In this paper, we are interested by the dissolution of NAPL (Non-Aqueous Phase Liquid) contaminants in heterogeneous soils or aquifers. The volume averaging technique is applied to 2D systems with Darcy-scale heteroge...In this paper, we are interested by the dissolution of NAPL (Non-Aqueous Phase Liquid) contaminants in heterogeneous soils or aquifers. The volume averaging technique is applied to 2D systems with Darcy-scale heterogeneities. A large-scale model is derived from a Darcy-scale dissolution model in the case of small and large Damkholer numbers, i.e., for smooth or sharp dissolution fronts. The resulting models in both cases have the mathematical structure of a non-equilibrium dissolution model. It is shown how to calculate the resulting mass exchange and relative permeability terms from the Darcy-scale heterogeneities and other fluid properties. One of the important finding is that the obtained values have a very different behavior compared to the Darcy-scale usual correlations. The large scale correlations are also very different between the two limit cases. The resulting large-scale models are compared favorably to Darcy-scale direct simulations.展开更多
AIM: To investigate the permeability characteristics of rebamipide across intestinal mucosa, and examine the effects of some absorption enhancers on the permeability across the colonic tissue. Another purpose is to de...AIM: To investigate the permeability characteristics of rebamipide across intestinal mucosa, and examine the effects of some absorption enhancers on the permeability across the colonic tissue. Another purpose is to demonstrate the colon-specific delivery of rebamipide with or without absorption enhancers using chitosan capsule as a carrier. METHODS: The permeability of rebamipide was evaluated using an in vitro diffusion chamber system, and the effects of some absorption enhancers on the permeability via colon were further investigated. The release of rebamipide from chitosan or gelatin capsule was studied by Japan Pharmacopoeia rotating basket method. The colonic and plasma concentrations were analyzed by high performance liquid chromatography (HPLC) to evaluate colon-targeting action after oral administration of various dosage forms, and rebamipide with absorption enhancers in chitosan dosage forms. RESULTS: The permeability of rebamipide across the jejunal or ileal membranes was higher than the colonic membranes. Both sodium laurate (C12) and labrasol signifi cantly increased permeability across the colon membranes. On the other hand, the release of rebamipide from chitosan capsule was less than 10%totally within 6 h. The area under concentration-time profile of drug in the colon mucosa using chitosan capsules (AUCLI, 1 6011.2 ng·h/g) was 2.5 times and 4.4 times greater than using gelatin capsules and CMC suspension, respectively. Meanwhile, the area under concentration-time profile of drug in the plasma (AUCPL) was 1016.0 ng·h/mL for chitosan capsule, 1887.9 ng·h/mL for CMC suspension p and 2163.5 ng·h/mL for gelatin capsule. Overall, both AUCLI and AUCPL were increased when C12 was co-administrated, but the increase of AUCLI was much greater; the drug delivery index (DDI) was more than 1 compared with simple chitosan capsule group. CONCLUSION: There was a regional difference in the permeability of Rabamipide across the jejunum, ileum and the colon, and passive diffusion seems to be one of the major transport mechanisms of rebamipide. Absorption enhancers can increase the permeability of rebamipide across the colon tissue signifi cantly. In addition, chitosan capsule may be a useful carrier to deliver rebamipide to the colon specifi cally and the co-administration of C12 with rebamipide may also be very useful in local treatment.展开更多
The flow of a micropolar fluid through a porous channel with expanding or contracting walls of different permeabilities is investigated. Two cases are considered, in which opposing walls undergo either uniform or non-...The flow of a micropolar fluid through a porous channel with expanding or contracting walls of different permeabilities is investigated. Two cases are considered, in which opposing walls undergo either uniform or non-uniform motion. In the first case, the homotopy analysis method （HAM） is used＇to obtain the expressions for the velocity and micro-rotation fields. Graphs are sketched for some parameters. The results show that the expansion ratio and the different permeabilities have important effects on the dynamic characteristics of the fluid. Following Xu＇s model, in the second case which is more general, the wall expansion ratio varies with time. Under this assumption, the governing equations axe transformed into nonlinear partial differential equations that can also be solved analytically by the HAM. In the process, both algebraic and exponential models are considered to describe the evolution of α（t） from the initial state α0 to the final state al. As a result, the time-dependent solutions are found to approach the steady state very rapidly. The results show that the time-dependent variation of the wall expansion ratio can be ignored because of its limited effects.展开更多
the vascular and cellular membranous permeabilities in the experimentally infected suckling BALB/c mice with Chen strain hemorrhagic fever with renal syndrome virus (HFRSV) were studied by employing horseradish peroxi...the vascular and cellular membranous permeabilities in the experimentally infected suckling BALB/c mice with Chen strain hemorrhagic fever with renal syndrome virus (HFRSV) were studied by employing horseradish peroxidase (HRP), colloidal lanthanum and colloidal gold labelled antibodies as tracers and applying the tracers to the mice in vivo via tail veins, and the tissues were observed under light mcroscope and electron microscope. The vascular and cellular membranous permeabilities in the infected increased as the tracers appeared in the perivascular and interstitial tissues as well as in the cytoplasms of some parenchymal cells of the organs ,while the permeabilities remained normal in the control. The rasults suggest that in the infected mice, it might be the virus infection that was mainly responsible for the abnormal permeabilities.展开更多
BACKGROUND Duodenal mucosal ablation(DMA)using irreversible electroporation(IRE)with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid deposition in non-alcoholic fatty liver d...BACKGROUND Duodenal mucosal ablation(DMA)using irreversible electroporation(IRE)with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid deposition in non-alcoholic fatty liver disease(NAFLD).However,the specific metabolic contributions of DMA using IRE in NAFLD remain unclear.AIM To assess the feasibility and effectiveness of DMA using IRE in NAFLD rat models.METHODS Seven-week-old male Sprague-Dawley rats underwent DMA using IRE after 8 weeks on a high-fat diet.Two weeks post-treatment,duodenal and liver tissues and blood samples were collected.We evaluated differences in the duodenal wall structure,liver lipid deposition,enteroendocrine,claudin,and zonula ocludens-1 in the duodenal mucosa.RESULTS DMA using IRE could be safely performed in rats with NAFLD without duodenal bleeding,perforation,or stenosis.The duodenum healed well 2 weeks after DMA and was characterized by slimmer villi,narrower and shallower crypts,and thicker myenterons compared with the sham-control setting.Liver lipid deposition was reduced and serum lipid index parameters were considerably improved in the DMA setting.However,these improvements were independent of food intake and weight loss.In addition,enteroendocrine parameters,such as claudin,and zonula ocludens-1 levels in the duodenal mucosa,differed between the different settings in the DMA group.CONCLUSION By altering enteroendocrine and duodenal permeability,simple DMA using IRE ameliorated liver lipid deposition and improved serum lipid parameters in NAFLD rats.展开更多
The physical properties of hydrocarbon reservoirs are important factors affecting the percolation ability of the reservoirs.Tight-sand reservoirs exhibit complex pore throat connectivity due to the extensive developme...The physical properties of hydrocarbon reservoirs are important factors affecting the percolation ability of the reservoirs.Tight-sand reservoirs exhibit complex pore throat connectivity due to the extensive development of micro-and nano-scale pore and throat systems.Characterizing the microscopic properties of these reservoirs using nondestructive,quantitative methods serves as an important means to determine the characteristics of microscopic pores and throats in tight-sand reservoirs and the mechanism behind the influence of these characteristics on reservoir porosity and permeability.In this study,a low-permeability sandstone sample and two tight sandstone samples collected from the Ordos Basin were nondestructively tested using high-resolution nano-CT technology to quantitively characterize their microscopic pore throat structures and model them three-dimensionally(in 3D)based on CT threshold differences and gray models.A thorough analysis and comparison reveal that the three samples exhibit a certain positive correlation between their porosity and permeability but the most important factor affecting both porosity and permeability is the microscopic pore throat structure.Although the number of pores in tight sandstones shows a minor impact on their porosity,large pores(more than 20μm)contribute predominantly to porosity,suggesting that the permeability of tight sandstones is controlled primarily by large pore throats.For these samples,higher permeability corresponds to larger average throat sizes.Therefore,throats with average radii greater than 2μm can significantly improve the permeability of tight sandstones.展开更多
