OBJECTIVE:To evaluate the effectiveness and safety of the sequential therapy in treating infertility with polycystic ovary syndrome(PCOS)and luteal phase defects(LPD)by Yangxin Dianji decoction(养心奠基方,YXDJ-D)and N...OBJECTIVE:To evaluate the effectiveness and safety of the sequential therapy in treating infertility with polycystic ovary syndrome(PCOS)and luteal phase defects(LPD)by Yangxin Dianji decoction(养心奠基方,YXDJ-D)and Nuangong Tiaojing decoction(暖宫调经方,NGTJ-D).METHODS:This study was undertaken in the Jiangsu Province Hospital of Chinese Medicine.Altogether 90 eligible patients with PCOS and LPD were assigned to exposed group A(Chinese Medicine therapy,YXDJ-D and NGTJ-D),exposed group B(Chinese Medicine plus Western Medicine therapy),control group(Western Medicine therapy).The exposed group A adopted the sequential therapy that YXDJ-D is taken in the postmenstrual period(follicular phase)and NGTJ-D is taken in premenstrual period(luteal phase).Control group took letrozole,dydrogesterone and was given intramuscular injection of human menopausal gonadotropin,human chorionic gonadotropin.The exposed group B was treated with the above-mentioned therapy project of integrated Chinese Medicine and Western Medicine.This study lasted for 2 courses for 6 months.The primary outcomes were pregnancy rate and early abortion rate.The secondary outcomes were the Traditional Chinese Medicine(TCM)syndrome scores,estrogen(E2)and progesterone(P),endometrial volume(EV),vascularity index(VI),flow index(FI)and vascularization flow index(VFI).These outcomes will be assessed at baseline and post-intervention.RESULTS:The pregnancy rates of the exposed group A and B were higher than the control group(60.00%vs 60.00%vs 53.33%),while early abortion rates of exposed groups A and B were lower than the control group(33.33%vs 16.67%vs 43.75%,P>0.05).Total efficacy rates in exposed group A and B were better than the control group(93.30%vs 93.30%vs 53.30%,P<0.01).TCM symptom scores and endometrial receptivity indexes(EV,FI,VFI)were significantly lower in exposed groups compared to the control group(P<0.05).P increase in exposed group B was superior to the other two groups(P<0.01).No noticeable abnormalities in safety indicators in the three groups.CONCLUSION:The sequential therapy of YXDJ-D and NGTJ-D can effectively increase pregnancy rate,reduce the early abortion rate and alleviate the clinical symptoms of infertility in patients with PCOS and LPD by improving luteal function and promoting the endometrial receptivity.展开更多
Optics surface phase defects induced intensity modulation in high-power laser facility for inertial confinement fusion research is studied. Calculations and experiments reveal an exact mapping of the modulation patter...Optics surface phase defects induced intensity modulation in high-power laser facility for inertial confinement fusion research is studied. Calculations and experiments reveal an exact mapping of the modulation patterns and the optics damage spot distributions from the surface phase defects. Origins are discussed during the processes of optics manufacturing and diagnostics, revealing potential improvements for future optics manufacturing techniques and diagnostic index, which is meaningful for fusion level laser facility construction and its operation safety.展开更多
MAX phases and corresponding 2 D derivative MXenes have attracted considerable interests due to not only their fascinating mechanical,physical and chemical properties but also their unique atomically laminated structu...MAX phases and corresponding 2 D derivative MXenes have attracted considerable interests due to not only their fascinating mechanical,physical and chemical properties but also their unique atomically laminated structures.As the most important way to tailor the materials properties,the structural defects in MAX phases and MXenes have been extensively investigated but lack of systematic survey although six reviews and two books in this field have been published.To make the defect-engineering based materials design and exploration more efficient and targeted,this paper provides a review of the recent progress on the nature of different-dimensional structural defects and their influence on the properties,in the hope of facilitating the conversion of established experiment and simulation results into practical guideline for optimizing defects in a broad range of demand-oriented materials development in the future.Also,unsolved issues on the structural defects of these scientifically and technologically important materials are also highlighted for the future study.展开更多
