Perfluorooctanoic acid(PFOA)is a highly bioaccumulative environmental endocrine disruptor and a persistent organic pollutant.Epigenetic modifications in DNA and RNA are crucial for regulating gene expression and are i...Perfluorooctanoic acid(PFOA)is a highly bioaccumulative environmental endocrine disruptor and a persistent organic pollutant.Epigenetic modifications in DNA and RNA are crucial for regulating gene expression and are involved in numerous physiological processes.However,research on the effects of PFOA on epigenetic modifications is still limited.In this study,we systematically investigated the alterations in epigenetic modifications in both DNA and RNA from the heart,liver,spleen,lung,kidney,and brain of C57BL/6N mice following exposure to PFOA at doses of 0,0.5,and 5 mg kg^(-1)d^(-1),utilizing liquid chromatography-tandem mass spectrometry(LC-MS/MS).The results indicated that exposure to PFOA inhibited weight gain in mice,and significant changes were observed in the organ coefficients of the liver,spleen,lungs,and heart in the high PFOA exposure group.Modifications in DNA and RNA exhibited tissue specificity.Orthogonal partial least squares discriminant analysis revealed that the control group and the high PFOA exposure group clustered well,suggesting that PFOA exposure significantly impacts epigenetic modifications in DNA and RNA.Specifically,PFOA exposure significantly affected the levels of 5-hydroxymethylcytosine(5hmC)in genomic DNA in the heart,lung,kidney,and liver tissues.For RNA modifications,significant changes were observed,with the levels of 12,13,10,6,12,and 14 modifications in the heart,liver,spleen,lung,kidney,and brain,respectively,altered in response to PFOA exposure.Our study highlights the significance of PFOA exposure in altering DNA and RNA modifications,providing a new perspective on understanding the toxicology of PFOA from an epigenetic standpoint.展开更多
Environmental contaminants such as persistent organic pollutants （POPs） are man-made bioaccumulative compounds with long half-lives that are found throughout the world as a result of heavy use in a variety of consum...Environmental contaminants such as persistent organic pollutants （POPs） are man-made bioaccumulative compounds with long half-lives that are found throughout the world as a result of heavy use in a variety of consumer products during the twentieth century. Wildlife and animal studies have long suggested adverse effects of exposure to these compounds on human reproductive health, which, according to the endocrine disrupter hypothesis, are ascribed to the compounds＇ potential to interfere with endocrine signaling, especially when exposure occurs during certain phases of fetal and childhood development. An extensive number of epidemiological studies have addressed the possible effects of exposure to POPs on male reproductive health, but the results are conflicting. Thus far, most studies have focused on investigating exposure and the different reproductive health outcomes during adulthood. Some studies have addressed the potential harmful effects of fetal exposure with respect to malformations at birth and/ or reproductive development, whereas only a few studies have been able to evaluate whether intrauterine exposure to POPs has long-term consequences for male reproductive health with measurable effects on semen quality markers and reproductive hormone levels in adulthood. Humans are not exposed to a single compound at a time, but rather, to a variety of different substances with potential divergent hormonal effects. Hence, how to best analyze epidemiological data on combined exposures remains a significant challenge. This review on POPs will focus on current knowledge regarding the potential effects of exposure to POPs during fetal and childhood life and during adulthood on male reproductive health, including a critical revision of the endocrine disruption hypothesis, a comment on pubertal development as part of reproductive development and a comment on how to account for combined exposures in epidemiological research.展开更多
The development of Persistent Organic Pollutants(POPs) control policy in China in the context of international concerns on POPs was reviewed. The aspects of the Chinese POPs control strategies were analyzed, and compa...The development of Persistent Organic Pollutants(POPs) control policy in China in the context of international concerns on POPs was reviewed. The aspects of the Chinese POPs control strategies were analyzed, and compared with those of developed counterparts (e.g. US, EU, Japan). Currently, while the legal framework on POPs management, which complies with international guidelines has been established, it should be improved in the areas of special POPs management, risk assessment, the precautionary principle, life-cycle management and technical support capacity. The analysis of Chinese POPs policy and suggestions for strengthening the science-based decision making capacity are not only useful for Chinese decision-makers, but also a case study for developing world and make a great contribution for the global elimination of POPs to make a toxic-free future.展开更多
Lakes are the main reservoirs of persistent organic pollutants(POPs)from land,atmo sphere and rivers.POPs in lakes undergo complex exchange,transformation,and degradation between water-air-sediment-biota interfaces,wh...Lakes are the main reservoirs of persistent organic pollutants(POPs)from land,atmo sphere and rivers.POPs in lakes undergo complex exchange,transformation,and degradation between water-air-sediment-biota interfaces,which are constrained and regulated by various physical,chemical and biological factors.POPs can affect ecological conditions,chemical properties of water and sedi ments,and biodiversity of the lake system.Therefore,it is important to study the sources,migration,transformation,environmental behavior and ecological impacts of POPs in lake ecosystems.This re view summarizes research progress on detection technologies,diversity and origins,historical records,migration and transformation,distribution patterns,degradation and toxic effects of POPs in lakes.Fi nally,future directions related to POPs in lakes were summarized.展开更多
Hexafluoropropylene oxide（HFPO） oligomers are toxic,bioaccumulative,and persistent organic pollutants（POPs）.Consuming the harmful chemicals to prevent them from releasing to nature is of serious significance as fa...Hexafluoropropylene oxide（HFPO） oligomers are toxic,bioaccumulative,and persistent organic pollutants（POPs）.Consuming the harmful chemicals to prevent them from releasing to nature is of serious significance as far as both natural environments and human health are concerned.In this study,investigation on degradation of HFPO oligomers to pentafluoropropionyl fluoride（PPF）,a valuable industrial chemical,is reported.Different combinations of alkali metal fluoride in either diglyme or tetraglyme under both flask and batch autoclave conditions were examined.Under the optimal reaction conditions,HFPO oligomers（n = 2-10） were completely degraded to PPF in over 90%yield.Reactions on200 g scale were tested and no deduction of efficiency was observed,which indicates the potential for practical industrial application of this chemistry.展开更多
The fate of persistent organic pollutants (POPs) and their interactions with aggregates of forest soils are not completely understood. Our objectives here were to quantify the distribution of different POPs in water-s...The fate of persistent organic pollutants (POPs) and their interactions with aggregates of forest soils are not completely understood. Our objectives here were to quantify the distribution of different POPs in water-stable aggregate fractions and to study their influence on soil organic carbon (C<sub>org</sub>) content. Soil samples were taken from a forest-site, Gogerddan (G) and a semi-rural site, Hazelrigg (H) in Great Britain, from 0-2 and 2-5 cm and 0-4 and 8-12 cm soil depth, respectively. POPs analyzed were PAHs, PCBs, total DDT, PBDEs and HCB. The bulk soil analysis showed that the concentration of POPs was significantly higher (p ≤ 0.05) in forest site G than in semi-rural site H, particularly at the surface soil levels compared to the subsurface soil depths in both sites. Total concentrations of PCBs and PAHs of both sites were positively correlated with C<sub>org</sub> contents. POPs concentrations and C<sub>org</sub>, N<sub>t</sub> contents of forest site G were significantly higher (p ≤ 0.05) in water-stable macro aggregates (>0.25, >1, >2 mm) than the micro aggregates (>0.053 mm). The POP concentrations of all aggregate fractions after normalizing to their respective C<sub>org</sub> content were increased due higher contamination and strong sorption by C<sub>org</sub>. These results showed a strong effect of C<sub>org</sub> on the partitioning of organic pollutants to soil aggregate size fractions. The present study affirms the ecological significance of forest soils act as a potential sink of POPs. In summary, our results suggest that aggregate fractions may promote soil C storage and act as a potential POP sink in surface soil without increasing their concentration in the aggregate fraction of subsoil.展开更多