Irregular bone scaffolds fabricated using the Voronoi tessellation method resemble the morphology and properties of human cancellous bones.This has become a prominent topic in bone tissue engineering research in recen...Irregular bone scaffolds fabricated using the Voronoi tessellation method resemble the morphology and properties of human cancellous bones.This has become a prominent topic in bone tissue engineering research in recent years.However,studies on the radial-gradient design of irregular bionic scaffolds are limited.Therefore,this study aims to develop a radial-gradient structure similar to that of natural long bones,enhancing the development of bionic bone scaffolds.A novel gradient method was adopted to maintain constant porosity,control the seed site-specific distribution within the irregular porous structure,and vary the strut diameter to generate radial gradients.The irregular scaffolds were compared with four conventional scaffolds(cube,pillar BCC,vintiles,and diamond)in terms of permeability,stress concentration characteristics,and mechanical properties.The results indicate that the radial-gradient irregular porous structure boasts the widest permeability range and superior stress distribution compared to conventional scaffolds.With an elastic modulus ranging from 4.20 GPa to 22.96 GPa and a yield strength between 68.37 MPa and 149.40 MPa,it meets bone implant performance requirements and demonstrates significant application potential.展开更多
CO_(2)flooding enhanced oil recovery(CO_(2)-EOR)represents a significant technology in the low permeability reservoir.With the fractures and heterogeneity in low permeability reservoirs,CO_(2)-EOR is susceptible to pe...CO_(2)flooding enhanced oil recovery(CO_(2)-EOR)represents a significant technology in the low permeability reservoir.With the fractures and heterogeneity in low permeability reservoirs,CO_(2)-EOR is susceptible to pessimistic gas channeling.Consequently,there is a need to develop conformance control materials that can be used in CO_(2)-EOR.Herein,to address the challenges of low strength and poor stability of polymer gel in high temperature and low permeability reservoirs,a new organic/metal ion composite crosslinking polymer gel(AR-Gel)is reported,which is formed by low hydrolysis and medium to high molecular weight polymer(CX-305),organic crosslinking agent(phenolic resin),and aluminium citrate(AI(Ⅲ)).The crosslinking of AI(Ⅲ)with carboxyl group and organic/metal ion double crosslinking can construct a more complex and stable polymer gel structure on the basis of traditional chemical crosslinking,to cope with the harsh conditions such as high temperature.The structure-activity relationship of AR-Gel was revealed by rheology behavior and micro-morphology.The applicability of AR-Gel in reservoir was investigated,as was its strength and stability in supercritical CO_(2).The anti-gas channeling and enhanced oil recovery of AR-Gel were investigated using low permeability fractured cores,and the field process parameters were provided.The gel can be used to meet supercritical CO_(2)reservoirs at 110℃and 20,000 mg/L salinity,with long-term stability over 60 days.The plugging rate of AR-Gel for fractured co re was 97%,with subsequent CO_(2)flooding re sulting in an enhanced oil recovery by 34.5%.ARGel can effectively control CO_(2)gas channeling and enhanced oil recovery.It offers a new material with high strength and temperature resistance,which is particularly beneficial in the CO_(2)flooding for the conformance control of oil field.展开更多
Permeable roads generally exhibit inferior mechanical properties and shorter service life than traditional dense-graded/impermeable roads.Furthermore,the incorporation of recycled aggregates in their construction may ...Permeable roads generally exhibit inferior mechanical properties and shorter service life than traditional dense-graded/impermeable roads.Furthermore,the incorporation of recycled aggregates in their construction may exacerbate these limitations.To address these issues,this study introduced a novel cement-stabilized permeable recycled aggregate material.A total of 162 beam specimens prepared with nine different levels of cement-aggregate ratio were tested to evaluate their permeability,bending load,and bending fatigue life.The experimental results indicate that increasing the content of recycled aggregates led to a reduction in both permeability and bending load.Additionally,the inclusion of recycled aggregates diminished the energy dissipation capacity of the specimens.These findings were used to establish a robust relationship between the initial damage in cement-stabilized permeable recycled aggregate material specimens and their fatigue life,and to propose a predictive model for their fatigue performance.Further,a method for assessing fatigue damage based on the evolution of fatigue-induced strain and energy dissipation was developed.The findings of this study provide valuable insights into the mechanical behavior and fatigue performance of cement-stabilized permeable recycled aggregate materials,offering guidance for the design of low-carbon-emission,permeable,and durable roadways incorporating recycled aggregates.展开更多
As the bed depth increases,sintering yield increases,but the productivity decreases.To reveal the reasons for the decrease in productivity and explore targeted solutions,the bed resistance of mixtures,wet zone,and com...As the bed depth increases,sintering yield increases,but the productivity decreases.To reveal the reasons for the decrease in productivity and explore targeted solutions,the bed resistance of mixtures,wet zone,and combustion zone was analyzed in the laboratory.The results showed that the decreased porosity of mixture resulted in the increased bed resistance by 160.56%when the bed depth increased from 600 to 1000 mm.After improving porosity of 1%by adding loosening bars with optimized size and distribution,the bed resistance decreased,and the productivity increased by 5%.The increase in bed depth increased the thickness of the wet zone from 120 to 680 mm and the resistance from 1.56 to 8.83 kPa.By using a three-stage intensive mixer and pre-adding water for granulation,the moisture of mixture was reduced by 0.6%,and the sintering productivity increased by 4%.Besides,the high bed resistance is mainly caused by the increase in the thickness of the combustion zone from 31.9 to 132.7 mm,and the bed resistance increased from 0.70 to 5.62 kPa.The bed resistance of the combustion zone at 900 mm was increased by 90.51%compared to 700 mm.After optimization of the distribution of coke breeze,the thickness of combustion zone at the lower layer decreased from 132.7 to 106.84 mm and permeability improved significantly.展开更多
Precast driven piles are extensively used for infrastructure on soft soils,but the buildup of excess pore water pressure associated with pile driving is a challenging issue.The process of soil consolidation could take...Precast driven piles are extensively used for infrastructure on soft soils,but the buildup of excess pore water pressure associated with pile driving is a challenging issue.The process of soil consolidation could take several months.Measures are sought to shorten the drainage path in the ground,and permeable pipe pile is a concept that involves drainage channels at the peak pore pressure locations around the pile circumference.Centrifuge tests were conducted to understand the responses of permeable pipe pile treated ground,experiencing the whole pile driving,soil consolidating,and axially loading process.Results show that the dissipation rate of pore pressures can be improved,especially at a greater depth or at a shorter distance from the pile,since the local hydraulic gradient was higher.Less significant buildup of pore pressures can be anticipated with the use of permeable pipe pile.For this,the bearing capacity of composite foundation with permeable pipe pile can be increased by over 36.9%,compared to the case with normal pipe pile at a specific time period.All these demonstrate the ability of permeable pipe pile in accelerating the consolidation process,mobilizing the bearing capacity of treated ground at an early stage,and minimizing the set-up effect.展开更多
