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Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor 被引量:3
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作者 Yuye Wang Shuwen Zeng +11 位作者 Aurelian Crunteanu Zhenming Xie Georges Humbert Libo Ma Yuanyuan Wei Aude Brunel Barbara Bessette Jean-Christophe Orlianges Fabrice Lalloué Oliver GSchmidt Nanfang Yu Ho-Pui Ho 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第6期284-294,共11页
Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer,monitoring treatm... Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer,monitoring treatment and detecting relapse.Here,a highly enhanced plasmonic biosensor that can overcome this challenge is developed using atomically thin two-dimensional phase change nanomaterial.By precisely engineering the configuration with atomically thin materials,the phase singularity has been successfully achieved with a significantly enhanced lateral position shift effect.Based on our knowledge,it is the first experimental demonstration of a lateral position signal change>340μm at a sensing interface from all optical techniques.With this enhanced plasmonic effect,the detection limit has been experimentally demonstrated to be 10^(-15) mol L^(−1) for TNF-α cancer marker,which has been found in various human diseases including inflammatory diseases and different kinds of cancer.The as-reported novel integration of atomically thin Ge_(2)Sb_(2)Te_(5) with plasmonic substrate, which results in a phase singularity and thus a giant lateral position shift, enables the detection of cancer markers with low molecular weight at femtomolar level. These results will definitely hold promising potential in biomedical application and clinical diagnostics. 展开更多
关键词 2D nanomaterials Cancer marker detection phase singularity Surface plasmon
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Spatial correlation properties and phase singularity annihilation of Gaussian Schell-model beams in the focal region
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作者 刘普生 潘留占 吕百达 《Chinese Physics B》 SCIE EI CAS CSCD 2008年第5期1752-1757,共6页
By using the generalized Debye diffraction integral, this paper studies the spatial correlation properties and phase singularity annihilation of apertured Gaussian Schell-model (GSM) beams in the focal region. It is... By using the generalized Debye diffraction integral, this paper studies the spatial correlation properties and phase singularity annihilation of apertured Gaussian Schell-model (GSM) beams in the focal region. It is shown that the width of the spectral degree of coherence can be larger, less than or equal to the corresponding width of spectral density, which depends not only on the scalar coherence length of the beams, but also on the truncation parameter. With a gradual increase of the truncation parameter, a pair of phase singularities of the spectral degree of coherence in the focal plane approaches each other, resulting in subwavelength structures. Finally, the annihilation of pairs of phase singularities takes place at a certain value of the truncation parameter. With increasing scalar coherence length, the annihilation occurs at the larger truncation parameter. However, the creation process of phase singularities outside the focal plane is not found for GSM beams. 展开更多
关键词 singular optics spatial correlation annihilation of phase singularities truncation parameter
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Observation of robust subwavelength phase singularity in chiral medium
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作者 Jun-Hee Park Jeongho Ha +4 位作者 Liyi Hsu Guang Yang Yeshaiahu Fainman Alexander V.Sergienko Abdoulaye Ndao 《Advanced Photonics》 2025年第3期132-138,共7页
Photonic devices that exhibit both sensitivity and robustness have long been sought;yet,these characteristics are thought to be mutually exclusive;through sensitivity,a sensor responds to external stimuli,whereas robu... Photonic devices that exhibit both sensitivity and robustness have long been sought;yet,these characteristics are thought to be mutually exclusive;through sensitivity,a sensor responds to external stimuli,whereas robustness embodies the inherent ability of a device to withstand weathering by these same stimuli.This challenge stems from the inherent contradiction between robustness and sensitivity in wave dynamics,which require the coexistence of noise-immune sensitive states and modulation-sensitive transitions between these states.We report and experimentally demonstrate a subwavelength phase singularity in a chiral medium that is resilient to fabrication imperfections and disorder while remaining highly responsive to external stimuli.The combination of subwavelength light confinement and its robustness lays the foundation for the development of hitherto unexplored chip-scale photonics devices,enabling a simultaneous development of high-sensitivity and robust devices in both quantum and classical realms. 展开更多
关键词 PLASMONIC RESONATOR ROBUSTNESS phase singularity SUBWAVELENGTH CHIRALITY METAMATERIALS
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Double topological phase singularities in highly absorbing ultra-thin film structures for ultrasensitive humidity sensing
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作者 Xiaowen Li Jie Sheng +8 位作者 Zhengji Wen Fangyuan Li Xiran Huang Mingqing Zhang Yi Zhang Duo Cao Xi Shi Feng Liu Jiaming Hao 《Opto-Electronic Advances》 2025年第3期37-47,共11页