The Stockholm Convention on Persistent Organic Pollutants (SCPOPs) is an international treaty that operates under the patronage of the United Nations (UN) to control certain chemicals that are considered persistent or...The Stockholm Convention on Persistent Organic Pollutants (SCPOPs) is an international treaty that operates under the patronage of the United Nations (UN) to control certain chemicals that are considered persistent organic pollutants (POPs). They are of great concern because of their adverse effects on human health and the environment. Exposure to POPs may lead to cancer, infertility, respiratory infections, and other health complications. It is therefore critical to study the degree of human and environmental exposure to these POPs. Passive air sampling was conducted in South Africa to evaluate the presence and trends of persistent organic pollutants at Barberspan (rural agricultural), Vanderbijl Park (urban industrial) and Molopo Nature Reserve (isolated nature reserve). Samples were collected in 2012. Passive air samplers using poly were used for sampling. The Buchi System B-811 automatic extractor was used to analyze for dichloro-diphenyl-trichlorethane (DDT), pentachlorobenzene (PeCB), hexechlorobenzene (HCB) polychlorinated biphenyls (PCBs) and hexachlorocyclohexane (HCH). Sampling was conducted for a period of one year. POPs concentrations were generally low at all sites, but Vanderbijl Park had the highest concentrations. Seasonal changes in concentrations were much the same at the three sites with temperatures and wind patterns being major factors. The presence of these chemicals in Molopo Nature Reserve and Barberspan is evidence of long range transportation over dry semi desert areas. Back-trajectories indicate possible sources, including areas where DDT is used for malaria control. The presence of POPs is areas they have never been in use poses health and environmental risks in these areas.展开更多
The exposure−response associations of ambient heavy metals and persistent organic pollutants(POPs)with mortality in the general population remain unclear.This cohort study aimed to explore the long-term effect of expo...The exposure−response associations of ambient heavy metals and persistent organic pollutants(POPs)with mortality in the general population remain unclear.This cohort study aimed to explore the long-term effect of exposure to four air pollutants,including lead(Pb),cadmium(Cd),mercury(Hg),and benzo(a)pyrene[B(a)P]on all-cause and cause-specific mortality.This study involved 497,056 participants from the UK Biobank cohort.We used the Cox proportional hazards model to calculate associations.Effects of joint exposure to heavy metals were estimated using quantile g-computation.Shape of the exposure−response association was examined by fitting penalty splines,in both the total population and subpopulations stratified by age,sex,smoking status,and genetic factors.Modifying effects of age,sex,smoking status,and genetic factors were also examined.Over a median follow-up of 13.7 years,we identified 39,530(8.0%)deaths.Exposure to mixtures of Pb,Cd,and Hg was associated with 1.040−1.154 times increased risk of all-cause cancer,cardiovascular disease(CVD),stroke,and respiratory disease mortality.Of the specific causes of mortality,Pb and Cd were most strongly associated with respiratory diseases,including chronic obstructive pulmonary disease,followed by ischemic heart disease,CVD,and cancer.Hg and B(a)P seemed to exhibit lower toxicity compared with Pb and Cd.Exposure−response curves demonstrated monotonically increased risk for most mortality outcomes,though Hg was found to be nonlinearly associated with all-cause and stroke mortality.Age,smoking status,and genetic factors were found to modify the susceptibility to heavy metals.Our findings suggested that long-term exposure to heavy metals and B(a)P was monotonically associated with elevated risk of multiple mortality outcomes,indicating there may be no safe threshold for these chemicals.Substantial benefits to public health could be achieved through stringent environmental regulations and clean air initiatives.展开更多
The Stockholm Convention on persistent organic pollutants （POPs） was adopted in 2001. This year is the 10th anniversary of the adoption of the Convention. Until now, 22 chemicals or chemical categories have been lis...The Stockholm Convention on persistent organic pollutants （POPs） was adopted in 2001. This year is the 10th anniversary of the adoption of the Convention. Until now, 22 chemicals or chemical categories have been listed as POPs in the Stockholm Convention. The POPs Research Center was established in Tsinghua University in the same year when the Convention was adopted. In the last ten years, much work has been done by Chinese researchers to understand the environ- mental risk of POPs in China. This article aims to review the recent research progress of our POPs Research Center and some other Chinese researchers＇ studies in addressing the environmental risk of POPs, including the priority screening and inventory study of POPs, monitoring and modeling of POPs pollution and exposure, and environ- mental risk assessment and modeling of POPs. Although great advances in addressing the environmental risk of POPs have been made in recent years, we are still facing quite a few problems, such as data scarcity and uncertainty in environmental risk assessment of POPs. The study on the effect of POPs mixtures is in its infancy and currently POPs are usually assessed from legal perspective by risk assessment of single chemicals. These problems should be well addressed by further efforts. Further studies should also be taken in future to study environment risk of POPs by considering aspects of coupled dynamics between climate processes and POPs. Such sound scientific, riskbased information can support decision-making aiming to effectively minimize the risk level of POPs.展开更多
Persistent organic pollutants(POPs),such as dioxins,polychlorinated biphenyls(PCBs),and organochlorine pesticides(OCPs),which are synthetic chemicals or by-products with an intrinsic resistance to natural degradation ...Persistent organic pollutants(POPs),such as dioxins,polychlorinated biphenyls(PCBs),and organochlorine pesticides(OCPs),which are synthetic chemicals or by-products with an intrinsic resistance to natural degradation processes,are released into the environment,resulting in the widespread dispersal and accumulation in the environment,as well as in human and ecological food chains.Due to their ubiquity in the environment and lipophilic properties,there is emerging concern over the potential risks of human exposure to POPs.Extensive growing evidence indicated that exposure to POPs might be strongly associated with increased risk of a worldwide epidemic of diabetes,especially type 2 diabetes,suggesting that POPs might play a key role in their pathogenesis.Based on summary of the related studies,this paper reviews the epidemiologic and experimental data that addresses the association between increased risk of diabetes and POP exposure,including dioxins,PCBs,OCPs,polybrominated flame retardants(PBFRs),and some environmental estrogens.The potential mechanisms whereby POPs cause diabetes were discussed,such as alterations in lipid metabolism,in glucose transport,in insulin signaling pathway,in steroid metabolism,and disruption of endocrine system,induction of tumor necrosis factor-α(TNF-α).However,with respect to diabetes,some of the evidence on POPs linked to risk of diabetes was suggestive of a direct or indirect association but was limited or inconclusive.Future research is urgently needed for determining the relative contribution of POPs to diabetes and elucidating the exact mechanisms.展开更多
