Traumatic spinal cord injury result in considerable and lasting functional impairments,triggering complex inflammatory and pathological events.Spinal cord scars,often metaphorically referred to as“fire barriers,”aim...Traumatic spinal cord injury result in considerable and lasting functional impairments,triggering complex inflammatory and pathological events.Spinal cord scars,often metaphorically referred to as“fire barriers,”aim to control the spread of neuroinflammation during the acute phase but later hinder axon regeneration in later stages.Recent studies have enhanced our understanding of immunomodulation,revealing that injury-associated inflammation involves various cell types and molecules with positive and negative effects.This review employs bibliometric analysis to examine the literature on inflammatory mediators in spinal cord injury,highlighting recent research and providing a comprehensive overview of the current state of research and the latest advances in studies on neuroinflammation related to spinal cord injury.We summarize the immune and inflammatory responses at different stages of spinal cord injury,offering crucial insights for future research.Additionally,we review repair strategies based on inflammatory mediators for the injured spinal cord.Finally,this review discusses the current status and future directions of translational research focused on immune-targeting strategies,including pharmaceuticals,biomedical engineering,and gene therapy.The development of a combined,precise,and multitemporal strategy for the repair of injured spinal cords represents a promising direction for future research.展开更多
Three dimensional printing（3DP） is a solid freeform fabrication technology which employs powder processing and a liquid binder material in the construction of parts in a layer-wise manner. 3DP can accommodate much g...Three dimensional printing（3DP） is a solid freeform fabrication technology which employs powder processing and a liquid binder material in the construction of parts in a layer-wise manner. 3DP can accommodate much geometric outline and be made with many materials due to its unprecedented flexibility. The technology can control over the material composition, microstructure and surface texture so it attracts great attentions in the pharmaceutics field. 3DP can offer many novel strategies and approaches for the research and is widely focused in the field of the controlled-release drug delivery systems. Through consulting a large number of documents the current development and the technical characteristics of 3DP in pharmaceutics field are discussed and reviewed. It is expected that 3DP technique may play a tremendous role in pharmaceutics field in the future.Three dimensional printing （3DP） is a solid freeform fabrication technology which employs powder processing and a liquid binder material in the construction of parts in a layer-wise manner. 3DP can accommodate much geometric outline and be made with many materials due to its unprecedented flexibility. The technology can control over the material composition, microstructure and surface texture so it attracts great attentions in the pharmaceutics field. 3DP can offer many novel strategies and approaches for the research and is widely focused in the field of the controlled-release drug delivery systems. Through consulting a large number of documents the current development and the technical characteristics of 3DP in pharmaceutics field are discussed and reviewed. It is expected that 3DP technique may play a tremendous role in pharmaceutics field in the future.展开更多
Background:In preclinical research,tumor growth inhibition in subcutaneous models is frequently employed to evaluate therapeutic efficacy;however,such models often lack clinical translatability.Methods:To better appro...Background:In preclinical research,tumor growth inhibition in subcutaneous models is frequently employed to evaluate therapeutic efficacy;however,such models often lack clinical translatability.Methods:To better approximate clinical reality,taking the case of doxorubicin treatment,we utilized an orthotopic transplant and resection(OtR)strategy to systematically assess the effects of neoadjuvant chemotherapy,adjuvant chem-otherapy,and their combination on tumor growth,recurrence,and malignant progression.Results:Surprisingly,none of the treatments improved mouse survival,with adjuvant therapy even shortening it.Although neoadjuvant chemotherapy delayed preopera-tive tumor growth,and all regimens reduced recurrence rates,none effectively pre-vented metastasis.Furthermore,all treatment groups exhibited weight loss,indicative of chemotherapy-induced cachexia.Conclusions:Collectively,these findings demonstrate that reduced tumor growth in preclinical mouse models does not necessarily translate into overall survival benefit.Our results emphasize the critical importance of prioritizing metastasis prevention over tumor growth inhibition as a key efficacy endpoint in antitumor drug evaluation.展开更多
