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A UNIVERSAL ANALYTIC POTENTIAL-ENERGY FUNCTION BASED ON A PHASE FACTOR 被引量:11
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作者 CFYu KYan DZLiu 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2006年第6期455-468,共14页
Using a field equation with a phase factor, a universal analytic potential-energy function applied to the interactions between diatoms or molecules is derived, and five kinds of potential curves of common shapes are o... Using a field equation with a phase factor, a universal analytic potential-energy function applied to the interactions between diatoms or molecules is derived, and five kinds of potential curves of common shapes are obtained adjusting the phase factors. The linear thermal expansion coefficients and Young's moduli of eleven kinds of face-centered cubic (fcc) metals - Al, Cu, Ag, etc. are calculated using the potential-energy function; the computational results are quite consistent with experimental values. Moreover, an analytic relation between the linear thermal expansion coefficients and Young's moduli of fcc metals is given using the potential-energy function. Finally, the force constants of fifty-five kinds of diatomic moleculars with low excitation state are computed using this theory, and they are quite consistent with RKR (Rydberg-Klein-Rees) experimental values. 展开更多
关键词 universal potential energy function field equation phase factor derivative renormalization linear thermal expansion coefficient Young's modulus force constant
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Low-complexity PTS scheme based on phase factor sequences optimization 被引量:2
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作者 JI Ce ZHANG Chao ZHU Wenjing 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2018年第4期707-713,共7页
In this paper, a new partial transmit sequence(PTS)scheme with low computational complexity is proposed for the problems of high computational complexity in the conventional PTS method. By analyzing the relationship... In this paper, a new partial transmit sequence(PTS)scheme with low computational complexity is proposed for the problems of high computational complexity in the conventional PTS method. By analyzing the relationship of candidate sequences in the PTS method under the interleaved partition method, it has been discovered that some candidate sequences generated by phase factor sequences have the same peak average power ratio(PAPR). Hence, phase factor sequences can be optimized to reduce their searching times. Then, the computational process of generating candidate sequences can be simplified by improving the utilization of data and minimizing the calculations of complex multiplication. The performance analysis shows that, compared with the conventional PTS scheme, the proposed approach significantly decreases the computational complexity and has no loss of PAPR performance. 展开更多
关键词 partial transmit sequence (PTS) peak average powerratio (PAPR) phase factor sequences optimization orthogonal frequency division multiplexing (OFDM) low computational com-plexity
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Diagnostic usefulness of selected proteases and acute phase factors in patients with colorectal adenocarcinoma
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作者 Tadeusz Sebzda Jan Gnus +2 位作者 Barbara Dziadkowiec Miroslaw Latka Jakub Gburek 《World Journal of Gastroenterology》 SCIE CAS 2021年第39期6673-6688,共16页
BACKGROUND Uncontrolled growth and loss of control over basic metabolic functions,leading to invasive proliferation and metastases,are the salient traits of malignant tumors in general and colorectal cancer in particu... BACKGROUND Uncontrolled growth and loss of control over basic metabolic functions,leading to invasive proliferation and metastases,are the salient traits of malignant tumors in general and colorectal cancer in particular.Invasion and metastases hinder effective tumor treatment.While surgical techniques and radiotherapy can be used to remove tumor focus,only chemotherapy can eliminate dispersed neoplastic cells.However,the efficacy of the latter method is limited in the advanced stages of the disease.Therefore,recognition of the mechanisms involved in neoplastic cell spreading is indispensable for developing effective therapies.AIM To use a number of biomarkers involved in cancer progression and identify a panel that could be used for effective early diagnosis.METHODS We recruited 185 patients with colorectal adenocarcinoma(98 men,87 women with