A novel method based on independent component analysis and phase congruency is proposed for detecting defects in textile fabric images. By independent component, we can obtain textile structural features of fabric-fre...A novel method based on independent component analysis and phase congruency is proposed for detecting defects in textile fabric images. By independent component, we can obtain textile structural features of fabric-free images. By phase congru- ency, structure information is reduced, which can distinguish the defect region from the defect-free regions. Finally, we have the detecting result from binary image which is obtained by a thresh- old step, Compared with other algorithms, the proposed method not only has robustness with high detection rate, but also detects various types of defects quite well.展开更多
Ferroelectric materials have enormous potential applications in advanced techniques. However, there are still many problems in its practical application. Dielectric and mechanical (internal friction) measurements are ...Ferroelectric materials have enormous potential applications in advanced techniques. However, there are still many problems in its practical application. Dielectric and mechanical (internal friction) measurements are very sensitive to phase transitions, relaxation process of point defects, domain walls and their mobility, which have severe effect on ferroelectric properties. These make them become very good means to investigate substantial information on structural features and to explore the fundamental principles in ferroelectric materials and their applications. In this paper, the dielectric and internal friction measurement were used to investigate the behaviors for point defects and phase transition in ferroelectric ceramics such as Bi_ 4-x La_ x Ti_ 3 O_ 12 , Bi_ 4 Ti_ 3-y Nb_ y O_ 12 , SrBi_ 2 Ti_ 2 O_ 9 , PbZr_ x Ti_ 1-x O_ 3 ,_ PMN-PT. They were used to clarify the mechanism for some ferroelectric behaviors.展开更多
Molecular dynamics simulations of the phase transformation from body- centered-cubic (bcc) to face-centered-cubic (fcc) structures were performed. A Morse-type function was applied, and the parameters were determined ...Molecular dynamics simulations of the phase transformation from body- centered-cubic (bcc) to face-centered-cubic (fcc) structures were performed. A Morse-type function was applied, and the parameters were determined so that both fcc and bcc structures were stable for the perfectcrystal model. When the fcc structure was superior to the bcc structure, the bcc model transformed to fcc. Two mechanisms, based on the Bain and Nishiyama- Wasserman (NW) relationships, were considered. Then, point or linear lattice defects, i.e., randomly scattered or regularly aligned vacancies, were introduced. Consequently, bcc models tended to transform to an fcc structure, whereas fcc models remained stable. The transformation process was also investigated in detail. BCC-to-FCC transformation is often considered as a homogeneous process based on changes in the axis lengths, and such a process was observed for the perfectcrystal model. Conversely, for the defect models, local heterogeneous deformation patterns, including cylindrical domain and planar interface formation, were observed. These behaviors are considered to be related to plastic deformation during phase transformation, and the validity of the presented model for further investigation was confirmed.展开更多
Phased array ultrasonic testing, an effective ultrasonic testing(UT) technology, has been widely used in steel inspection because of its high accuracy, sensitivity, and efficiency. However, as its application in as-ca...Phased array ultrasonic testing, an effective ultrasonic testing(UT) technology, has been widely used in steel inspection because of its high accuracy, sensitivity, and efficiency. However, as its application in as-cast magnesium alloys has just begun, more research is needed. Considering the important role of the gain compensation in quantifying defects in magnesium alloys by ultrasonic phased array technology, the effects of microstructure, the position, size, and overlap of defects, and boundary distance(distance from the defect position to the side surface of the test casting) on gain compensation of as-cast AZ80 and AZ31 magnesium alloys were studied. Results show the gain compensation increases with the increase of grain size. There is a strict linear positive correlation between gain compensation and defect depth, but such relationship no longer exists due to the defects overlap, orientation and boundary distance. In addition, there is a strict linear negative correlation between the gain compensation and defect size.展开更多