Organic and pharmaceutical synthesis have traditionally relied on the stepwise transformation ofactivated functional groups to synthesize cyclic molecules.The design of valuable heterocyclic compounds,for instance,has...Organic and pharmaceutical synthesis have traditionally relied on the stepwise transformation ofactivated functional groups to synthesize cyclic molecules.The design of valuable heterocyclic compounds,for instance,has depended on multi-step routes such as polar or radical cyclization,cycloadditions,and the manipulation of various functional groups to achieve ring formation or connection[1,2].展开更多
Membrane technology holds significant potential for augmenting or partially substituting conventional separation techniques,such as heatdriven distillation,thereby reducing energy consumption.Organic solvent nanofiltr...Membrane technology holds significant potential for augmenting or partially substituting conventional separation techniques,such as heatdriven distillation,thereby reducing energy consumption.Organic solvent nanofiltration represents an advanced membrane separation technology capable of discerning molecules within a molecular weight range of approximately 100-1000 Da in organic solvents,offering low energy requirements and minimal carbon footprints.Molecular separation in non-polar solvent system,such as toluene,n-hexane,and n-heptane,has gained paramount importance due to their extensive use in the pharmaceutical,biochemical,and petrochemical industries.In this review,we presented recent advancements in membrane materials,membrane fabrication techniques and their promising applications for separation in nonpolar solvent system,encompassing hydrocarbon separation,bioactive molecule purification and organic solvent recovery.Furthermore,this review highlighted the challenges and opportunities associated with membrane scale-up strategies and the direct translation of this promising technology into industrial applications.展开更多
Infrared(IR)spectroscopy,a technique within the realm of molecular vibrational spectroscopy,furnishes distinctive chemical signatures pivotal for both structural analysis and compound identification.A notable challeng...Infrared(IR)spectroscopy,a technique within the realm of molecular vibrational spectroscopy,furnishes distinctive chemical signatures pivotal for both structural analysis and compound identification.A notable challenge emerges from the misalignment between the mid-IR light wavelength range and molecular dimensions,culminating in a constrained absorption cross-section and diminished vibrational absorption coefficients(Supplementary data).展开更多
China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co....China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co.Ltd.plant is set to reshape Cameroon’s pharmaceutical landscape.展开更多
Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field face...Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field faces considerable challenges,including the continuous emergence of potential health threats,as well as novel pathogen strains and viruses.The advent and implementation of advanced technologies,such as culture strategies,genomics mining,and artificial intelligence(AI),are facilitating a paradigm shift in pharmaceutical research,introducing innovative methodologies and perspectives.The development and maturation of these technologies have enhanced the exploration of microbial-derived NPs,thereby advancing pharmaceutical research and development.This review synthesizes recent developments in this context,emphasizing their applications in pharmaceutical discovery and development.Through systematic analysis and synthesis,it provides objective insights into the promising prospects and future direction of this essential field.展开更多
Biological sensing technology plays a crucial role in various key areas such as disease diagnosis,environmental monitoring,and biotechnology.Luminescent metal-organic frameworks(LMOFs),with their remarkable advantages...Biological sensing technology plays a crucial role in various key areas such as disease diagnosis,environmental monitoring,and biotechnology.Luminescent metal-organic frameworks(LMOFs),with their remarkable advantages including large surface area,customizable pore structures,and highly active functional sites,have emerged as a frontier in biosensor research.This review clarifies the potential of LMOFs in biological sensing applications,with particular emphasis on their efficient performance in detecting amino acids,biomarkers,and drugs,explore the possibility of integrating LMOFs with portable analytical techniques,providing an innovative perspective for advancing luminescence detection technology.Some effective characterization methods to encode these sensing mechanisms including F?rster resonance energy transfer(FRET),photoinduced electron transfer(PET)and thermally activated energy back transfer(BENT)highlighted their connection and difference.Finally,the article summarizes the achievements of LMOFs in biological sensing and provides a perspective on future research directions and potential applications,aiming to propel the continuous development of this field.展开更多