2'-Fucosyllactose(2'-FL)shows the potential to support intestinal health as a natural prebiotic that bridges the gap between infant formula feeding and breastfeeding.However,the effect and mechanism of 2'-...2'-Fucosyllactose(2'-FL)shows the potential to support intestinal health as a natural prebiotic that bridges the gap between infant formula feeding and breastfeeding.However,the effect and mechanism of 2'-FL in improving intestinal permeability are not clear.In this study,we constructed human microbiota-associated(HMA)mouse models by colonizing healthy infant feces in mice with antibiotic-depleted intestinal microbiota.The protective effect of 2'-FL on the intestinal permeability was explored using the HMA mouse models,and the combination of metagenomics was used to analyze the possible mechanisms by which the microorganisms reduced the intestinal permeability.The results showed that 2'-FL decreased the concentration of markers of intestinal permeability(enterotoxin and diamine oxidase(DAO))and increased the expression levels of tight junctions(occludin and claudin).Metagenomics revealed the enrichment of Bifidobacterium and increased the expression of glycoside hydrolases(GHs),including GH31,GH28,and GH5.In conclusion,2'-FL strengthened intestinal permeability function by improving microbiota composition to control the translocation of harmful substance.展开更多
As the first gold mine discovered at the sea in China and the only coastal gold mine currently mined there,Sanshandao Gold Mine faces unique challenges.The mine's safety is under continual threat from its faulted ...As the first gold mine discovered at the sea in China and the only coastal gold mine currently mined there,Sanshandao Gold Mine faces unique challenges.The mine's safety is under continual threat from its faulted structure coupled with the overlying water.As the mining proceeds deeper,the risk of water inrush increases.The mine's maximum water yield reaches 15000 m3/day,which is attributable to water channels present in fault zones.Predominantly composed of soil–rock mixtures(SRM),these fault zones'seepage characteristics significantly impact water inrush risk.Consequently,investigating the seepage characteristics of SRM is of paramount importance.However,the existing literature mostly concentrates on a single stress state.Therefore,this study examined the characteristics of the permeability coefficient under three distinct stress states:osmotic,osmotic–uniaxial,and osmotic–triaxial pressure.The SRM samples utilized in this study were extracted from in situ fault zones and then reshaped in the laboratory.In addition,the micromechanical properties of the SRM samples were analyzed using computed tomography scanning.The findings reveal that the permeability coefficient is the highest under osmotic pressure and lowest under osmotic–triaxial pressure.The sensitivity coefficient shows a higher value when the rock block percentage ranges between 30%and 40%,but it falls below 1.0 when this percentage exceeds 50%under no confining pressure.Notably,rock block percentages of 40%and 60%represent the two peak points of the sensitivity coefficient under osmotic–triaxial pressure.However,SRM samples with a 40%rock block percentage consistently show the lowest permeability coefficient under all stress states.This study establishes that a power function can model the relationship between the permeability coefficient and osmotic pressure,while its relationship with axial pressure can be described using an exponential function.These insights are invaluable for developing water inrush prevention and control strategies in mining environments.展开更多
The strength of the sliding zone soil determines the stability of reservoir landslides.Fluctuations in water levels cause a change in the seepage field,which serves as both the external hydrogeological environment and...The strength of the sliding zone soil determines the stability of reservoir landslides.Fluctuations in water levels cause a change in the seepage field,which serves as both the external hydrogeological environment and the internal component of a landslide.Therefore,considering the strength changes of the sliding zone with seepage effects,they correspond with the actual hydrogeological circumstances.To investigate the shear behavior of sliding zone soil under various seepage pressures,24 samples were conducted by a self-developed apparatus to observe the shear strength and measure the permeability coefficients at different deformation stages.After seepage-shear tests,the composition of clay minerals and microscopic structure on the shear surface were analyzed through X-ray and scanning electron microscope(SEM)to understand the coupling effects of seepage on strength.The results revealed that the sliding zone soil exhibited strain-hardening without seepage pressure.However,the introduction of seepage caused a significant reduction in shear strength,resulting in strain-softening characterized by a three-stage process.Long-term seepage action softened clay particles and transported broken particles into effective seepage channels,causing continuous damage to the interior structure and reducing the permeability coefficient.Increased seepage pressure decreased the peak strength by disrupting occlusal and frictional forces between sliding zone soil particles,which carried away more clay particles,contributing to an overhead structure in the soil that raised the permeability coefficient and decreased residual strength.The internal friction angle was less sensitive to variations in seepage pressure than cohesion.展开更多
Understanding the storage mechanisms in CO_(2)flooding is crucial,as many carbon capture,utilization,and storage(CCUS)projects are related to enhanced oil recovery(EOR).CO_(2)storage in reservoirs across large timesca...Understanding the storage mechanisms in CO_(2)flooding is crucial,as many carbon capture,utilization,and storage(CCUS)projects are related to enhanced oil recovery(EOR).CO_(2)storage in reservoirs across large timescales undergoes the two storage stages of oil displacement and well shut-in,which cover mul-tiple replacement processes of injection-production synchronization,injection only with no production,and injection-production stoppage.Because the controlling mechanism of CO_(2)storage in different stages is unknown,the evolution of CO_(2)storage mechanisms over large timescales is not understood.A math-ematical model for the evaluation of CO_(2)storage,including stratigraphic,residual,solubility,and mineral trapping in low-permeability tight sandstone reservoirs,was established using experimental and theoret-ical analyses.Based on a detailed geological model of the Huaziping Oilfield,calibrated with reservoir permeability and fracture characteristic parameters obtained from well test results,a dynamic simulation of CO_(2)storage for the entire reservoir life cycle under two scenarios of continuous injection and water-gas alternation were considered.The results show that CO_(2)storage exhibits the significant stage charac-teristics of complete storage,dynamic storage,and stable storage.The CO_(2)storage capacity and storage rate under the continuous gas injection scenario(scenario 1)were 6.34×10^(4)t and 61%,while those under the water-gas alternation scenario(scenario 2)were 4.62×10^(4)t and 46%.The proportions of stor-age capacity under scenarios 1 and 2 for structural or stratigraphic,residual,solubility,and mineral trap-ping were 33.36%,33.96%,32.43%,and 0.25%;and 15.09%,38.65%,45.77%,and 0.49%,respectively.The evolution of the CO_(2)storage mechanism showed an overall trend:stratigraphic and residual trapping first increased and then decreased,whereas solubility trapping gradually decreased,and mineral trapping continuously increased.Based on these results,an evolution diagram of the CO_(2)storage mechanism of low-permeability tight sandstone reservoirs across large timescales was established.展开更多
Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsu...Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsulation,slow release and skin impermeability,and provided an excellent nanolipid slow-release encapsulation system for sunscreens.As observed by transmission electron microscopy,the nanolipid carriers were spherical shape,with smooth surface and uniform distribution,and the particle sizes were mainly concentrated in the range of 230 to 250 nm without agglomeration.The nanolipid carriers significantly improved the sunscreen performance through the synergistic effect of scattering and chemical absorption,and showed better UV stability than traditional sunscreen,indicating their photoprotective function.In vitro release experiments showed that the nano-lipidic carriers exhibited better release control when loaded with octyl methoxycinnamate(OMC)and butylmethoxydibenzoylmethane(BDFM)sunscreens than traditional traditional emulsions,with the cumulative release rate of OMC in the nano-lipidic carriers decreasing by 17.17% to 30.24% within 12 hours,and that of BDFM decreasing by 26.67% to 44.67%.26.67% to 44.16%.The results of the in vitro permeation experiment further confirmed that the nanolipid carriers could effectively encapsulate the sunscreens and prevent them from penetrating the skin barrier,thus reducing the skin irritation.Compared with traditional traditional emulsion,the cumulative penetration of OMC in nanostructured lipid carriers was 2.24μg/cm^(2)in 4 hours,while the cumulative penetration was reduced by 68.05%.The cumulative penetration of BDFM in the nanostructured lipid carrier was 3.24μg/cm^(2),with a 64.04%reduction in cumulative penetration.展开更多
