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An in-Pixel Histogramming TDC Based on Octonary Search and 4-Tap Phase Detection for SPAD-Based Flash LiDAR Sensor
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作者 HE Wenjie NIE Kaiming WU Haoran 《传感技术学报》 北大核心 2025年第9期1547-1558,共12页
An in-pixel histogramming time-to-digital converter(hTDC)based on octonary search and 4-tap phase detection is presented,aiming to improve frame rate while ensuring high precicion.The proposed hTDC is a 12-bit two-ste... An in-pixel histogramming time-to-digital converter(hTDC)based on octonary search and 4-tap phase detection is presented,aiming to improve frame rate while ensuring high precicion.The proposed hTDC is a 12-bit two-step converter consisting of a 6-bit coarse quantization and a 6-bit fine quantization,which supports a time resolution of 120 ps and multiphoton counting up to 2 GHz without a GHz reference frequency.The proposed hTDC is designed in 0.11μm CMOS process with an area consumption of 6900μm^(2).The data from a behavioral-level model is imported into the designed hTDC circuit for simulation verification.The post-simulation results show that the proposed hTDC achieves 0.8%depth precision in 9 m range for short-range system design specifications and 0.2%depth precision in 48 m range for long-range system design specifications.Under 30×10^(3) lux background light conditions,the proposed hTDC can be used for SPAD-based flash LiDAR sensor to achieve a frame rate to 40 fps with 200 ps resolution in 9 m range. 展开更多
关键词 LiDAR sensor histogramming time-to-digital converter hybrid time of flight octonary search 4-tap phase detection
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Applying deep learning to teleseismic phase detection and picking:PcP and PKiKP cases
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作者 Congcong Yuan Jie Zhang 《Artificial Intelligence in Geosciences》 2025年第1期25-32,共8页
The availability of a tremendous amount of seismic data demands seismological researchers to analyze seismic phases efficiently.Recently,deep learning algorithms exhibit a powerful capability of detecting and picking ... The availability of a tremendous amount of seismic data demands seismological researchers to analyze seismic phases efficiently.Recently,deep learning algorithms exhibit a powerful capability of detecting and picking on P-and S-wave phases.However,it remains a challenge to effeciently process enormous teleseismic phases,which are crucial to probe Earth’s interior structures and their dynamics.In this study,we propose a scheme to detect and pick teleseismic phases,such as seismic phase that reflects off the core-mantle boundary(i.e.,PcP)and that reflects off the inner-core boundary(i.e.,PKiKP),from a seismic dataset in Japan.The scheme consists of three steps:1)latent phase traces are truncated from the whole seismogram with theoretical arrival times;2)latent phases are recognized and evaluated by convolutional neural network(CNN)models;3)arrivals of good or fair phase are picked with another CNN models.The testing detection result on 7386 seismograms shows that the scheme recognizes 92.15%and 94.13%of PcP and PKiKP phases.The testing picking result has a mean absolute error of 0.0742 s and 0.0636 s for the PcP and PKiKP phases,respectively.These seismograms were processed in just 5 min for phase detection and picking,demonstrating the efficiency of the proposed scheme in automatic teleseismic phase analysis. 展开更多
关键词 Earth’s interior Teleseismic phases phase detection phase picking Deep learning
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A new measuring technique in detecting of high voltage three phase induction motor for single phasing
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作者 Ali M El-Rifaie Hala M Abdel Mageed 《Journal of Measurement Science and Instrumentation》 CAS 2014年第3期6-11,共6页
Open phase in three phase induction motors is a common fault that can occur as a result of a fuse blowing or a pro- tective device failing on one phase of the motor. This paper introduces a new method,which is based o... Open phase in three phase induction motors is a common fault that can occur as a result of a fuse blowing or a pro- tective device failing on one phase of the motor. This paper introduces a new method,which is based on the transient mea- surement and can distinguish the fault of one phase connecting ground. The method has been proved to be in correspondence with the simulation results by Matlab and LabVIEW in practice, The method has merits of simplicity, accuracy and ease of USe. 展开更多
关键词 high voltage induction motor transient protection single phasing detection
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Enhanced Long-Distance Weak Signal Transmission Capabilities via Weak Measurement
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作者 Ding Wang Qi Song +3 位作者 Hongjing Li Zhiqiang Liu Jingzheng Huang Guihua Zeng 《Chinese Physics Letters》 2025年第11期118-125,共8页