This study presents a systematic review of applications of artificial intelligence(abbreviated as AI)and blockchain in supply chain provenance traceability and legal forensics cover five sectors:integrated circuits(ab...This study presents a systematic review of applications of artificial intelligence(abbreviated as AI)and blockchain in supply chain provenance traceability and legal forensics cover five sectors:integrated circuits(abbreviated as ICs),pharmaceuticals,electric vehicles(abbreviated as EVs),drones(abbreviated as UAVs),and robotics—in response to rising trade tensions and geopolitical conflicts,which have heightened concerns over product origin fraud and information security.While previous literature often focuses on single-industry contexts or isolated technologies,this reviewcomprehensively surveys these sectors and categorizes 116 peer-reviewed studies by application domain,technical architecture,and functional objective.Special attention is given to traceability control mechanisms,data integrity,and the use of forensic technologies to detect origin fraud.The study further evaluates real-world implementations,including blockchain-enabled drug tracking systems,EV battery raw material traceability,and UAV authentication frameworks,demonstrating the practical value of these technologies.By identifying technological challenges and policy implications,this research provides a comprehensive foundation for future academic inquiry,industrial adoption,and regulatory development aimed at enhancing transparency,resilience,and trust in global supply chains.展开更多
A prominent issue in current postgraduate education is the lack of essential differentiation between the training of professional degree postgraduates and academic degree postgraduates,which has led to a disconnection...A prominent issue in current postgraduate education is the lack of essential differentiation between the training of professional degree postgraduates and academic degree postgraduates,which has led to a disconnection between professional postgraduate training and industry demands.To address this issue,this paper takes the Master’s program in Biological and Pharmaceutical Sciences at Guangdong Pharmaceutical University as a case study.Targeting the urgent needs of the high-quality development of the biopharmaceutical industry,and aiming to strengthen students’professional competence and sustainable development capabilities while focusing on improving their practical and innovative abilities,this study explores implementation paths for integrating industry,education,and research with a dual-tutor collaborative training model.These include the development of a dual-tutor team,curriculum system optimization,the improvement of a quality assurance system,and the construction of practical training platforms.The paper demonstrates the outcomes of this model and proposes strategies for promotion and future outlooks,offering new ideas for training high-quality talent in the biological and pharmaceutical fields.展开更多
AI is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.AI driven drug discovery is based on biomedical big data and new algorithms to i...AI is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.AI driven drug discovery is based on biomedical big data and new algorithms to identify drug targets,screen and optimize active compounds,analyze drug properties,and facilitate drug production and quality control.On this basis,we organized this special issue entitled"Innovative Pharmaceutical Research Driven by AI",and collected Original research articles,Reviewpapers.展开更多
Inappropriate use of paracetamol (PA) can induce serious liver injury,and developing accurate PA detecting methods holds great importance in the fields of drug quality control and therapeutic drug monitoring.In this w...Inappropriate use of paracetamol (PA) can induce serious liver injury,and developing accurate PA detecting methods holds great importance in the fields of drug quality control and therapeutic drug monitoring.In this work,a novel electrochemical sensor for detecting PA was successfully fabricated based on iron single atoms distributed on multiwall carbon nanotubes (Fe/MWCNTs)that were prepared through the Lewis acid doping strategy.MWCNTs wrapped by polyaniline-derived N-doped carbon not only provide the anchoring sites for Fe,but also endow the catalyst with high conductivity and mass transfer ability.Theoretical calculation results reveal that atomically dispersed Fe sites hold good catalytic activity toward PA oxidation reaction,because of easier OH absorption at the first step and more facile occurrence of the key transformation from OH*+PA into H2O*+PA_H,during which electrons transferred from PA to catalysts,thereby facilitating the dissociation of N-H bond and the oxidation of PA.The Fe/MWCNTs sensor showed excellent PA detecting performance,delivering a low detection limit of 0.14μM in wide ranges of 0.5-100μM and 100-500μM.Without any pretreatments,the built sensor can directly and accurately detect PA in several complex commercial pharmaceutical formulations and spiked human urine samples with satisfactory recoveries from 96.98% to 107.59%,thereby fully demonstrating its practical application prospects.展开更多