Non-Darcian flow in rock fractures exhibits significant anisotropic characteristics,which can be affected by mechanical processes,such as cyclic shearing.Understanding the evolution of anisotropic nonDarcian flow is c...Non-Darcian flow in rock fractures exhibits significant anisotropic characteristics,which can be affected by mechanical processes,such as cyclic shearing.Understanding the evolution of anisotropic nonDarcian flow is crucial for characterizing groundwater flow and mass/heat transport in fractured rock masses.In this study,we conducted experiments on non-Darcian flow in single rough fractures under cyclic shearing conditions,aiming to analyze the anisotropic evolution of inertial permeability and viscous permeability.We established quantitative characterization models for the two types of permeability.First,we conducted cyclic shearing experiments on four sets of 24 rough rock fractures,investigating their shear characteristics.Then,we performed 480 non-Darcian flow experiments to analyze the anisotropic evolution of viscous permeability and inertial permeability of these rock fractures.The results showed that viscous permeability exhibited significant differences only in the orthogonal direction,while inertial permeability exhibited differences in both orthogonal and opposite directions.With increase in the shear cycles,the differences in the orthogonal direction gradually increased,while those in opposite direction gradually decreased.Finally,we established characterization equations for the two permeabilities based on the proposed directional geometric parameters and validated the performance of these equations with experimental data.These findings are useful for the quantitative characterization of the evolution of non-Darcian flow in fractures under dynamic loading conditions.展开更多
Current protective clothing often lacks sufficient comfort to ensure efficient performance of healthcare workers.Developing protective textiles with high air and moisture permeability is a potential and effective solu...Current protective clothing often lacks sufficient comfort to ensure efficient performance of healthcare workers.Developing protective textiles with high air and moisture permeability is a potential and effective solution to discomfort of medical protective clothing.However,realizing the facile production of a protective textile that combines safety and comfort remains a challenge.Herein,we report the fabrication of highly permeable protective textiles(HPPT)with micro/nano-networks,using non-solvent induced phase separation synergistically driven by CaCl_(2) and fluorinated polyurethane,combined with spraying technique.The HPPT demonstrates excellent liquid repellency and comfort,ensuring high safety and a dry microenvironment for the wearer.The textile exhibits not only a high hydrostatic pressure(12.86 kPa)due to its tailored small mean pore size(1.03μm)and chemical composition,but also demonstrates excellent air permeability(14.24 mm s^(−1))and moisture permeability(7.92 kg m^(−2)d^(−1))owing to the rational combination of small pore size and high porosity(69%).The HPPT offers superior comfort compared to the commercially available protective materials.Additionally,we elucidated a molding mechanism synergistically inducted by diffusion-dissolution-phase separation.This research provides an innovative perspective on enhancing the comfort of medical protective clothing and offers theoretical support for regulating of pore structure during phase separations.展开更多
The effect of depositional facies and diagenesis on the reservoir potential of the Sakesar limestone has been assessed through core plug porosity and permeability data,scanning electron microscope(SEM),and petrographi...The effect of depositional facies and diagenesis on the reservoir potential of the Sakesar limestone has been assessed through core plug porosity and permeability data,scanning electron microscope(SEM),and petrographic study in three stratigraphic sections(Karuli,Badshah Pur,and Sardhai)of Central Salt Range.Field observations reveal three lithofacies:thin-bedded limestone with shale intercalation,thick-bedded nodular limestone,and highly fractured limestone.Based on a petrographic study,six microfacies have been identified:bioclastic mudstone facies(SKF-1),Lockhartia-nummulitic wackestone facies(SKF-2),Assilina-Alveolina packstone facies(SKF-3),Lockhartia-nummulitic packstone facies(SKF-4),Alveolina grainstone facies(SKF-5),and nummulitic grainstone facies(SKF-6).The Sakesar limestone shows various diagenetic changes such as compaction,dissolution,dolomitization,cementation,and fracturing,resulting in different types of pores.Two reservoir zones are identified in the Sakesar limestone:a mud-dominated reservoir in an outer ramp setting with interparticle and micropores and a bioclastic grain-dominated facies in an inner ramp setting with intraskeletal and fracture porosity.The porosity and permeability of grain-dominated facies(8%-30%and 0.8-8 mD)are higher than mud-dominated facies(4%-15%and 0.5-4 mD)due to intraskeletal/intraparticle pores and dolomitization.展开更多
Background:The efficient transdermal delivery of biologically active molecules remains a major challenge because of the structural barrier of the stratum corneum,which limits the penetration of large or hydrophilic mo...Background:The efficient transdermal delivery of biologically active molecules remains a major challenge because of the structural barrier of the stratum corneum,which limits the penetration of large or hydrophilic molecules.Low-molecular-weight protamine(LMWP)has a structure similar to that of the HIV TAT protein-derived peptide and is a representative cell-penetrating peptide(CPP)used to increase cell permeability.However,protamine has been reported to have many toxicities and side effects.Objectives:We developed human-derived low-molecular-weight protamine(hLMWP),which is based on fish-derived LMWP but designed using human protein sequences to improve safety and functionality.As it is derived from human proteins,it may reduce side effects and immune rejection during long-term or repeated administration.Additionally,we confirmed in our preliminary study that hLMWP enhances permeability compared to LMWP.In this study,we evaluated physiological activities and skin cell penetration of hLMWP conjugates to assess the potential applications of hLMWP.Methods:cDNA sequences for hLMWP-EGF(His)and hLMWP-SOD-1(His)were synthesized by connecting hLMWP(RSRRRRRRSCQTRRR)to the N-terminus of Epidermal growth factor(EGF)and Superoxide dismutase 1(SOD-1),respectively,with a 6 His-tag added to the C-terminus.The constructs were cloned into a expression vector and expressed in E.coli BL21-CodonPlus pET-41b(+)(DE3)-RIL cells.Expressed proteins were purified using a nickel column and eluted with imidazole buffer.Protein purity was confirmed by SDS-PAGE,and concentrations were quantified using a BCA assay.To evaluate the functional properties of these hLMWP-protein conjugates,a series of in vitro assays were conducted using keratinocyte and macrophage cell lines.These included assessments of permeability,proliferation,wound healing,and anti-inflammatory activity.Results:The results demonstrated that hLMWP-EGF and hLMWP-SOD-1 exhibited superior biological activities,including increased cell proliferation,wound healing,and anti-inflammatory effects,compared to EGF and SOD-1.Moreover,hLMWP-EGF and hLMWP-SOD-1 significantly enhanced the skin permeability of both EGF and SOD-1,as shown by Franz diffusion cell assay and immunofluorescence analysis.Conclusion:Our findings demonstrate that hLMWP significantly enhances skin permeability and biological activity of functional proteins such as EGF and SOD-1 while maintaining safety.This suggests its potential for application in transdermal drug delivery,regenerative medicine,and cosmeceutical formulations.展开更多
文摘In this paper, we are interested by the dissolution of NAPL (Non-Aqueous Phase Liquid) contaminants in heterogeneous soils or aquifers. The volume averaging technique is applied to 2D systems with Darcy-scale heterogeneities. A large-scale model is derived from a Darcy-scale dissolution model in the case of small and large Damkholer numbers, i.e., for smooth or sharp dissolution fronts. The resulting models in both cases have the mathematical structure of a non-equilibrium dissolution model. It is shown how to calculate the resulting mass exchange and relative permeability terms from the Darcy-scale heterogeneities and other fluid properties. One of the important finding is that the obtained values have a very different behavior compared to the Darcy-scale usual correlations. The large scale correlations are also very different between the two limit cases. The resulting large-scale models are compared favorably to Darcy-scale direct simulations.
