We present a systematic study of homogenization of diffusion in random me- dia with emphasis on tile-based random microstructures. We give detailed examples of several such media starting from their physical descripti...We present a systematic study of homogenization of diffusion in random me- dia with emphasis on tile-based random microstructures. We give detailed examples of several such media starting from their physical descriptions, then construct the associated probability spaces and verify their ergodicity. After a discussion of material symmetries of random media, we derive criteria for the isotropy of the homogenized limits in tile-based structures. ~rthermore, we study the periodization Mgorithm for the numerical approxi- mation of the homogenized diffusion tensor and study the algorithm＇s rate of convergence. For one dimensional tile-based media, we prove a central limit result, giving a concrete rate of convergence for periodization. We also provide numerical evidence for a similar central limit behavior in the case of two dimensional tile-based structures.展开更多
study drifting modulation instability(MI)that exhibits asymmetric discrete spectrum recurrences in the nonlinear stage within the framework of the focusing nonlinear Schr¨odinger equation.We demonstrate that such...study drifting modulation instability(MI)that exhibits asymmetric discrete spectrum recurrences in the nonlinear stage within the framework of the focusing nonlinear Schr¨odinger equation.We demonstrate that such drifting MI can arise either from the local periodization of general breathers or from numerical simulations starting with an initial modulation containing asymmetric sidebands.展开更多
The coupling reactions of methanol and long-chain alkanes(n-dodecane,n-tetradecane and n-hexadecane)over CHA-type molecular sieves were studied in a fixed bed reactor.Over SAPO-34 and SSZ-13,it was found that the indu...The coupling reactions of methanol and long-chain alkanes(n-dodecane,n-tetradecane and n-hexadecane)over CHA-type molecular sieves were studied in a fixed bed reactor.Over SAPO-34 and SSZ-13,it was found that the induction period of methanol conversion was shortened by the introduction of long-chain alkanes.However,the addition of long-chain alkanes had little influence on the product distribution.Polymethylbenzenes and the derivatives were the main retained species on spent SSZ-13 catalyst,while adamantanes were the main retained species on SAPO-34.This indicates that coking species formation was mainly related to the further transformation of long-chain alkane/methanol coupling products at acid sites of the molecular sieve.These findings provide valuable information of long chain alkanes conversion and methanol reaction behavior of induction period over small pore CHA molecular sieves.展开更多
The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitte...The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitter,plays a crucial role in coordinating synapse formation,neuronal proliferation,and migration during this time.展开更多
Background Different periodization models have been widely used to improve maximum and rapid force in aging adults.However,it is unclear if some specific model can influence the remarkable heterogeneity of responsiven...Background Different periodization models have been widely used to improve maximum and rapid force in aging adults.However,it is unclear if some specific model can influence the remarkable heterogeneity of responsiveness to rapid torque improvements following resistance training.Aims Compare the effects of mixed session periodization(MSP)and traditional(TP)models on neuromuscular performance and individual responsiveness in aging adults.Methods Twenty-two aging men and women(64.6±5.2 years old;1.68±0.1 m;77.8±16.0 kg)completed the intervention period.They were assigned into MSP(n=11)or TP(n=11)resistance training for lower limbs.The outcome measures normalized dynamic leg press(5-RM:BM),absolute and normalized knee isometric peak torque(PT and PT:BM)and rate of torque development,and impulse were assessed at baseline and after three blocks of a 9-wk resistance training(3 sessions per week).Thigh leg lean mass was assessed by dual-energy x-ray absorptiometry at baseline and after the intervention.Results Similar increases were observed for 5-RM:BM(MSP:28.8%±13.5%and TP:26.4%±7.6%,P<0.001),PT(MSP:223.7±50.7 N·m and TP:189.9±58.6 N·m,P<0.001),but it was not observed for PT:BM(MSP:16.4%±16.5%and TP:4.7%±9.2%,P>0.05).Absolute and normalized RTD remained unchanged throughout intervention(P>0.05),but both groups improved impulse(MSP:22.1%±25.7%and TP:12.6%±45.2%,P<0.001).Only MSP responders(n=5)presented significant time effect for absolute RTD(P<0.05)and impulse(P<0.05).Conclusion Although both periodization protocols increased 5-RM:BM and PT,it was not interchangeable through improve-ments in RTD even adopting power training session.Furthermore,these results suggest a great inter-individual variability following different periodization models for aging people.展开更多
This study systematically analyzed the primary causes of malnutrition in children with leukemia during chemotherapy,clarified the status of malnutrition and specific nutritional intervention measures,and comprehensive...This study systematically analyzed the primary causes of malnutrition in children with leukemia during chemotherapy,clarified the status of malnutrition and specific nutritional intervention measures,and comprehensively evaluated the research progress.The research indicates a shift from basic supportive care toward precision intervention strategies.Immunonutrition approaches,such as omega-3 fatty acid supplementation and probiotics for gut microbiota modulation,significantly mitigate chemotherapy-related side effects and enhance nutritional status.These targeted novel regimens demonstrate clear clinical advantages.The success of nutritional management depends on a multidisciplinary collaboration mechanism.The organic integration of innovative nutritional protocols with standard treatments from hematology,pediatrics,and nutrition departments significantly optimizes treatment outcomes and long-term quality of life for children with leukemia.This interdisciplinary synergy is reshaping contemporary medical models.展开更多