Extraction unit operation is the first step in traditional Chinese medicine(TCM)product manufacturing,and it is crucial in determining the quality of the produced medicine.However,due to a lack of effective multimodal...Extraction unit operation is the first step in traditional Chinese medicine(TCM)product manufacturing,and it is crucial in determining the quality of the produced medicine.However,due to a lack of effective multimodal monitoring and adjustment strategies,achieving high quality and efficiency remains a challenge.In this work,we proposed an artificial intelligence(AI)-based robot platform for the multi-objective optimization of the extraction process.First,a perception intelligence method for multimodal process monitoring was established to track active ingredient transfer and production changes during the extraction process.Second,a digital twin model was developed to reconstruct the field information,which interacted with real-time monitoring data.Furthermore,the model performed real-time inference to predict future production process states by using the reconstructing information.Finally,according to the predicted process states,the autonomous decision-making robot implemented multi-objective optimization,ensuring efficient process adjustments for global optimization.Experimental and industrial results demonstrated that the platform could effectively infer component transfer dynamics,monitor temperature variations,and identify boiling states,ensuring product quality while reducing energy consumption.This pharmaceutical robot could promote the integration of AI and pharmaceutical engineering,thereby accelerating the iterative development and improvement of China’s pharmaceutical industry.展开更多
Following the COVID-19 outbreak,a vast array of chlorine disinfectants was used to eliminate the virus,leading to inevitable discharge into aquatic ecosystems.These environments also contain various anthropogenic micr...Following the COVID-19 outbreak,a vast array of chlorine disinfectants was used to eliminate the virus,leading to inevitable discharge into aquatic ecosystems.These environments also contain various anthropogenic micropollutants,such as pharmaceuticals,which pose threats to the survival and activities of biological communities.Consequently,the presence of discharged chlorine disinfectants and pharmaceuticals can simultaneously impact the structure and function of aquatic ecosystems.To investigate the combined effects of chlorine disinfectants and pharmaceuticals on the periphyton and zoobenthos(Limnodrilus hoffmeisteri)community composition and function,we conducted a 12-flume reactor experiment using sodium hypochlorite and representative pharmaceuticals(abundant in the Yangtze River)as influents.Results demonstrated that the discharge of chlorine disinfectants further altered the composition of river prokaryotic communities.Eukaryotic organisms within the periphyton exhibited greater resilience to chlorine exposure compared to prokaryotic communities.Metagenomic analysis revealed that prokaryotic communities with different compositions can execute similar functions,while RNA sequencing indicated that co-exposure promoted biological processes such as focal adhesion and ribosome synthesis,but inhibited activities related to nitrogen metabolism and resistance to folate antimicrobials.Additionally,co-exposure induced oxidative stress in L.hoffmeisteri,leading to stronger environmental adaptation.展开更多
Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery betwe...Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82272470 (to GN),82072439 (to GN),81930070 (to SF)the Tianjin Health Key Discipline Special Project,No.TJWJ2022XK011 (to GN)+2 种基金the Outstanding Youth Foundation of Tianjin Medical University General Hospital,No.22ZYYJQ01 (to GN)Tianjin Key Medical Disciplines,No.TJYXZDXK-027A (to SF)National Key Research and Development Program-Stem Cells and Transformation Research,No.2019YFA0112100 (to SF)
文摘Traumatic spinal cord injury result in considerable and lasting functional impairments,triggering complex inflammatory and pathological events.Spinal cord scars,often metaphorically referred to as“fire barriers,”aim to control the spread of neuroinflammation during the acute phase but later hinder axon regeneration in later stages.Recent studies have enhanced our understanding of immunomodulation,revealing that injury-associated inflammation involves various cell types and molecules with positive and negative effects.This review employs bibliometric analysis to examine the literature on inflammatory mediators in spinal cord injury,highlighting recent research and providing a comprehensive overview of the current state of research and the latest advances in studies on neuroinflammation related to spinal cord injury.We summarize the immune and inflammatory responses at different stages of spinal cord injury,offering crucial insights for future research.Additionally,we review repair strategies based on inflammatory mediators for the injured spinal cord.Finally,this review discusses the current status and future directions of translational research focused on immune-targeting strategies,including pharmaceuticals,biomedical engineering,and gene therapy.The development of a combined,precise,and multitemporal strategy for the repair of injured spinal cords represents a promising direction for future research.
