Phosphate plays a critical role in maintaining homeostasis and engaging in cellular metabolism and energy transduction within the human body.Dysregulation of phosphate concentration can lead to various disorders.Howev...Phosphate plays a critical role in maintaining homeostasis and engaging in cellular metabolism and energy transduction within the human body.Dysregulation of phosphate concentration can lead to various disorders.However,current detection methods face significant challenges,including low sensitivity,narrow linear ranges,and extended response times.To address these issues,we employ a ligand-regulation strategy and adopt a bottom-up approach to synthesize a series of Ce-based metal organic frameworks(MOFs)with diff erent substituents(–NO_(2),–OH,–NH_(2)).These materials demonstrate outstanding performance in phosphate ion detection using the fluorescence analytical method.Notably,they exhibit a broad linear range(0–250μmol/L),low detection limit(1.8×10^(–9)mol/L),and rapid response time(4 min).Furthermore,hydroxyl and amino-functionalized Ce-MOFs exhibit successful application in intracellular fluorescence imaging.This capability is significant for detecting phosphate in biological systems and holds promise for contributing to diagnosing and treating diseases.展开更多
This review article presents a variety of luminescent chemosensors for the selective detection of assorted biologically relevant phosphates(phosphate ion,pyrophosphate ion and AMP,ADP and ATP)via the“Turn-On”emissio...This review article presents a variety of luminescent chemosensors for the selective detection of assorted biologically relevant phosphates(phosphate ion,pyrophosphate ion and AMP,ADP and ATP)via the“Turn-On”emission mechanism.The focus has been placed to understand the design aspects,chemical structures and luminescence properties including binding constants,detection limits and lifetime parameters of the chemosensors and their emission enhancement based detection mechanism.The article concludes by addressing various future prospects both for the biological and the environmental challenges in front of the scientific community to develop intelligent chemosensors not only for detection purposes but also for remediation processes.展开更多
基金financially supported by the National Natural Science Foundation of China(22074095 and 22374103)Beijing Municipal Natural Science Foundation(2222005)。
文摘Phosphate plays a critical role in maintaining homeostasis and engaging in cellular metabolism and energy transduction within the human body.Dysregulation of phosphate concentration can lead to various disorders.However,current detection methods face significant challenges,including low sensitivity,narrow linear ranges,and extended response times.To address these issues,we employ a ligand-regulation strategy and adopt a bottom-up approach to synthesize a series of Ce-based metal organic frameworks(MOFs)with diff erent substituents(–NO_(2),–OH,–NH_(2)).These materials demonstrate outstanding performance in phosphate ion detection using the fluorescence analytical method.Notably,they exhibit a broad linear range(0–250μmol/L),low detection limit(1.8×10^(–9)mol/L),and rapid response time(4 min).Furthermore,hydroxyl and amino-functionalized Ce-MOFs exhibit successful application in intracellular fluorescence imaging.This capability is significant for detecting phosphate in biological systems and holds promise for contributing to diagnosing and treating diseases.
基金support from the Science and Engineering Research Board(EMR/2016/000888)New Delhi and the Council of Scientific and Industrial Research(01(2841)/16/EMR-II)New Delhi.PK thanks CSIR,New Delhi for the Senior Research Associateship“Scientists’Pool Scheme”(IA-27577).
文摘This review article presents a variety of luminescent chemosensors for the selective detection of assorted biologically relevant phosphates(phosphate ion,pyrophosphate ion and AMP,ADP and ATP)via the“Turn-On”emission mechanism.The focus has been placed to understand the design aspects,chemical structures and luminescence properties including binding constants,detection limits and lifetime parameters of the chemosensors and their emission enhancement based detection mechanism.The article concludes by addressing various future prospects both for the biological and the environmental challenges in front of the scientific community to develop intelligent chemosensors not only for detection purposes but also for remediation processes.