基金Research Funding of Medical Association of Japanese-Chinese, Japan
文摘AIM: To investigate the permeability characteristics of rebamipide across intestinal mucosa, and examine the effects of some absorption enhancers on the permeability across the colonic tissue. Another purpose is to demonstrate the colon-specific delivery of rebamipide with or without absorption enhancers using chitosan capsule as a carrier. METHODS: The permeability of rebamipide was evaluated using an in vitro diffusion chamber system, and the effects of some absorption enhancers on the permeability via colon were further investigated. The release of rebamipide from chitosan or gelatin capsule was studied by Japan Pharmacopoeia rotating basket method. The colonic and plasma concentrations were analyzed by high performance liquid chromatography (HPLC) to evaluate colon-targeting action after oral administration of various dosage forms, and rebamipide with absorption enhancers in chitosan dosage forms. RESULTS: The permeability of rebamipide across the jejunal or ileal membranes was higher than the colonic membranes. Both sodium laurate (C12) and labrasol signifi cantly increased permeability across the colon membranes. On the other hand, the release of rebamipide from chitosan capsule was less than 10%totally within 6 h. The area under concentration-time profile of drug in the colon mucosa using chitosan capsules (AUCLI, 1 6011.2 ng·h/g) was 2.5 times and 4.4 times greater than using gelatin capsules and CMC suspension, respectively. Meanwhile, the area under concentration-time profile of drug in the plasma (AUCPL) was 1016.0 ng·h/mL for chitosan capsule, 1887.9 ng·h/mL for CMC suspension p and 2163.5 ng·h/mL for gelatin capsule. Overall, both AUCLI and AUCPL were increased when C12 was co-administrated, but the increase of AUCLI was much greater; the drug delivery index (DDI) was more than 1 compared with simple chitosan capsule group. CONCLUSION: There was a regional difference in the permeability of Rabamipide across the jejunum, ileum and the colon, and passive diffusion seems to be one of the major transport mechanisms of rebamipide. Absorption enhancers can increase the permeability of rebamipide across the colon tissue signifi cantly. In addition, chitosan capsule may be a useful carrier to deliver rebamipide to the colon specifi cally and the co-administration of C12 with rebamipide may also be very useful in local treatment.
基金Project supported by the National Natural Science Foundation of China (Nos. 50936003 and50905013)the Open Project of State Key Laboratory for Advanced Materials (No. 2009z-02)
文摘The flow of a micropolar fluid through a porous channel with expanding or contracting walls of different permeabilities is investigated. Two cases are considered, in which opposing walls undergo either uniform or non-uniform motion. In the first case, the homotopy analysis method （HAM） is used＇to obtain the expressions for the velocity and micro-rotation fields. Graphs are sketched for some parameters. The results show that the expansion ratio and the different permeabilities have important effects on the dynamic characteristics of the fluid. Following Xu＇s model, in the second case which is more general, the wall expansion ratio varies with time. Under this assumption, the governing equations axe transformed into nonlinear partial differential equations that can also be solved analytically by the HAM. In the process, both algebraic and exponential models are considered to describe the evolution of α（t） from the initial state α0 to the final state al. As a result, the time-dependent solutions are found to approach the steady state very rapidly. The results show that the time-dependent variation of the wall expansion ratio can be ignored because of its limited effects.
文摘the vascular and cellular membranous permeabilities in the experimentally infected suckling BALB/c mice with Chen strain hemorrhagic fever with renal syndrome virus (HFRSV) were studied by employing horseradish peroxidase (HRP), colloidal lanthanum and colloidal gold labelled antibodies as tracers and applying the tracers to the mice in vivo via tail veins, and the tissues were observed under light mcroscope and electron microscope. The vascular and cellular membranous permeabilities in the infected increased as the tracers appeared in the perivascular and interstitial tissues as well as in the cytoplasms of some parenchymal cells of the organs ,while the permeabilities remained normal in the control. The rasults suggest that in the infected mice, it might be the virus infection that was mainly responsible for the abnormal permeabilities.
基金Supported by the National Key Research and Development Program,No.2023YFF0713700 and No.2023YFF0713705Common Technology R&D Platform of Shaanxi Province,No.2023GXJS-01-1-2the Cyrus Tang Foundation Chung Ying Young Scholars Program.
文摘BACKGROUND Duodenal mucosal ablation(DMA)using irreversible electroporation(IRE)with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid deposition in non-alcoholic fatty liver disease(NAFLD).However,the specific metabolic contributions of DMA using IRE in NAFLD remain unclear.AIM To assess the feasibility and effectiveness of DMA using IRE in NAFLD rat models.METHODS Seven-week-old male Sprague-Dawley rats underwent DMA using IRE after 8 weeks on a high-fat diet.Two weeks post-treatment,duodenal and liver tissues and blood samples were collected.We evaluated differences in the duodenal wall structure,liver lipid deposition,enteroendocrine,claudin,and zonula ocludens-1 in the duodenal mucosa.RESULTS DMA using IRE could be safely performed in rats with NAFLD without duodenal bleeding,perforation,or stenosis.The duodenum healed well 2 weeks after DMA and was characterized by slimmer villi,narrower and shallower crypts,and thicker myenterons compared with the sham-control setting.Liver lipid deposition was reduced and serum lipid index parameters were considerably improved in the DMA setting.However,these improvements were independent of food intake and weight loss.In addition,enteroendocrine parameters,such as claudin,and zonula ocludens-1 levels in the duodenal mucosa,differed between the different settings in the DMA group.CONCLUSION By altering enteroendocrine and duodenal permeability,simple DMA using IRE ameliorated liver lipid deposition and improved serum lipid parameters in NAFLD rats.
文摘The physical properties of hydrocarbon reservoirs are important factors affecting the percolation ability of the reservoirs.Tight-sand reservoirs exhibit complex pore throat connectivity due to the extensive development of micro-and nano-scale pore and throat systems.Characterizing the microscopic properties of these reservoirs using nondestructive,quantitative methods serves as an important means to determine the characteristics of microscopic pores and throats in tight-sand reservoirs and the mechanism behind the influence of these characteristics on reservoir porosity and permeability.In this study,a low-permeability sandstone sample and two tight sandstone samples collected from the Ordos Basin were nondestructively tested using high-resolution nano-CT technology to quantitively characterize their microscopic pore throat structures and model them three-dimensionally(in 3D)based on CT threshold differences and gray models.A thorough analysis and comparison reveal that the three samples exhibit a certain positive correlation between their porosity and permeability but the most important factor affecting both porosity and permeability is the microscopic pore throat structure.Although the number of pores in tight sandstones shows a minor impact on their porosity,large pores(more than 20μm)contribute predominantly to porosity,suggesting that the permeability of tight sandstones is controlled primarily by large pore throats.For these samples,higher permeability corresponds to larger average throat sizes.Therefore,throats with average radii greater than 2μm can significantly improve the permeability of tight sandstones.