文摘Three dimensional printing（3DP） is a solid freeform fabrication technology which employs powder processing and a liquid binder material in the construction of parts in a layer-wise manner. 3DP can accommodate much geometric outline and be made with many materials due to its unprecedented flexibility. The technology can control over the material composition, microstructure and surface texture so it attracts great attentions in the pharmaceutics field. 3DP can offer many novel strategies and approaches for the research and is widely focused in the field of the controlled-release drug delivery systems. Through consulting a large number of documents the current development and the technical characteristics of 3DP in pharmaceutics field are discussed and reviewed. It is expected that 3DP technique may play a tremendous role in pharmaceutics field in the future.Three dimensional printing （3DP） is a solid freeform fabrication technology which employs powder processing and a liquid binder material in the construction of parts in a layer-wise manner. 3DP can accommodate much geometric outline and be made with many materials due to its unprecedented flexibility. The technology can control over the material composition, microstructure and surface texture so it attracts great attentions in the pharmaceutics field. 3DP can offer many novel strategies and approaches for the research and is widely focused in the field of the controlled-release drug delivery systems. Through consulting a large number of documents the current development and the technical characteristics of 3DP in pharmaceutics field are discussed and reviewed. It is expected that 3DP technique may play a tremendous role in pharmaceutics field in the future.
文摘Background:In preclinical research,tumor growth inhibition in subcutaneous models is frequently employed to evaluate therapeutic efficacy;however,such models often lack clinical translatability.Methods:To better approximate clinical reality,taking the case of doxorubicin treatment,we utilized an orthotopic transplant and resection(OtR)strategy to systematically assess the effects of neoadjuvant chemotherapy,adjuvant chem-otherapy,and their combination on tumor growth,recurrence,and malignant progression.Results:Surprisingly,none of the treatments improved mouse survival,with adjuvant therapy even shortening it.Although neoadjuvant chemotherapy delayed preopera-tive tumor growth,and all regimens reduced recurrence rates,none effectively pre-vented metastasis.Furthermore,all treatment groups exhibited weight loss,indicative of chemotherapy-induced cachexia.Conclusions:Collectively,these findings demonstrate that reduced tumor growth in preclinical mouse models does not necessarily translate into overall survival benefit.Our results emphasize the critical importance of prioritizing metastasis prevention over tumor growth inhibition as a key efficacy endpoint in antitumor drug evaluation.
基金supported by the MSIT(2022R1F1A106268,RS-2023-00213491,RS-2023-00219859,RS-2024-00405261,RS-2024-00409589,RS-2025-25460522,and RS-2025-00642970)Republic of Korea,the InnoCORE program of the Ministry of Science and ICT of Korea(N10250153 and 1.250022.01)the Creative Research Program and KAIST Cross-Generation Collaborative Lab Project.
文摘Organic and pharmaceutical synthesis have traditionally relied on the stepwise transformation ofactivated functional groups to synthesize cyclic molecules.The design of valuable heterocyclic compounds,for instance,has depended on multi-step routes such as polar or radical cyclization,cycloadditions,and the manipulation of various functional groups to achieve ring formation or connection[1,2].
基金supported by the National Natural Science Foundation of China(Grant No.2230081973)Shanghai Pilot Program for Basic Research(22TQ1400100-4).