Reliable detection of weak phase signals under significant channel loss and complex noise environments is a crucial step for practical applications of optical integrated communication and sensing systems. In this lett... Reliable detection of weak phase signals under significant channel loss and complex noise environments is a crucial step for practical applications of optical integrated communication and sensing systems. In this letter, we propose and experimentally demonstrate an enhanced long-distance weak signal transmission method assisted by weak measurement. Performing heterodyne detection and light intensity compensation on two nearly symmetric post-selected paths, the method enables real-time estimation of a time-varying phase while maintaining robustness against technical noises proportional to light intensity or photon number, detector common-mode noise, and significant attenuation over long-distance transmission. Experimental results indicate a potential phase sensitivity at the level of 10-8rad even with a signal light intensity attenuation of 48.1 d B. Potentially, combining the adaptive adjustment strategy, the method may provide a viable solution in remote weak signal detection and extraction,thereby contributing to optical integrated communication and sensing. 展开更多
关键词 weak measurement detection weak phase signals heterodyne detection optical integrated communication sensing systems light intensity compensation enhanced long distance weak signal transmission
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Research of the Phase Sensitive Detection Property of Magnetic Sensor Based on Hall Effect
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作者 陈金岳 周立伟 +1 位作者 丁守谦 李文深 《Journal of Beijing Institute of Technology》 EI CAS 1998年第1期32-38,共7页
Aim to detect the characteristic weak magnetic field signal against the strong noises background. Methods In combination with a low-pass-filter, the correlation output of magne-* tic sensors between the magnetic field... Aim to detect the characteristic weak magnetic field signal against the strong noises background. Methods In combination with a low-pass-filter, the correlation output of magne-* tic sensors between the magnetic field and reference current was utilized to provide a DC output voltage proportional to the applied magnetic induction, computer simulation was* done to investigate the correlation output of the Hall-effect sensors. Results Some analysis results concerning the noise property, harmonic supppression and the sensitivity were given. Conclsion The minimum detection signal of the equipment evolved from the mentioned cor-* relation theory can be 10-6 T. In addition to the DC output, such sensors can also measure the phase of the detected magnetic induction and has good harmonic suppression as well as* noise elimination. 展开更多
关键词 CORRELATION Hall magnetic sensor phase sensitive detection*
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A novel phase-sensitive scanning near-field optical microscope 被引量:2
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作者 武晓宇 孙琳 +1 位作者 谭峭峰 王佳 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第5期346-351,共6页
Phase is one of the most important parameters of electromagnetic waves. It is the phase distribution that determines the propagation, reflection, refraction, focusing, divergence, and coupling features of light, and f... Phase is one of the most important parameters of electromagnetic waves. It is the phase distribution that determines the propagation, reflection, refraction, focusing, divergence, and coupling features of light, and further affects the intensity distribution. In recent years, the designs of surface plasmon polariton (SPP) devices have mostly been based on the phase modulation and manipulation. Here we demonstrate a phase sensitive multi-parameter heterodyne scanning near-field opti- cal microscope (SNOM) with an aperture probe in the visible range, with which the near field optical phase and amplitude distributions can be simultaneously obtained. A novel architecture combining a spatial optical path and a fiber optical path is employed for stability and flexibility. Two kinds of typical nano-photonic devices are tested with the system. With the phase-sensitive SNOM, the phase and amplitude distributions of any nano-optical field and localized field generated with any SPP nano-structures and irregular phase modulation surfaces can be investigated. The phase distribution and the interference pattern will help us to gain a better understanding of how light interacts with SPP structures and how SPP waves generate, localize, convert, and propagate on an SPP surface. This will be a significant guidance on SPP nano-structure design and optimization. 展开更多
关键词 phase detection scanning near-field optical microscope (SNOM) heterodyne interferometry surface plasmon polariton (SPP) devices
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Advances in Phase Detection Technique of Surface Plasmon Resonance Biosensor 被引量:1
