In order to investigate ATM in mediating DNA damage signal to p53 in the cellular response to IR, kinase activities of ATM and c-Abl immunoprecipitates and its activation by IR and damaged DNA have been analyzed. Resu...In order to investigate ATM in mediating DNA damage signal to p53 in the cellular response to IR, kinase activities of ATM and c-Abl immunoprecipitates and its activation by IR and damaged DNA have been analyzed. Results demonstrate that deficient ATM caused failure to activate phosphorylation of many proteins in response to radiation . ATM展开更多
文摘In order to investigate ATM in mediating DNA damage signal to p53 in the cellular response to IR, kinase activities of ATM and c-Abl immunoprecipitates and its activation by IR and damaged DNA have been analyzed. Results demonstrate that deficient ATM caused failure to activate phosphorylation of many proteins in response to radiation . ATM
