism,insulin resistance,and inflammation.We also discuss how exercise increases adiponectin secretion and its potential benefits for learning and memory.Finally,we highlight the latest research on chemical compounds that mimic exerciseenhanced secretion of adiponectin and its receptor in Alzheimer's disease.展开更多
Background:Depression is prevalent among female college students,with eating behavior potentially related to this issue.This study examines the relationship between eating behavior and depression,focusing on the role ...Background:Depression is prevalent among female college students,with eating behavior potentially related to this issue.This study examines the relationship between eating behavior and depression,focusing on the role of social appearance anxiety and physical activity.Methods:We recruited 2161 female college students from nine universities in China via convenience sampling.Data was collected via an online questionnaire.Eating behavior was assessed via the Eating Behavior Scale short form(EBS-SF),depression was measured via the Center for Epidemiological Studies Depression Scale(CES-D),social appearance anxiety was evaluated via the Social Appearance Anxiety Scale,and physical activity was assessed via a single-item question.Descriptive statistics were analyzed via SPSS 26.0,and moderated mediation analysis was conducted via PROCESS version 3.5.Results:Unhealthy eating behavior was significantly associated with higher levels of depression(β=0.285,p<0.001).Social appearance anxiety mediated this relationship,accounting for 46%of the total effect(β=0.132,95%CI=[0.108,0.158]).The interaction effect between eating behavior and physical activity was significantly and negatively correlated with depression(β=−0.052,p<0.01).The association between eating behavior and depression was stronger under conditions of low physical activity(β=0.210,p<0.001)than under conditions of high physical activity(β=0.105,p<0.001).Conclusions:Integrating nutritional guidance,body image acceptance training,and exercise promotion into campus mental health programs is crucial for addressing depression in female college students.Future research should use longitudinal designs and broader participant ranges to increase the general applicability of the findings.展开更多
Background:The topic of this review is the study of the gut microbiota(GM),and the use of probiotics,especially in humans,as a new frontier in the field of prevention and health in general.The beneficial effects and f...Background:The topic of this review is the study of the gut microbiota(GM),and the use of probiotics,especially in humans,as a new frontier in the field of prevention and health in general.The beneficial effects and functions performed by probiotics in the GM are increasingly at the centre of both scientific,medical,and pharmaceutical interest.It is now known that diet and probiotics can modify the GM,although in these situations there is a need for greater and more in-depth research regarding the methods and timing of treatment.However,the relationship between physical activity,GM,and probiotics is still largely unclear,as regards certain mechanisms between physical exercise and probiotics in humans.Discussion:In this study,we tried to demonstrate whether and how physical exercise was able to alter the composition of the microbiota and how probiotics can facilitate it.Therefore,alteration of the microbiota was considered in terms of both diversity and composition.Conclusions:The ones examined propose vastly different physical exercises,both in terms of timing and type of intervention itself,and the use of probiotics.展开更多
This study introduces a new ocean surface friction velocity scheme and a modified Thompson cloud microphysics parameterization scheme into the CMA-TYM model.The impact of these two parameterization schemes on the pred...This study introduces a new ocean surface friction velocity scheme and a modified Thompson cloud microphysics parameterization scheme into the CMA-TYM model.The impact of these two parameterization schemes on the prediction of the movement track and intensity of Typhoon Kompasu in 2021 is examined.Additionally,the possible reasons for their effects on tropical cyclone(TC)intensity prediction are analyzed.Statistical results show that both parameterization schemes improve the predictions of Typhoon Kompasu’s track and intensity.The influence on track prediction becomes evident after 60 h of model integration,while the significant positive impact on intensity prediction is observed after 66 h.Further analysis reveals that these two schemes affect the timing and magnitude of extreme TC intensity values by influencing the evolution of the TC’s warm-core structure.展开更多
Objective:To analyze the impact of maternal-infant separation on the physical and mental state of high-risk pregnancy patients and explore the clinical efficacy of targeted nursing interventions.Methods:A total of 80 ...Objective:To analyze the impact of maternal-infant separation on the physical and mental state of high-risk pregnancy patients and explore the clinical efficacy of targeted nursing interventions.Methods:A total of 80 high-risk pregnancy patients treated in our hospital from January 2023 to January 2024 were selected as the study subjects.These patients were randomly divided into an observation group and a control group(40 cases each)using a random number table.The control group received routine high-risk pregnancy nursing care,while the observation group received specialized maternal-infant separation nursing interventions in addition to routine care.The psychological and physiological states and nursing satisfaction of the two groups were compared before and after the intervention.Results:The SAS scores,SDS scores,and sleep quality scores of the observation group were significantly lower than those of the control group,with statistically significant differences(p<0.05).The incidence of postpartum hemorrhage in the observation group was significantly lower than that in the control group,and the initiation time of lactation was significantly earlier than that in the control group,with both differences being statistically significant(p<0.05).The nursing satisfaction of the observation group was significantly higher than that of the control group(80%vs.32/40),with a statistically significant difference(p<0.05).Conclusion:Maternal-infant separation exacerbates anxiety and depression in high-risk pregnancy patients,reduces sleep quality,increases the risk of postpartum hemorrhage,and delays the initiation of lactation.Specialized nursing interventions for maternal-infant separation can improve the physical and mental state of high-risk pregnancy patients,reduce the incidence of postpartum complications,and enhance nursing satisfaction,making them worthy of clinical application and promotion.展开更多