Objective:To investigate the impact of targeted nursing interventions based on frailty prediction models on peri-hospitalization clinical outcomes in middle-aged and elderly patients with upper gastrointestinal bleedi...Objective:To investigate the impact of targeted nursing interventions based on frailty prediction models on peri-hospitalization clinical outcomes in middle-aged and elderly patients with upper gastrointestinal bleeding(UGIB).Methods:A prospective cohort study was conducted,and 126 middle-aged and elderly patients with UGIB admitted from August 2024 to August 2025 were selected as the study subjects.The patients were divided into the intervention group(63 cases)and the control group(63 cases)based on whether they received nursing intervention based on frailty prediction models.The control group received routine care,while the intervention group,on the basis of routine care,used the FRAIL scale combined with laboratory indicators(albumin,hemoglobin,etc.)to establish a predictive model to evaluate patients within 24 hours of admission,and implemented multi-dimensional targeted nursing intervention for pre-frailty or frailty patients screened out.The incidence of frailty,rebleeding rate,average length of stay,hospitalization cost,and nursing satisfaction during hospitalization were compared between the two groups.Results:The incidence of frailty during hospitalization in the intervention group was 11.1%(7 cases/63 cases),significantly lower than 31.7%(20 cases/63 cases)in the control group,and the difference was statistically significant(p<0.05).The rebleeding rate of 4.8%vs 12.7%,the average length of stay of(7.2±1.5)days vs(9.1±2.2)days,and the average hospitalization cost of(23,000±6,000)yuan vs(28,000±7,000)yuan in the intervention group were all lower than those in the control group(all p<0.05).The nursing satisfaction score of the intervention group(93.5±4.2)points was higher than that of the control group(86.3±5.8)points(p<0.05).Conclusion:The frailty prediction model applied to the peri-hospitalization care of middle-aged and elderly patients with UGIB can effectively identify frailty risk.Through early targeted intervention,the incidence of frailty and rebleeding rate can be reduced,the length of hospital stay can be shortened,medical expenses can be reduced,and nursing satisfaction can be improved,which has clinical promotion value.展开更多
Objective:To explore the intervention effect of comprehensive perioperative blood glucose management on patients with diabetes complicated with cataract surgery.Method:A total of 68 patients in our hospital from July ...Objective:To explore the intervention effect of comprehensive perioperative blood glucose management on patients with diabetes complicated with cataract surgery.Method:A total of 68 patients in our hospital from July 2024 to July 2025 were selected and randomly divided into the experimental group and the control group,with 34 cases in each group.The control group received routine blood glucose management,while the experimental group,on this basis,implemented individualized intervention 3 days before the operation,real-time regulation during the operation,dynamic management 7 days after the operation,and self-management training.Result:The blood glucose control in the experimental group was more stable 7 days after the operation.The total incidence of complications(2.9%)was significantly lower than that in the control group(38.2%),and the average hospital stay(5.1±1.0 days)was shorter than that in the control group(7.3±1.4 days).One week after the operation,the proportions of uncorrected visual acuity and visual acuity≥0.6(67.6%)were both better than those of the control group(p<0.001).Conclusion:The whole-course management of perioperative blood glucose can enhance the stability of blood glucose control,reduce the risk of complications,shorten the length of hospital stay,promote visual recovery,and has high clinical promotion value.展开更多
The outbreak of infectious diseases is the result of a combination of various factors,including season,the movement of individuals,non-pharmaceutical interventions(NPIs)and the effectiveness and availability of vaccin...The outbreak of infectious diseases is the result of a combination of various factors,including season,the movement of individuals,non-pharmaceutical interventions(NPIs)and the effectiveness and availability of vaccines.Taking these key elements into consideration,an almost periodic SVEIR warning model in the patch environment is here proposed.First,in terms of reproduction numbers,our results imply that if the effective reproduction numbers are R_(e)<1,then the disease dies out;if R_(e)>1,then the disease spreads and leads to local outbreaks.Second,the relationships between R_(e)and C_(s1),C_(a1)(see Section 2)are given by numerical simulations.The numerical results show that even if all people are vaccinated,NPIs are still needed because of the potentially low efficacy of vaccines.Furthermore,the numerical results suggest that NPIs and the strengthening of the effective rate of vaccination are essential in order to achieve herd immunity.Theories involving this model effectively explain the transmission mechanism of most infectious diseases,and provide a valuable theoretical basis for analyzing new infectious diseases in the future.Moreover,this model is helpful for the prevention and control of infectious diseases and the formulation of public health safety policies.展开更多
Objective:To explore the impact of evidence-based predictive nursing intervention on psychological stress and physiological indicator stability of elderly cataract patients during the perioperative period(1 day before...Objective:To explore the impact of evidence-based predictive nursing intervention on psychological stress and physiological indicator stability of elderly cataract patients during the perioperative period(1 day before surgery to 1 day after surgery),and to provide a basis for optimizing clinical nursing plans for elderly cataract surgery.Methods:A retrospective selection of 90 elderly patients(aged≥60 years)who underwent cataract surgery in the Ophthalmology Department of our hospital from August 2024 to December 2024 was conducted.They were divided into an observation group(n=45)and a control group(n=45)using a random number table method.The control group received routine nursing for cataract surgery,while the observation group implemented evidence-based predictive nursing intervention(including the establishment of a multidisciplinary evidence-based team,hierarchical psychological intervention,perioperative environment optimization,intraoperative personalized cooperation,and video-based health education).Psychological stress indicators[Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS),General Self-Efficacy Scale(GSES)]on the 1st day before surgery and 1st day