基金the National Natural Science Foundation of China(No.52165026)。
文摘Irregular bone scaffolds fabricated using the Voronoi tessellation method resemble the morphology and properties of human cancellous bones.This has become a prominent topic in bone tissue engineering research in recent years.However,studies on the radial-gradient design of irregular bionic scaffolds are limited.Therefore,this study aims to develop a radial-gradient structure similar to that of natural long bones,enhancing the development of bionic bone scaffolds.A novel gradient method was adopted to maintain constant porosity,control the seed site-specific distribution within the irregular porous structure,and vary the strut diameter to generate radial gradients.The irregular scaffolds were compared with four conventional scaffolds(cube,pillar BCC,vintiles,and diamond)in terms of permeability,stress concentration characteristics,and mechanical properties.The results indicate that the radial-gradient irregular porous structure boasts the widest permeability range and superior stress distribution compared to conventional scaffolds.With an elastic modulus ranging from 4.20 GPa to 22.96 GPa and a yield strength between 68.37 MPa and 149.40 MPa,it meets bone implant performance requirements and demonstrates significant application potential.
基金project was supported by the Fund of State Key Laboratory of Deep Oil and Gas,China University of Petroleum(East China)(No.SKLDOG2024-ZYRC-06)Key Program of National Natural Science Foundation of China(52130401)+1 种基金National Natural Science Foundation of China(52104055,52374058)Shandong Provincial Natural Science Foundation,China(ZR2021ME171,ZR2024YQ043)。
文摘CO_(2)flooding enhanced oil recovery(CO_(2)-EOR)represents a significant technology in the low permeability reservoir.With the fractures and heterogeneity in low permeability reservoirs,CO_(2)-EOR is susceptible to pessimistic gas channeling.Consequently,there is a need to develop conformance control materials that can be used in CO_(2)-EOR.Herein,to address the challenges of low strength and poor stability of polymer gel in high temperature and low permeability reservoirs,a new organic/metal ion composite crosslinking polymer gel(AR-Gel)is reported,which is formed by low hydrolysis and medium to high molecular weight polymer(CX-305),organic crosslinking agent(phenolic resin),and aluminium citrate(AI(Ⅲ)).The crosslinking of AI(Ⅲ)with carboxyl group and organic/metal ion double crosslinking can construct a more complex and stable polymer gel structure on the basis of traditional chemical crosslinking,to cope with the harsh conditions such as high temperature.The structure-activity relationship of AR-Gel was revealed by rheology behavior and micro-morphology.The applicability of AR-Gel in reservoir was investigated,as was its strength and stability in supercritical CO_(2).The anti-gas channeling and enhanced oil recovery of AR-Gel were investigated using low permeability fractured cores,and the field process parameters were provided.The gel can be used to meet supercritical CO_(2)reservoirs at 110℃and 20,000 mg/L salinity,with long-term stability over 60 days.The plugging rate of AR-Gel for fractured co re was 97%,with subsequent CO_(2)flooding re sulting in an enhanced oil recovery by 34.5%.ARGel can effectively control CO_(2)gas channeling and enhanced oil recovery.It offers a new material with high strength and temperature resistance,which is particularly beneficial in the CO_(2)flooding for the conformance control of oil field.
基金Project(2024JJ2073)supported by the Science Fund for Distinguished Young Scholars of Hunan Province,ChinaProjects(2023YFC3807205,2019YFC1904704)+4 种基金supported by the National Key R&D Program of ChinaProject(52178443)supported by the National Natural Science Foundation of ChinaProject(2024ZZTS0109)supported by Fundamental Research Funds for the Central Universities of Central South University,China。
文摘Permeable roads generally exhibit inferior mechanical properties and shorter service life than traditional dense-graded/impermeable roads.Furthermore,the incorporation of recycled aggregates in their construction may exacerbate these limitations.To address these issues,this study introduced a novel cement-stabilized permeable recycled aggregate material.A total of 162 beam specimens prepared with nine different levels of cement-aggregate ratio were tested to evaluate their permeability,bending load,and bending fatigue life.The experimental results indicate that increasing the content of recycled aggregates led to a reduction in both permeability and bending load.Additionally,the inclusion of recycled aggregates diminished the energy dissipation capacity of the specimens.These findings were used to establish a robust relationship between the initial damage in cement-stabilized permeable recycled aggregate material specimens and their fatigue life,and to propose a predictive model for their fatigue performance.Further,a method for assessing fatigue damage based on the evolution of fatigue-induced strain and energy dissipation was developed.The findings of this study provide valuable insights into the mechanical behavior and fatigue performance of cement-stabilized permeable recycled aggregate materials,offering guidance for the design of low-carbon-emission,permeable,and durable roadways incorporating recycled aggregates.
基金supported by the Basic Science Center Project for the National Natural Science Foundation of China(No.72088101)the S&T Program of Hebei(No.23564101D).
文摘As the bed depth increases,sintering yield increases,but the productivity decreases.To reveal the reasons for the decrease in productivity and explore targeted solutions,the bed resistance of mixtures,wet zone,and combustion zone was analyzed in the laboratory.The results showed that the decreased porosity of mixture resulted in the increased bed resistance by 160.56%when the bed depth increased from 600 to 1000 mm.After improving porosity of 1%by adding loosening bars with optimized size and distribution,the bed resistance decreased,and the productivity increased by 5%.The increase in bed depth increased the thickness of the wet zone from 120 to 680 mm and the resistance from 1.56 to 8.83 kPa.By using a three-stage intensive mixer and pre-adding water for granulation,the moisture of mixture was reduced by 0.6%,and the sintering productivity increased by 4%.Besides,the high bed resistance is mainly caused by the increase in the thickness of the combustion zone from 31.9 to 132.7 mm,and the bed resistance increased from 0.70 to 5.62 kPa.The bed resistance of the combustion zone at 900 mm was increased by 90.51%compared to 700 mm.After optimization of the distribution of coke breeze,the thickness of combustion zone at the lower layer decreased from 132.7 to 106.84 mm and permeability improved significantly.
基金supported by the National Natural Science Foundation of China(Grant Nos.52168046 and 52178321)the Natural Science Foundation of Guangxi Province,China(Grant No.2021AC18019).
文摘Precast driven piles are extensively used for infrastructure on soft soils,but the buildup of excess pore water pressure associated with pile driving is a challenging issue.The process of soil consolidation could take several months.Measures are sought to shorten the drainage path in the ground,and permeable pipe pile is a concept that involves drainage channels at the peak pore pressure locations around the pile circumference.Centrifuge tests were conducted to understand the responses of permeable pipe pile treated ground,experiencing the whole pile driving,soil consolidating,and axially loading process.Results show that the dissipation rate of pore pressures can be improved,especially at a greater depth or at a shorter distance from the pile,since the local hydraulic gradient was higher.Less significant buildup of pore pressures can be anticipated with the use of permeable pipe pile.For this,the bearing capacity of composite foundation with permeable pipe pile can be increased by over 36.9%,compared to the case with normal pipe pile at a specific time period.All these demonstrate the ability of permeable pipe pile in accelerating the consolidation process,mobilizing the bearing capacity of treated ground at an early stage,and minimizing the set-up effect.