White matter injury is a key factor impacting stroke recovery.Physical exercise can promote white matter repair.Immune cells,especially regulatory T(Treg)cells,contribute to strengthening white matter integrity,yet li...White matter injury is a key factor impacting stroke recovery.Physical exercise can promote white matter repair.Immune cells,especially regulatory T(Treg)cells,contribute to strengthening white matter integrity,yet little is known about the underlying mechanism.To examine this,we established a transient middle cerebral artery occlusion male mouse model.We found that physical exercise elevated brain Treg cells,thereby enhancing neurological recovery,reducing neuroinflammation,promoting myelin debris clearance,and accelerating white matter repair.Depletion of Treg cells caused a decrease in these positive effects of physical exercise.Mechanistically,the rise in osteopontin triggered by physical exercise is dampened when Treg cells are depleted.In addition,Treg-conditioned medium reduced oxygen-glucose deprivation/re-oxygenation-induced microglial inflammation and enhanced phagocytosis,which could be blocked by osteopontin antibodies.Importantly,although Treg infusion could mimic the protective effects of physical exercise,osteopontin blockade partially countered the effects of physical exercise and Treg cells.Finally,our sequencing data revealed a marked upregulation of C-X-C motif chemokine ligand 12(CXCL12)mRNA expression subsequent to physical exercise,which was confirmed at the protein level.Stimulation of Treg cells with stroke brain lysates increased C-X-C motif chemokine receptor 4(CXCR4)expression,indicating a potential role for the CXCL12-CXCR4 axis in recruiting Treg cells.These findings suggest that physical exercise promotes white matter repair after ischemic stroke by Treg cells.展开更多
The ongoing revolution in information technology is reshaping human life. In the realm of health behavior, wearable technology emerges as a leading digital solution,capturing physical behaviors (i.e., physical activit...The ongoing revolution in information technology is reshaping human life. In the realm of health behavior, wearable technology emerges as a leading digital solution,capturing physical behaviors (i.e., physical activity, sedentary habits, sleep patterns) within the 24-h cycle of daily life. Wearables are applied in research, clinical practice, and as lifestyle devices;most obvious, they promise to be a key element for increasing human physical activity, one of the biggest health challenges nowadays.展开更多
Today, most people know that physical activity(PA) is beneficial for their health ^(1,2)and aspire to engage in regular PA.^(3,4)However, despite their awareness of the importance of PA, it is evident that the transit...Today, most people know that physical activity(PA) is beneficial for their health ^(1,2)and aspire to engage in regular PA.^(3,4)However, despite their awareness of the importance of PA, it is evident that the transition from intention to action is challenging-a situation that has important public health implications. According to the World Health Organization,^(5)1 person dies every 6 s worldwide from causes related to physical inactivity, which underscores the urgency of addressing this situation.展开更多
Concerned that fewer than 20%of adolescents meet the World Health Organization(WHO)’s physical activity(PA)guidelines of engaging in≥60 min each day of the week of moderate-to-vigorous PA(MVPA),classifying them as i...Concerned that fewer than 20%of adolescents meet the World Health Organization(WHO)’s physical activity(PA)guidelines of engaging in≥60 min each day of the week of moderate-to-vigorous PA(MVPA),classifying them as insufficiently active,1 Araujo et al.2 sought to identify the global prevalence of adolescents reporting less frequent MVPA(≥60 min per day of MVPA≥1 days per week)and identify differences in this prevalence by age,gender.展开更多
Energy expenditure estimation can be used to measure the exercise load and physical condition of different individuals, such as soldiers, athletes, firemen, etc., during their training and work. Energy expenditure est...Energy expenditure estimation can be used to measure the exercise load and physical condition of different individuals, such as soldiers, athletes, firemen, etc., during their training and work. Energy expenditure estimation methods based on computer vision have rapidly developed in recent years. Compared with sensor-based methods, such methods are capable of monitoring several target persons at the same time, and the subjects do not need to wear different sensor devices that hamper their movement. In this paper, we propose a cross-attention spatial–temporal convolutional neural network to predict the energy expenditure of people under different exercise intensities. The model explores the relationship between changes in the human skeleton and energy expenditure intensity. In addition, a cross-attention correction module is used to reduce the negative effects of individual physical fitness characteristics during energy expenditure estimation. The experimental results show that our proposed method achieves high accuracy for energy expenditure estimation and performs better than existing computer vision-based energy expenditure estimation methods do. The proposed method can be widely used in various physical activity scenarios to measure energy expenditure, increasing the convenience of usage.展开更多
Accurate estimation of mineralogy from geophysical well logs is crucial for characterizing geological formations,particularly in hydrocarbon exploration,CO_(2) sequestration,and geothermal energy development.Current t...Accurate estimation of mineralogy from geophysical well logs is crucial for characterizing geological formations,particularly in hydrocarbon exploration,CO_(2) sequestration,and geothermal energy development.Current techniques,such as multimineral petrophysical analysis,offer details into mineralogical distribution.However,it is inherently time-intensive and demands substantial geological expertise for accurate model evaluation.Furthermore,traditional machine learning techniques often struggle to predict mineralogy accurately and sometimes produce estimations that violate fundamental physical principles.To address this,we present a new approach using Physics-Integrated Neural Networks(PINNs),that combines data-driven learning with domain-specific physical constraints,embedding petrophysical relationships directly into the neural network architecture.This approach enforces that predictions adhere to physical laws.The methodology is applied to the Broom Creek Deep Saline aquifer,a CO_(2) sequestration site in the Williston Basin,to predict the volumes of key mineral constituents—quartz,dolomite,feldspar,anhydrite,illite—along with porosity.Compared to traditional artificial neural networks (ANN),the PINN approach demonstrates higher accuracy and better generalizability,significantly enhancing predictive performance on unseen well datasets.The average mean error across the three blind wells is 0.123 for ANN and 0.042 for PINN,highlighting the superior accuracy of the PINN approach.This method reduces uncertainties in reservoir characterization by improving the reliability of mineralogy and porosity predictions,providing a more robust tool for decision-making in various subsurface geoscience applications.展开更多