Phase singularities(PSs)in topological darkness-based sensors have received significant attention in optical sensing due to their rapid,ultra-sensitive,and label-free detection capabilities.Here,we present both experi... Phase singularities(PSs)in topological darkness-based sensors have received significant attention in optical sensing due to their rapid,ultra-sensitive,and label-free detection capabilities.Here,we present both experimental and theoretical investigations of an ultrasensitive and multiplexed phase-sensitive sensor utilizing dual topological PSs in the visible and near-infrared regions.This sensor uses a simple structure,which consists of an ultra-thin highly absorbing film deposited on a metal substrate.We demonstrate the achievement of dual-polarization darkness points for s-and p-polarizations at different incident angles.Furthermore,we theoretically explain the double topological PSs accompanied by a perfect±π-jump near a zero-reflection point,based on the temporal coupled-mode formalism.To validate its multifunctional capabilities,humidity sensing tests were carried out.The results demonstrate that the sensor has a detection limit reaching the level of 0.12‰.These findings go beyond the scope of conventional interference optical coatings and highlight the potential applications of this technology in gas sensing and biosensing domains. 展开更多
关键词 double topological darkness phase singularity thin-film optics ultrasensitive sensing
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Knotted Topological Phase Singularities of Electromagnetic Field
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作者 REN Ji-Rong ZHU Tao MO Shu-Fan 《Communications in Theoretical Physics》 SCIE CAS CSCD 2008年第11期1071-1076,共6页
In this paper,knotted objects (RS vortices) in the theory of topological phase singularity in electromagneticfield have been investigated in details.By using the Duan's topological current theory,we rewrite the to... In this paper,knotted objects (RS vortices) in the theory of topological phase singularity in electromagneticfield have been investigated in details.By using the Duan's topological current theory,we rewrite the topological currentform of RS vortices and use this topological current we reveal that the Hopf invariant of RS vortices is just the sum ofthe linking and self-linking numbers of the knotted RS vortices.Furthermore,the conservation of the Hopf invariant inthe splitting,the mergence and the intersection processes of knotted RS vortices is also discussed. 展开更多
关键词 knotted optical vortex topological current phase singularity
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Abnormal focal length increase of terajet generated in reflection mode
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作者 Yu-Jing Yang Jiang-Tao Qin +2 位作者 De-Long Zhang Sai-Dong Xue Ning Yuan 《Chinese Physics B》 2025年第9期204-209,共6页
We report an interesting and abnormal electromagnetic phenomenon with regard to a terajet(TJ)that is generated in a reflection mode,which is realized by placing a dielectric scatterer onto a metal reflection plate.We ... We report an interesting and abnormal electromagnetic phenomenon with regard to a terajet(TJ)that is generated in a reflection mode,which is realized by placing a dielectric scatterer onto a metal reflection plate.We show that the introduction of an air hollow into metal reflection plate beneath the scatterer does not induce an expected decrease but an abnormal increase of focal length of the TJ by as much as more than three times.This abnormal phenomenon takes place in case that the air hollow is shallow and there exists a critical hollow depth for a given lateral size of air hollow.Larger than the critical depth,the phenomenon no longer occurs.It is explained from viewpoints of both ray optics in terms of role of relative portion of central waves in TJ formation and electromagnetic field theory with regard to hollow-induced phase singularities. 展开更多
关键词 terajet reflection mode air hollow focal length phase singularity
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Propagation dynamics and experimental observation of quadratic vortex beam
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作者 Chen Zi-Yang Pu Ji-Xiong 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第2期286-291,共6页
The concept of a quadratic vortex beam is proposed, in which phase term of the beam is given by exp(i mθ2). The phase of the quadratic vortex beam increases with azimuthal angle nonlinearly. This change in phase pr... The concept of a quadratic vortex beam is proposed, in which phase term of the beam is given by exp(i mθ2). The phase of the quadratic vortex beam increases with azimuthal angle nonlinearly. This change in phase produces several unexpected effects. Unlike the circularly symmetric beam spot of normal vortex beams, the intensity distribution of the quadratic vortex beam is shown to be asymmetric. The phase singularities will shift in the transverse beam plane on propagation. 展开更多
关键词 vortex beam phase singularity propagation dynamics
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Focusing of Partially Coherent Vortex Beams by an Aperture Lens 被引量:6
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作者 饶连周 蒲继雄 《Chinese Physics Letters》 SCIE CAS CSCD 2007年第5期1252-1255,共4页
The focusing properties of partially coherent vortex wave fields are studied. Expressions are derived for the intensity distribution and the degree of coherence near the geometrical focus. It is found that the size of... The focusing properties of partially coherent vortex wave fields are studied. Expressions are derived for the intensity distribution and the degree of coherence near the geometrical focus. It is found that the size of coherence vortex dark core in the focal region depends on the topological charges and normalized coherence lengths. It is found that the desired vortex dark core near the geometrical focus can be generated by choosing appropriate values of parameters. The degree of coherence possesses a pair of phase singularities regions in the geometrical focus neighbourhood. 展开更多