after surgery,and fluctuations of physiological indicators[Heart Rate(HR),Systolic Blood Pressure(SBP),Diastolic Blood Pressure(DBP)]on the 1st day before surgery and during surgery were compared between the two groups.Results:Before intervention,there were no statistically significant differences in SAS,SDS,GSES scores,HR,SBP,or DBP between the two groups(p>0.05);after intervention,the SAS score(33.62±5.72)and SDS score(32.14±4.86)of the observation group on the 1st day after surgery were significantly lower than those of the control group[(41.05±5.56),(43.59±4.75)],and the GSES score(31.15±3.28)was significantly higher than that of the control group(24.84±3.52)(all p<0.05);during surgery,the fluctuations of HR(74.0±6.0)beats/min,SBP(127.0±15.8)mmHg,and DBP(75.0±5.9)mmHg in the observation group were significantly smaller than those in the control group(all p<0.05).Conclusion:Evidence-based predictive nursing intervention can effectively alleviate anxiety and depression in elderly cataract patients during the perioperative period,improve self-efficacy,stabilize intraoperative physiological status,and enhance surgical cooperation,which is worthy of clinical promotion.展开更多
BACKGROUND Gastrointestinal(GI)tumors are among the most prevalent malignancies,and surgical intervention remains a primary treatment modality.However,the complexity of GI surgery often leads to prolonged recovery and...BACKGROUND Gastrointestinal(GI)tumors are among the most prevalent malignancies,and surgical intervention remains a primary treatment modality.However,the complexity of GI surgery often leads to prolonged recovery and high postoperative complication rates,which threaten patient safety and functional outcomes.Enhanced recovery after surgery(ERAS)principles have been shown to improve perioperative outcomes through evidence-based,multidisciplinary care pathways.Despite its widespread adoption,there is a paucity of research focusing specifically on optimizing ERAS-guided nursing processes in the post-anesthesia care unit(PACU)and evaluating its impact on perioperative safety in patients undergoing GI tumor surgery.This study aimed to investigate whether an ERASbased PACU nursing protocol could enhance recovery,reduce complications,and improve patient safety in this surgical population.AIM To explore the impact of optimizing the recovery room nursing process based on ERAS on the perioperative safety of patients with GI tumors.METHODS A total of 260 patients with GI tumors who underwent elective surgeries under general anesthesia in our hospital from August 2023 to August 2025 and were then observed in the recovery unit(PACU)were selected.They were randomly divided into the observation group(the PACU nursing process was optimized based on ERAS)and the control group(the conventional PACU nursing process was adopted)by the random number grouping method,with 130 cases in each group.The time of gastric tube removal,urinary catheter removal,defecation time,hospital stay,time of leaving the room after tube removal,retention time in the recovery room,occurrence of complications,satisfaction and readmission rate were compared between the two groups after entering the room.Compare the occurrence of adverse events in the PACU nursing process between the two groups.RESULTS The time of gastric tube removal,urinary catheter removal,defecation time,hospital stay,retention time in the recovery room,total incidence of complications and readmission rate in the observation group were significantly lower than those in the control group,and the satisfaction rate was higher than that in the control group(P<0.05).The occurrence of adverse events in the PACU nursing process in the observation group was lower than that in the control group(P<0.05).CONCLUSION Optimizing the PACU nursing process based on ERAS can effectively accelerate the recovery process of patients undergoing GI tumor surgery,reduce adverse events,improve nursing satisfaction,and at the same time,lower the incidence of adverse events in the PACU nursing process,providing a more refined management basis for clinical practice.展开更多
General Journal of Beijing Institute of Technology (JBIT)is a periodical publication on science and technology published by Beijing Institute of Technology under the sponsorship of the Ministry of Industry and Informa...General Journal of Beijing Institute of Technology (JBIT)is a periodical publication on science and technology published by Beijing Institute of Technology under the sponsorship of the Ministry of Industry and Information Technology of the People’s Republic of China.JBIT was inaugurated in 1992.展开更多
This study aims to explore the Qing court’s emphasis on traditional Chinese medicine(TCM)culture and technology,as well as the role of ingots as a carrier of imperial medical culture.By systematically sorting out the...This study aims to explore the Qing court’s emphasis on traditional Chinese medicine(TCM)culture and technology,as well as the role of ingots as a carrier of imperial medical culture.By systematically sorting out the types,quantities,and shapes of medicinal ingots recorded in Huo Ji Dang(活计档Archives of Imperial Workshops)during the 13-year Yongzheng reign,and by combining these records with existing ingot-related molds,physical specimens,and other collections in the Palace Museum,this research finds that:the Yongzheng Emperor incorporated ingots into the production list of the Imperial Workshop and established standardized preparation procedures,making them a technical practice for displaying imperial power;the fixed system of rewarding ingots during the Dragon Boat Festival turned ingots into a product of Manchu-Han cultural integration and formed a custom;the evolution of ingot equipment was dynamically related to military activities in the mid-Qing dynasty,confirming its function in court politics;and the integration of the preparation and packaging process of ingots into the power operation system,and transforming TCM-related knowledge and technology into means of exercising power,constructed a materialized path for imperial power to regulate the bureaucratic system and social order.The conclusion reveals the inherent logic of the Qing court:establishing authoritative identity through material culture.展开更多