Background:Taking actions to maintain a healthy lifestyle,including regular engagement in physical activity(PA)and reducing sedentary behavior(SB),may protect against the development of internalizing problems among he...Background:Taking actions to maintain a healthy lifestyle,including regular engagement in physical activity(PA)and reducing sedentary behavior(SB),may protect against the development of internalizing problems among healthy youth.However,it remains unclear whether such associations exist among youth with chronic pain who often report symptoms of depression and anxiety.To this end,we aimed to investigate the associations between independent and combined PA and/or SB patterns with indicators of internalizing problems in this vulnerable population.Methods:Data used in this cross-sectional study were retrieved from the U.S.National Survey of Children’s Health for the years 2021-2022.Specifically,caregiver proxy reports on sociodemgraphic factors and lifestyle behaviors of 4735 U.S.children and adolescents(referring to youth)aged 6-17 years were collected.We examined independent and combined patterns of PA and SB as exposures,with internalizing problems serving as outcomes of interest.Logistic regressions were used to examine the independent and combined associations of PA and/or SB patterns with anxiety and depression symptoms among youth with chronic pain while adjusting for covariates including age,sex,ethnicity,primary caregivers’education level,overweight status,and household federal poverty level.Results:Overall,our results indicated that PA was negatively associated with anxiety and depressive symptoms.Specifically,youth with chronic pain who engaged in at least 60-minute PA for 1-3 days,4-6 days,or every day reported significantly lower likelihood of experiencing symptoms of anxiety(OR=0.71,95%CI:0.60-0.84;OR=0.44,95%CI:0.36-0.53;OR=0.50,95%CI:0.40-0.63,respectively;all p-value<0.001)and depression(OR=0.63,95%CI:0.53-0.75;OR=0.38,95%CI:0.31-0.47;OR=0.46,95%CI:0.36-0.59,respectively;all p-value<0.001)symptoms compared to those with 0 days.Conversely,SB(operationalized via the proxy screen time)was positively associated with anxiety and depression symptoms.Youth with chronic pain who reported 4 or more hours of daily screen time had significantly higher odds of experiencing symptoms of anxiety(OR=2.17,95%CI:1.52-3.09,p<0.001)and depression(OR=2.30,95%CI:1.48-3.59,p<0.001).Furthermore,youth with chronic pain who engaged in higher PA levels and reported lower SB levels had a lower likelihood of experiencing symptoms of anxiety(OR=0.68,95%CI:0.52-0.87,p=0.003)and depression(OR=0.49,95%CI:0.34-0.70,p<0.001)symptoms compared to those with lower PA levels and higher SB levels.Conclusions:Higher PA levels and lower SB levels were associated with a reduced likelihood of developing anxiety and depression symptoms,which are indicative of internalizing problems,among youth with chronic pain.Future public health actions in this vulnerable population should prioritize intervention programs that promote PA engagement to reduce SB levels.展开更多
Background There is a lack of research examining the interplay between objectively measured physical activity volume and intensity with life expectancy.The purpose of the study was to investigate the interplay between...Background There is a lack of research examining the interplay between objectively measured physical activity volume and intensity with life expectancy.The purpose of the study was to investigate the interplay between objectively measured PA volume and intensity profiles with modeled life expectancy in women and men within the UK Biobank cohort study and interpret findings in relation to brisk walking.Methods Individuals from UK Biobank with wrist-worn accelerometer data were included.The average acceleration and intensity gradient were extracted to describe the physical activity volume and intensity profile.Mortality data were obtained from national registries.Adjusted life expectancies were estimated using parametric flexible survival models.Results 40,953(57.1%)women(median age=61.9 years)and 30,820(42.9%)men(63.1 years)were included.Over a median follow-up of 6.9 years,there were 1719(2.4%)deaths(733 in women;986 in men).At 60 years,life expectancy was progressively longer for higher physical activity volume and intensity profiles,reaching 95.6 years in women and 94.5 years in men at the 90th centile for both volume and intensity,corresponding to 3.4 additional years(95%confidence interval(95%CI):2.4-4.4)in women and 4.6 additional years(95%CI:3.6-5.6)in men compared to those at the 10th centiles.An additional 10-min or 30-min daily brisk walk was associated with 0.9(95%CI:0.5-1.3)and 1.4 years(95%CI:0.9-1.9)longer life expectancy,respectively,in inactive women;and 1.4 years(95%CI:1.0-1.8)and 2.5(95%CI:1.9-3.1)in inactive men.Conclusion Higher physical activity volumes were associated with longer life expectancy,with a higher physical activity intensity profile further adding to a longer life.Adding as little as a 10-min brisk walk to daily activity patterns may result in a meaningful benefit to life expectancy.展开更多
BACKGROUND Depression is a widespread psychological disorder that has substantial effects on public health and society.Conventional therapies include medication and psycho-therapy,recent investigations have highlighte...BACKGROUND Depression is a widespread psychological disorder that has substantial effects on public health and society.Conventional therapies include medication and psycho-therapy,recent investigations have highlighted the possible advantages of multi-modal treatments,such as physical therapy,for improving depression.AIM To perform a meta-analysis of how multimodal physical therapy can help treat depression.METHODS We searched for collection of articles that satisfied the inclusion and exclusion criteria,encompassing randomized controlled research-related sources.We incorporated these studies into the meta-analysis using terms such as“findings”,“intervention”,and“population attributes”.We used statistical examination to measure the total impact magnitude and evaluate study variability.RESULTS The encouraging aspect is that multi-modal physical therapy is being considered for its effectiveness in treating symptoms related to depression.Sensitivity analysis was conducted to identify key factors and determine their impact on quality.CONCLUSION Regarding treatment for depression,this meta-analysis extends the increasing number of studies demonstrating the effectiveness of multimodal physical therapy.展开更多