基金financially supported by the National Key Research and Development Program of China(2022YFF1100402)National Center of Technology Innovation for Dairy(2022-Open subject-11)+1 种基金Young Elite Scientist Sponsorship Program by CAST(YESS20200271)the National Natural Science Foundation of China(32101919)。
文摘2'-Fucosyllactose(2'-FL)shows the potential to support intestinal health as a natural prebiotic that bridges the gap between infant formula feeding and breastfeeding.However,the effect and mechanism of 2'-FL in improving intestinal permeability are not clear.In this study,we constructed human microbiota-associated(HMA)mouse models by colonizing healthy infant feces in mice with antibiotic-depleted intestinal microbiota.The protective effect of 2'-FL on the intestinal permeability was explored using the HMA mouse models,and the combination of metagenomics was used to analyze the possible mechanisms by which the microorganisms reduced the intestinal permeability.The results showed that 2'-FL decreased the concentration of markers of intestinal permeability(enterotoxin and diamine oxidase(DAO))and increased the expression levels of tight junctions(occludin and claudin).Metagenomics revealed the enrichment of Bifidobacterium and increased the expression of glycoside hydrolases(GHs),including GH31,GH28,and GH5.In conclusion,2'-FL strengthened intestinal permeability function by improving microbiota composition to control the translocation of harmful substance.
基金State Key Research Development Program of China,Grant/Award Number:2021YFC3001301。
文摘As the first gold mine discovered at the sea in China and the only coastal gold mine currently mined there,Sanshandao Gold Mine faces unique challenges.The mine's safety is under continual threat from its faulted structure coupled with the overlying water.As the mining proceeds deeper,the risk of water inrush increases.The mine's maximum water yield reaches 15000 m3/day,which is attributable to water channels present in fault zones.Predominantly composed of soil–rock mixtures(SRM),these fault zones'seepage characteristics significantly impact water inrush risk.Consequently,investigating the seepage characteristics of SRM is of paramount importance.However,the existing literature mostly concentrates on a single stress state.Therefore,this study examined the characteristics of the permeability coefficient under three distinct stress states:osmotic,osmotic–uniaxial,and osmotic–triaxial pressure.The SRM samples utilized in this study were extracted from in situ fault zones and then reshaped in the laboratory.In addition,the micromechanical properties of the SRM samples were analyzed using computed tomography scanning.The findings reveal that the permeability coefficient is the highest under osmotic pressure and lowest under osmotic–triaxial pressure.The sensitivity coefficient shows a higher value when the rock block percentage ranges between 30%and 40%,but it falls below 1.0 when this percentage exceeds 50%under no confining pressure.Notably,rock block percentages of 40%and 60%represent the two peak points of the sensitivity coefficient under osmotic–triaxial pressure.However,SRM samples with a 40%rock block percentage consistently show the lowest permeability coefficient under all stress states.This study establishes that a power function can model the relationship between the permeability coefficient and osmotic pressure,while its relationship with axial pressure can be described using an exponential function.These insights are invaluable for developing water inrush prevention and control strategies in mining environments.
基金supported by the Major Program of the National Natural Science Foundation of China (Grant No.42090055)the National Major Scientific Instruments and Equipment Development Projects of China (Grant No.41827808)the National Nature Science Foundation of China (Grant No.42207216).
文摘The strength of the sliding zone soil determines the stability of reservoir landslides.Fluctuations in water levels cause a change in the seepage field,which serves as both the external hydrogeological environment and the internal component of a landslide.Therefore,considering the strength changes of the sliding zone with seepage effects,they correspond with the actual hydrogeological circumstances.To investigate the shear behavior of sliding zone soil under various seepage pressures,24 samples were conducted by a self-developed apparatus to observe the shear strength and measure the permeability coefficients at different deformation stages.After seepage-shear tests,the composition of clay minerals and microscopic structure on the shear surface were analyzed through X-ray and scanning electron microscope(SEM)to understand the coupling effects of seepage on strength.The results revealed that the sliding zone soil exhibited strain-hardening without seepage pressure.However,the introduction of seepage caused a significant reduction in shear strength,resulting in strain-softening characterized by a three-stage process.Long-term seepage action softened clay particles and transported broken particles into effective seepage channels,causing continuous damage to the interior structure and reducing the permeability coefficient.Increased seepage pressure decreased the peak strength by disrupting occlusal and frictional forces between sliding zone soil particles,which carried away more clay particles,contributing to an overhead structure in the soil that raised the permeability coefficient and decreased residual strength.The internal friction angle was less sensitive to variations in seepage pressure than cohesion.
基金supported by the National Key Research and Development Program of China(2022YFE0206700).
文摘Understanding the storage mechanisms in CO_(2)flooding is crucial,as many carbon capture,utilization,and storage(CCUS)projects are related to enhanced oil recovery(EOR).CO_(2)storage in reservoirs across large timescales undergoes the two storage stages of oil displacement and well shut-in,which cover mul-tiple replacement processes of injection-production synchronization,injection only with no production,and injection-production stoppage.Because the controlling mechanism of CO_(2)storage in different stages is unknown,the evolution of CO_(2)storage mechanisms over large timescales is not understood.A math-ematical model for the evaluation of CO_(2)storage,including stratigraphic,residual,solubility,and mineral trapping in low-permeability tight sandstone reservoirs,was established using experimental and theoret-ical analyses.Based on a detailed geological model of the Huaziping Oilfield,calibrated with reservoir permeability and fracture characteristic parameters obtained from well test results,a dynamic simulation of CO_(2)storage for the entire reservoir life cycle under two scenarios of continuous injection and water-gas alternation were considered.The results show that CO_(2)storage exhibits the significant stage charac-teristics of complete storage,dynamic storage,and stable storage.The CO_(2)storage capacity and storage rate under the continuous gas injection scenario(scenario 1)were 6.34×10^(4)t and 61%,while those under the water-gas alternation scenario(scenario 2)were 4.62×10^(4)t and 46%.The proportions of stor-age capacity under scenarios 1 and 2 for structural or stratigraphic,residual,solubility,and mineral trap-ping were 33.36%,33.96%,32.43%,and 0.25%;and 15.09%,38.65%,45.77%,and 0.49%,respectively.The evolution of the CO_(2)storage mechanism showed an overall trend:stratigraphic and residual trapping first increased and then decreased,whereas solubility trapping gradually decreased,and mineral trapping continuously increased.Based on these results,an evolution diagram of the CO_(2)storage mechanism of low-permeability tight sandstone reservoirs across large timescales was established.
文摘Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsulation,slow release and skin impermeability,and provided an excellent nanolipid slow-release encapsulation system for sunscreens.As observed by transmission electron microscopy,the nanolipid carriers were spherical shape,with smooth surface and uniform distribution,and the particle sizes were mainly concentrated in the range of 230 to 250 nm without agglomeration.The nanolipid carriers significantly improved the sunscreen performance through the synergistic effect of scattering and chemical absorption,and showed better UV stability than traditional sunscreen,indicating their photoprotective function.In vitro release experiments showed that the nano-lipidic carriers exhibited better release control when loaded with octyl methoxycinnamate(OMC)and butylmethoxydibenzoylmethane(BDFM)sunscreens than traditional traditional emulsions,with the cumulative release rate of OMC in the nano-lipidic carriers decreasing by 17.17% to 30.24% within 12 hours,and that of BDFM decreasing by 26.67% to 44.67%.26.67% to 44.16%.The results of the in vitro permeation experiment further confirmed that the nanolipid carriers could effectively encapsulate the sunscreens and prevent them from penetrating the skin barrier,thus reducing the skin irritation.Compared with traditional traditional emulsion,the cumulative penetration of OMC in nanostructured lipid carriers was 2.24μg/cm^(2)in 4 hours,while the cumulative penetration was reduced by 68.05%.The cumulative penetration of BDFM in the nanostructured lipid carrier was 3.24μg/cm^(2),with a 64.04%reduction in cumulative penetration.