Contaminated surfaces of the feedstock materials in aluminum alloy casting processes often produce various types of defects which can affect the tensile properties of the final products as well as their fatigue reliab...Contaminated surfaces of the feedstock materials in aluminum alloy casting processes often produce various types of defects which can affect the tensile properties of the final products as well as their fatigue reliabilities.Semi-solid processing takes advantage of a much higher apparent viscosity of the die cast materials by limiting the risk of oxides formed at the free surfaces to become incorporated into the casting when the material is injected into the die.Most of existing semi-solid processes that use billets as feedstock material are however tied up with a different type of contaminated surface.During the injection phase,the external-skin on the periphery of the billet,which has been in contact with air and lubricant during the transfer in the shot sleeve,can be incorporated into the casting.When subjected to a heat treatment,the lubricant is decomposed and produces lens shape porosities.This might be a cause of reject for most structural parts.To avoid this kind of defects,the paths along which the billet skin evolves must be controlled during filling.In order to investigate the possibility of skin inclusion into cast parts during injection of the billet,a two-phase finite element mixture model is employed to model the metal flow.The formation of a skin on the periphery of the billet is modeled by setting an initial solid phase concentration profile in the radial direction.Microscopic observations of the real castings show that the approach is able to model the shear layers and to predict the paths along which the"lens porosity"defects could be formed.An Arbitrary Eulerian-Lagangian(ALE) method is also investigated and appears to be very promising to follow the skin movement in the casting.展开更多
The metamaterial constructed by Helmholtz resonators (HR) has low-frequency acoustic forbidden bands and possesses negative mass density and effective bulk modulus at particular frequencies. The resonant modes in one-...The metamaterial constructed by Helmholtz resonators (HR) has low-frequency acoustic forbidden bands and possesses negative mass density and effective bulk modulus at particular frequencies. The resonant modes in one-dimensional HR structure with point defect were studied using finite element method (FEM). The results show that the acoustic energy is localized between the resonant HR and the opening in the local-resonant-type gap. There is a high pressure area around the defect resonator at the frequency of defect mode. In the Bragg type gap, the energy mainly distributes in the waveguide with harmonic attenuation due to the multi-scattering. Phase opposition demonstrates the existence of negative dynamic mass density. Local negative parameter is observed in the pass band due to the defect mode. Based on further investigation of the acoustic intensity and phase distributions in the resonators corresponding to two different forbidden bands, only one local resonant mode is verified, which is different from the three-component local resonant phononics. This work will be useful for understanding the mechanisms of acoustic forbidden bands and negative parameters in the HR metamaterial, and of help for designing new functional acoustic devices.展开更多
Software reliability modeling and prediction are important issues during software development, especially when one has to reach a desired reliability prior to software release. Various techniques, both static and dyna...Software reliability modeling and prediction are important issues during software development, especially when one has to reach a desired reliability prior to software release. Various techniques, both static and dynamic, are used for reliability modeling and prediction in the context of software risk management. The single-phase Rayleigh model is a dynamic reliability model;however, it is not suitable for software release date prediction. We propose a new multi-phase truncated Rayleigh model and obtain parameter estimation using the nonlinear least squares method. The proposed model has been successfully tested in a large software company for several software projects. It is shown that the two-phase truncated Rayleigh model outperforms the traditional single-phase Rayleigh model in modeling weekly software defect arrival data. The model is useful for project management in planning release times and defect management.展开更多