median age 63).Thirty-five healthy controls were sex and age-matched.Dukes’staging was as follows:A=22,B=52,C=72,D=39.We analyzed patients'blood serum before surgery.We determined:(1)Cathepsin B(CB)with Barrett's method(fluorogenic substrate);(2)Leukocytic elastase(LE)in a complex with alpha 1 trypsin inhibitor(AAT)using the immunoenzymatic MERCK test;(3)Total sialic acid(TSA)with the colorimetric periodate-resorcinol method;(4)Lipid-bound sialic acid(LASA)with the colorimetric Taut's method;and(5)The antitrypsin activity(ATA)employing the colorimetric test.RESULTS In patients,the values of the five biochemical parameters were as follows:CB=16.1±8.8 mU/L,LE=875±598μg/L,TSA=99±31 mg%,LASA=0.68±0.33 mg%,and ATA=3211±1504 U/mL.Except for LASA,they were significantly greater than those of controls:CB=11.4±6.5 mU/L,LE=379±187μg/L,TSA=71.4±15.1 mg%,LASA=0.69±0.28 mg%,and ATA=2016±690 U/mL.For CB and LASA,the differences between the four Dukes’stages and controls were not statistically significant.The inter-stage differences for CB and LASA were also absent.The receiver operating characteristic(ROC)analysis revealed the potential diagnostic value of CB,TSA,and ATA.The area under ROC,sensitivity,and specificity for these three parameters were:0.85,72%,90%;0.75,66%,77%;and 0.77,63%,84%,respectively.The sensitivity and specificity for the threeparameter panel CB-TSA-ATA were equal to 88.2%and 100%,respectively.CONCLUSION The increased value of CB,TSA,and ATA parameters are associated with tumor biology,invasion,and metastasis of colorectal cancer.The presented evidence suggests the potential value of the CB-TSA-ATA biochemical marker panel in early diagnostics. 展开更多
关键词 Colorectal cancer Cathepsin B Acute phase reactants Colorectal adenocarcinoma Acute phase factor
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Beyond the Dirac Phase Factor: Dynamical Quantum Phase-Nonlocalities in the Schrödinger Picture
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作者 Konstantinos Moulopoulos 《Journal of Modern Physics》 2011年第11期1250-1271,共22页
Generalized solutions of the standard gauge transformation equations are presented and discussed in physical terms. They go beyond the usual Dirac phase factors and they exhibit nonlocal quantal behavior, with the wel... Generalized solutions of the standard gauge transformation equations are presented and discussed in physical terms. They go beyond the usual Dirac phase factors and they exhibit nonlocal quantal behavior, with the well-known Relativistic Causality of classical fields affecting directly the phases of wavefunctions in the Schr?dinger Picture. These nonlocal phase behaviors, apparently overlooked in path-integral approaches, give a natural account of the dynamical nonlocality character of the various (even static) Aharonov-Bohm phenomena, while at the same time they seem to respect Causality. For particles passing through nonvanishing magnetic or electric fields they lead to cancellations of Aharonov-Bohm phases at the observation point, generalizing earlier semiclassical experimental observations (of Werner & Brill) to delocalized (spread-out) quantum states. This leads to a correction of previously unnoticed sign-errors in the literature, and to a natural explanation of the deeper reason why certain time-dependent semiclassical arguments are consistent with static results in purely quantal Aharonov-Bohm configurations. These nonlocalities also provide a remedy for misleading results propagating in the literature (concerning an uncritical use of Dirac phase factors, that persists since the time of Feynman’s work on path integrals). They are shown to conspire in such a way as to exactly cancel the instantaneous Aharonov-Bohm phase and recover Relativistic Causality in earlier “paradoxes” (such as the van Kampen thought-experiment), and to also complete Peshkin’s discussion of the electric Aharonov-Bohm effect in a causal manner. The present formulation offers a direct way to address time-dependent single- vs double-slit experiments and the associated causal issues—issues that have recently attracted attention, with respect to the inability of current theories to address them. 展开更多
关键词 AHARONOV-BOHM GAUGE TRANSFORMATIONS DIRAC phase factor Quantum phases
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Non-Abelian Berry phase Factor of the Degenerate states
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作者 Wang Jianbo Shanxi Teacher’s University 《山西师范大学学报(自然科学版)》 1991年第4期30-35,共6页