基金supported by the National Natural Science Foundation of China (Grant No.12075326)the Guangdong Basic and Applied Basic Research Foundation (Grant No.2025A1515010669)+2 种基金the Natural Science Foundation of Guangzhou (Grant No.2024A04J6243)the Fundamental Research Funds for the Central Universities in Sun Yat-sen University (No.23xkjc017)the Innovation Training Program for bachelor students in Sun Yat-sen University。
文摘In response to the capabilities presented by the High-Intensity Heavy Ion Accelerator Facility(HIAF) and the Accelerator-Driven Subcritical System(Ci ADS), as well as the proposed Chinese Advanced Nuclear Physics Research Facility(CNUF), we are assembling a consortium of experts in relevant disciplines, both domestically and internationally,to delineate high-precision physics experiments that leverage the state-of-the-art research environment afforded by CNUF.Our focus encompasses six primary domains of inquiry: hadron physics—including endeavors such as the super eta factory and investigations into light hadron structures;muon physics;neutrino physics;neutron physics;the testing of fundamental symmetries;and the exploration of quantum effects within nuclear physics, along with the utilization of vortex accelerators.We aim to foster a well-rounded portfolio of large, medium, and small-scale projects, thus unlocking new scientific avenues and optimizing the potential of the Huizhou large scientific facility. The aspiration for international leadership in scientific research will be a guiding principle in our strategic planning. This initiative will serve as a foundational reference for the Institute of Modern Physics in its strategic planning and goal-setting, ensuring alignment with its developmental objectives while striving to secure a competitive edge in technological advancement. Our ambition is to engage in substantive research within these realms of high-precision physics, to pursue groundbreaking discoveries, and to stimulate progress in China's nuclear physics landscape, positioning Huizhou as a preeminent global hub for advanced nuclear physics research.
文摘Lithium–sulfur(Li–S)batteries are promisingcandidates for next-generation energy storagegiven their high energy density and potential low cost.Chemically activated carbon(CAC)is often used fortheir cathodes,because it has a high specific surfacearea for sulfur loading.We have developed a pressurizedphysical activation(PPA)method that producedan activated carbon(PPAC)with a high specific surfacearea comparable to that of CAC.The pore structure of PPAC could be changed and its use as a cathode material for Li–Sbatteries was investigated.Battery tests at different capacity rates(C-rates)showed that it had a much improved high-rate performancewith a discharge capacity of 900 mAh/(g of sulfur)at 1 C,in contrast to only 600 mAh/(g of sulfur)for CAC.Porestructure analyses showed that PPAC prepared at a high activation temperature(1000℃)had unusual channel-like mesoporesbetween the microdomains that are the basic structural units of artificial carbon materials.These are connected to microporesdeveloped in each microdomain,and deliver ions from the surroundings to the internal pores and vice versa.The well-developedmicropores and mesopores of PPAC respectively ensured the high adsorption of lithium polysulfides and a high rate ofion diffusion.Compared to CAC,PPAC is a high-performance,low-cost cathode material that is promising for use in futureLi–S batteries.
基金supported by National Key R&D Program of China (2022YFD1900104)。
文摘To maintain soil quality under long-term saline water irrigation,the influence of manure on soil physical properties was examined.Long-term saline irrigation has been conducted from 2015 to 2024 at the Nanpi Eco-Agricultural Experimental Station of Chinese Academy Sciences in the Low Plain of the North China Plain,comprising four irrigation treatments:irrigation once at the jointing stage for winter wheat with irrigation water containing salt at fresh water,3,4 and 5 g·L^(–1),and maize irrigation at sowing using fresh water.Manure application was conducted under all irrigation treatments,with treatments without manure application used as controls.The results showed that under long-term irrigation with saline water,the application of manure increased the soil organic matter content,exchangeable potassium,available phosphorus,and total nitrogen content in the 0–20 cm soil layer by 46.8%,117.0%,75.7%,and 45.5%,respectively,compared to treatments without manure application.The application of manure reduced soil bulk density.It also increased the proportion of water-stable aggregates and the abundance of bacteria,fungi,and actinomycetes in the tillage soil layer compared to the controls.Because of the salt contained in the manure,the application of manure had dual effects on soil salt content.During the winter wheat season,manure application increased soil salt content.The salt content was significantly reduced during the summer maize season,owing to the strong salt-leaching effects under manure application,resulting in a smaller difference in salt content between the manure and non-manure treatments.During the summer rainfall season,improvements in soil structure under manure application increased the soil desalination rate for the 1 m top soil layer.The desalination rate for 0–40 cm and 40–100 cm was averagely by 39.1%and 18.9%higher,respectively,under manure application as compared with that under the nomanure treatments.The yield of winter wheat under manure application was 0.12%lower than that of the control,owing to the higher salt content during the winter wheat season.In contrast,the yield of summer maize improved by 3.9%under manure application,owing to the increased soil nutrient content and effective salt leaching.The results of this study indicated that manure application helped maintain the soil physical structure,which is important for the long-term use of saline water.In practice,using manure with a low salt content is suggested to reduce the adverse effects of saline water irrigation on soil properties and achieve sustainable saline water use.