Quantitative structure-activity relationships(QSARs)were determined using partial least square(PLS)and support vector machine(SVM).The predicted values by the final QSAR models were in good agreement with the correspo...Quantitative structure-activity relationships(QSARs)were determined using partial least square(PLS)and support vector machine(SVM).The predicted values by the final QSAR models were in good agreement with the corresponding experimental values.Chemical estrogenic activities are related to atomic properties(atomic Sanderson electronegativities,van der Waals volumes and polarizabilities).Comparison of the results obtained from two models,the SVM method exhibited better overall performances.Besides,three PLS models were constructed for some specific families based on their chemical structures.These predictive models should be useful to rapidly identify potential estrogenic endocrine disrupting chemicals.展开更多
Polychlorinated biphenyls(PCBs)and organochlorine pesticides(OCPs)are persistent organic pollutants(POPs)that bioaccumulate in adipose tissue.We investigated the relationship between change in central adiposity and ch...Polychlorinated biphenyls(PCBs)and organochlorine pesticides(OCPs)are persistent organic pollutants(POPs)that bioaccumulate in adipose tissue.We investigated the relationship between change in central adiposity and changes in circulating concentrations of POPs over a 12-year period during the midlife.Serum concentrations of 34 PCBs and 19 OCPs were measured at four time points(1999/2000,2002/03,2005/06,2009/11)in a cohort of midlife women,the Study of Women’s Health Across the Nation.Linear mixed models were used to test the association between a change in waist circumference and a change in serum POP concentrations.Sixty-five women contributed 181 PCB observations.Fifty-nine women contributed 151 OCP observations.After adjustment for covariates(study site,race and ethnicity,age at baseline,parity),a one-inch(2.54 cm)increase in the change in waist circumference between visits was associated with a 4.9%decrease in the change in serum concentration of PCB 194(95%CI:−8.0%,−1.6%).No associations were observed for other PCB congeners or the presence of OCPs.An increase in the difference in waist circumference over time was not associated with a change in the difference in serum concentrations of PCBs and OCPs except for PCB 194,possibly due to the high lipophilicity.展开更多
Exposure to persistent organic pollutants(POPs)has been reported as a potential risk factor for diabetes in adults.However,effect modifications by sex and age,especially among Asian populations,have seldom been invest...Exposure to persistent organic pollutants(POPs)has been reported as a potential risk factor for diabetes in adults.However,effect modifications by sex and age,especially among Asian populations,have seldom been investigated.In the present study,we assessed associations of major POPs exposure including organochlorine pesticides(OCPs),polychlorinated biphenyls(PCBs),and polybrominated diphenyl ethers(PBDEs),with diabetes in Korean adults(n=1,295),a subset of the Korean National Environmental Health Survey(KoNEHS)Cycle 3(2015−2017).In the adult population,serum levels of dichlorodiphenyltrichloroethanes(DDTs)and PCB167 showed an increased odds ratio(OR)for diabetes.When stratified by gender,associations became stronger and more consistent in women:In women,serum levels of OCPs including p,p′-DDT,p,p′-dichlorodiphenyldichloroethylene(p,p′-DDE),andΣOCPs and mono-ortho PCBs,such as PCB118 and PCB157,were significantly associated with diabetes.In the male participants,however,no significant positive associations were detected.When stratified by a cutoff age of 50 years,most studied POPs except PBDEs,i.e.,p,p′-DDT,p,p′-DDE,PCB118,PCB157,PCB167,PCB138,and PCB153,showed significant associations with diabetes,in the older adults.In the younger group,however,no measured POPs showed a significant positive association.Effects of endogenous sex hormones or interaction of POPs on aryl hydrocarbon receptors may partly explain the observed differences by gender and age,although further experimental confirmations should follow.Our findings show that POPs exposure at the current levels is associated with diabetes among general Korean adults,and such associations could be modified by gender and age.展开更多
Modeling the fate and transport of organic pollutants at contaminated sites is critical for risk assessment and management practices,such as establishing realistic cleanup standards or remediation endpoints.Against th...Modeling the fate and transport of organic pollutants at contaminated sites is critical for risk assessment and management practices,such as establishing realistic cleanup standards or remediation endpoints.Against the conventional wisdom that highly hydrophobic persistent organic pollutants(POPs)(e.g.,polybrominated diphenyl ethers and polycyclic aromatic hydrocarbons)in surface soils are essentially immobile,mounting evidence has demonstrated the potential of these contaminants leaching into the groundwater,due to enhanced transport by soil colloids.Here,we develop a Colloids-Enhanced Transport(CET)model,which can be used as a simple screening tool to predict the leaching potential of POPs into groundwater,as mediated by soil colloids.The CET model incorporates several processes,including the release of POPs-bearing colloids into the porewater,the vertical transport of colloids and associated POPs in the vadose zone,themixing of POPs-containing soil leachate with groundwater,and the migration of POPs-bearing colloids in saturated zone.Thus,using parameters that can be easily obtained(e.g.,annual rainfall,soil type,and common hydrogeological properties of the subsurface porous media),the CET model can estimate the concentrations of POPs in the saturated zone from the observed POPs concentrations in surface or shallow subsurface zones.The CET model can also be used to derive soil quality standards or cleanup endpoints by back-calculating soil concentrations based on groundwater protection limits.展开更多
Persistent halogenated organic pollutants(HOPs)are globally concerned owing to their persistence,bioaccumulation,and potential toxicity to aquatic organisms.The trophic transfer of HOPs can affect their toxic effects ...Persistent halogenated organic pollutants(HOPs)are globally concerned owing to their persistence,bioaccumulation,and potential toxicity to aquatic organisms.The trophic transfer of HOPs can affect their toxic effects on both humans and ecosystems.Previous studies mostly focused on HOPs biomagnification within specific regional or ecosystem contexts,however,the variation in trophicmagnification factors(TMFs)among different HOPs across a spectrum of diverse aquatic systems globally remains unclear.By collating literatures encompassing TMFs of polychlorinated biphenyls(PCBs),polybrominated diphenyl ethers(PBDEs),or perfluoroalkyl acids(PFAAs)along invertebrate–fish food webs on a global scale,our analysis revealed that Asia,North America,and Europe exhibited the highest pollution levels of HOPs.PCBs were found to have the highest trophicmagnification capability(TMF=3.14),followed by PBDEs(TMF=2.48)and PFAAs(TMF=1.97).TMF values and the probability of TMF exceeding 1 for PCB,PBDE and PFAA congeners showed a parabolic relationship with halogenation degree and carbon chain length.Specifically,PCBswith 6 chlorines,PBDEs with 5 bromines,and PFAAs with 12 carbons exhibited maximum trophic transfer capability and potential along food webs.Fractionation of PCBs and PFAAs was observed,with the proportions of higher chlorination degree and longer chain PFAAs increasing while the others decreased with trophic levels.Surprisingly,we also found a positive relationship between site latitude and TMF values of HOP congeners.This study provides a valuable basis for gauging ecological and health risks of HOPs,facilitating the development of robust standards for aquatic environment management.展开更多