关键词 ORBITAL ANGULAR-MOMENTUM HOLLOW GAUSSIAN BEAMS phase SINGULARITIES OPTICALVORTICES
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Topological Properties of Spatial Coherence Function
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作者 任继荣 朱涛 段一士 《Chinese Physics Letters》 SCIE CAS CSCD 2008年第2期367-370,共4页
The topological properties of the spatial coherence function are investigated rigorously. The phase singular structures (coherence vortices) of coherence function can be naturally deduced from the topological curren... The topological properties of the spatial coherence function are investigated rigorously. The phase singular structures (coherence vortices) of coherence function can be naturally deduced from the topological current, which is an abstract mathematical object studied previously. We find that coherence vortices are characterized by the Hopf index and Brouwer degree in topology. The coherence flux quantization and the linking of the closed coherence vortices are also studied from the topological properties of the spatial coherence function. 展开更多
关键词 WAVE DISLOCATION LINES phase SINGULARITIES BEAMS LIGHT KNOTS
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Metrology with a twist:probing and sensing with vortex light 被引量:2
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作者 Mingjian Cheng Wenjie Jiang +2 位作者 Lixin Guo Jiangting Li Andrew Forbes 《Light: Science & Applications》 2025年第3期591-609,共19页
Optical metrology is a well-established subject,dating back to early interferometry techniques utilizing light's linear momentum through fringes.In recent years,significant interest has arisen in using vortex ligh... Optical metrology is a well-established subject,dating back to early interferometry techniques utilizing light's linear momentum through fringes.In recent years,significant interest has arisen in using vortex light with orbital angular momentum(OAM),where the phase twists around a singular vortex in space or time.This has expanded metrology's boundaries to encompass highly sensitive chiral interactions between light and matter,three-dimensional motion detection via linear and rotational Doppler effects,and modal approaches surpassing the resolution limit for improved profling and quantification.The intricate structure of vortex light,combined with the integration of artifcial intelligence into optical metrology,unlocks new paradigms for expanding measurement frameworks through additional degrees of freedom,offering the potential for more effcient and accurate sensing and metrological advancements.This review aims to provide a comprehensive overview of recent advances and future trends in optical metrology with structured light,specifically focusing on how utilizing vortex beams has revolutionized metrology and remote sensing,transitioning from classical to quantum approaches. 展开更多
关键词 orbital angular momentum oam where orbital angular momentum optical metrology chiral interactions interferometry techniques vortex light phase twists singular vortex space timethis metrologys boundaries
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Momentum-dependent topological transitions in C-point singularities
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作者 Dongmin Jeon Junsuk Rho 《Science China(Physics,Mechanics & Astronomy)》 2025年第8期277-277,共1页
Singularities are the positions at which a physical quantity becomes not well-behaved or undefined.In the context of optics,singularities can manifest in various forms,including amplitude,phase,and polarization singul... Singularities are the positions at which a physical quantity becomes not well-behaved or undefined.In the context of optics,singularities can manifest in various forms,including amplitude,phase,and polarization singularities.Among these,polarization singularities are typically classified into V-points,C-points,and L-lines. 展开更多
关键词 c point singularities polarization singularities optics v points phase singularities amplitude singularities l lines momentum dependent topological transitions
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Topological links and knots of speckled light mediated by coherence singularities
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作者 Zhuoyi Wang Xingyuan Lu +2 位作者 Zhigang Chen Yangjian Cai Chengliang Zhao 《Light: Science & Applications》 2025年第7期1842-1850,共9页
Links and knots are exotic topological structures that have garnered significant interest across multiple branches of natural sciences.Coherent links and knots,such as those constructed by phase or polarization singul... Links and knots are exotic topological structures that have garnered significant interest across multiple branches of natural sciences.Coherent links and knots,such as those constructed by phase or polarization singularities of coherent light,have been observed in various three-dimensional optical settings.However,incoherent links and knots—knotted or connected lines of coherence singularities—arise from a fundamentally different concept.They are"hidden"in the statistic properties of a randomly fluctuating field,making their presence often elusive or undetectable.Here,we theoretically construct and experimentally demonstrate such topological entities of incoherent light.By leveraging a state-of-the-art incoherent modal-decomposition scheme,we unveil incoherent topological structures from fluctuating light speckles,including Hopf links and Trefoil knots of coherence singularities that are robust against coherence and intensity fluctuations.Our work is applicable to diverse wave systems where incoherence or practical coherence is prevalent,and may pave the way for design and implementation of statistically-shaped topological structures for various applications such as high-dimensional optical information encoding and optical communications. 展开更多