基金supported by the National Institutes of Health for the Kansas Center for Metabolism and Obesity Research(award No.P20GM144269)support from the Center for Advancing Translational Sciences of the National Institutes of Health(award No.KL2TR002367)supported by the National Center for Advancing Translational Sciences of the National Institutes of Health(award No.TL1TR002368)。
文摘Overweight and obesity are significant public health concerns worldwide due to their association with many chronic health conditions.This has resulted in the development of various interventions focused on weight loss to reduce the associated health burden.Physical activity is an important lifestyle behavior associated with enhanced health.Evidence supports that many of the benefits of physical activity are realized independent of initial weight status or whether weight loss is achieved,with some benefits additive to what is achieved with weight loss alone.These benefits include enhanced cardiometabolic,brain,cognitive and psychological health,and others.Moreover,in adults with overweight or obesity,physical activity has independent effects on cardiorespiratory fitness,muscular strength,physical function,and mobility.There are also benefits to body composition,with physical activity improving the quality of key tissues,such as skeletal muscle,which may not occur with diet-induced weight loss.Therefore,physical activity is an important public health target for adults with overweight or obesity to provide a wide range of health benefits that extend beyond those of weight loss alone.However,physical activity recommendations and programming efforts should consider the unique characteristics of adults with overweight or obesity to be most effective,and should support a focus on mobility,physical function,and other health outcomes.
基金supported by the Fund for Health Promotion from Osaka Prefecture。
文摘Objective:We assessed the risk for physical inactivity due to inadequate health literacy using multivariable analysis in a large middleaged population.Methods:This cross-sectional mail survey using a self-administered questionnaire was conducted in 2020 and included 33,902 community residents aged 40-64 years from 5 cities in Osaka Prefecture,Japan.Of these,12,446(36.7%)agreed to participate in the survey.After exclusion of those with regular visits to medical institutions and those with missing data,the analysis included 3742 participants.Health literacy was measured by the communicative and critical health literacy(CCHL)scale,and participants were classified into 3 groups(low,medium,and high health literacy groups)by the tertiles of the CCHL scale score.Physical inactivity was defined as not completing at least 150 min of moderate-intensity physical activity throughout the week.Results:After adjustment for age,gender,education level,occupation,economic status,living alone,and stages of health behavior change,the multivariable-adjusted odds ratios(ORs)for physical inactivity were 1.36(95% confidence interval[CI]:1.16-1.59,P<0.001)in the medium health literacy group and 1.70(95%CI:1.36-2.11,P<0.001)in the low health literacy group compared with the high health literacy group.Conclusions:This large-scale study provides compelling evidence that those with inadequate health literacy are at higher risk for physical inactivity among middle-aged adults.
基金the financial support from the National Key Research and Development Program of China(Grant No.2022YFB4400100)the NSFC under Grant Nos.92477102 and 62122084the open research fund of Songshan Lake Materials Laboratory 2023SLABFK09。
文摘The increasing complexity of intelligent sensing environments,driven by the growth of Internet of Things technologies,has created a strong demand for neuromorphic systems capable of real-time,low-power multisensory perception.Traditional sensory architectures,constrained by single-modal processing and centralized computing,struggle to meet the requirements of diverse and dynamic input conditions.Multisensory neuromorphic devices offer a promising solution by mimicking the distributed,event-driven processing of biological systems.Recent efforts have explored synaptic devices and material systems that respond to various input modalities,including visual,tactile,thermal,and chemical stimuli.However,challenges remain in signal conversion,encoding compatibility,and the fusion of heterogeneous inputs without loss of unisensory information.This review provides a comprehensive overview of the physical mechanisms,device behaviors,and integration strategies that underpin signal processing in neuromorphic hardware.We highlight synaptic mechanisms conducive to cross-modal interaction,analyze representative signal fusion approaches at the device level,and discuss future directions for constructing efficient,scalable,and biologically inspired multisensory neuromorphic systems.
基金supported by the National Natural Science Foundation of China,No.82072529(to HWHT)Key Laboratory of Guangdong Higher Education Institutes,No.2021KSYS009(to HWHT)the China Postdoctoral Science Foundation,No.2022M720907(to HHG)。
文摘Alzheimer's disease is the primary cause of dementia and imposes a significant socioeconomic burden globally.Physical exercise,as an effective strategy for improving general health,has been largely reported for its effectiveness in slowing neurodegeneration and increasing brain functional plasticity,particularly in aging brains.However,the underlying mechanisms of exercise in cognitive aging remain largely unclear.Adiponectin,a cell-secreted protein hormone,has recently been found to regulate synaptic plasticity and mediate the antidepressant effects of physical exercise.Studies on the neuroprotective effects of adiponectin have revealed potential innovative treatments for Alzheimer's disease.Here,we reviewed the functions of adiponectin and its receptor in the brains of human and animal models of cognitive impairment.We summarized the role of adiponectin in Alzheimer's disease,focusing on its impact on energy metabolism,insulin resistance,and inflammation.We also discuss how exercise increases adiponectin secretion and its potential benefits for learning and memory.Finally,we highlight the latest research on chemical compounds that mimic exerciseenhanced secretion of adiponectin and its receptor in Alzheimer's disease.