Observational analysis of the Earth’s stratospheric temperature structure and its dynamical behavior is of great significance for atmospheric dynamics research.In this paper,we present stratospheric temperatures in t...Observational analysis of the Earth’s stratospheric temperature structure and its dynamical behavior is of great significance for atmospheric dynamics research.In this paper,we present stratospheric temperatures in the range of 30–50 km above the Yinchuan observation site,retrieved from diurnal continuous Rayleigh scattering signal observation data collected by a 589 nm lidar throughout a single day.We also present observational studies of atmospheric tides and gravity wave cases.The diurnal temperature background field and perturbation field were obtained from the lidar data using the linear fitting method;these results exhibit good consistency with the temperature perturbation field extracted from ERA5.An obvious quasi-monochromatic inertial gravity wave was detected by application of a two-dimensional Fourier transform to the nighttime observation data with complete height coverage,which revealed these characteristic gravity wave parameters:a vertical wavelength of 8.53 km,a period of 8.46 h,and a downward-propagating vertical phase velocity.A nonlinear least-squares harmonic fitting method was used to extract amplitudes and phases of atmospheric diurnal and semi-diurnal tides in the 30−34 km range,where the diurnal data were relatively complete.The amplitudes increased with height,ranging from 0.6 to 2.5 K(diurnal tide)and 0.3 to 1.9 K(semi-diurnal tide),respectively.The phases showed a decreasing trend with height,indicating that the vertical phase velocity of the tides propagates downward while the energy propagates upward.These results indicate that diurnal 589 nm lidar observations data can provide important reference values for understanding the temperature structure of the stratosphere and the dynamical characteristics of atmospheric gravity waves and tides.展开更多
Antibiotics are emerging pollutants that pose significant risks to environmental and human health.Periodate(PI)-based advanced oxidation processes have shown promise for their effective degradation.In this study,we sy...Antibiotics are emerging pollutants that pose significant risks to environmental and human health.Periodate(PI)-based advanced oxidation processes have shown promise for their effective degradation.In this study,we systematically investigate the structure-activity relationship of four representative Fe-based metal-organic frameworks(Fe-MOFs)-MIL-101(Fe),MIL-88B(Fe),MIL-88A(Fe),and MIL-53(Fe)-as PI activators for tetracycline(TC)degradation.Among them,MIL-101(Fe)exhibited the highest catalytic performance,owing to its unique Fe3O-OH nodes and mesoporous architecture.The MIL-101(Fe)/PI system achieved 93.3%TC degradation and 55.9%mineralization rate within 60 min.Mechanistic studies combining scavenger quenching,sulfoxide probe transformation,X-ray photoelectron spectroscopy,and X-ray absorption fine structure confirmed the generation of multiple reactive oxygen species,and high-valent Fe(IV)]O and O_(2)^(·-)played major roles in the tetracycline degradation process.Density functional theory calculations further revealed that MIL-101(Fe)and MIL-88B(Fe)effectively interact with PI to form Fe(Ⅲ)-superoxide(Fe(Ⅲ)-O-O^(·-)),a key intermediate in Fe(IV)]O generation.In contrast,the adsorption energy of MIL-53(Fe)and MIL-88A(Fe)was relatively weak,with fewer binding sites,resulting in poor performance.The synergy between Fe(Ⅲ)-O-O^(·-)formation and the pore accessibility of MIL-101(Fe)accounted for its superior catalytic efficiency.This work not only clarifies the structural factors governing PI activation in Fe-MOFs,but also proposes a mechanistically informed strategy for designing high-performance catalysts for antibiotic degradation.展开更多
In this paper,a class of discontinuous Cohen-Grossberg neural networks with timevarying delays is considered.Firstly,under the extended Filippov differential inclusions framework,the problem of periodic solutions of t...In this paper,a class of discontinuous Cohen-Grossberg neural networks with timevarying delays is considered.Firstly,under the extended Filippov differential inclusions framework,the problem of periodic solutions of the considered neural networks with more relaxed conditions imposed on the amplification functions is analyzed by using set-valued mapping and Kakutani's fixed point theorem,which has rarely been used to study such problem.Secondly,the fixed-time synchronization of the error system of the considered neural networks is also investigated by designing a novel control strategy,which can improve not only the previous ones with sign function greatly,but also can reduce the chattering phenomenon.Finally,two numerical examples are presented to further illustrate the validity of the obtained results.展开更多
Next-generation craniomaxillofacial implants(CMFIs) are redefining personalized bone reconstruction by balancing and optimizing biomechanics,biocompatibility,and bioactivity—the "3Bs".This review highlights...Next-generation craniomaxillofacial implants(CMFIs) are redefining personalized bone reconstruction by balancing and optimizing biomechanics,biocompatibility,and bioactivity—the "3Bs".This review highlights recent progress in implant design,material development,additive manufacturing,and preclinical evaluation.Emerging biomaterials,including bioresorbable polymers,magnesium alloys,and composites with bioactive ceramics,enable patient-specific solutions with improved safety and functionality.Triply periodic minimal surface(TPMS) architectures exemplify how structural design can enhance both mechanical performance and biological integration.Additive manufacturing technologies further allow the fabrication of geometrically complex,customized impla nts that meet individual anatomical and pathological needs.In parallel,multiscale evaluation techniques—from mechanical testing to in vitro and in vivo models—provide comprehensive insights into implant performance and safety.Looking ahead,the field is poised to benefit from several transformative trends:the development of smart and multifunctional biomaterials;Al-driven design frameworks that leverage patient-specific data and computational modeling;predictive additive manufacturing with real-time quality control;and advanced biological testing platforms for preclinical evaluation.Together,these advances form the foundation of a data-informed,translational pipeline from bench to bedside.Realizing the full potential of nextgene ration CMFIs will require close interdisciplina ry collaboration across mate rials science,computational engineering,and clinical medicine.展开更多