Suppose the degenerate states wave function of a Hamitonian operatorHis accompanied by a natural phase factor, then we can own it to the role of sometransformation generator played by some non--degenerate Hermitian op... Suppose the degenerate states wave function of a Hamitonian operatorHis accompanied by a natural phase factor, then we can own it to the role of sometransformation generator played by some non--degenerate Hermitian operator containedin the complete set of conserved mechanical quantities. When this idea is extended tothe spece coordinated by parameters and the momentum--like operator is introduced,thenon-Abelian Berry phose factor of degenerate wave function can be easily gotter afterthe system evolves along a closed adiabatic curve. 展开更多
关键词 Degnerate STATE Non-Abelian BERRY phase factor
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Bainite isothermal transformation of Si–Mn–Mo alloy by phase structure factor calculation under different rare earth contents 被引量:1
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作者 Yan-Liang Yi Yi-Long Liang Qi-Bing Tan 《Rare Metals》 SCIE EI CAS CSCD 2014年第4期427-432,共6页
The effect of rare earth (RE) on bainite trans- formation mechanism is not yet unified in the academia. Therefore, further studying the effect of RE on bainite transformation mechanism will have important guiding si... The effect of rare earth (RE) on bainite trans- formation mechanism is not yet unified in the academia. Therefore, further studying the effect of RE on bainite transformation mechanism will have important guiding significance for the development of bainite steels. In this paper, using differential dilatometer (DIL805A/D), heat treatment was performed and C-curve was drawn. The effect of phase structure factor on bainite transformation under two different fractions of RE in Si-Mn-Mo bainite steels was investigated by the empirical electron theory (EET) of solids, molecules, dilatometry, and metallogra- phy. Experimental results show that RE makes Fe-C- RE segregation structural unit of Si-Mn-Mo bainite steels increase, i.e., the values of phase structure factor (na, FDC) increase, and delay bainite transformation due to the drag effect resulting from the segregation of RE ferrite island interphase and the retardation of RE to carbon diffusion in Si-Mn-Mo bainite steels. Beside this, C-curve is shifted to right and down, and microstructures of bainite ferrite and substructures are finer. 展开更多
关键词 phase structure factor C-CURVE SUBSTRUCTURE Rare earths
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Influencing factors for catalytic oxidation of mine gas to methanol in liquid phase 被引量:2
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作者 ZHU Lihua XU Feng +1 位作者 BI Yewu SHEN Bin 《Chinese Journal Of Geochemistry》 EI CAS CSCD 2014年第2期183-186,共4页
The influencing factors for liquid phase catalytic oxidation of mine gas to methanol(in form of CH3COOCH3) are studied using the self-established experimental apparatus. The results show that CH3COOCH3(target product)... The influencing factors for liquid phase catalytic oxidation of mine gas to methanol(in form of CH3COOCH3) are studied using the self-established experimental apparatus. The results show that CH3COOCH3(target product) is obtained by using CH3COOH as reaction solvent, and the yield of target product increases with the increasing of reaction temperature, gas pressure and reaction time. In the mine gas-Pd(OAc)2-CH3COOH system, the yield of CH3COOCH3 increases with the increasing of addition of Pd(OAc)2 which is redox catalyst for mine gas conversion. The yield of CH3COOCH3 will be greatly improved by composite additional oxidant which is obtained by equimolar mix of p-benzoquinone with NO2. 展开更多
关键词 液相催化氧化 矿井瓦斯 影响因素 甲醇 还原催化剂 实验装置 反应溶剂 反应温度
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DYNAMIC LIE ALGEBRA STRUCTURE OF QUANTAL SYSTEM AND BERRY'S PHASE FACTOR
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作者 孙昌璞 葛墨林 《Chinese Science Bulletin》 SCIE EI CAS 1990年第21期1784-1789,共6页
At present, Berry’s topological phase factor and the studies of its relevant problem have drawn considerable attention . It concerns the theoretical analysis of chiral anomaly, etc., which is also experimentally conf... At present, Berry’s topological phase factor and the studies of its relevant problem have drawn considerable attention . It concerns the theoretical analysis of chiral anomaly, etc., which is also experimentally confirmed. In general, the explicit determination of the 展开更多
关键词 SEMISIMPLE LIE ALGEBRA ADIABATIC approximation Berry’s phase factor.