文摘Background:Depression is prevalent among female college students,with eating behavior potentially related to this issue.This study examines the relationship between eating behavior and depression,focusing on the role of social appearance anxiety and physical activity.Methods:We recruited 2161 female college students from nine universities in China via convenience sampling.Data was collected via an online questionnaire.Eating behavior was assessed via the Eating Behavior Scale short form(EBS-SF),depression was measured via the Center for Epidemiological Studies Depression Scale(CES-D),social appearance anxiety was evaluated via the Social Appearance Anxiety Scale,and physical activity was assessed via a single-item question.Descriptive statistics were analyzed via SPSS 26.0,and moderated mediation analysis was conducted via PROCESS version 3.5.Results:Unhealthy eating behavior was significantly associated with higher levels of depression(β=0.285,p<0.001).Social appearance anxiety mediated this relationship,accounting for 46%of the total effect(β=0.132,95%CI=[0.108,0.158]).The interaction effect between eating behavior and physical activity was significantly and negatively correlated with depression(β=−0.052,p<0.01).The association between eating behavior and depression was stronger under conditions of low physical activity(β=0.210,p<0.001)than under conditions of high physical activity(β=0.105,p<0.001).Conclusions:Integrating nutritional guidance,body image acceptance training,and exercise promotion into campus mental health programs is crucial for addressing depression in female college students.Future research should use longitudinal designs and broader participant ranges to increase the general applicability of the findings.
文摘Background:The topic of this review is the study of the gut microbiota(GM),and the use of probiotics,especially in humans,as a new frontier in the field of prevention and health in general.The beneficial effects and functions performed by probiotics in the GM are increasingly at the centre of both scientific,medical,and pharmaceutical interest.It is now known that diet and probiotics can modify the GM,although in these situations there is a need for greater and more in-depth research regarding the methods and timing of treatment.However,the relationship between physical activity,GM,and probiotics is still largely unclear,as regards certain mechanisms between physical exercise and probiotics in humans.Discussion:In this study,we tried to demonstrate whether and how physical exercise was able to alter the composition of the microbiota and how probiotics can facilitate it.Therefore,alteration of the microbiota was considered in terms of both diversity and composition.Conclusions:The ones examined propose vastly different physical exercises,both in terms of timing and type of intervention itself,and the use of probiotics.
基金supported by the National Key R&D Program of China[grant number 2023YFC3008004]。
文摘This study introduces a new ocean surface friction velocity scheme and a modified Thompson cloud microphysics parameterization scheme into the CMA-TYM model.The impact of these two parameterization schemes on the prediction of the movement track and intensity of Typhoon Kompasu in 2021 is examined.Additionally,the possible reasons for their effects on tropical cyclone(TC)intensity prediction are analyzed.Statistical results show that both parameterization schemes improve the predictions of Typhoon Kompasu’s track and intensity.The influence on track prediction becomes evident after 60 h of model integration,while the significant positive impact on intensity prediction is observed after 66 h.Further analysis reveals that these two schemes affect the timing and magnitude of extreme TC intensity values by influencing the evolution of the TC’s warm-core structure.
文摘Objective:To analyze the impact of maternal-infant separation on the physical and mental state of high-risk pregnancy patients and explore the clinical efficacy of targeted nursing interventions.Methods:A total of 80 high-risk pregnancy patients treated in our hospital from January 2023 to January 2024 were selected as the study subjects.These patients were randomly divided into an observation group and a control group(40 cases each)using a random number table.The control group received routine high-risk pregnancy nursing care,while the observation group received specialized maternal-infant separation nursing interventions in addition to routine care.The psychological and physiological states and nursing satisfaction of the two groups were compared before and after the intervention.Results:The SAS scores,SDS scores,and sleep quality scores of the observation group were significantly lower than those of the control group,with statistically significant differences(p<0.05).The incidence of postpartum hemorrhage in the observation group was significantly lower than that in the control group,and the initiation time of lactation was significantly earlier than that in the control group,with both differences being statistically significant(p<0.05).The nursing satisfaction of the observation group was significantly higher than that of the control group(80%vs.32/40),with a statistically significant difference(p<0.05).Conclusion:Maternal-infant separation exacerbates anxiety and depression in high-risk pregnancy patients,reduces sleep quality,increases the risk of postpartum hemorrhage,and delays the initiation of lactation.Specialized nursing interventions for maternal-infant separation can improve the physical and mental state of high-risk pregnancy patients,reduce the incidence of postpartum complications,and enhance nursing satisfaction,making them worthy of clinical application and promotion.
基金supported by the National Natural Science Foundation of China,Nos.82172546(to XH),82172547(to ZZ)the Natural ScienceFoundation of Guangdong Province,Nos.2023A1515012695(to XH),2024A1515010419(to ZZ)the Science and Technology Plan Project of Guangzhou,Nos.202201020413(to ZZ),2023A04J1099(to ZZ).
文摘White matter injury is a key factor impacting stroke recovery.Physical exercise can promote white matter repair.Immune cells,especially regulatory T(Treg)cells,contribute to strengthening white matter integrity,yet little is known about the underlying mechanism.To examine this,we established a transient middle cerebral artery occlusion male mouse model.We found that physical exercise elevated brain Treg cells,thereby enhancing neurological recovery,reducing neuroinflammation,promoting myelin debris clearance,and accelerating white matter repair.Depletion of Treg cells caused a decrease in these positive effects of physical exercise.Mechanistically,the rise in osteopontin triggered by physical exercise is dampened when Treg cells are depleted.In addition,Treg-conditioned medium reduced oxygen-glucose deprivation/re-oxygenation-induced microglial inflammation and enhanced phagocytosis,which could be blocked by osteopontin antibodies.Importantly,although Treg infusion could mimic the protective effects of physical exercise,osteopontin blockade partially countered the effects of physical exercise and Treg cells.Finally,our sequencing data revealed a marked upregulation of C-X-C motif chemokine ligand 12(CXCL12)mRNA expression subsequent to physical exercise,which was confirmed at the protein level.Stimulation of Treg cells with stroke brain lysates increased C-X-C motif chemokine receptor 4(CXCR4)expression,indicating a potential role for the CXCL12-CXCR4 axis in recruiting Treg cells.These findings suggest that physical exercise promotes white matter repair after ischemic stroke by Treg cells.