文摘Membrane technology holds significant potential for augmenting or partially substituting conventional separation techniques,such as heatdriven distillation,thereby reducing energy consumption.Organic solvent nanofiltration represents an advanced membrane separation technology capable of discerning molecules within a molecular weight range of approximately 100-1000 Da in organic solvents,offering low energy requirements and minimal carbon footprints.Molecular separation in non-polar solvent system,such as toluene,n-hexane,and n-heptane,has gained paramount importance due to their extensive use in the pharmaceutical,biochemical,and petrochemical industries.In this review,we presented recent advancements in membrane materials,membrane fabrication techniques and their promising applications for separation in nonpolar solvent system,encompassing hydrocarbon separation,bioactive molecule purification and organic solvent recovery.Furthermore,this review highlighted the challenges and opportunities associated with membrane scale-up strategies and the direct translation of this promising technology into industrial applications.
基金supported by National Natural Science Foundation of China(Grant No.:32301161)the Natural Scientific Foundation of Hunan Province,China(Grant No.:2023JJ60052)+3 种基金the Scientific Research Project of Hunan Provincial Health Commission,China(Grant No.:202112062218,20190161)the Scientific Research Project of Hunan Provincial Department of Education,China(Grant No.:22B0455)the Clinical“4310”Project of the University of South China,China(Grant No.:20224310NHYCG02)the Doctoral Scientific Research Foundation of University of South China,China(Grant No.:200XQD042).
文摘Infrared(IR)spectroscopy,a technique within the realm of molecular vibrational spectroscopy,furnishes distinctive chemical signatures pivotal for both structural analysis and compound identification.A notable challenge emerges from the misalignment between the mid-IR light wavelength range and molecular dimensions,culminating in a constrained absorption cross-section and diminished vibrational absorption coefficients(Supplementary data).
文摘China-Cameroon pharmaceutical cooperation is expected to bring benefits beyond its borders A new chapter in Sino-Cameroonian cooperation is being written.The $948.7 million Yicheng Pharmaceutical Group Fabrication Co.Ltd.plant is set to reshape Cameroon’s pharmaceutical landscape.
基金supported by Nanjing Science and Technology Bureau International,Hong Kong,Macao,and Taiwan Science and Technology Cooperation Program(No.202401042)。
文摘Microorganisms,abundant in nature,are prolific producers of a diverse array of natural products(NPs)that are fundamental in the development of innovative therapeutics.Despite their significant potential,the field faces considerable challenges,including the continuous emergence of potential health threats,as well as novel pathogen strains and viruses.The advent and implementation of advanced technologies,such as culture strategies,genomics mining,and artificial intelligence(AI),are facilitating a paradigm shift in pharmaceutical research,introducing innovative methodologies and perspectives.The development and maturation of these technologies have enhanced the exploration of microbial-derived NPs,thereby advancing pharmaceutical research and development.This review synthesizes recent developments in this context,emphasizing their applications in pharmaceutical discovery and development.Through systematic analysis and synthesis,it provides objective insights into the promising prospects and future direction of this essential field.
基金supported financially by Natural Science Foundation of Tianjin(No.18JCYBJC89700)Science&Technology Development Fund of Tianjin Education Commission for Higher Education(No.2019ZD15)。
文摘Biological sensing technology plays a crucial role in various key areas such as disease diagnosis,environmental monitoring,and biotechnology.Luminescent metal-organic frameworks(LMOFs),with their remarkable advantages including large surface area,customizable pore structures,and highly active functional sites,have emerged as a frontier in biosensor research.This review clarifies the potential of LMOFs in biological sensing applications,with particular emphasis on their efficient performance in detecting amino acids,biomarkers,and drugs,explore the possibility of integrating LMOFs with portable analytical techniques,providing an innovative perspective for advancing luminescence detection technology.Some effective characterization methods to encode these sensing mechanisms including F?rster resonance energy transfer(FRET),photoinduced electron transfer(PET)and thermally activated energy back transfer(BENT)highlighted their connection and difference.Finally,the article summarizes the achievements of LMOFs in biological sensing and provides a perspective on future research directions and potential applications,aiming to propel the continuous development of this field.