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液液相分离研究进展:从基础到应用
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作者 耿铁 付雯雯 +3 位作者 温从仑 于浩 李洪光 刘雪婧 《化学研究与应用》 北大核心 2026年第2期249-265,共17页
液液相分离(Liquid-liquid Phase Separation,LLPS)是指均相溶液自发地转变为两个或多个不混溶相的现象,分为两大类:隔离型LLPS和关联型LLPS。前者形成的水相两相系统(Aqueous Two-Phase System,ATPS)具备操作条件温和及构建过程灵活、... 液液相分离(Liquid-liquid Phase Separation,LLPS)是指均相溶液自发地转变为两个或多个不混溶相的现象,分为两大类:隔离型LLPS和关联型LLPS。前者形成的水相两相系统(Aqueous Two-Phase System,ATPS)具备操作条件温和及构建过程灵活、可设计的优势;后者涉及的凝聚(Coacervation)现象与前细胞系统、无膜细胞器高度相似,被认为与生命起源相关。近年来,LLPS还展现出高度生物相容性、环境友好性及广阔的应用场景,引起研究者的广泛关注。本文分别从ATPS和凝聚的构建出发,概述了双液相体系构建方法的创新和延伸,讨论了其优劣点并且分析了聚合物特性、盐类型与浓度、pH值、温度对相分离行为和体系性质等方面的影响;重点介绍了LLPS在生物医学、环境监测、食品安全、化学分析和药物递送等方面的应用,并提出了面临的挑战与未来发展趋势,为开发和优化LLPS相关技术提供一定参考。 展开更多
关键词 液液相分离 水相两相体系 凝聚 构建 影响因素 提取与纯化 生物相容材料
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基于多相质点网格法的复杂裂缝网络支撑剂运移规律模拟
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作者 王强 杨郁 +7 位作者 赵金洲 庄文龙 徐岩光 侯杰 张艺宣 胡永全 王玉丰 李小伟 《石油勘探与开发》 北大核心 2026年第1期213-222,共10页
采用三维多相质点网格方法,建立考虑复杂缝网的液-固两相流模型,同时采用物理实验数据验证模型的可靠性,在此基础上,分析影响裂缝网络中支撑剂运移规律的主要因素。研究表明:支撑剂在缝网中的运移可划分为初始充填、优势通道形成、缝网... 采用三维多相质点网格方法,建立考虑复杂缝网的液-固两相流模型,同时采用物理实验数据验证模型的可靠性,在此基础上,分析影响裂缝网络中支撑剂运移规律的主要因素。研究表明:支撑剂在缝网中的运移可划分为初始充填、优势通道形成、缝网延伸3个阶段,分别对应近井区域形成斑块状堆积、支撑剂沿主裂缝优先铺置、流体进入分支级缝提升平面铺置效果3种支撑剂运移规律。支撑剂密度越高、压裂液黏度越低、注入排量越低、支撑剂粒径越大,支撑剂在裂缝中的运移距离越短、支撑剂平面铺置系数越小,采用低密度、小粒径支撑剂与高黏度压裂液,同时适当提高压裂液注入排量可有效扩大改造范围。主裂缝-分支缝夹角越小,支撑剂在分支缝中形成的砂堤长度越大,覆盖范围越广,分布越均匀,改造效果越好;主裂缝-分支缝夹角越大,支撑剂在分支缝入口附近堆积的可能性越大,支撑剂平面铺置系数越小。 展开更多
关键词 多相质点网格法 复杂缝网 液-固两相流 支撑剂运移 压裂施工参数 影响因素
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X波段双偏振相控阵和S波段双偏振雷达观测一致性分析
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作者 李媛 陈超 +1 位作者 高必通 李少远 《气象水文海洋仪器》 2026年第1期6-8,13,共4页
文章利用连州S波段双偏振雷达(CINRAD-SAD)和清远南部佛冈、英德、清城、清新4站X波段双偏振相控阵雷达(XPAR)2022年7月1日-12月31日各单部雷达及组网观测资料,运用时空数据匹配对比分析的方法,对两种雷达的一致性、稳定性和反射率因子... 文章利用连州S波段双偏振雷达(CINRAD-SAD)和清远南部佛冈、英德、清城、清新4站X波段双偏振相控阵雷达(XPAR)2022年7月1日-12月31日各单部雷达及组网观测资料,运用时空数据匹配对比分析的方法,对两种雷达的一致性、稳定性和反射率因子差异进行对比分析。结果表明,经过联合组网后,10~35 dBZ区域反射率拟合结果相对理想,20~35 dBZ拟合效果最佳。随着SAD反射率增强,XDPAR反射率与SAD反射率差值也随之增大,总体差值在-1~7 dBZ,中位数在1~4 dBZ,偏差较小,但5~35 dBZ区域存在较多奇异值。 展开更多
关键词 反射率因子 相控阵雷达 偏差订正 拟合订正
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原发性高血压合并射血分数降低的心力衰竭患者易损期预后影响因素分析
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作者 张露 陆红红 周碧蓉 《中国循证心血管医学杂志》 2026年第1期53-58,共6页
目的探讨原发性高血压合并射血分数降低的心力衰竭患者易损期预后的影响因素。方法收集2022年12月至2024年10月于安徽医科大学第一附属医院门诊及住院的263例原发性高血压合并射血分数降低的心力衰竭患者的一般资料及预后资料。所有患... 目的探讨原发性高血压合并射血分数降低的心力衰竭患者易损期预后的影响因素。方法收集2022年12月至2024年10月于安徽医科大学第一附属医院门诊及住院的263例原发性高血压合并射血分数降低的心力衰竭患者的一般资料及预后资料。所有患者在出院后3个月接受电话追踪随访,以3个月内疾病进展,包括因心力衰竭再住院、心源性死亡为随访终点。根据患者是否发生终点事件及随访左室射血分数(LVEF)情况将入组患者分为预后不良组、预后一般组及预后良好组,应用Logistic回归分析该人群易损期预后的影响因素,P<0.050为差异有统计学意义。结果(1)预后不良组患者共68例,包括心源性死亡5例,因心力衰竭再住院患者63例;预后一般组患者共174例;预后良好组21例。