Both linoleic acid(18:2 n-6,LA)andα-linolenic acid(18:3 n-3,ALA)are essential fatty acids for infants.The contents of LA and ALA,and their ratio exhibited significant changes in human milk over the past 4 decades,whi...Both linoleic acid(18:2 n-6,LA)andα-linolenic acid(18:3 n-3,ALA)are essential fatty acids for infants.The contents of LA and ALA,and their ratio exhibited significant changes in human milk over the past 4 decades,which were not well summarized.Here,we summarized these values in 9898 human breast milk samples of 6664 mothers from 50 countries in 81 studies.A literature search was conducted using PubMed,Embase,and Web of Science between January 1980 and October 2023.The 95%confidence interval of LA/ALA ratio across lactation and gestation ranged from 14.24 to 31.26.The LA content was higher in China and Turkey(>20%)whereas the ALA content was below 1%in Africa.The LA/ALA ratio in countries along the Mediterranean coast exceeded 20 or even 30.LA and ALA contents increased significantly(P<0.01)while the ratio remained stable over the last 40 years.Multivariate meta-regression results showed that regions significantly(P<0.01)determined the LA,ALA,and LA/ALA ratio.Especially,maternal diet could definitely explain the variation while the effects of gestational age,lactation period was not significant.Clinical trials demonstrated that decreasing the LA/ALA ratio increased docosahexaenoic acid(22:6 n-3,DHA)status,reduced arachidonic acid(20:4 n-6,AA)contents,exerted no effect on the visual function of infants,and reached no consensus on growth.The current review aims to provide an overview on the LA and ALA contents and their ratio in human breast milk to raise concern in infant formula.展开更多
Circumferentially non-uniform tip clearances induced by rotor eccentricity significantly affect the overall performance of axial compressors,particularly the stability margin.Currently,Computational Fluid Dynamics(CFD...Circumferentially non-uniform tip clearances induced by rotor eccentricity significantly affect the overall performance of axial compressors,particularly the stability margin.Currently,Computational Fluid Dynamics(CFD)plays a crucial role in the aerodynamic analysis of eccentric compressors.However,conventional full-annulus Unsteady Reynolds-Averaged Navier-Stokes(URANS)simulations are prohibitively expensive for routine design and analysis purposes.To address this issue,the paper presents a novel Fourier-based method,called the Time-Space Collocation(TSC)method,for efficient simulations of eccentric compressors.This method coherently treats temporal and spatial harmonics,making it well-suited to tackle the rotor eccentricity problem,as the perturbation waves induced by eccentricity are time-periodic with respect to the rotor and space-periodic with respect to the stator.Three numerical cases,including NASA Rotor 67,original Stage 67,and Stage 67 with a reduced rotor-stator axial gap,were conducted to verify the effectiveness of the TSC method.The results indicate that,for the rotor eccentricity levels studied in this paper,the influence of weak rotor-stator interactions can be disregarded in the original Stage 67.In this situation,applying three harmonics can accurately capture both the performance variations and the non-uniformly distributed flowfields of eccentric compressors,while achieving a reduction in run time by two orders of magnitude compared to full-annulus URANS simulations.However,in Stage 67 with a reduced rotor-stator axial gap,the results that include rotor-stator interactions align much more closely with the URANS results.Nevertheless,the TSC simulations can still achieve speed-ups of several dozen times.Overall,the TSC method shows promising potential for application within the engineering community.展开更多
文摘We present a systematic study of homogenization of diffusion in random me- dia with emphasis on tile-based random microstructures. We give detailed examples of several such media starting from their physical descriptions, then construct the associated probability spaces and verify their ergodicity. After a discussion of material symmetries of random media, we derive criteria for the isotropy of the homogenized limits in tile-based structures. ~rthermore, we study the periodization Mgorithm for the numerical approxi- mation of the homogenized diffusion tensor and study the algorithm＇s rate of convergence. For one dimensional tile-based media, we prove a central limit result, giving a concrete rate of convergence for periodization. We also provide numerical evidence for a similar central limit behavior in the case of two dimensional tile-based structures.
基金work was supported by the NSFC(Grant Nos.12522501 and 12247103)the Sci-entific Research Innovation Capability Support Project for Young Faculty(Grant No.SRICSPYF-BS2025131).
文摘study drifting modulation instability(MI)that exhibits asymmetric discrete spectrum recurrences in the nonlinear stage within the framework of the focusing nonlinear Schr¨odinger equation.We demonstrate that such drifting MI can arise either from the local periodization of general breathers or from numerical simulations starting with an initial modulation containing asymmetric sidebands.
基金Supported by National Natural Science Foundation of China(21991093)。
文摘The coupling reactions of methanol and long-chain alkanes(n-dodecane,n-tetradecane and n-hexadecane)over CHA-type molecular sieves were studied in a fixed bed reactor.Over SAPO-34 and SSZ-13,it was found that the induction period of methanol conversion was shortened by the introduction of long-chain alkanes.However,the addition of long-chain alkanes had little influence on the product distribution.Polymethylbenzenes and the derivatives were the main retained species on spent SSZ-13 catalyst,while adamantanes were the main retained species on SAPO-34.This indicates that coking species formation was mainly related to the further transformation of long-chain alkane/methanol coupling products at acid sites of the molecular sieve.These findings provide valuable information of long chain alkanes conversion and methanol reaction behavior of induction period over small pore CHA molecular sieves.
基金supported by the Center for Cognition and Sociality,Institute for Basic Science(IBS)(IBS-R001-D2)(to WK).
文摘The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitter,plays a crucial role in coordinating synapse formation,neuronal proliferation,and migration during this time.
基金supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil(CAPES)-Finance Code 001 for PhD fellowship to BMM and master fellowship for LBRO,FAPEAM for PhD fellowship to ESBConselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)research grants for FD.