文摘This study presents a systematic review of applications of artificial intelligence(abbreviated as AI)and blockchain in supply chain provenance traceability and legal forensics cover five sectors:integrated circuits(abbreviated as ICs),pharmaceuticals,electric vehicles(abbreviated as EVs),drones(abbreviated as UAVs),and robotics—in response to rising trade tensions and geopolitical conflicts,which have heightened concerns over product origin fraud and information security.While previous literature often focuses on single-industry contexts or isolated technologies,this reviewcomprehensively surveys these sectors and categorizes 116 peer-reviewed studies by application domain,technical architecture,and functional objective.Special attention is given to traceability control mechanisms,data integrity,and the use of forensic technologies to detect origin fraud.The study further evaluates real-world implementations,including blockchain-enabled drug tracking systems,EV battery raw material traceability,and UAV authentication frameworks,demonstrating the practical value of these technologies.By identifying technological challenges and policy implications,this research provides a comprehensive foundation for future academic inquiry,industrial adoption,and regulatory development aimed at enhancing transparency,resilience,and trust in global supply chains.
基金Undergraduate Teaching Quality and Teaching Reform Project,Guangdong Province(Project No.:Yue Jiao Gao Han[2024]No.9)Graduate Education Innovation Plan Project,Guangdong Province(Project No.:Yue Jiao Tong Han[2024]No.1)+2 种基金First-Class Undergraduate Course Construction Project,Guangdong Province(Project No.:Yue Jiao Gao Han[2022]No.10)Undergraduate Curriculum Ideological and Political Reform Demonstration Project,Guangdong Province(Project No.:Yue Jiao Gao Han[2021]No.22)Higher Education Research Project,Guangdong Pharmaceutical University(Project No.:GGP202402).
文摘A prominent issue in current postgraduate education is the lack of essential differentiation between the training of professional degree postgraduates and academic degree postgraduates,which has led to a disconnection between professional postgraduate training and industry demands.To address this issue,this paper takes the Master’s program in Biological and Pharmaceutical Sciences at Guangdong Pharmaceutical University as a case study.Targeting the urgent needs of the high-quality development of the biopharmaceutical industry,and aiming to strengthen students’professional competence and sustainable development capabilities while focusing on improving their practical and innovative abilities,this study explores implementation paths for integrating industry,education,and research with a dual-tutor collaborative training model.These include the development of a dual-tutor team,curriculum system optimization,the improvement of a quality assurance system,and the construction of practical training platforms.The paper demonstrates the outcomes of this model and proposes strategies for promotion and future outlooks,offering new ideas for training high-quality talent in the biological and pharmaceutical fields.
文摘AI is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.AI driven drug discovery is based on biomedical big data and new algorithms to identify drug targets,screen and optimize active compounds,analyze drug properties,and facilitate drug production and quality control.On this basis,we organized this special issue entitled"Innovative Pharmaceutical Research Driven by AI",and collected Original research articles,Reviewpapers.