关键词 topological links links knotssuch coherence singularities knots knotted connected lines coherence singularities arise incoherent light KNOTS phase polarization singularities links knots
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Tunable azimuthally non-uniform orbital angular momentum carried by vector optical fields
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作者 Yue Pan Xu-Zhen Gao +3 位作者 Rende Ma Chenghou Tu Yongnan Li Hui-Tian Wang 《Chinese Optics Letters》 SCIE EI CAS CSCD 2020年第12期73-77,共5页
Orbital angular momentum(OAM), as a fundamental parameter of a photon, has attracted great attention in recent years. Although various properties and applications have been developed by modulating the OAM of photons, ... Orbital angular momentum(OAM), as a fundamental parameter of a photon, has attracted great attention in recent years. Although various properties and applications have been developed by modulating the OAM of photons, there is rare research about the non-uniform OAM. We propose and generate a new kind of continuously tunable azimuthally non-uniform OAM for the first time, to the best of our knowledge, which is carried by a hybridly polarized vector optical field with a cylindrically symmetric intensity profile and a complex polarization singularity. We also present the perfect vector optical field carrying non-uniform OAM with a fixed radius independent of topological charges, which can propagate steadily without radial separation, solving the problem of the unsteady propagation due to the broadened OAM spectrum of the non-uniform OAM. This new kind of tunable non-uniform OAM with a cylindrical symmetric intensity profile, complex polarization singularity, and propagation stability enriches the family of OAMs and can be widely used in many regions such as optical manipulation, quantum optics, and optical communications. 展开更多
关键词 orbital angular momentum vector optical field singular optics phase singularity polarization singularity.
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Chip-scale metaphotonic singularities:topological,dynamical,and practical aspects 被引量:2
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作者 Tianyue Li Mengjiao Liu +6 位作者 Jiahao Hou Xing Yang Shubo Wang Shuming Wang Shining Zhu Din Ping Tsai Zhenlin Wang 《Chip》 2024年第4期16-42,共27页
Research aboutsingularities has been driving scientific advancements across mathematics and physics.Comprehending and harnessing the novel properties of singularities in photonics can facilitate the development of int... Research aboutsingularities has been driving scientific advancements across mathematics and physics.Comprehending and harnessing the novel properties of singularities in photonics can facilitate the development of integrated micro-nano devices in diverse platforms.Herein,we provide a comprehensive overview of photonic singularities emerging in structured lightfields and metamaterial structures.We classify them into several representative types:real-space singularities,momentum-space singularities,and parameter-space singularities,with discussions of their intriguing topological and dynamical properties.Moreover,we report on the latest applications of photonic singularities in broad areas,ranging from light routing,lasing,sensing,and optical manipulation to imaging and display.This review connects the singularity phenomena in different photonic systems,bridging the abstract concepts with emerging practical applications.It underscores the significance of photonic singularities in both fundamental science and various on-chip applications. 展开更多
关键词 Photonic singularities Metasurface photonics Topological metasurfaces phase singularities Polarization singularities Exceptional point
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Improved Hrmander’s Theorem and New Methods for Oscillatory Integral Operators
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作者 Sheng-Ming MA 《Acta Mathematica Sinica,English Series》 SCIE CSCD 2009年第11期1865-1874,共10页
This paper proves a theorem on the decay rate of the oscillatory integral operator with a degenerate C^∞ phase function, thus improving a classical theorem of HSrmander. The proof invokes two new methods to resolve t... This paper proves a theorem on the decay rate of the oscillatory integral operator with a degenerate C^∞ phase function, thus improving a classical theorem of HSrmander. The proof invokes two new methods to resolve the singularity of such kind of operators: a delicate method to decompose the operator and balance the L^2 norm estimates; and a method for resolution of singularity of the convolution type. The operator is decomposed into four major pieces instead of infinite dyadic pieces, which reveals that Cotlar's Lemma is not essential for the L^2 estimate of the operator. In the end the conclusion is further improved from the degenerate C^∞ phase function to the degenerate C^4 phase function. 展开更多
关键词 oscillatory integral operators decay rate Fourier integral operators degenerate phase resolution of singularity
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