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作者 Yu Xinglong Wei Xing Deng Yan Liu Fangfang 《稀有金属材料与工程》 SCIE EI CAS CSCD 北大核心 2006年第A03期299-304,共6页
Surface plasmon resonance (SPR) sensing is an optical method based on evanescent wave.SPR biosensor can detect interaction of label-free biomolecules in real-time.With further development,it can become a research ins... Surface plasmon resonance (SPR) sensing is an optical method based on evanescent wave.SPR biosensor can detect interaction of label-free biomolecules in real-time.With further development,it can become a research instrument in proteomics.SPR biosensor can be divided intensity measurement and phase measurement,and the latter possesses higher sensitivity than the former one.This paper attempts to summarize the SPR phase detection theory,discuss the major developments,compare the merits and deficiencies of various methods,and look forward to future prospects. 展开更多
关键词 surface plasmon resonance(SPR) phase detection ELLIPSOMETRY HETERODYNE INTERFEROMETRY
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Line spectrum detection algorithm based on the phase feature of target radiated noise 被引量:4
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作者 Enming Zheng Huabing Yu +1 位作者 Xinhua Chen Changyu Sun 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2016年第1期72-80,共9页
In order to improve the performance of line spectrum detection,according to the feature that the underwater target radiated noise containing stable line spectrum,the differences of the phase difference between line sp... In order to improve the performance of line spectrum detection,according to the feature that the underwater target radiated noise containing stable line spectrum,the differences of the phase difference between line spectrum and background noise,a weighted line spectrum detection algorithm based on the phase variance is proposed in frequency domain.After phase difference alignment,the phase variance of line spectrum and the phase of background noise,respectively,are small and big in frequency domain,this method utilizes the weighted statistical algorithm to cumulate the frequency spectrum based on the phase variance,which can restrain the background noise disturbance,and enhance the signal to noise ratio(SNR).The theory analysis and experimental results both verify that the proposed method can well enhance the energy of line spectrum,restrain the energy of background noise,and have better detection performance under lower SNR. 展开更多
关键词 information processing underwater target detection line spectrum detection phase variance.
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General seismic wave and phase detection software driven by deep learning 被引量:1
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作者 Ming Zhao Jiahui Ma +1 位作者 Hao Chang Shi Chen 《Earthquake Research Advances》 CSCD 2021年第3期38-45,共8页
We developed an automatic seismic wave and phase detection software based on PhaseNet,an efficient and highly generalized deep learning neural network for P-and S-wave phase picking.The software organically combines m... We developed an automatic seismic wave and phase detection software based on PhaseNet,an efficient and highly generalized deep learning neural network for P-and S-wave phase picking.The software organically combines multiple modules including application terminal interface,docker container,data visualization,SSH protocol data transmission and other auxiliary modules.Characterized by a series of technologically powerful functions,the software is highly convenient for all users.To obtain the P-and S-wave picks,one only needs to prepare threecomponent seismic data as input and customize some parameters in the interface.In particular,the software can automatically identify complex waveforms(i.e.continuous or truncated waves)and support multiple types of input data such as SAC,MSEED,NumPy array,etc.A test on the dataset of the Wenchuan aftershocks shows the generalization ability and detection accuracy of the software.The software is expected to increase the efficiency and subjectivity in the manual processing of large amounts of seismic data,thereby providing convenience to regional network monitoring staffs and researchers in the study of Earth's interior. 展开更多
关键词 Deep learning neural network Seismic phase detection Docker container
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High-performance liquid chromatography utilization of ionic liquids as mobile phase additives for separation and determination of the isomers of amino benzoic acids 被引量:3
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作者 Ya-Jie Ma Chao Guan +1 位作者 Ying-Jie Dong Hong Yu 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第5期749-752,共4页