基金financially supported by the National Natural Science Foundation of China(Nos.22375005 and 22474003)the Provincial University Research and Innovation Team(No.2022AH010023)+4 种基金the Natural Science Foundation of Anhui Province(No.2408085JX004)the Natural Science Research Project of Anhui Province Education Department(No.2022AH050323)the Postdoctoral Start-up Funding of Anhui University of Technology(No.DT2300001444)the Doctoral Start-up Funding of Anhui University of Technology(No.DT2300000981)Anhui Medical University Research Fund Project(No.2022xkj130)
文摘Inappropriate use of paracetamol (PA) can induce serious liver injury,and developing accurate PA detecting methods holds great importance in the fields of drug quality control and therapeutic drug monitoring.In this work,a novel electrochemical sensor for detecting PA was successfully fabricated based on iron single atoms distributed on multiwall carbon nanotubes (Fe/MWCNTs)that were prepared through the Lewis acid doping strategy.MWCNTs wrapped by polyaniline-derived N-doped carbon not only provide the anchoring sites for Fe,but also endow the catalyst with high conductivity and mass transfer ability.Theoretical calculation results reveal that atomically dispersed Fe sites hold good catalytic activity toward PA oxidation reaction,because of easier OH absorption at the first step and more facile occurrence of the key transformation from OH*+PA into H2O*+PA_H,during which electrons transferred from PA to catalysts,thereby facilitating the dissociation of N-H bond and the oxidation of PA.The Fe/MWCNTs sensor showed excellent PA detecting performance,delivering a low detection limit of 0.14μM in wide ranges of 0.5-100μM and 100-500μM.Without any pretreatments,the built sensor can directly and accurately detect PA in several complex commercial pharmaceutical formulations and spiked human urine samples with satisfactory recoveries from 96.98% to 107.59%,thereby fully demonstrating its practical application prospects.
基金funded by the National Key Research and Development Program of China(2024YFC3506900)the Special Project for Technological Innovation in New Productive Forces of Modern Chinese Medicines(24ZXZKSY00010 and 24ZXZKSY00040)the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202002)。
文摘Extraction unit operation is the first step in traditional Chinese medicine(TCM)product manufacturing,and it is crucial in determining the quality of the produced medicine.However,due to a lack of effective multimodal monitoring and adjustment strategies,achieving high quality and efficiency remains a challenge.In this work,we proposed an artificial intelligence(AI)-based robot platform for the multi-objective optimization of the extraction process.First,a perception intelligence method for multimodal process monitoring was established to track active ingredient transfer and production changes during the extraction process.Second,a digital twin model was developed to reconstruct the field information,which interacted with real-time monitoring data.Furthermore,the model performed real-time inference to predict future production process states by using the reconstructing information.Finally,according to the predicted process states,the autonomous decision-making robot implemented multi-objective optimization,ensuring efficient process adjustments for global optimization.Experimental and industrial results demonstrated that the platform could effectively infer component transfer dynamics,monitor temperature variations,and identify boiling states,ensuring product quality while reducing energy consumption.This pharmaceutical robot could promote the integration of AI and pharmaceutical engineering,thereby accelerating the iterative development and improvement of China’s pharmaceutical industry.
基金supported by the National Natural Science Foundation of China(Nos.52293442,52300249,and 52388101)the Scientific Research Project of China Three Gorges Corporation(No.201903139).
文摘Following the COVID-19 outbreak,a vast array of chlorine disinfectants was used to eliminate the virus,leading to inevitable discharge into aquatic ecosystems.These environments also contain various anthropogenic micropollutants,such as pharmaceuticals,which pose threats to the survival and activities of biological communities.Consequently,the presence of discharged chlorine disinfectants and pharmaceuticals can simultaneously impact the structure and function of aquatic ecosystems.To investigate the combined effects of chlorine disinfectants and pharmaceuticals on the periphyton and zoobenthos(Limnodrilus hoffmeisteri)community composition and function,we conducted a 12-flume reactor experiment using sodium hypochlorite and representative pharmaceuticals(abundant in the Yangtze River)as influents.Results demonstrated that the discharge of chlorine disinfectants further altered the composition of river prokaryotic communities.Eukaryotic organisms within the periphyton exhibited greater resilience to chlorine exposure compared to prokaryotic communities.Metagenomic analysis revealed that prokaryotic communities with different compositions can execute similar functions,while RNA sequencing indicated that co-exposure promoted biological processes such as focal adhesion and ribosome synthesis,but inhibited activities related to nitrogen metabolism and resistance to folate antimicrobials.Additionally,co-exposure induced oxidative stress in L.hoffmeisteri,leading to stronger environmental adaptation.
文摘Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.