Rice cultivation,vital to global food security and the United Nations Sustainable Development Goals(SDGs),faces increasing threats from industrial pollution,which contaminates soil and water,endangers human health,and...Rice cultivation,vital to global food security and the United Nations Sustainable Development Goals(SDGs),faces increasing threats from industrial pollution,which contaminates soil and water,endangers human health,and weakens agricultural resilience.Studies indicate that contaminants such as persistent organic pollutants,radioactive elements,dyes,and potentially toxic elements,particularly from mining and industrial activities,significantly degrade soil fertility,impair plant health,and introduce harmful residues into the food chain.This contamination compromises food safety and diminishes agricultural productivity,posing a serious challenge to sustainability.Addressing these impacts requires sustainable industrial practices,advanced technologies,and eco-friendly remediation techniques.Solutions like biochar applications,precision farming,and artificial intelligence(AI)-driven pollution detection provide effective measures for restoring soil health,protecting crop integrity,and ensuring the resilience of rice farming.These approaches align rice cultivation with global sustainability goals by integrating sustainable soil and water management,adaptive crop selection,and AI innovations.Protecting rice cultivation upholds farmer livelihoods and strengthens global commitments to SDGs Zero Hunger and a resilient,safe food supply,underscoring the essential balance between industrial progress and sustainable rice cultivation.展开更多
Background:Current guidelines for the treatment of patients with necrotizing acute pancreatitis(NAP)recommend that invasive intervention for pancreatic necrosis should be deferred to 4 or more weeks from disease onset...Background:Current guidelines for the treatment of patients with necrotizing acute pancreatitis(NAP)recommend that invasive intervention for pancreatic necrosis should be deferred to 4 or more weeks from disease onset to allow necrotic collections becoming“walled-off”.However,for patients showing signs of clinical deterioration,especially those with persistent organ failure(POF),it is controversial whether this delayed approach should always be adopted.In this study,we aimed to assess the impact of differently timed intervention on clinical outcomes in a group of NAP patients complicated by POF.Methods:All NAP patients admitted to our hospital from January 2013 to December 2017 were screened for potential inclusion.They were divided into two groups based on the timing of initial interven-tion(within 4 weeks and beyond 4 weeks).All the data were extracted from a prospectively collected database.Results:Overall,131 patients were included for analysis.Among them,100(76.3%)patients were in-tervened within 4 weeks and 31(23.7%)underwent delayed interventions.As for organ failure prior to intervention,the incidences of respiratory failure,renal failure and cardiovascular failure were not signifi-cantly different between the two groups(P>0.05).The mortality was not significantly different between the two groups(35.0%vs.32.3%,P=0.83).The incidences of new-onset multiple organ failure(8.0%vs.6.5%,P=1.00),gastrointestinal fistula(29.0%vs.12.9%,P=0.10)and bleeding(35.0%vs.35.5%,P=1.00),and length of ICU(30.0 vs.22.0 days,P=0.61)and hospital stay(42.5 vs.40.0 days,P=0.96)were com-parable between the two groups.Conclusion:Intervention within 4 weeks did not worsen the clinical outcomes in NAP patients compli-cated by POF.展开更多
BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various diseases.We categorize acute p...BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various diseases.We categorize acute pancreatitis by etiology into acute biliary pancreatitis(ABP)and hypertriglyceridemia-induced acute pancreatitis(HTGP).AIM To investigate the clinical significance of NLR and PLR in assessing persistent organ failure(POF)in HTGP and ABP.METHODS A total of 1450 patients diagnosed with acute pancreatitis(AP)for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were enrolled.The patients were categorized into two groups according to the etiology of AP:ABP in 530 patients and HTGP in 241 patients.We collected and compared the clinical data of the patients,including NLR,PLR,and AP prognostic scoring systems,within 48 h of hospital admission.RESULTS The NLR(9.1 vs 6.9,P<0.001)and PLR(203.1 vs 160.5,P<0.001)were significantly higher in the ABP group than in the HTGP group.In the HTGP group,both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score≥3.Likewise,in the ABP group,NLR and PLR were significantly elevated in patients with severe AP,modified computed tomography severity index score≥4,Japanese Severity Score≥3,and modified Marshall score≥2.Moreover,NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP groups.CONCLUSION NLR and PLR vary between ABP and HTGP,are strongly associated with AP prognostic scoring systems,and have predictive potential for the occurrence of POF in both ABP and HTGP.展开更多
Dibromoethane is a widespread,persistent organic pollutant.Biochars are known mediators of reductive dehalogenation by layered Fe^(Ⅱ)-Fe^(Ⅲ)hydroxides(green rust),which can reduce 1,2-dibromoethane to innocuous brom...Dibromoethane is a widespread,persistent organic pollutant.Biochars are known mediators of reductive dehalogenation by layered Fe^(Ⅱ)-Fe^(Ⅲ)hydroxides(green rust),which can reduce 1,2-dibromoethane to innocuous bromide and ethylene.However,the critical characteristics that determine mediator functionality are lesser known.Fifteen biochar substrates were pyrolyzed at 600℃and 800℃,characterized by elemental analysis,X-ray photo spectrometry C and N surface speciation,X-ray powder diffraction,specific surface area analysis,and tested for mediation of reductive debromination of 1,2-dibromoethane by a green rust reductant under anoxic conditions.A statistical analysis was performed to determine the biochar properties,critical for debromination kinetics and total debromination extent.It was shown that selected plant based biochars can mediate debromination of 1,2-dibromoethane,that the highest first order rate constant was 0.082/hr,and the highest debromination extent was 27%in reactivity experiments with 0.1μmol(20μmol/L)1,2-dibromoethane,≈22 mmol/L Fe^(Ⅱ)GR,and 0.12 g/L soybean meal biochar(7 days).Contents of Ni,Zn,N,and P,and the relative contribution of quinone surface functional groups were significantly(p<0.05)positively correlated with 1,2-dibromoethane debromination,while adsorption,specific surface area,and the relative contribution of pyridinic N oxide surface groups were significantly negatively correlated with debromination.展开更多
基金supported by the National Key R&D Program of China(Nos.2022YFA0806600,2022YFC3400700)the Fundamental Research Funds for the Central Universities(No.2042024kf1045)+2 种基金the National Natural Science Foundation of China(No.22277093)the Key Research and Development Project of Hubei Province(No.2023BCB094)the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(No.JCRCGW-2022008)。
文摘Perfluorooctanoic acid(PFOA)is a highly bioaccumulative environmental endocrine disruptor and a persistent organic pollutant.Epigenetic modifications in DNA and RNA are crucial for regulating gene expression and are involved in numerous physiological processes.However,research on the effects of PFOA on epigenetic modifications is still limited.In this study,we systematically investigated the alterations in epigenetic modifications in both DNA and RNA from the heart,liver,spleen,lung,kidney,and brain of C57BL/6N mice following exposure to PFOA at doses of 0,0.5,and 5 mg kg^(-1)d^(-1),utilizing liquid chromatography-tandem mass spectrometry(LC-MS/MS).The results indicated that exposure to PFOA inhibited weight gain in mice,and significant changes were observed in the organ coefficients of the liver,spleen,lungs,and heart in the high PFOA exposure group.Modifications in DNA and RNA exhibited tissue specificity.Orthogonal partial least squares discriminant analysis revealed that the control group and the high PFOA exposure group clustered well,suggesting that PFOA exposure significantly impacts epigenetic modifications in DNA and RNA.Specifically,PFOA exposure significantly affected the levels of 5-hydroxymethylcytosine(5hmC)in genomic DNA in the heart,lung,kidney,and liver tissues.For RNA modifications,significant changes were observed,with the levels of 12,13,10,6,12,and 14 modifications in the heart,liver,spleen,lung,kidney,and brain,respectively,altered in response to PFOA exposure.Our study highlights the significance of PFOA exposure in altering DNA and RNA modifications,providing a new perspective on understanding the toxicology of PFOA from an epigenetic standpoint.