基金funded in part by the German Research Foundation(Grant reference:496846758).
文摘The ongoing revolution in information technology is reshaping human life. In the realm of health behavior, wearable technology emerges as a leading digital solution,capturing physical behaviors (i.e., physical activity, sedentary habits, sleep patterns) within the 24-h cycle of daily life. Wearables are applied in research, clinical practice, and as lifestyle devices;most obvious, they promise to be a key element for increasing human physical activity, one of the biggest health challenges nowadays.
基金supported by The Shenzhen Educational Research Funding(zdzb2014)The Shenzhen Science and Technology Innovation Commission(202307313000096)+4 种基金The Social Science Foundation from the China's Ministry of Education(23YJA880093)The Post-Doctoral Fellowship(2022M711174)The National Center for Mental Health(Z014)BC is supported by the Chaires de recherche Rennes Métropole(23C 0909)SM is supported by the National Insti-tutes of Health(R01AG72445).
文摘Today, most people know that physical activity(PA) is beneficial for their health ^(1,2)and aspire to engage in regular PA.^(3,4)However, despite their awareness of the importance of PA, it is evident that the transition from intention to action is challenging-a situation that has important public health implications. According to the World Health Organization,^(5)1 person dies every 6 s worldwide from causes related to physical inactivity, which underscores the urgency of addressing this situation.
文摘Concerned that fewer than 20%of adolescents meet the World Health Organization(WHO)’s physical activity(PA)guidelines of engaging in≥60 min each day of the week of moderate-to-vigorous PA(MVPA),classifying them as insufficiently active,1 Araujo et al.2 sought to identify the global prevalence of adolescents reporting less frequent MVPA(≥60 min per day of MVPA≥1 days per week)and identify differences in this prevalence by age,gender.
基金supported by the National Key Research and Development Program of China (Grant No.2022YFC3600403)Emerging Interdisciplinary Platform for Medicine and Engineering in Sports (EIPMES),Beijing,China。
文摘Energy expenditure estimation can be used to measure the exercise load and physical condition of different individuals, such as soldiers, athletes, firemen, etc., during their training and work. Energy expenditure estimation methods based on computer vision have rapidly developed in recent years. Compared with sensor-based methods, such methods are capable of monitoring several target persons at the same time, and the subjects do not need to wear different sensor devices that hamper their movement. In this paper, we propose a cross-attention spatial–temporal convolutional neural network to predict the energy expenditure of people under different exercise intensities. The model explores the relationship between changes in the human skeleton and energy expenditure intensity. In addition, a cross-attention correction module is used to reduce the negative effects of individual physical fitness characteristics during energy expenditure estimation. The experimental results show that our proposed method achieves high accuracy for energy expenditure estimation and performs better than existing computer vision-based energy expenditure estimation methods do. The proposed method can be widely used in various physical activity scenarios to measure energy expenditure, increasing the convenience of usage.
基金the North Dakota Industrial Commission (NDIC) for their financial supportprovided by the University of North Dakota Computational Research Center。
文摘Accurate estimation of mineralogy from geophysical well logs is crucial for characterizing geological formations,particularly in hydrocarbon exploration,CO_(2) sequestration,and geothermal energy development.Current techniques,such as multimineral petrophysical analysis,offer details into mineralogical distribution.However,it is inherently time-intensive and demands substantial geological expertise for accurate model evaluation.Furthermore,traditional machine learning techniques often struggle to predict mineralogy accurately and sometimes produce estimations that violate fundamental physical principles.To address this,we present a new approach using Physics-Integrated Neural Networks(PINNs),that combines data-driven learning with domain-specific physical constraints,embedding petrophysical relationships directly into the neural network architecture.This approach enforces that predictions adhere to physical laws.The methodology is applied to the Broom Creek Deep Saline aquifer,a CO_(2) sequestration site in the Williston Basin,to predict the volumes of key mineral constituents—quartz,dolomite,feldspar,anhydrite,illite—along with porosity.Compared to traditional artificial neural networks (ANN),the PINN approach demonstrates higher accuracy and better generalizability,significantly enhancing predictive performance on unseen well datasets.The average mean error across the three blind wells is 0.123 for ANN and 0.042 for PINN,highlighting the superior accuracy of the PINN approach.This method reduces uncertainties in reservoir characterization by improving the reliability of mineralogy and porosity predictions,providing a more robust tool for decision-making in various subsurface geoscience applications.
基金supported by Shenzhen Educational Research Funding(zdzb2014)Shenzhen Science and Technology Innovation Commission Foundation(202307313000096)+4 种基金Social Science Foundation from China’s Ministry of Education(23YJA880093)China Postdoctoral Science Foundation(2022M711174)National Center for Mental Health Foundation(Z014),Research Excellence Scholarships of Shenzhen University(ZYZD2305)Research Funding for Society of Sport Science(PT2023030)Natural Science Foundation of Shenzhen University(000311).