(2)与预后良好组相比,预后一般组中合并心房颤动、糖尿病病史患者的比例更高,C反应蛋白(CRP)、入院时脑钠肽(BNP)水平异常增高,估算的肾小球滤过率值(eGFR)显著降低(P<0.050);与预后良好组相比,预后不良组男性、有吸烟、合并心房颤动、糖尿病、慢性肾脏病病史患者的比例更高,血清白蛋白(ALB)水平、LVEF、eGFR水平显著降低,CRP水平、入院BNP水平异常增高(P<0.050);与预后一般组相比,预后不良组中男性、有吸烟、合并慢性肾脏病病史患者的比例更高,eGFR水平显著降低,入院BNP水平异常增高(P<0.050)。(3)有序多因素Logistic回归分析,结果显示患者男性(OR=1.322,95%CI:1.035~1.689)、ALB<35 g/L(OR=1.340,95%CI:1.031~1.744)、eGFR<60 mL/(min·1.73m^(2))(OR=1.644,95%CI:1.173~2.303)、入院BNP水平>1500 pg/mL(OR=1.765,95%CI:1.190~2.617)、LVEF基线值(OR=0.868,95%CI:0.778~0.969)是高血压伴射血分数降低的心力衰竭患者易损期预后的独立影响因素。结论原发性高血压合并射血分数降低的心力衰竭患者易损期拥有较高的心力衰竭再入院率及心血管死亡风险,部分患者预后良好。其中男性、ALB水平、eGFR、入院BNP水平、LVEF基线值是此类患者易损期预后的独立影响因素。 展开更多
关键词 原发性高血压 射血分数降低性心力衰竭 易损期 预后 危险因素
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五运六气理论在疾病预测模型中的研究进展
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作者 李佩洋 郭宇祺 张真 《中国民族民间医药》 2026年第3期71-74,共4页
五运六气理论是中医学的重要组成部分。近年来,随着“未病先防”理念的传播,五运六气理论在疾病防治中的价值逐渐得到重视。通过梳理相关文献,文章整理了五运六气理论的历史发展过程,分析了构建五运六气理论模型的必要性及其特点,并总... 五运六气理论是中医学的重要组成部分。近年来,随着“未病先防”理念的传播,五运六气理论在疾病防治中的价值逐渐得到重视。通过梳理相关文献,文章整理了五运六气理论的历史发展过程,分析了构建五运六气理论模型的必要性及其特点,并总结了五运六气疾病预测模型在传染性疾病、心血管疾病、呼吸系统疾病、消化系统疾病和内伤杂病及其他方面中的应用。此外,还对五运六气理论的研究价值及难点进行讨论,为五运六气理论在临床的深入研究提供参考。 展开更多
关键词 五运六气 运气学说 综述
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短暂性脑缺血发作进展为急性脑梗死患者的临床特点及影响因素分析
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作者 路莹 陈洁云 +1 位作者 张威威 赵瑞豪 《实用医院临床杂志》 2026年第1期97-101,共5页
目的调查短暂性脑缺血发作(TIA)进展为急性脑梗死(ACI)患者的临床特点,并分析其影响因素。方法回顾性分析2022年1月至2024年1月河北省邢台市中心医院神经内科收治的TIA患者177例。随访6个月依据是否进展为ACI分为进展组(n=48)与未进展组... 目的调查短暂性脑缺血发作(TIA)进展为急性脑梗死(ACI)患者的临床特点,并分析其影响因素。方法回顾性分析2022年1月至2024年1月河北省邢台市中心医院神经内科收治的TIA患者177例。随访6个月依据是否进展为ACI分为进展组(n=48)与未进展组(n=129)。采用多元Logistic回归模型分析影响TIA患者进展为ACI的独立危险因素,并采用受试者操作特征(ROC)曲线及最大约登指数分析各因素对TIA患者进展为ACI的预测价值。结果与未进展组比较,进展组合并高脂血症、动脉狭窄率>70%、存在颈动脉粥样硬化斑块及单次发作时间≥30 min的占比均更高(P<0.05),且ABCD2评分、和肽素与Lp-PLA_(2)水平均更高(P<0.05)。Logistic回归分析结果显示,ABCD2评分、和肽素与Lp-PLA_(2)水平均是影响TIA患者进展为ACI的独立危险因素;ROC曲线结果显示ABCD2评分、和肽素与Lp-PLA_(2)水平的AUC分别为0.791、0.697与0.542,截断值分别为4分、188.17 mg/L与16.89 pmol/L;联合预测的AUC为0.851。结论ABCD2评分作为独立危险因素,预测TIA患者进展为ACI具有较高临床价值,以及联合Lp-PLA_(2)与和肽素水平的预测价值更高。临床上三者同时异常时,患者进展为ACI的风险极高,建议立即采取强化干预措施;而对于仅满足一或两项指标的患者,也应纳入重点随访范围,以实现对TIA后ACI风险的早期识别和分层管理。 展开更多
关键词 短暂性脑缺血发作 脑梗死 急性期 危险因素 临床特点
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钢圆筒岛壁结构施工阶段碳排放测算及分析
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作者 刘丽斌 谢俊 +1 位作者 张曦 谢锦波 《水运工程》 2026年第1期257-264,共8页
随着全球气候问题日益严峻,社会对低碳发展愈发关注。碳核算是实现碳达峰、碳中和的关键基础,碳排放测算成为核心环节。围海填陆工程因占地面积广、工程量大,碳排量显著;而钢圆筒作为其核心结构之一,碳排放测算具有重要意义。运用碳排... 随着全球气候问题日益严峻,社会对低碳发展愈发关注。碳核算是实现碳达峰、碳中和的关键基础,碳排放测算成为核心环节。围海填陆工程因占地面积广、工程量大,碳排量显著;而钢圆筒作为其核心结构之一,碳排放测算具有重要意义。运用碳排放因子法,针对某项目钢圆筒岛壁结构施工阶段碳排放进行测算分析,并与斜坡式、桶式基础护岸碳排放量对比。结果表明:钢圆筒施工阶段碳排放主要来源于材料,占比94%,钢材是主要碳排放源。材料使用间接排放高于直接排放。运输船和起重船碳排放量在船机设备中居前两位。钢圆筒护岸结构主要材料每延米碳排放量为77 t,高于斜坡堤的69 t,低于桶式基础的103.5 t。该研究为工程碳减排策略的制定提供了科学依据,有助于推动围海填陆工程向低碳化方向发展。 展开更多