文摘Environmental contaminants such as persistent organic pollutants （POPs） are man-made bioaccumulative compounds with long half-lives that are found throughout the world as a result of heavy use in a variety of consumer products during the twentieth century. Wildlife and animal studies have long suggested adverse effects of exposure to these compounds on human reproductive health, which, according to the endocrine disrupter hypothesis, are ascribed to the compounds＇ potential to interfere with endocrine signaling, especially when exposure occurs during certain phases of fetal and childhood development. An extensive number of epidemiological studies have addressed the possible effects of exposure to POPs on male reproductive health, but the results are conflicting. Thus far, most studies have focused on investigating exposure and the different reproductive health outcomes during adulthood. Some studies have addressed the potential harmful effects of fetal exposure with respect to malformations at birth and/ or reproductive development, whereas only a few studies have been able to evaluate whether intrauterine exposure to POPs has long-term consequences for male reproductive health with measurable effects on semen quality markers and reproductive hormone levels in adulthood. Humans are not exposed to a single compound at a time, but rather, to a variety of different substances with potential divergent hormonal effects. Hence, how to best analyze epidemiological data on combined exposures remains a significant challenge. This review on POPs will focus on current knowledge regarding the potential effects of exposure to POPs during fetal and childhood life and during adulthood on male reproductive health, including a critical revision of the endocrine disruption hypothesis, a comment on pubertal development as part of reproductive development and a comment on how to account for combined exposures in epidemiological research.
文摘The development of Persistent Organic Pollutants(POPs) control policy in China in the context of international concerns on POPs was reviewed. The aspects of the Chinese POPs control strategies were analyzed, and compared with those of developed counterparts (e.g. US, EU, Japan). Currently, while the legal framework on POPs management, which complies with international guidelines has been established, it should be improved in the areas of special POPs management, risk assessment, the precautionary principle, life-cycle management and technical support capacity. The analysis of Chinese POPs policy and suggestions for strengthening the science-based decision making capacity are not only useful for Chinese decision-makers, but also a case study for developing world and make a great contribution for the global elimination of POPs to make a toxic-free future.
基金supported by the National Natural Science Foundation of China(No.42172336).
文摘Lakes are the main reservoirs of persistent organic pollutants(POPs)from land,atmo sphere and rivers.POPs in lakes undergo complex exchange,transformation,and degradation between water-air-sediment-biota interfaces,which are constrained and regulated by various physical,chemical and biological factors.POPs can affect ecological conditions,chemical properties of water and sedi ments,and biodiversity of the lake system.Therefore,it is important to study the sources,migration,transformation,environmental behavior and ecological impacts of POPs in lake ecosystems.This re view summarizes research progress on detection technologies,diversity and origins,historical records,migration and transformation,distribution patterns,degradation and toxic effects of POPs in lakes.Fi nally,future directions related to POPs in lakes were summarized.
基金the National Natural Science Foundation of China (Nos. 21372127, 21572104)Program for New Century Excellent Talents in UniversityChanglu Engineering Research Center of New Chemical Materials for financial support
文摘Hexafluoropropylene oxide（HFPO） oligomers are toxic,bioaccumulative,and persistent organic pollutants（POPs）.Consuming the harmful chemicals to prevent them from releasing to nature is of serious significance as far as both natural environments and human health are concerned.In this study,investigation on degradation of HFPO oligomers to pentafluoropropionyl fluoride（PPF）,a valuable industrial chemical,is reported.Different combinations of alkali metal fluoride in either diglyme or tetraglyme under both flask and batch autoclave conditions were examined.Under the optimal reaction conditions,HFPO oligomers（n = 2-10） were completely degraded to PPF in over 90%yield.Reactions on200 g scale were tested and no deduction of efficiency was observed,which indicates the potential for practical industrial application of this chemistry.
基金financed by the Higher Education Commission(HEC) of Pakistan and German Academic Exchange Service(DAAD)
文摘The fate of persistent organic pollutants (POPs) and their interactions with aggregates of forest soils are not completely understood. Our objectives here were to quantify the distribution of different POPs in water-stable aggregate fractions and to study their influence on soil organic carbon (C<sub>org</sub>) content. Soil samples were taken from a forest-site, Gogerddan (G) and a semi-rural site, Hazelrigg (H) in Great Britain, from 0-2 and 2-5 cm and 0-4 and 8-12 cm soil depth, respectively. POPs analyzed were PAHs, PCBs, total DDT, PBDEs and HCB. The bulk soil analysis showed that the concentration of POPs was significantly higher (p ≤ 0.05) in forest site G than in semi-rural site H, particularly at the surface soil levels compared to the subsurface soil depths in both sites. Total concentrations of PCBs and PAHs of both sites were positively correlated with C<sub>org</sub> contents. POPs concentrations and C<sub>org</sub>, N<sub>t</sub> contents of forest site G were significantly higher (p ≤ 0.05) in water-stable macro aggregates (>0.25, >1, >2 mm) than the micro aggregates (>0.053 mm). The POP concentrations of all aggregate fractions after normalizing to their respective C<sub>org</sub> content were increased due higher contamination and strong sorption by C<sub>org</sub>. These results showed a strong effect of C<sub>org</sub> on the partitioning of organic pollutants to soil aggregate size fractions. The present study affirms the ecological significance of forest soils act as a potential sink of POPs. In summary, our results suggest that aggregate fractions may promote soil C storage and act as a potential POP sink in surface soil without increasing their concentration in the aggregate fraction of subsoil.