利用对原子尺度缺陷特别灵敏的正电子湮没谱学技术,并结合X射线衍射(X-ray Diffraction,XRD)、扫描电子显微镜(Scanning Electron Microscopy,SEM)等表征手段,研究了少量氧化钙添加量对氧化铝纳米陶瓷烧结过程中的微观缺陷、物相和显微...利用对原子尺度缺陷特别灵敏的正电子湮没谱学技术,并结合X射线衍射(X-ray Diffraction,XRD)、扫描电子显微镜(Scanning Electron Microscopy,SEM)等表征手段,研究了少量氧化钙添加量对氧化铝纳米陶瓷烧结过程中的微观缺陷、物相和显微形貌的影响。XRD及SEM实验结果表明,CaO/Al_(2)O_(3)纳米陶瓷的烧结过程可以分为两个阶段:室温至900℃未发生相变,而900~1100℃发生明显相变。少量Ca O的添加(如1%质量分数)起初均匀地分布在Al_(2)O_(3)中,随着烧结温度升高将与Al_(2)O_(3)反应形成第二相并在高温下转变为液相,传质机理由固相扩散变成液相流动,可以降低烧结温度,延缓γ-Al_(2)O_(3)纳米陶瓷转变为α-Al_(2)O_(3)过程,在1100℃烧结后出现不同网状结构的板片状结构。正电子湮没寿命谱分析表明,相变前后Ca O/Al_(2)O_(3)纳米陶瓷中的空位团和微孔洞的大小及数量随烧结温度的变化规律与Al_(2)O_(3)纳米陶瓷不同,由于第二相的形成并在高温下转变为液相,导致CaO/Al_(2)O_(3)纳米陶瓷中更容易产生空位团及微孔洞,并且一部分微孔洞相变前会逐渐合并形成宏观孔洞,而Al_(2)O_(3)纳米陶瓷内的微孔洞则会随着相转变及晶粒生长而消失,仅在样品表面还存留微量的微孔洞。展开更多
基金Supported by National Natural Science Foundation of China:Elucidation of a New Mechanism of the Prescription for Reinforcing Kidney and Promoting Pregnancy (Bushen Zhuyun Decoction) in Treating Luteal Phase Defects Infertility based on Coenzyme Q10/Ubiquinol Mediated New Ferroptosis Pathway in Endometrium During Implantation (No. 82474567)Jiangsu Province Key Research and Development Plan (Society Development) Project:a Multicenter Real-world Study of Sequential Treatment of Luteal Phase Defects Infertility with “Improving Endometrial Receptivity” as the Effect Point (No. BE2021726)Project of Clinical Innovation Center of Traditional Chinese Medicine in Jiangsu Province:Clinical And Basic Research on the Treatment of Luteal Phase Defects Infertility with “Improving Endometrial Receptivity” as the Effect Point (No. k2021j18-1)
文摘OBJECTIVE:To evaluate the effectiveness and safety of the sequential therapy in treating infertility with polycystic ovary syndrome(PCOS)and luteal phase defects(LPD)by Yangxin Dianji decoction(养心奠基方,YXDJ-D)and Nuangong Tiaojing decoction(暖宫调经方,NGTJ-D).METHODS:This study was undertaken in the Jiangsu Province Hospital of Chinese Medicine.Altogether 90 eligible patients with PCOS and LPD were assigned to exposed group A(Chinese Medicine therapy,YXDJ-D and NGTJ-D),exposed group B(Chinese Medicine plus Western Medicine therapy),control group(Western Medicine therapy).The exposed group A adopted the sequential therapy that YXDJ-D is taken in the postmenstrual period(follicular phase)and NGTJ-D is taken in premenstrual period(luteal phase).Control group took letrozole,dydrogesterone and was given intramuscular injection of human menopausal gonadotropin,human chorionic gonadotropin.The exposed group B was treated with the above-mentioned therapy project of integrated Chinese Medicine and Western Medicine.This study lasted for 2 courses for 6 months.The primary outcomes were pregnancy rate and early abortion rate.The secondary outcomes were the Traditional Chinese Medicine(TCM)syndrome scores,estrogen(E2)and progesterone(P),endometrial volume(EV),vascularity index(VI),flow index(FI)and vascularization flow index(VFI).These outcomes will be assessed at baseline and post-intervention.RESULTS:The pregnancy rates of the exposed group A and B were higher than the control group(60.00%vs 60.00%vs 53.33%),while early abortion rates of exposed groups A and B were lower than the control group(33.33%vs 16.67%vs 43.75%,P>0.05).Total efficacy rates in exposed group A and B were better than the control group(93.30%vs 93.30%vs 53.30%,P<0.01).TCM symptom scores and endometrial receptivity indexes(EV,FI,VFI)were significantly lower in exposed groups compared to the control group(P<0.05).P increase in exposed group B was superior to the other two groups(P<0.01).No noticeable abnormalities in safety indicators in the three groups.CONCLUSION:The sequential therapy of YXDJ-D and NGTJ-D can effectively increase pregnancy rate,reduce the early abortion rate and alleviate the clinical symptoms of infertility in patients with PCOS and LPD by improving luteal function and promoting the endometrial receptivity.