For the isomers of amino benzoic acid, including o-, m-, p-amino benzoic acid, the beneficial effects of using the ionic liquid, l-butyl-3-methylimidazolium tetrafluoroborate ([BMIm][BF4]), as mobile phase additives... For the isomers of amino benzoic acid, including o-, m-, p-amino benzoic acid, the beneficial effects of using the ionic liquid, l-butyl-3-methylimidazolium tetrafluoroborate ([BMIm][BF4]), as mobile phase additives on retention behavior and separation were investigated. Chromatographic separation of the o-, m-, p-amino benzoic acid was performed on a reversed-phase C18 column by ultraviolet detection at 245 nm. The effects of several chromatographic parameters, concentrations and pH values of [BMIm][BF4] solutions, methanol concentration and length of alkyl chain on different ionic liquids, on the separation and determination of the isomers were evaluated. The optimized chromatographic conditions were established using an aqueous 0.5 mmol/L [BMIm][BF4] solution (pH 3.0)/methanol (40:60, v/v) as mobile phase without need of gradient eiution, with separation of three amino benzoic acids achieved within four min. The calibration curve showed good linearity over the tested range of 2 mg/L to 120 mg/L for the three isomers with a correlation coefficients of 0.9999. The recoveries of the three amino benzoic acids of spiked components were between 99.8% and 100%. The method has been successfully applied to the determination of p-amino benzoic acid in the pharmaceutical, Bromine Mitag Procaine Injection. 展开更多
关键词 Ionic liquid Reverse phase liquid chromatographyAmino benzoic acids Ultraviolet detection Pharmaceutical
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A Simple Model for On-Sensor Phase-Detection Autofocusing Algorithm 被引量:2
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作者 Przemyslaw Sliwinski Pawel Wachel 《Journal of Computer and Communications》 2013年第6期11-17,共7页
A simple model of the phase-detection autofocus device based on the partially masked sensor pixels is described. The cross-correlation function of the half-images registered by the masked pixels is proposed as a focus... A simple model of the phase-detection autofocus device based on the partially masked sensor pixels is described. The cross-correlation function of the half-images registered by the masked pixels is proposed as a focus function. It is shown that—in such setting—focusing is equivalent to searching of the cross-correlation function maximum. Application of stochastic approximation algorithms to unimodal and non-unimodal focus functions is shortly discussed. 展开更多
关键词 phase Detection Autofocus On-Sensor Circuit Formal Model CROSS-CORRELATION Stochastic Approximation
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Arrival picking method for microseismic phases based on curve fi tting
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作者 Yu Zhi-Chao Yu Jing +3 位作者 Feng Fang-Fang Tan Yu-Yang Hou Gui-Ting He Chuan 《Applied Geophysics》 SCIE CSCD 2020年第3期453-464,共12页
Microseismic phase detection and arrival picking are critical steps in the processing of hydraulic fracturing microseismic monitoring data.As the signal-to-noise ratios of P-and S-waves diff er because of the infl uen... Microseismic phase detection and arrival picking are critical steps in the processing of hydraulic fracturing microseismic monitoring data.As the signal-to-noise ratios of P-and S-waves diff er because of the infl uence of focal mechanisms,geometry,and background noise,diffi culties are introduced in the eff ective discrimination of seismic phases and the accurate acquisition of arrivals in conventional processing methods.In this paper,we propose a method for identifying microseismic phase arrival time by comprehensively analyzing the variation of moveout curves and combining the intra-event waveform similarities with the energy ratio of multitrace signals.First,a curve-fi tting formula is constructed with perforation arrivals,and event detection is achieved by adopting an energy-weighted similarity coeffi cient that seeks plausible fi tting curves with a sliding time window in continuous microseismic recordings.Then,the P-and S-waves are separated by the fitting parameters.The known arrival time trend of the microseismic phase is employed to calculate residual time corrections.Finally,the accurate arrival results of the microseismic phases can be obtained by picking the arrivals of stacked traces.The reliability and eff ectiveness of the proposed method for microseismic phase detection and arrival picking were determined through tests using field data.Arrival results indicate that the proposed method can improve accuracy compared with the traditional energy ratio method. 展开更多
关键词 Microseismic moveout curves phase detection arrival picking
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TOPOLOGICAL STRUCTURE OF THE SINGULAR POINTS OF THE THIRD ORDER PHASE LOCKED LOOP EQUATIONS WITH THE CHARACTER OF DETECTED PHASE BEING g(φ)=(1+k)sinφ/(1+kcosφ)
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作者 金均 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1992年第9期883-889,共7页
In this paper, we study the topological structure of the singular points of the third order phase locked loop equations with the character of detected phase being g(?) =(1+k)sin?/1+kcos?.