关键词 钢圆筒 碳排放 施工阶段 碳排放因子
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miR-21-5p靶向调控SKP2/p27通路参与转化生长因子β1诱导人肾小管上皮细胞纤维化的作用机制
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作者 雷波 黄建林 刘健男 《临床肾脏病杂志》 2026年第2期162-168,共7页
目的探究miR-21-5p靶向调控S期激酶相关蛋白2(S-phase kinase-associated protein 2,SKP2)/p27通路参与转化生长因子β1(transforming growth factor-β1,TGF-β1)诱导人肾小管上皮细胞纤维化的作用机制。方法将人肾小管上皮细胞(human ... 目的探究miR-21-5p靶向调控S期激酶相关蛋白2(S-phase kinase-associated protein 2,SKP2)/p27通路参与转化生长因子β1(transforming growth factor-β1,TGF-β1)诱导人肾小管上皮细胞纤维化的作用机制。方法将人肾小管上皮细胞(human kidney-2,HK-2)随机分为对照组、模型组(TGF-β1诱导)、miR-NC组、miR-21-5p mimic组、miR-21-5p mimic+pcDNA-NC组与miR-21-5p mimic+SKP2过表达组(miR-21-5p mimic+pcDNA-SKP2组)。采用CCK-8实验检测各组HK-2细胞的活力;酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)法检测各组细胞上清液中肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素(interleukin,IL)1β的水平;实时荧光定量PCR(real-time quantitative PCR,RT-qPCR)法检测各组HK-2细胞中miR-21-5p、SKP2、p27mRNA的表达;蛋白质印迹法检测各组HK-2细胞中SKP2/p27信号通路相关蛋白表达和纤维化相关蛋白平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)、纤维连接蛋白(fibronectin,Fn)、胶原蛋白Ⅰ(CollagenⅠ)的表达;双荧光素酶报告基因实验探究miR-21-5p与SKP2的靶向关系。结果与对照组比较,模型组48 h细胞活力[(98.42±3.69)%比(67.49±6.21)%]、72 h细胞活力[(101.35±4.20)%比(62.78±6.48)%]、miR-21-5p水平(1.00±0.10比0.34±0.03)、p27 mRNA(1.00±0.11比0.43±0.04)与蛋白表达(0.85±0.09比0.20±0.02)显著降低,差异具有统计学意义(P<0.05);细胞上清液TNF-α[(57.34±8.22)ng/L比(317.59±26.38)ng/L]、IL-1β水平[(73.49±8.56)ng/L比(372.60±27.55)ng/L]、SKP2 mRNA表达水平(1.00±0.09比2.18±0.22)和蛋白表达(0.21±0.02比0.84±0.08)、α-SMA(0.26±0.03比0.97±0.10)、Fn(0.30±0.03比1.04±0.10)、CollagenⅠ(0.17±0.02比0.87±0.09)蛋白表达显著升高,差异具有统计学意义(P<0.05)。与模型组、miR-NC组相比,miR-21-5p mimic组HK-2细胞相关指标变化与上述相反,差异具有统计学意义(P<0.05)。过表达SKP2逆转了过表达miR-21-5p对TGF-β1诱导的HK-2纤维化的抑制作用。miR-21-5p靶向负调控SKP2的表达。结论miR-21-5p能靶向抑制SKP2/p27通路减轻TGF-β1诱导的HK-2纤维化。 展开更多
关键词 微小核糖核酸21-5p S期激酶相关蛋白2/p27通路 转化生长因子Β1 肾小管上皮细胞 纤维化
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基于健全线路倍增系数的配电网单相接地故障测试
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作者 杜涛 赵隆乾 +2 位作者 索吉鑫 李文娟 吕海霞 《微型电脑应用》 2026年第1期180-183,共4页
为了提高配电网单相接地故障能力,引入健全线路倍增系数进行测试分析。研究结果表明,以中性点作为参考,健全线路零序电流幅值比均表现出增大变化,相故障线路零序电流幅值比则表现出减小变化。故障距离几乎不对各线路倍增系数产生影响,... 为了提高配电网单相接地故障能力,引入健全线路倍增系数进行测试分析。研究结果表明,以中性点作为参考,健全线路零序电流幅值比均表现出增大变化,相故障线路零序电流幅值比则表现出减小变化。故障距离几乎不对各线路倍增系数产生影响,相比预设阀值,故障线路倍增系数依然较小,这表示故障线路L1能被准确识别。当对地电流不一致时,故障线路L2可被所提出的方法准确识别,且裕度充足。将零序CT(current transformer)极性反接,发现所提出的方法对线路可进行准确识别,同时也表明不引入零序电压也可以正确地识别。所提出的方法为实现故障选线自适应,将幅值比变化趋势通过倍增系数进行定量刻画。 展开更多
关键词 单相接地 幅值比 倍增系数 故障选线
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产妇泌乳Ⅱ期启动延迟发生现状及影响因素和干预措施探析
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作者 许子清 《中国医院统计》 2026年第1期27-30,共4页