基金supported by the National Natural Science Foundation of China(Grant No.42202316)the China Postdoctoral Science Foundation(Grant No.2022M712963)the Open Fund of Badong National Observation and Research Station of Geohazards(Grant No.BNORSG-202309).
文摘Non-Darcian flow in rock fractures exhibits significant anisotropic characteristics,which can be affected by mechanical processes,such as cyclic shearing.Understanding the evolution of anisotropic nonDarcian flow is crucial for characterizing groundwater flow and mass/heat transport in fractured rock masses.In this study,we conducted experiments on non-Darcian flow in single rough fractures under cyclic shearing conditions,aiming to analyze the anisotropic evolution of inertial permeability and viscous permeability.We established quantitative characterization models for the two types of permeability.First,we conducted cyclic shearing experiments on four sets of 24 rough rock fractures,investigating their shear characteristics.Then,we performed 480 non-Darcian flow experiments to analyze the anisotropic evolution of viscous permeability and inertial permeability of these rock fractures.The results showed that viscous permeability exhibited significant differences only in the orthogonal direction,while inertial permeability exhibited differences in both orthogonal and opposite directions.With increase in the shear cycles,the differences in the orthogonal direction gradually increased,while those in opposite direction gradually decreased.Finally,we established characterization equations for the two permeabilities based on the proposed directional geometric parameters and validated the performance of these equations with experimental data.These findings are useful for the quantitative characterization of the evolution of non-Darcian flow in fractures under dynamic loading conditions.
基金the Fundamental Research Funds for the Central Universities(No.2232023Y-01)the National Natural Science Foundation of China(Nos.52073052)the Fundamental Research Funds for the Central Universities and Graduate Student Innovation Fund of Donghua University(No.CUSF-DH-D-2023015).
文摘Current protective clothing often lacks sufficient comfort to ensure efficient performance of healthcare workers.Developing protective textiles with high air and moisture permeability is a potential and effective solution to discomfort of medical protective clothing.However,realizing the facile production of a protective textile that combines safety and comfort remains a challenge.Herein,we report the fabrication of highly permeable protective textiles(HPPT)with micro/nano-networks,using non-solvent induced phase separation synergistically driven by CaCl_(2) and fluorinated polyurethane,combined with spraying technique.The HPPT demonstrates excellent liquid repellency and comfort,ensuring high safety and a dry microenvironment for the wearer.The textile exhibits not only a high hydrostatic pressure(12.86 kPa)due to its tailored small mean pore size(1.03μm)and chemical composition,but also demonstrates excellent air permeability(14.24 mm s^(−1))and moisture permeability(7.92 kg m^(−2)d^(−1))owing to the rational combination of small pore size and high porosity(69%).The HPPT offers superior comfort compared to the commercially available protective materials.Additionally,we elucidated a molding mechanism synergistically inducted by diffusion-dissolution-phase separation.This research provides an innovative perspective on enhancing the comfort of medical protective clothing and offers theoretical support for regulating of pore structure during phase separations.
基金funded by the National Key Research and Development Program of China(Nos.2022YFF0801202,2022YFF0801200)。
文摘The effect of depositional facies and diagenesis on the reservoir potential of the Sakesar limestone has been assessed through core plug porosity and permeability data,scanning electron microscope(SEM),and petrographic study in three stratigraphic sections(Karuli,Badshah Pur,and Sardhai)of Central Salt Range.Field observations reveal three lithofacies:thin-bedded limestone with shale intercalation,thick-bedded nodular limestone,and highly fractured limestone.Based on a petrographic study,six microfacies have been identified:bioclastic mudstone facies(SKF-1),Lockhartia-nummulitic wackestone facies(SKF-2),Assilina-Alveolina packstone facies(SKF-3),Lockhartia-nummulitic packstone facies(SKF-4),Alveolina grainstone facies(SKF-5),and nummulitic grainstone facies(SKF-6).The Sakesar limestone shows various diagenetic changes such as compaction,dissolution,dolomitization,cementation,and fracturing,resulting in different types of pores.Two reservoir zones are identified in the Sakesar limestone:a mud-dominated reservoir in an outer ramp setting with interparticle and micropores and a bioclastic grain-dominated facies in an inner ramp setting with intraskeletal and fracture porosity.The porosity and permeability of grain-dominated facies(8%-30%and 0.8-8 mD)are higher than mud-dominated facies(4%-15%and 0.5-4 mD)due to intraskeletal/intraparticle pores and dolomitization.
基金financially supported by the Ministry of Small and Mediumsized Enterprises(SMEs)and Startups(MSS),Republic of Korea,under the“Regional Specialized Industry Development Plus Program(R&D,S3363773)”supervised by the Korea Technology and Information Promotion Agency(TIPA)for SMEs.
文摘Background:The efficient transdermal delivery of biologically active molecules remains a major challenge because of the structural barrier of the stratum corneum,which limits the penetration of large or hydrophilic molecules.Low-molecular-weight protamine(LMWP)has a structure similar to that of the HIV TAT protein-derived peptide and is a representative cell-penetrating peptide(CPP)used to increase cell permeability.However,protamine has been reported to have many toxicities and side effects.Objectives:We developed human-derived low-molecular-weight protamine(hLMWP),which is based on fish-derived LMWP but designed using human protein sequences to improve safety and functionality.As it is derived from human proteins,it may reduce side effects and immune rejection during long-term or repeated administration.Additionally,we confirmed in our preliminary study that hLMWP enhances permeability compared to LMWP.In this study,we evaluated physiological activities and skin cell penetration of hLMWP conjugates to assess the potential applications of hLMWP.Methods:cDNA sequences for hLMWP-EGF(His)and hLMWP-SOD-1(His)were synthesized by connecting hLMWP(RSRRRRRRSCQTRRR)to the N-terminus of Epidermal growth factor(EGF)and Superoxide dismutase 1(SOD-1),respectively,with a 6 His-tag added to the C-terminus.The constructs were cloned into a expression vector and expressed in E.coli BL21-CodonPlus pET-41b(+)(DE3)-RIL cells.Expressed proteins were purified using a nickel column and eluted with imidazole buffer.Protein purity was confirmed by SDS-PAGE,and concentrations were quantified using a BCA assay.To evaluate the functional properties of these hLMWP-protein conjugates,a series of in vitro assays were conducted using keratinocyte and macrophage cell lines.These included assessments of permeability,proliferation,wound healing,and anti-inflammatory activity.Results:The results demonstrated that hLMWP-EGF and hLMWP-SOD-1 exhibited superior biological activities,including increased cell proliferation,wound healing,and anti-inflammatory effects,compared to EGF and SOD-1.Moreover,hLMWP-EGF and hLMWP-SOD-1 significantly enhanced the skin permeability of both EGF and SOD-1,as shown by Franz diffusion cell assay and immunofluorescence analysis.Conclusion:Our findings demonstrate that hLMWP significantly enhances skin permeability and biological activity of functional proteins such as EGF and SOD-1 while maintaining safety.This suggests its potential for application in transdermal drug delivery,regenerative medicine,and cosmeceutical formulations.