文摘The Stockholm Convention on Persistent Organic Pollutants (SCPOPs) is an international treaty that operates under the patronage of the United Nations (UN) to control certain chemicals that are considered persistent organic pollutants (POPs). They are of great concern because of their adverse effects on human health and the environment. Exposure to POPs may lead to cancer, infertility, respiratory infections, and other health complications. It is therefore critical to study the degree of human and environmental exposure to these POPs. Passive air sampling was conducted in South Africa to evaluate the presence and trends of persistent organic pollutants at Barberspan (rural agricultural), Vanderbijl Park (urban industrial) and Molopo Nature Reserve (isolated nature reserve). Samples were collected in 2012. Passive air samplers using poly were used for sampling. The Buchi System B-811 automatic extractor was used to analyze for dichloro-diphenyl-trichlorethane (DDT), pentachlorobenzene (PeCB), hexechlorobenzene (HCB) polychlorinated biphenyls (PCBs) and hexachlorocyclohexane (HCH). Sampling was conducted for a period of one year. POPs concentrations were generally low at all sites, but Vanderbijl Park had the highest concentrations. Seasonal changes in concentrations were much the same at the three sites with temperatures and wind patterns being major factors. The presence of these chemicals in Molopo Nature Reserve and Barberspan is evidence of long range transportation over dry semi desert areas. Back-trajectories indicate possible sources, including areas where DDT is used for malaria control. The presence of POPs is areas they have never been in use poses health and environmental risks in these areas.
基金the National Natural Science Foundation of China(72125009,82204137,82003529)National Key R&D Program of the Ministry of Science and Technology of China(2022YFF1203001)+3 种基金Young Elite Scientists Sponsorship Program by CAST(2022QNRC001,2023QNRC001)National High Level Hospital Clinical Research Funding(“Star of Outlook”Scientific Research Project of Peking University First Hospital,2022XW06)CAMS Innovation Fund for Medical Sciences(2019-I2M-5-046)PKU-Baidu Fund(2020BD032).
文摘The exposure−response associations of ambient heavy metals and persistent organic pollutants(POPs)with mortality in the general population remain unclear.This cohort study aimed to explore the long-term effect of exposure to four air pollutants,including lead(Pb),cadmium(Cd),mercury(Hg),and benzo(a)pyrene[B(a)P]on all-cause and cause-specific mortality.This study involved 497,056 participants from the UK Biobank cohort.We used the Cox proportional hazards model to calculate associations.Effects of joint exposure to heavy metals were estimated using quantile g-computation.Shape of the exposure−response association was examined by fitting penalty splines,in both the total population and subpopulations stratified by age,sex,smoking status,and genetic factors.Modifying effects of age,sex,smoking status,and genetic factors were also examined.Over a median follow-up of 13.7 years,we identified 39,530(8.0%)deaths.Exposure to mixtures of Pb,Cd,and Hg was associated with 1.040−1.154 times increased risk of all-cause cancer,cardiovascular disease(CVD),stroke,and respiratory disease mortality.Of the specific causes of mortality,Pb and Cd were most strongly associated with respiratory diseases,including chronic obstructive pulmonary disease,followed by ischemic heart disease,CVD,and cancer.Hg and B(a)P seemed to exhibit lower toxicity compared with Pb and Cd.Exposure−response curves demonstrated monotonically increased risk for most mortality outcomes,though Hg was found to be nonlinearly associated with all-cause and stroke mortality.Age,smoking status,and genetic factors were found to modify the susceptibility to heavy metals.Our findings suggested that long-term exposure to heavy metals and B(a)P was monotonically associated with elevated risk of multiple mortality outcomes,indicating there may be no safe threshold for these chemicals.Substantial benefits to public health could be achieved through stringent environmental regulations and clean air initiatives.
文摘The Stockholm Convention on persistent organic pollutants （POPs） was adopted in 2001. This year is the 10th anniversary of the adoption of the Convention. Until now, 22 chemicals or chemical categories have been listed as POPs in the Stockholm Convention. The POPs Research Center was established in Tsinghua University in the same year when the Convention was adopted. In the last ten years, much work has been done by Chinese researchers to understand the environ- mental risk of POPs in China. This article aims to review the recent research progress of our POPs Research Center and some other Chinese researchers＇ studies in addressing the environmental risk of POPs, including the priority screening and inventory study of POPs, monitoring and modeling of POPs pollution and exposure, and environ- mental risk assessment and modeling of POPs. Although great advances in addressing the environmental risk of POPs have been made in recent years, we are still facing quite a few problems, such as data scarcity and uncertainty in environmental risk assessment of POPs. The study on the effect of POPs mixtures is in its infancy and currently POPs are usually assessed from legal perspective by risk assessment of single chemicals. These problems should be well addressed by further efforts. Further studies should also be taken in future to study environment risk of POPs by considering aspects of coupled dynamics between climate processes and POPs. Such sound scientific, riskbased information can support decision-making aiming to effectively minimize the risk level of POPs.
基金support from the National Program on Key Basic Research Project(2008CB418206)National R&D Special Fund for Public Welfare Industry(200709052)+2 种基金Key Projects in the National Science&Technology Pillar Program in the Eleventh Five-year Plan Period(2007BAC16B07)National Natural Science Foundation of China(20677018)Program for New Century Excellent Talents in University(NCET-04-0697)
文摘Persistent organic pollutants(POPs),such as dioxins,polychlorinated biphenyls(PCBs),and organochlorine pesticides(OCPs),which are synthetic chemicals or by-products with an intrinsic resistance to natural degradation processes,are released into the environment,resulting in the widespread dispersal and accumulation in the environment,as well as in human and ecological food chains.Due to their ubiquity in the environment and lipophilic properties,there is emerging concern over the potential risks of human exposure to POPs.Extensive growing evidence indicated that exposure to POPs might be strongly associated with increased risk of a worldwide epidemic of diabetes,especially type 2 diabetes,suggesting that POPs might play a key role in their pathogenesis.Based on summary of the related studies,this paper reviews the epidemiologic and experimental data that addresses the association between increased risk of diabetes and POP exposure,including dioxins,PCBs,OCPs,polybrominated flame retardants(PBFRs),and some environmental estrogens.The potential mechanisms whereby POPs cause diabetes were discussed,such as alterations in lipid metabolism,in glucose transport,in insulin signaling pathway,in steroid metabolism,and disruption of endocrine system,induction of tumor necrosis factor-α(TNF-α).However,with respect to diabetes,some of the evidence on POPs linked to risk of diabetes was suggestive of a direct or indirect association but was limited or inconclusive.Future research is urgently needed for determining the relative contribution of POPs to diabetes and elucidating the exact mechanisms.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA11020405)the Key Research Program of the Chinese Academy of Sciences(Grant No.KZZD-EW-14).