基金supported by the SG-Ⅲ laser facility upgrade project
文摘Optics surface phase defects induced intensity modulation in high-power laser facility for inertial confinement fusion research is studied. Calculations and experiments reveal an exact mapping of the modulation patterns and the optics damage spot distributions from the surface phase defects. Origins are discussed during the processes of optics manufacturing and diagnostics, revealing potential improvements for future optics manufacturing techniques and diagnostic index, which is meaningful for fusion level laser facility construction and its operation safety.
文摘MAX phases and corresponding 2 D derivative MXenes have attracted considerable interests due to not only their fascinating mechanical,physical and chemical properties but also their unique atomically laminated structures.As the most important way to tailor the materials properties,the structural defects in MAX phases and MXenes have been extensively investigated but lack of systematic survey although six reviews and two books in this field have been published.To make the defect-engineering based materials design and exploration more efficient and targeted,this paper provides a review of the recent progress on the nature of different-dimensional structural defects and their influence on the properties,in the hope of facilitating the conversion of established experiment and simulation results into practical guideline for optimizing defects in a broad range of demand-oriented materials development in the future.Also,unsolved issues on the structural defects of these scientifically and technologically important materials are also highlighted for the future study.
基金Supported by the National Natural Science Foundation of China(61072135)
文摘A novel method based on independent component analysis and phase congruency is proposed for detecting defects in textile fabric images. By independent component, we can obtain textile structural features of fabric-free images. By phase congru- ency, structure information is reduced, which can distinguish the defect region from the defect-free regions. Finally, we have the detecting result from binary image which is obtained by a thresh- old step, Compared with other algorithms, the proposed method not only has robustness with high detection rate, but also detects various types of defects quite well.
文摘Ferroelectric materials have enormous potential applications in advanced techniques. However, there are still many problems in its practical application. Dielectric and mechanical (internal friction) measurements are very sensitive to phase transitions, relaxation process of point defects, domain walls and their mobility, which have severe effect on ferroelectric properties. These make them become very good means to investigate substantial information on structural features and to explore the fundamental principles in ferroelectric materials and their applications. In this paper, the dielectric and internal friction measurement were used to investigate the behaviors for point defects and phase transition in ferroelectric ceramics such as Bi_ 4-x La_ x Ti_ 3 O_ 12 , Bi_ 4 Ti_ 3-y Nb_ y O_ 12 , SrBi_ 2 Ti_ 2 O_ 9 , PbZr_ x Ti_ 1-x O_ 3 ,_ PMN-PT. They were used to clarify the mechanism for some ferroelectric behaviors.
文摘Molecular dynamics simulations of the phase transformation from body- centered-cubic (bcc) to face-centered-cubic (fcc) structures were performed. A Morse-type function was applied, and the parameters were determined so that both fcc and bcc structures were stable for the perfectcrystal model. When the fcc structure was superior to the bcc structure, the bcc model transformed to fcc. Two mechanisms, based on the Bain and Nishiyama- Wasserman (NW) relationships, were considered. Then, point or linear lattice defects, i.e., randomly scattered or regularly aligned vacancies, were introduced. Consequently, bcc models tended to transform to an fcc structure, whereas fcc models remained stable. The transformation process was also investigated in detail. BCC-to-FCC transformation is often considered as a homogeneous process based on changes in the axis lengths, and such a process was observed for the perfectcrystal model. Conversely, for the defect models, local heterogeneous deformation patterns, including cylindrical domain and planar interface formation, were observed. These behaviors are considered to be related to plastic deformation during phase transformation, and the validity of the presented model for further investigation was confirmed.