目的探析产妇泌乳Ⅱ期启动延迟发生现状、影响因素、干预措施。方法选择2021年12月至2023年12月赣州市妇幼保健院产科197例产妇,调查产妇泌乳Ⅱ期启动时间,统计产妇泌乳Ⅱ期启动延迟发生率,logistic回归分析其影响因素,针对性设计干预... 目的探析产妇泌乳Ⅱ期启动延迟发生现状、影响因素、干预措施。方法选择2021年12月至2023年12月赣州市妇幼保健院产科197例产妇,调查产妇泌乳Ⅱ期启动时间,统计产妇泌乳Ⅱ期启动延迟发生率,logistic回归分析其影响因素,针对性设计干预措施。结果197例产妇泌乳Ⅱ期启动时间平均(74.34±5.78)min,43例产妇发生泌乳Ⅱ期启动延迟,发生率为21.83%(43/197)。单因素分析结果显示,2组患者年龄、初产、剖宫产、妊娠期糖尿病、产后开奶时间、焦虑、抑郁比较,差异有统计学意义(P<0.05)。logistic回归分析显示,年龄≥35岁、初产、剖宫产、妊娠期糖尿病、产后开奶时间>30 min、焦虑、抑郁是产妇泌乳Ⅱ期启动延迟发生的影响因素(P<0.05)。结论产妇泌乳Ⅱ期启动延迟与多种生理、心理及产科因素密切相关,应重点关注高龄、初产、剖宫产等高风险人群,通过优化产后早期母婴接触、加强妊娠期糖尿病管理及心理疏导等措施,降低延迟发生率,促进母乳喂养成功。 展开更多
关键词 产妇 泌乳Ⅱ期启动延迟 母乳喂养 影响因素
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Morphological Evolution of Fe-Rich Phases in the AlSi_9Cu_3Mg_(0.19)(Fe)Alloy with the Addition of Minor Mn and Cr 被引量:3
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作者 Zhi-Qiang Qiu Xiang-Chen Meng +5 位作者 Qiu-Hong Yuan Xiao-Shu Zeng Xi-Xin Rao Yan Ding Lan Luo Yong Liu 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2018年第6期629-640,共12页
The morphological evolution of Fe-rich phases in the Alalloy has been investigated with various contents of Fe,Mn,and Cr.The results show that coarse Chinese script Fe-rich phases appear in the alloy with 0.6 wt%Fe co... The morphological evolution of Fe-rich phases in the Alalloy has been investigated with various contents of Fe,Mn,and Cr.The results show that coarse Chinese script Fe-rich phases appear in the alloy with 0.6 wt%Fe combined with trace Mn,while the blocky Fe-rich phases appear combined with trace Cr.Under the coexistence of trace Mn and Cr,a large number of fine Chinese script Fe-rich phases could be visible in the low iron-bearing AlSi_9Cu_3-alloy(0.60 wt%).At high Fe level(1.30 wt%),numerous Fe-rich phases with hexagonal morphologies are observed with the trace Cr,while fish-bone and pentagonal morphologies of Fe-rich phases could be simultaneously observed with the addition of both Mn and Cr.The results reveal that the trace Mn and Cr promote the morphological evolution of Fe-rich phases.The morphology evolution mechanism of Fe-rich phases has been discussed by using the atom radius and electronegativity differences of Fe,Mn,and Cr. 展开更多
关键词 AlSi_9Cu_3Mg_(0.19)(Fe) alloy Fe-rich phase Sludge factor Microalloying Electronegativity differences
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The Formula of Dependence of Mechanical Characteristics of Materials on Crystalline Phase Composition in the Matrix 被引量:1
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作者 Z. Kovziridze 《Advances in Materials Physics and Chemistry》 2020年第8期178-188,共11页