文摘Quantitative structure-activity relationships(QSARs)were determined using partial least square(PLS)and support vector machine(SVM).The predicted values by the final QSAR models were in good agreement with the corresponding experimental values.Chemical estrogenic activities are related to atomic properties(atomic Sanderson electronegativities,van der Waals volumes and polarizabilities).Comparison of the results obtained from two models,the SVM method exhibited better overall performances.Besides,three PLS models were constructed for some specific families based on their chemical structures.These predictive models should be useful to rapidly identify potential estrogenic endocrine disrupting chemicals.
基金The Study of Women’s Health Across the Nation(SWAN)has grant support from the National Institutes of Health(NIH),DHHS,through the National Institute on Aging(NIA),the National Institute of Nursing Research(NINR),and the NIH Office of Research on Women’s Health(ORWH)(Grants U01NR004061,U01AG012505,U01AG012535,U01AG012531,U01AG012539,U01AG012546,U01AG012553,U01AG012554,U01AG012495,and U19AG063720)supported by the SWAN Repository(U01AG017719)+3 种基金the National Center for Research Resources and the National Center for Advancing Translational Sciences,National Institutes of Health,through UCSFCTSI Grant Number UL1 RR024131supported by grants from the National Institute of Environmental Health Sciences(NIEHS)R01-ES026578,R01-ES026964,and P30-ES017885the Center for Disease Control and Prevention(CDC)/National Institute for Occupational Safety and Health(NIOSH)Grant T42-OH008455supported by the Environmental Toxicology and Epidemiology(ETEP)training grant from NIEHS(T32 ES007062).
文摘Polychlorinated biphenyls(PCBs)and organochlorine pesticides(OCPs)are persistent organic pollutants(POPs)that bioaccumulate in adipose tissue.We investigated the relationship between change in central adiposity and changes in circulating concentrations of POPs over a 12-year period during the midlife.Serum concentrations of 34 PCBs and 19 OCPs were measured at four time points(1999/2000,2002/03,2005/06,2009/11)in a cohort of midlife women,the Study of Women’s Health Across the Nation.Linear mixed models were used to test the association between a change in waist circumference and a change in serum POP concentrations.Sixty-five women contributed 181 PCB observations.Fifty-nine women contributed 151 OCP observations.After adjustment for covariates(study site,race and ethnicity,age at baseline,parity),a one-inch(2.54 cm)increase in the change in waist circumference between visits was associated with a 4.9%decrease in the change in serum concentration of PCB 194(95%CI:−8.0%,−1.6%).No associations were observed for other PCB congeners or the presence of OCPs.An increase in the difference in waist circumference over time was not associated with a change in the difference in serum concentrations of PCBs and OCPs except for PCB 194,possibly due to the high lipophilicity.
基金supported by grants from the National Institute of Environmental Research funded by the Ministry of Environment(MOE)of Korea(NIER-2019-01-02-082)National Research Foundation(NRF)of Korea(NRF-2020R1A2C3011269 and NRF-2022R1C1C2006982).
文摘Exposure to persistent organic pollutants(POPs)has been reported as a potential risk factor for diabetes in adults.However,effect modifications by sex and age,especially among Asian populations,have seldom been investigated.In the present study,we assessed associations of major POPs exposure including organochlorine pesticides(OCPs),polychlorinated biphenyls(PCBs),and polybrominated diphenyl ethers(PBDEs),with diabetes in Korean adults(n=1,295),a subset of the Korean National Environmental Health Survey(KoNEHS)Cycle 3(2015−2017).In the adult population,serum levels of dichlorodiphenyltrichloroethanes(DDTs)and PCB167 showed an increased odds ratio(OR)for diabetes.When stratified by gender,associations became stronger and more consistent in women:In women,serum levels of OCPs including p,p′-DDT,p,p′-dichlorodiphenyldichloroethylene(p,p′-DDE),andΣOCPs and mono-ortho PCBs,such as PCB118 and PCB157,were significantly associated with diabetes.In the male participants,however,no significant positive associations were detected.When stratified by a cutoff age of 50 years,most studied POPs except PBDEs,i.e.,p,p′-DDT,p,p′-DDE,PCB118,PCB157,PCB167,PCB138,and PCB153,showed significant associations with diabetes,in the older adults.In the younger group,however,no measured POPs showed a significant positive association.Effects of endogenous sex hormones or interaction of POPs on aryl hydrocarbon receptors may partly explain the observed differences by gender and age,although further experimental confirmations should follow.Our findings show that POPs exposure at the current levels is associated with diabetes among general Korean adults,and such associations could be modified by gender and age.
基金supported by the National Key Research and Development Program of China(No.2019YFC1804202)the National Natural Science Foundation of China(Nos.22020102004 and 22125603)+1 种基金Tianjin Municipal Science and Technology Bureau(No.21JCZDJC00280)the Fundamental Research Funds for the Central Universities,and the Ministry of Education of China(No.T2017002).
文摘Modeling the fate and transport of organic pollutants at contaminated sites is critical for risk assessment and management practices,such as establishing realistic cleanup standards or remediation endpoints.Against the conventional wisdom that highly hydrophobic persistent organic pollutants(POPs)(e.g.,polybrominated diphenyl ethers and polycyclic aromatic hydrocarbons)in surface soils are essentially immobile,mounting evidence has demonstrated the potential of these contaminants leaching into the groundwater,due to enhanced transport by soil colloids.Here,we develop a Colloids-Enhanced Transport(CET)model,which can be used as a simple screening tool to predict the leaching potential of POPs into groundwater,as mediated by soil colloids.The CET model incorporates several processes,including the release of POPs-bearing colloids into the porewater,the vertical transport of colloids and associated POPs in the vadose zone,themixing of POPs-containing soil leachate with groundwater,and the migration of POPs-bearing colloids in saturated zone.Thus,using parameters that can be easily obtained(e.g.,annual rainfall,soil type,and common hydrogeological properties of the subsurface porous media),the CET model can estimate the concentrations of POPs in the saturated zone from the observed POPs concentrations in surface or shallow subsurface zones.The CET model can also be used to derive soil quality standards or cleanup endpoints by back-calculating soil concentrations based on groundwater protection limits.
基金supported by the National Natural Science Foundation of China(Nos.T2421005,T2261129474,52039001,and 52270148).