基金financially supported by the National Key Research and Development Program of China(Grant No.2017YFB0305504)the National Natural Science Foundation of China(Grant No.51771043)
文摘Phased array ultrasonic testing, an effective ultrasonic testing(UT) technology, has been widely used in steel inspection because of its high accuracy, sensitivity, and efficiency. However, as its application in as-cast magnesium alloys has just begun, more research is needed. Considering the important role of the gain compensation in quantifying defects in magnesium alloys by ultrasonic phased array technology, the effects of microstructure, the position, size, and overlap of defects, and boundary distance(distance from the defect position to the side surface of the test casting) on gain compensation of as-cast AZ80 and AZ31 magnesium alloys were studied. Results show the gain compensation increases with the increase of grain size. There is a strict linear positive correlation between gain compensation and defect depth, but such relationship no longer exists due to the defects overlap, orientation and boundary distance. In addition, there is a strict linear negative correlation between the gain compensation and defect size.
文摘Contaminated surfaces of the feedstock materials in aluminum alloy casting processes often produce various types of defects which can affect the tensile properties of the final products as well as their fatigue reliabilities.Semi-solid processing takes advantage of a much higher apparent viscosity of the die cast materials by limiting the risk of oxides formed at the free surfaces to become incorporated into the casting when the material is injected into the die.Most of existing semi-solid processes that use billets as feedstock material are however tied up with a different type of contaminated surface.During the injection phase,the external-skin on the periphery of the billet,which has been in contact with air and lubricant during the transfer in the shot sleeve,can be incorporated into the casting.When subjected to a heat treatment,the lubricant is decomposed and produces lens shape porosities.This might be a cause of reject for most structural parts.To avoid this kind of defects,the paths along which the billet skin evolves must be controlled during filling.In order to investigate the possibility of skin inclusion into cast parts during injection of the billet,a two-phase finite element mixture model is employed to model the metal flow.The formation of a skin on the periphery of the billet is modeled by setting an initial solid phase concentration profile in the radial direction.Microscopic observations of the real castings show that the approach is able to model the shear layers and to predict the paths along which the"lens porosity"defects could be formed.An Arbitrary Eulerian-Lagangian(ALE) method is also investigated and appears to be very promising to follow the skin movement in the casting.
文摘The metamaterial constructed by Helmholtz resonators (HR) has low-frequency acoustic forbidden bands and possesses negative mass density and effective bulk modulus at particular frequencies. The resonant modes in one-dimensional HR structure with point defect were studied using finite element method (FEM). The results show that the acoustic energy is localized between the resonant HR and the opening in the local-resonant-type gap. There is a high pressure area around the defect resonator at the frequency of defect mode. In the Bragg type gap, the energy mainly distributes in the waveguide with harmonic attenuation due to the multi-scattering. Phase opposition demonstrates the existence of negative dynamic mass density. Local negative parameter is observed in the pass band due to the defect mode. Based on further investigation of the acoustic intensity and phase distributions in the resonators corresponding to two different forbidden bands, only one local resonant mode is verified, which is different from the three-component local resonant phononics. This work will be useful for understanding the mechanisms of acoustic forbidden bands and negative parameters in the HR metamaterial, and of help for designing new functional acoustic devices.
文摘Software reliability modeling and prediction are important issues during software development, especially when one has to reach a desired reliability prior to software release. Various techniques, both static and dynamic, are used for reliability modeling and prediction in the context of software risk management. The single-phase Rayleigh model is a dynamic reliability model;however, it is not suitable for software release date prediction. We propose a new multi-phase truncated Rayleigh model and obtain parameter estimation using the nonlinear least squares method. The proposed model has been successfully tested in a large software company for several software projects. It is shown that the two-phase truncated Rayleigh model outperforms the traditional single-phase Rayleigh model in modeling weekly software defect arrival data. The model is useful for project management in planning release times and defect management.