文摘Background:Taking actions to maintain a healthy lifestyle,including regular engagement in physical activity(PA)and reducing sedentary behavior(SB),may protect against the development of internalizing problems among healthy youth.However,it remains unclear whether such associations exist among youth with chronic pain who often report symptoms of depression and anxiety.To this end,we aimed to investigate the associations between independent and combined PA and/or SB patterns with indicators of internalizing problems in this vulnerable population.Methods:Data used in this cross-sectional study were retrieved from the U.S.National Survey of Children’s Health for the years 2021-2022.Specifically,caregiver proxy reports on sociodemgraphic factors and lifestyle behaviors of 4735 U.S.children and adolescents(referring to youth)aged 6-17 years were collected.We examined independent and combined patterns of PA and SB as exposures,with internalizing problems serving as outcomes of interest.Logistic regressions were used to examine the independent and combined associations of PA and/or SB patterns with anxiety and depression symptoms among youth with chronic pain while adjusting for covariates including age,sex,ethnicity,primary caregivers’education level,overweight status,and household federal poverty level.Results:Overall,our results indicated that PA was negatively associated with anxiety and depressive symptoms.Specifically,youth with chronic pain who engaged in at least 60-minute PA for 1-3 days,4-6 days,or every day reported significantly lower likelihood of experiencing symptoms of anxiety(OR=0.71,95%CI:0.60-0.84;OR=0.44,95%CI:0.36-0.53;OR=0.50,95%CI:0.40-0.63,respectively;all p-value<0.001)and depression(OR=0.63,95%CI:0.53-0.75;OR=0.38,95%CI:0.31-0.47;OR=0.46,95%CI:0.36-0.59,respectively;all p-value<0.001)symptoms compared to those with 0 days.Conversely,SB(operationalized via the proxy screen time)was positively associated with anxiety and depression symptoms.Youth with chronic pain who reported 4 or more hours of daily screen time had significantly higher odds of experiencing symptoms of anxiety(OR=2.17,95%CI:1.52-3.09,p<0.001)and depression(OR=2.30,95%CI:1.48-3.59,p<0.001).Furthermore,youth with chronic pain who engaged in higher PA levels and reported lower SB levels had a lower likelihood of experiencing symptoms of anxiety(OR=0.68,95%CI:0.52-0.87,p=0.003)and depression(OR=0.49,95%CI:0.34-0.70,p<0.001)symptoms compared to those with lower PA levels and higher SB levels.Conclusions:Higher PA levels and lower SB levels were associated with a reduced likelihood of developing anxiety and depression symptoms,which are indicative of internalizing problems,among youth with chronic pain.Future public health actions in this vulnerable population should prioritize intervention programs that promote PA engagement to reduce SB levels.
基金funded by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC)the Applied Research Collaborations East Midlands (ARC-EM)supported by a UKRI project grant (MR/T031816/1)。
文摘Background There is a lack of research examining the interplay between objectively measured physical activity volume and intensity with life expectancy.The purpose of the study was to investigate the interplay between objectively measured PA volume and intensity profiles with modeled life expectancy in women and men within the UK Biobank cohort study and interpret findings in relation to brisk walking.Methods Individuals from UK Biobank with wrist-worn accelerometer data were included.The average acceleration and intensity gradient were extracted to describe the physical activity volume and intensity profile.Mortality data were obtained from national registries.Adjusted life expectancies were estimated using parametric flexible survival models.Results 40,953(57.1%)women(median age=61.9 years)and 30,820(42.9%)men(63.1 years)were included.Over a median follow-up of 6.9 years,there were 1719(2.4%)deaths(733 in women;986 in men).At 60 years,life expectancy was progressively longer for higher physical activity volume and intensity profiles,reaching 95.6 years in women and 94.5 years in men at the 90th centile for both volume and intensity,corresponding to 3.4 additional years(95%confidence interval(95%CI):2.4-4.4)in women and 4.6 additional years(95%CI:3.6-5.6)in men compared to those at the 10th centiles.An additional 10-min or 30-min daily brisk walk was associated with 0.9(95%CI:0.5-1.3)and 1.4 years(95%CI:0.9-1.9)longer life expectancy,respectively,in inactive women;and 1.4 years(95%CI:1.0-1.8)and 2.5(95%CI:1.9-3.1)in inactive men.Conclusion Higher physical activity volumes were associated with longer life expectancy,with a higher physical activity intensity profile further adding to a longer life.Adding as little as a 10-min brisk walk to daily activity patterns may result in a meaningful benefit to life expectancy.
基金Supported by Pharmaceutical Science and Technology Project in Zhejiang Province,No.2023RC266Natural Science Foundation of Ningbo,No.202003N4266.
文摘BACKGROUND Depression is a widespread psychological disorder that has substantial effects on public health and society.Conventional therapies include medication and psycho-therapy,recent investigations have highlighted the possible advantages of multi-modal treatments,such as physical therapy,for improving depression.AIM To perform a meta-analysis of how multimodal physical therapy can help treat depression.METHODS We searched for collection of articles that satisfied the inclusion and exclusion criteria,encompassing randomized controlled research-related sources.We incorporated these studies into the meta-analysis using terms such as“findings”,“intervention”,and“population attributes”.We used statistical examination to measure the total impact magnitude and evaluate study variability.RESULTS The encouraging aspect is that multi-modal physical therapy is being considered for its effectiveness in treating symptoms related to depression.Sensitivity analysis was conducted to identify key factors and determine their impact on quality.CONCLUSION Regarding treatment for depression,this meta-analysis extends the increasing number of studies demonstrating the effectiveness of multimodal physical therapy.
