Objective To investigate the growth parameters of children with phenylketonuria and assess the impact of a phenylalanine-restricted diet on their physical development.Methods The study involved 39 children diagnosed w...Objective To investigate the growth parameters of children with phenylketonuria and assess the impact of a phenylalanine-restricted diet on their physical development.Methods The study involved 39 children diagnosed with phenylketonuria through newborn screening at the Central Child Teaching Hospital,Baghdad,Iraq.Data were collected during scheduled monthly check-ups,including phenylalanine levels,diet compliance,and anthropometric measurements.The children were divided into two groups based on their phenylalanine levels during the 3-year follow up period:well-controlled group(average phenylalanine level of less than 360μmol/L,with no single reading exceeding 600μmol/L;n=14)and poorly-controlled group(one or more phenylalanine readings above 600μmol/L during the follow-up period;n=25).Results The mean height readings for all time points(at birth and 3,6,9,12,15,18,21,24 and 36 months of age)were higher in the well-controlled group than the poorly-controlled group,however,only at 3 months of age the difference was statistically significant.Height Z-scores revealed a clearer pattern:although the poorly controlled group had higher height Z-scores at birth(P=0.001),the well-controlled group showed significantly higher height Z-scores at 3,6,12,15,18,24,and 36 months(P<0.05).The well-controlled group exhibited significantly higher mean weight measurements compared to the poorly-controlled group at 3,6,9,15,18 months and 21 months(P<0.05).From 6 to 36 months,the well-controlled group consistently had significantly higher weight Z-scores than the poorly controlled group(P<0.05).The well-controlled group showed more favorable height and weight Z-score distributions at 36 months of age compared to the poorly-controlled group,but the differences were not statistically significant(P>0.05).Both groups had height and weight Z-scores within the normal range at 36 months of age.Conclusions The children with phenylketonuria who receive good dietary control show better improvements in growth parameters compared to those with poor dietary control,however,both groups maintain height and weight Z-scores within the normal range,indicating generally adequate physical development across the cohort.展开更多
The damage distribution of the same type of aircraft in similar service environments should be similar. Based on this assumption, to perform the maintenance and repair of aircraft composite structures, the damage of c...The damage distribution of the same type of aircraft in similar service environments should be similar. Based on this assumption, to perform the maintenance and repair of aircraft composite structures, the damage of composite structures in a certain type of aircraft were investigated. The time-varying damage distribution model was established and verified based on the damage of a 16-aircraft fleet. The results show that the quantitative proportions of structural damage are 74% for skin delamination, 22% for stringer delamination and 3% for stringer-skin interface debonding. The amount of structural damages increases linearly with service time while the proportion of different damages does not change. As the service time increases, the geometric parameter distribution of damage for the same type of aircraft gradually converges, which can be approximated using the same function. There are certain differences in the proportion and geometric parameter distribution of damages among different components and locations, and the differences do not change over time.展开更多
文摘Objective To investigate the growth parameters of children with phenylketonuria and assess the impact of a phenylalanine-restricted diet on their physical development.Methods The study involved 39 children diagnosed with phenylketonuria through newborn screening at the Central Child Teaching Hospital,Baghdad,Iraq.Data were collected during scheduled monthly check-ups,including phenylalanine levels,diet compliance,and anthropometric measurements.The children were divided into two groups based on their phenylalanine levels during the 3-year follow up period:well-controlled group(average phenylalanine level of less than 360μmol/L,with no single reading exceeding 600μmol/L;n=14)and poorly-controlled group(one or more phenylalanine readings above 600μmol/L during the follow-up period;n=25).Results The mean height readings for all time points(at birth and 3,6,9,12,15,18,21,24 and 36 months of age)were higher in the well-controlled group than the poorly-controlled group,however,only at 3 months of age the difference was statistically significant.Height Z-scores revealed a clearer pattern:although the poorly controlled group had higher height Z-scores at birth(P=0.001),the well-controlled group showed significantly higher height Z-scores at 3,6,12,15,18,24,and 36 months(P<0.05).The well-controlled group exhibited significantly higher mean weight measurements compared to the poorly-controlled group at 3,6,9,15,18 months and 21 months(P<0.05).From 6 to 36 months,the well-controlled group consistently had significantly higher weight Z-scores than the poorly controlled group(P<0.05).The well-controlled group showed more favorable height and weight Z-score distributions at 36 months of age compared to the poorly-controlled group,but the differences were not statistically significant(P>0.05).Both groups had height and weight Z-scores within the normal range at 36 months of age.Conclusions The children with phenylketonuria who receive good dietary control show better improvements in growth parameters compared to those with poor dietary control,however,both groups maintain height and weight Z-scores within the normal range,indicating generally adequate physical development across the cohort.
文摘The damage distribution of the same type of aircraft in similar service environments should be similar. Based on this assumption, to perform the maintenance and repair of aircraft composite structures, the damage of composite structures in a certain type of aircraft were investigated. The time-varying damage distribution model was established and verified based on the damage of a 16-aircraft fleet. The results show that the quantitative proportions of structural damage are 74% for skin delamination, 22% for stringer delamination and 3% for stringer-skin interface debonding. The amount of structural damages increases linearly with service time while the proportion of different damages does not change. As the service time increases, the geometric parameter distribution of damage for the same type of aircraft gradually converges, which can be approximated using the same function. There are certain differences in the proportion and geometric parameter distribution of damages among different components and locations, and the differences do not change over time.