关键词 singular point topological structure character of detected phase exponentially asymptotically stable Jordan form
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NON-AQUEOUS REVERSED PHASE HPLC WITH LOW-WAVELENGTH UV DETECTION FOR TRIGLYCERIDE ANALYSIS
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作者 Yi Cheng LONG Wan Zhen LU 《Chinese Chemical Letters》 SCIE CAS CSCD 1991年第5期393-396,共4页
Glycerides are first separated to classes of triglycerides(TGs), diglycerides(DGs) and monoglycerides(MGs) by normal phase HPLC on silica gel column. Individual triglyceride separation is then achieved by non-aqueous ... Glycerides are first separated to classes of triglycerides(TGs), diglycerides(DGs) and monoglycerides(MGs) by normal phase HPLC on silica gel column. Individual triglyceride separation is then achieved by non-aqueous reversed phase(NARP) HPLC on C_(18) column with UV detection at 215nm. 展开更多
关键词 HPLC TG NON-AQUEOUS REVERSED phase HPLC WITH LOW-WAVELENGTH UV DETECTION FOR TRIGLYCERIDE ANALYSIS NARP UV
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Role of serum alanine am inotransferase (ALT) test for detection of blood donors in window phase hepatitis virus infection
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《中国输血杂志》 CAS CSCD 2001年第S1期330-,共1页
关键词 ALT test for detection of blood donors in window phase hepatitis virus infection Role of serum alanine am inotransferase
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Low-cost optical sensors in electrified lab-on-a-disc platforms:liquid-phase boundary detection and automated diagnostics
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作者 Vahid Kordzadeh-Kermani Maryam Vahid +3 位作者 Seyed Nezameddin Ashrafizadeh Sergio O.Martinez-Chapa Marc J.Madou Masoud Madadelahi 《Microsystems & Nanoengineering》 2025年第2期449-462,共14页
Centrifugal microfluidic platforms are highly regarded for their potential in multiplexing and automation,as well as their wide range of applications,especially in separating blood plasma and manipulating two-phase fl... Centrifugal microfluidic platforms are highly regarded for their potential in multiplexing and automation,as well as their wide range of applications,especially in separating blood plasma and manipulating two-phase flows.However,the need to use stroboscopes or high-speed cameras for monitoring these tasks hinders the extensive use of these platforms in research and commercial settings.In this study,we introduce an innovative and cost-effective strategy for using an array of light-dependent resistors(LDRs)as optical sensors in microfluidic devices,particularly centrifugal platforms.While LDRs are attractive for their potential use as photodetectors,their bulky size frequently restricts their ability to provide high-resolution detection in microfluidic systems.Here,we use specific waveguides to direct light beams from narrow apertures onto the surface of LDRs.We integrated these LDRs into electrified Lab-on-a-Disc(eLOD)devices,with wireless connectivity to smartphones and laptops.This enables many applications,such as droplet/particle counting and velocity measurement,concentration analysis,fluidic interface detection in multiphase flows,real-time monitoring of sample volume on centrifugal platforms,and detection of blood plasma separation as an alternative to costly stroboscope devices,microscopes,and high-speed imaging.We used numerical simulations to evaluate various fluids and scenarios,which include rotation speeds of up to 50 rad/s and a range of droplet sizes.For the testbed,we used the developed eLOD device to analyze red blood cell(RBC)deformability and improve the automated detection of sickle cell anemia by monitoring differences in RBC deformability during centrifugation using the sensors’signals.In addition to sickle cell anemia,this device has the potential to facilitate low-cost automated detection of other medical conditions characterized by altered RBC deformability,such as thalassemia,malaria,and diabetes. 展开更多
关键词 liquid phase boundary detection separating blood plasma low cost optical sensors light dependent resistors automated diagnostics centrifugal microfluidic platforms waveguides electrified lab disc
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RNN-Based Demand Awareness in Smart Library Using CRFID 被引量:7
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作者 Ruiqin Bai Jumin Zhao +3 位作者 Dengao Li Xiaoyu Lv Qiang Wang Biaokai Zhu 《China Communications》 SCIE CSCD 2020年第5期284-294,共11页
To provide more intelligence service in the smart library, we need to better perceive the reader’s preferences. In addition to perceiving online records based on readers’ search history and borrowing records, advanc... To provide more intelligence service in the smart library, we need to better perceive the reader’s preferences. In addition to perceiving online records based on readers’ search history and borrowing records, advanced information technologies give us more chance to perceive the behavior of readers in the actual reading process and further discover the need for reading. In this paper, we use CRFID and RNN deep learning network to recognize book motions in the reading process, so as to judge readers’ need degree for the book, which can provide a basis for library book purchases and readers personalized service. In order to improve the recognition accuracy, we use the RSS as well as acceleration magnitude gathered from CRFID as the input data for RNN, and design a new encoding scheme. We trained and tested the deep learning network using real-world data, recorded during actual reading in our lab environment which mimics a typical reading room, from the experimental results, we conclude that our approach is feasible to recognize different reading phase to perceiving the needs of the readers. 展开更多