<strong>Objective:</strong> For materials science and generally, for long-term operation of work-pieces in industry the significant role is attributed to dependence of macro-mechanical properties of consol... <strong>Objective:</strong> For materials science and generally, for long-term operation of work-pieces in industry the significant role is attributed to dependence of macro-mechanical properties of consolidated body on crystalline phase composition, its dimensions, form, distribution in matrix and the form factor. While working in responsible fields of technology of ceramics and ceramic composites the above referred properties are attributed extremely great role with the view of durability and endurance at the terms of heavy mechanical loads. For description of the resistance of any concrete type work-piece, the crystalline phase plays the greatest role in mechanical strength or deformation of any material. It plays the important role in correlative explanation of materials mechanics and matrix properties. In our case, in the process of destruction of ceramic materials and composites, which will give us exhaustive response to the role of macro- and micro-mechanical properties of materials, the role of a macro- and micro-structural component, that is, of crystalline phase in the process of transition of stable state of materials into meta-stable state is extremely big. Our study aims to develop a formula of dependence of macro-mechanical properties of ceramic and ceramic composites on crystalline phase, the most powerful component of their structure, which will enable theorists and practitioners to select and develop technologies and technological processes correctly. <strong>Method:</strong> On the basis of the study of micro- and macro-mechanical properties of ceramics and ceramic composites and the morphology of crystalline phase and the analysis of the study we determined and created parameters of the formula. <strong>Results:</strong> The formula covers macro-mechanical properties, that is when the work-piece is thoroughly destructed: mechanic at bending at three and four-point load, mechanic at contraction;among morphological characteristics: composition of crystalline phase and their spreading in matrix, their sizes, form factor;correlative dependence of the above listed properties. Absolutely new definition of a factor of spreading of crystalline phase in matrix is offered. <strong>Conclusion: </strong>The created formula is of consolidated nature and it can be used in technology of any ceramic material and ceramic composites. The formula will help practitioners to plan correctly and fulfill accurately all positions of technology of production of work-pieces, to carry out the most responsible thermal treatment process of technology of manufacture of work-pieces;to determine correlation between mechanical and matrix properties of materials. 展开更多
关键词 Crystalline phase Macro-Mechanical Properties Mechanic at Bending Mechanic at Compaction factor of Spreading of Crystalline phase in Matrix
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