文摘Persistent halogenated organic pollutants(HOPs)are globally concerned owing to their persistence,bioaccumulation,and potential toxicity to aquatic organisms.The trophic transfer of HOPs can affect their toxic effects on both humans and ecosystems.Previous studies mostly focused on HOPs biomagnification within specific regional or ecosystem contexts,however,the variation in trophicmagnification factors(TMFs)among different HOPs across a spectrum of diverse aquatic systems globally remains unclear.By collating literatures encompassing TMFs of polychlorinated biphenyls(PCBs),polybrominated diphenyl ethers(PBDEs),or perfluoroalkyl acids(PFAAs)along invertebrate–fish food webs on a global scale,our analysis revealed that Asia,North America,and Europe exhibited the highest pollution levels of HOPs.PCBs were found to have the highest trophicmagnification capability(TMF=3.14),followed by PBDEs(TMF=2.48)and PFAAs(TMF=1.97).TMF values and the probability of TMF exceeding 1 for PCB,PBDE and PFAA congeners showed a parabolic relationship with halogenation degree and carbon chain length.Specifically,PCBswith 6 chlorines,PBDEs with 5 bromines,and PFAAs with 12 carbons exhibited maximum trophic transfer capability and potential along food webs.Fractionation of PCBs and PFAAs was observed,with the proportions of higher chlorination degree and longer chain PFAAs increasing while the others decreased with trophic levels.Surprisingly,we also found a positive relationship between site latitude and TMF values of HOP congeners.This study provides a valuable basis for gauging ecological and health risks of HOPs,facilitating the development of robust standards for aquatic environment management.
文摘Rice cultivation,vital to global food security and the United Nations Sustainable Development Goals(SDGs),faces increasing threats from industrial pollution,which contaminates soil and water,endangers human health,and weakens agricultural resilience.Studies indicate that contaminants such as persistent organic pollutants,radioactive elements,dyes,and potentially toxic elements,particularly from mining and industrial activities,significantly degrade soil fertility,impair plant health,and introduce harmful residues into the food chain.This contamination compromises food safety and diminishes agricultural productivity,posing a serious challenge to sustainability.Addressing these impacts requires sustainable industrial practices,advanced technologies,and eco-friendly remediation techniques.Solutions like biochar applications,precision farming,and artificial intelligence(AI)-driven pollution detection provide effective measures for restoring soil health,protecting crop integrity,and ensuring the resilience of rice farming.These approaches align rice cultivation with global sustainability goals by integrating sustainable soil and water management,adaptive crop selection,and AI innovations.Protecting rice cultivation upholds farmer livelihoods and strengthens global commitments to SDGs Zero Hunger and a resilient,safe food supply,underscoring the essential balance between industrial progress and sustainable rice cultivation.
文摘Background:Current guidelines for the treatment of patients with necrotizing acute pancreatitis(NAP)recommend that invasive intervention for pancreatic necrosis should be deferred to 4 or more weeks from disease onset to allow necrotic collections becoming“walled-off”.However,for patients showing signs of clinical deterioration,especially those with persistent organ failure(POF),it is controversial whether this delayed approach should always be adopted.In this study,we aimed to assess the impact of differently timed intervention on clinical outcomes in a group of NAP patients complicated by POF.Methods:All NAP patients admitted to our hospital from January 2013 to December 2017 were screened for potential inclusion.They were divided into two groups based on the timing of initial interven-tion(within 4 weeks and beyond 4 weeks).All the data were extracted from a prospectively collected database.Results:Overall,131 patients were included for analysis.Among them,100(76.3%)patients were in-tervened within 4 weeks and 31(23.7%)underwent delayed interventions.As for organ failure prior to intervention,the incidences of respiratory failure,renal failure and cardiovascular failure were not signifi-cantly different between the two groups(P>0.05).The mortality was not significantly different between the two groups(35.0%vs.32.3%,P=0.83).The incidences of new-onset multiple organ failure(8.0%vs.6.5%,P=1.00),gastrointestinal fistula(29.0%vs.12.9%,P=0.10)and bleeding(35.0%vs.35.5%,P=1.00),and length of ICU(30.0 vs.22.0 days,P=0.61)and hospital stay(42.5 vs.40.0 days,P=0.96)were com-parable between the two groups.Conclusion:Intervention within 4 weeks did not worsen the clinical outcomes in NAP patients compli-cated by POF.
基金Supported by Shanxi Province“136”Revitalization Medical Project Construction Funds,No.2019XY004.
文摘BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various diseases.We categorize acute pancreatitis by etiology into acute biliary pancreatitis(ABP)and hypertriglyceridemia-induced acute pancreatitis(HTGP).AIM To investigate the clinical significance of NLR and PLR in assessing persistent organ failure(POF)in HTGP and ABP.METHODS A total of 1450 patients diagnosed with acute pancreatitis(AP)for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were enrolled.The patients were categorized into two groups according to the etiology of AP:ABP in 530 patients and HTGP in 241 patients.We collected and compared the clinical data of the patients,including NLR,PLR,and AP prognostic scoring systems,within 48 h of hospital admission.RESULTS The NLR(9.1 vs 6.9,P<0.001)and PLR(203.1 vs 160.5,P<0.001)were significantly higher in the ABP group than in the HTGP group.In the HTGP group,both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score≥3.Likewise,in the ABP group,NLR and PLR were significantly elevated in patients with severe AP,modified computed tomography severity index score≥4,Japanese Severity Score≥3,and modified Marshall score≥2.Moreover,NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP groups.CONCLUSION NLR and PLR vary between ABP and HTGP,are strongly associated with AP prognostic scoring systems,and have predictive potential for the occurrence of POF in both ABP and HTGP.
文摘Dibromoethane is a widespread,persistent organic pollutant.Biochars are known mediators of reductive dehalogenation by layered Fe^(Ⅱ)-Fe^(Ⅲ)hydroxides(green rust),which can reduce 1,2-dibromoethane to innocuous bromide and ethylene.However,the critical characteristics that determine mediator functionality are lesser known.Fifteen biochar substrates were pyrolyzed at 600℃and 800℃,characterized by elemental analysis,X-ray photo spectrometry C and N surface speciation,X-ray powder diffraction,specific surface area analysis,and tested for mediation of reductive debromination of 1,2-dibromoethane by a green rust reductant under anoxic conditions.A statistical analysis was performed to determine the biochar properties,critical for debromination kinetics and total debromination extent.It was shown that selected plant based biochars can mediate debromination of 1,2-dibromoethane,that the highest first order rate constant was 0.082/hr,and the highest debromination extent was 27%in reactivity experiments with 0.1μmol(20μmol/L)1,2-dibromoethane,≈22 mmol/L Fe^(Ⅱ)GR,and 0.12 g/L soybean meal biochar(7 days).Contents of Ni,Zn,N,and P,and the relative contribution of quinone surface functional groups were significantly(p<0.05)positively correlated with 1,2-dibromoethane debromination,while adsorption,specific surface area,and the relative contribution of pyridinic N oxide surface groups were significantly negatively correlated with debromination.