关键词 demand awareness detection of phases CRFID RNN smart library
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High-Sensitivity Sensor Based on Surface Plasmon Resonance Enhanced Lateral Optical Beam Displacements 被引量:2
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作者 杨晓燕 刘德明 +1 位作者 谢文冲 李春芳 《Chinese Physics Letters》 SCIE CAS CSCD 2007年第2期458-461,共4页
We present a new optical sensor based on surface plasmon resonance (SPIt) enhanced lateral optical beam displacements. Compared with the traditional SPIt methods, the new method provides higher sensitivity to the se... We present a new optical sensor based on surface plasmon resonance (SPIt) enhanced lateral optical beam displacements. Compared with the traditional SPIt methods, the new method provides higher sensitivity to the sensor system. Theoretical simulations show that the refractive index (RI) detection sensitivity of the SPR sensor based on the displacement measurement has a strong dependence on the thickness of the metal film. When the optimal thickness of the metal film is selected, the RI resolutlon of the SPIt sensor is predicted to be 2.2 × 10^-7 refractive index units (RIU). Furthermore, it is found that the incidence angle can be used as a parameter to adjust the operating range of the sensor to different refractive index ranges. 展开更多
关键词 phase DETECTION SHIFT EXCITATION
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Photoacoustic viscoelasticity imaging dedicated to mechanical characterization of biological tissues 被引量:2
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作者 Yujiao Shi Fen Yang Qian Wang 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2017年第4期29-41,共13页
Since changes in mechanical properties of biological tissues are often closely related to pathology,the viscoelastic properties are important physical parameters for medical diagnosis.A photoacoustic(PA)phase-resolved... Since changes in mechanical properties of biological tissues are often closely related to pathology,the viscoelastic properties are important physical parameters for medical diagnosis.A photoacoustic(PA)phase-resolved method for noninvasively characterizing the biological tissue viscoelasticity has been proposed by Gao et al.[G.Gao,S.Yang,D.Xing,\Viscoelasticity imaging of biological tissues with phase-resolved photoacoustic measurement,"Opt.Lett.36,3341–3343(2011)].The mathematical relationship between the PA phase delay and the viscosity–elasticity ratio has been theoretically deduced.Moreover,systems of PA viscoelasticity(PAVE)imaging including PAVE microscopy and PAVE endoscopy were developed,and high-PA-phase contrast images re°ecting the tissue viscoelasticity information have been successfully achieved.The PAVE method has been developed in tumor detection,atherosclerosis characterization and related vascular endoscopy.We reviewed the development of the PAVE technique and its applications in biomedical¯elds.It is believed that PAVE imaging is of great potential in both biomedical applications and clinical studies. 展开更多
关键词 Photoacoustic imaging VISCOELASTICITY phase detection ATHEROSCLEROSIS
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Rapid, simple and selective determination of 2,4-dinitrophenol by molecularly imprinted spin column extraction coupled with fluorescence detection 被引量:4
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作者 Min Fang Fang Lei +2 位作者 Jia Zhou Yong-Ning Wu Zhi-Yong Gong 《Chinese Chemical Letters》 SCIE CAS CSCD 2014年第11期1492-1494,共3页
A rapid, simple and selective method based on molecularly imprinted, spin column extraction coupled with fluorescence detection was successfully established for the determination of 2,4-dinitrophenol in serum samples.... A rapid, simple and selective method based on molecularly imprinted, spin column extraction coupled with fluorescence detection was successfully established for the determination of 2,4-dinitrophenol in serum samples. The 2,4-dinitrophenol imprinted polymers exhibited highly selective recognition for the template molecule and the maximum adsorption capacity was 138.9 mg/g. The results indicated that when water is used as the loading solution, only 2,4-dinitrophenol could be adsorbed on the spin column without the remaining structural analogs(2-nitrophenol, 4-nitrophenol and phenol). After eluting with acetonitrile/acetic acid(9/1, v/v), 2,4-dinitrophenol in serum samples could be determined by using the fluorescence spectrometer, based on the fluorescence enhancement of fluorescein by the template molecule. Under the optimal conditions, the spiked recovery ranged from 95.8% to 103.4% and the detection limit was 1 nmol/L. The results confirmed the reliability and practicality of the protocol and revealed a good perspective of this method for biological sample analysis. 展开更多
关键词 Molecularly imprinted solid phase extraction Indirect fluorescence detection Spin column 2 4-Dinitrophenol
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