文摘Background Different periodization models have been widely used to improve maximum and rapid force in aging adults.However,it is unclear if some specific model can influence the remarkable heterogeneity of responsiveness to rapid torque improvements following resistance training.Aims Compare the effects of mixed session periodization(MSP)and traditional(TP)models on neuromuscular performance and individual responsiveness in aging adults.Methods Twenty-two aging men and women(64.6±5.2 years old;1.68±0.1 m;77.8±16.0 kg)completed the intervention period.They were assigned into MSP(n=11)or TP(n=11)resistance training for lower limbs.The outcome measures normalized dynamic leg press(5-RM:BM),absolute and normalized knee isometric peak torque(PT and PT:BM)and rate of torque development,and impulse were assessed at baseline and after three blocks of a 9-wk resistance training(3 sessions per week).Thigh leg lean mass was assessed by dual-energy x-ray absorptiometry at baseline and after the intervention.Results Similar increases were observed for 5-RM:BM(MSP:28.8%±13.5%and TP:26.4%±7.6%,P<0.001),PT(MSP:223.7±50.7 N·m and TP:189.9±58.6 N·m,P<0.001),but it was not observed for PT:BM(MSP:16.4%±16.5%and TP:4.7%±9.2%,P>0.05).Absolute and normalized RTD remained unchanged throughout intervention(P>0.05),but both groups improved impulse(MSP:22.1%±25.7%and TP:12.6%±45.2%,P<0.001).Only MSP responders(n=5)presented significant time effect for absolute RTD(P<0.05)and impulse(P<0.05).Conclusion Although both periodization protocols increased 5-RM:BM and PT,it was not interchangeable through improve-ments in RTD even adopting power training session.Furthermore,these results suggest a great inter-individual variability following different periodization models for aging people.
文摘This study systematically analyzed the primary causes of malnutrition in children with leukemia during chemotherapy,clarified the status of malnutrition and specific nutritional intervention measures,and comprehensively evaluated the research progress.The research indicates a shift from basic supportive care toward precision intervention strategies.Immunonutrition approaches,such as omega-3 fatty acid supplementation and probiotics for gut microbiota modulation,significantly mitigate chemotherapy-related side effects and enhance nutritional status.These targeted novel regimens demonstrate clear clinical advantages.The success of nutritional management depends on a multidisciplinary collaboration mechanism.The organic integration of innovative nutritional protocols with standard treatments from hematology,pediatrics,and nutrition departments significantly optimizes treatment outcomes and long-term quality of life for children with leukemia.This interdisciplinary synergy is reshaping contemporary medical models.
基金Construction and Application of Frailty Trajectory Prediction Model for Middle-aged and Elderly Patients with Upper Gastrointestinal Bleeding,Project Source:Sichuan Vocational College of Nursing(Project No.:2024ZRY25)。
文摘Objective:To investigate the impact of targeted nursing interventions based on frailty prediction models on peri-hospitalization clinical outcomes in middle-aged and elderly patients with upper gastrointestinal bleeding(UGIB).Methods:A prospective cohort study was conducted,and 126 middle-aged and elderly patients with UGIB admitted from August 2024 to August 2025 were selected as the study subjects.The patients were divided into the intervention group(63 cases)and the control group(63 cases)based on whether they received nursing intervention based on frailty prediction models.The control group received routine care,while the intervention group,on the basis of routine care,used the FRAIL scale combined with laboratory indicators(albumin,hemoglobin,etc.)to establish a predictive model to evaluate patients within 24 hours of admission,and implemented multi-dimensional targeted nursing intervention for pre-frailty or frailty patients screened out.The incidence of frailty,rebleeding rate,average length of stay,hospitalization cost,and nursing satisfaction during hospitalization were compared between the two groups.Results:The incidence of frailty during hospitalization in the intervention group was 11.1%(7 cases/63 cases),significantly lower than 31.7%(20 cases/63 cases)in the control group,and the difference was statistically significant(p<0.05).The rebleeding rate of 4.8%vs 12.7%,the average length of stay of(7.2±1.5)days vs(9.1±2.2)days,and the average hospitalization cost of(23,000±6,000)yuan vs(28,000±7,000)yuan in the intervention group were all lower than those in the control group(all p<0.05).The nursing satisfaction score of the intervention group(93.5±4.2)points was higher than that of the control group(86.3±5.8)points(p<0.05).Conclusion:The frailty prediction model applied to the peri-hospitalization care of middle-aged and elderly patients with UGIB can effectively identify frailty risk.Through early targeted intervention,the incidence of frailty and rebleeding rate can be reduced,the length of hospital stay can be shortened,medical expenses can be reduced,and nursing satisfaction can be improved,which has clinical promotion value.
文摘Objective:To explore the intervention effect of comprehensive perioperative blood glucose management on patients with diabetes complicated with cataract surgery.Method:A total of 68 patients in our hospital from July 2024 to July 2025 were selected and randomly divided into the experimental group and the control group,with 34 cases in each group.The control group received routine blood glucose management,while the experimental group,on this basis,implemented individualized intervention 3 days before the operation,real-time regulation during the operation,dynamic management 7 days after the operation,and self-management training.Result:The blood glucose control in the experimental group was more stable 7 days after the operation.The total incidence of complications(2.9%)was significantly lower than that in the control group(38.2%),and the average hospital stay(5.1±1.0 days)was shorter than that in the control group(7.3±1.4 days).One week after the operation,the proportions of uncorrected visual acuity and visual acuity≥0.6(67.6%)were both better than those of the control group(p<0.001).Conclusion:The whole-course management of perioperative blood glucose can enhance the stability of blood glucose control,reduce the risk of complications,shorten the length of hospital stay,promote visual recovery,and has high clinical promotion value.
基金supported by the NSFC(11501269)and the Natural Science Foundation of Gansu Province(23JRRA1041).
