1.EMT in cancer metastasis and chemoresistance Cancer metastasis is contingent on the epithelial-mesenchymal transition(EMT)of cancer cells.During EMT,epithelial cancer cells transform into a mesenchymal phenotype,whi...1.EMT in cancer metastasis and chemoresistance Cancer metastasis is contingent on the epithelial-mesenchymal transition(EMT)of cancer cells.During EMT,epithelial cancer cells transform into a mesenchymal phenotype,which endows cancer cells with enhanced migratory and invasive abilities,promoting their dissemination throughout the body.EMT also contributes significantly to chemoresistance,allowing cancer cells to survive and metastasize even after chemotherapy[1].展开更多
基金support from the National Science Foundation CAREER Award,USA(Grant No.:2143972)the National Institutes of Health through the Award,USA(Grant No.:R15CA274349).
文摘1.EMT in cancer metastasis and chemoresistance Cancer metastasis is contingent on the epithelial-mesenchymal transition(EMT)of cancer cells.During EMT,epithelial cancer cells transform into a mesenchymal phenotype,which endows cancer cells with enhanced migratory and invasive abilities,promoting their dissemination throughout the body.EMT also contributes significantly to chemoresistance,allowing cancer cells to survive and metastasize even after chemotherapy[1].