文摘The outbreak of infectious diseases is the result of a combination of various factors,including season,the movement of individuals,non-pharmaceutical interventions(NPIs)and the effectiveness and availability of vaccines.Taking these key elements into consideration,an almost periodic SVEIR warning model in the patch environment is here proposed.First,in terms of reproduction numbers,our results imply that if the effective reproduction numbers are R_(e)<1,then the disease dies out;if R_(e)>1,then the disease spreads and leads to local outbreaks.Second,the relationships between R_(e)and C_(s1),C_(a1)(see Section 2)are given by numerical simulations.The numerical results show that even if all people are vaccinated,NPIs are still needed because of the potentially low efficacy of vaccines.Furthermore,the numerical results suggest that NPIs and the strengthening of the effective rate of vaccination are essential in order to achieve herd immunity.Theories involving this model effectively explain the transmission mechanism of most infectious diseases,and provide a valuable theoretical basis for analyzing new infectious diseases in the future.Moreover,this model is helpful for the prevention and control of infectious diseases and the formulation of public health safety policies.
基金Hospital Quality Management Research Fund Project of China Medical Quality Management Association(Project No.:YLZG202511)。
文摘Objective:To explore the impact of evidence-based predictive nursing intervention on psychological stress and physiological indicator stability of elderly cataract patients during the perioperative period(1 day before surgery to 1 day after surgery),and to provide a basis for optimizing clinical nursing plans for elderly cataract surgery.Methods:A retrospective selection of 90 elderly patients(aged≥60 years)who underwent cataract surgery in the Ophthalmology Department of our hospital from August 2024 to December 2024 was conducted.They were divided into an observation group(n=45)and a control group(n=45)using a random number table method.The control group received routine nursing for cataract surgery,while the observation group implemented evidence-based predictive nursing intervention(including the establishment of a multidisciplinary evidence-based team,hierarchical psychological intervention,perioperative environment optimization,intraoperative personalized cooperation,and video-based health education).Psychological stress indicators[Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS),General Self-Efficacy Scale(GSES)]on the 1st day before surgery and 1st day after surgery,and fluctuations of physiological indicators[Heart Rate(HR),Systolic Blood Pressure(SBP),Diastolic Blood Pressure(DBP)]on the 1st day before surgery and during surgery were compared between the two groups.Results:Before intervention,there were no statistically significant differences in SAS,SDS,GSES scores,HR,SBP,or DBP between the two groups(p>0.05);after intervention,the SAS score(33.62±5.72)and SDS score(32.14±4.86)of the observation group on the 1st day after surgery were significantly lower than those of the control group[(41.05±5.56),(43.59±4.75)],and the GSES score(31.15±3.28)was significantly higher than that of the control group(24.84±3.52)(all p<0.05);during surgery,the fluctuations of HR(74.0±6.0)beats/min,SBP(127.0±15.8)mmHg,and DBP(75.0±5.9)mmHg in the observation group were significantly smaller than those in the control group(all p<0.05).Conclusion:Evidence-based predictive nursing intervention can effectively alleviate anxiety and depression in elderly cataract patients during the perioperative period,improve self-efficacy,stabilize intraoperative physiological status,and enhance surgical cooperation,which is worthy of clinical promotion.
基金Supported by 2025 Henan Medical Education Research Project,No.WJLX2025038.
文摘BACKGROUND Gastrointestinal(GI)tumors are among the most prevalent malignancies,and surgical intervention remains a primary treatment modality.However,the complexity of GI surgery often leads to prolonged recovery and high postoperative complication rates,which threaten patient safety and functional outcomes.Enhanced recovery after surgery(ERAS)principles have been shown to improve perioperative outcomes through evidence-based,multidisciplinary care pathways.Despite its widespread adoption,there is a paucity of research focusing specifically on optimizing ERAS-guided nursing processes in the post-anesthesia care unit(PACU)and evaluating its impact on perioperative safety in patients undergoing GI tumor surgery.This study aimed to investigate whether an ERASbased PACU nursing protocol could enhance recovery,reduce complications,and improve patient safety in this surgical population.AIM To explore the impact of optimizing the recovery room nursing process based on ERAS on the perioperative safety of patients with GI tumors.METHODS A total of 260 patients with GI tumors who underwent elective surgeries under general anesthesia in our hospital from August 2023 to August 2025 and were then observed in the recovery unit(PACU)were selected.They were randomly divided into the observation group(the PACU nursing process was optimized based on ERAS)and the control group(the conventional PACU nursing process was adopted)by the random number grouping method,with 130 cases in each group.The time of gastric tube removal,urinary catheter removal,defecation time,hospital stay,time of leaving the room after tube removal,retention time in the recovery room,occurrence of complications,satisfaction and readmission rate were compared between the two groups after entering the room.Compare the occurrence of adverse events in the PACU nursing process between the two groups.RESULTS The time of gastric tube removal,urinary catheter removal,defecation time,hospital stay,retention time in the recovery room,total incidence of complications and readmission rate in the observation group were significantly lower than those in the control group,and the satisfaction rate was higher than that in the control group(P<0.05).The occurrence of adverse events in the PACU nursing process in the observation group was lower than that in the control group(P<0.05).CONCLUSION Optimizing the PACU nursing process based on ERAS can effectively accelerate the recovery process of patients undergoing GI tumor surgery,reduce adverse events,improve nursing satisfaction,and at the same time,lower the incidence of adverse events in the PACU nursing process,providing a more refined management basis for clinical practice.
文摘General Journal of Beijing Institute of Technology (JBIT)is a periodical publication on science and technology published by Beijing Institute of Technology under the sponsorship of the Ministry of Industry and Information Technology of the People’s Republic of China.JBIT was inaugurated in 1992.
文摘This study aims to explore the Qing court’s emphasis on traditional Chinese medicine(TCM)culture and technology,as well as the role of ingots as a carrier of imperial medical culture.By systematically sorting out the types,quantities,and shapes of medicinal ingots recorded in Huo Ji Dang(活计档Archives of Imperial Workshops)during the 13-year Yongzheng reign,and by combining these records with existing ingot-related molds,physical specimens,and other collections in the Palace Museum,this research finds that:the Yongzheng Emperor incorporated ingots into the production list of the Imperial Workshop and established standardized preparation procedures,making them a technical practice for displaying imperial power;the fixed system of rewarding ingots during the Dragon Boat Festival turned ingots into a product of Manchu-Han cultural integration and formed a custom;the evolution of ingot equipment was dynamically related to military activities in the mid-Qing dynasty,confirming its function in court politics;and the integration of the preparation and packaging process of ingots into the power operation system,and transforming TCM-related knowledge and technology into means of exercising power,constructed a materialized path for imperial power to regulate the bureaucratic system and social order.The conclusion reveals the inherent logic of the Qing court:establishing authoritative identity through material culture.
基金supported by the Key Research Program of the Chinese Academy of Sciences(Grant NO.KGFZD-145-23-17)the Specialized Research Fund for State Key Laboratories.
文摘Observational analysis of the Earth’s stratospheric temperature structure and its dynamical behavior is of great significance for atmospheric dynamics research.In this paper,we present stratospheric temperatures in the range of 30–50 km above the Yinchuan observation site,retrieved from diurnal continuous Rayleigh scattering signal observation data collected by a 589 nm lidar throughout a single day.We also present observational studies of atmospheric tides and gravity wave cases.The diurnal temperature background field and perturbation field were obtained from the lidar data using the linear fitting method;these results exhibit good consistency with the temperature perturbation field extracted from ERA5.An obvious quasi-monochromatic inertial gravity wave was detected by application of a two-dimensional Fourier transform to the nighttime observation data with complete height coverage,which revealed these characteristic gravity wave parameters:a vertical wavelength of 8.53 km,a period of 8.46 h,and a downward-propagating vertical phase velocity.A nonlinear least-squares harmonic fitting method was used to extract amplitudes and phases of atmospheric diurnal and semi-diurnal tides in the 30−34 km range,where the diurnal data were relatively complete.The amplitudes increased with height,ranging from 0.6 to 2.5 K(diurnal tide)and 0.3 to 1.9 K(semi-diurnal tide),respectively.The phases showed a decreasing trend with height,indicating that the vertical phase velocity of the tides propagates downward while the energy propagates upward.These results indicate that diurnal 589 nm lidar observations data can provide important reference values for understanding the temperature structure of the stratosphere and the dynamical characteristics of atmospheric gravity waves and tides.
基金National Natural Science Foundation of China(Nos.42177405,42377359,12075152)Energy Science and Technology discipline under the Shanghai Class IV Peak Disciplinary Development Program for the financial support.W.Y.Huang thanks the China Scholarship Council(CSC)for funding.
文摘Antibiotics are emerging pollutants that pose significant risks to environmental and human health.Periodate(PI)-based advanced oxidation processes have shown promise for their effective degradation.In this study,we systematically investigate the structure-activity relationship of four representative Fe-based metal-organic frameworks(Fe-MOFs)-MIL-101(Fe),MIL-88B(Fe),MIL-88A(Fe),and MIL-53(Fe)-as PI activators for tetracycline(TC)degradation.Among them,MIL-101(Fe)exhibited the highest catalytic performance,owing to its unique Fe3O-OH nodes and mesoporous architecture.The MIL-101(Fe)/PI system achieved 93.3%TC degradation and 55.9%mineralization rate within 60 min.Mechanistic studies combining scavenger quenching,sulfoxide probe transformation,X-ray photoelectron spectroscopy,and X-ray absorption fine structure confirmed the generation of multiple reactive oxygen species,and high-valent Fe(IV)]O and O_(2)^(·-)played major roles in the tetracycline degradation process.Density functional theory calculations further revealed that MIL-101(Fe)and MIL-88B(Fe)effectively interact with PI to form Fe(Ⅲ)-superoxide(Fe(Ⅲ)-O-O^(·-)),a key intermediate in Fe(IV)]O generation.In contrast,the adsorption energy of MIL-53(Fe)and MIL-88A(Fe)was relatively weak,with fewer binding sites,resulting in poor performance.The synergy between Fe(Ⅲ)-O-O^(·-)formation and the pore accessibility of MIL-101(Fe)accounted for its superior catalytic efficiency.This work not only clarifies the structural factors governing PI activation in Fe-MOFs,but also proposes a mechanistically informed strategy for designing high-performance catalysts for antibiotic degradation.
基金Supported by the National Natural Science Foundation of China(62576008)University Annual Scientific Research Plan of Anhui Province(2022AH030023)。
文摘In this paper,a class of discontinuous Cohen-Grossberg neural networks with timevarying delays is considered.Firstly,under the extended Filippov differential inclusions framework,the problem of periodic solutions of the considered neural networks with more relaxed conditions imposed on the amplification functions is analyzed by using set-valued mapping and Kakutani's fixed point theorem,which has rarely been used to study such problem.Secondly,the fixed-time synchronization of the error system of the considered neural networks is also investigated by designing a novel control strategy,which can improve not only the previous ones with sign function greatly,but also can reduce the chattering phenomenon.Finally,two numerical examples are presented to further illustrate the validity of the obtained results.
基金Financial support from National University of Singapore (NUS)(AcRF A-8000-126-00-00)。
文摘Next-generation craniomaxillofacial implants(CMFIs) are redefining personalized bone reconstruction by balancing and optimizing biomechanics,biocompatibility,and bioactivity—the "3Bs".This review highlights recent progress in implant design,material development,additive manufacturing,and preclinical evaluation.Emerging biomaterials,including bioresorbable polymers,magnesium alloys,and composites with bioactive ceramics,enable patient-specific solutions with improved safety and functionality.Triply periodic minimal surface(TPMS) architectures exemplify how structural design can enhance both mechanical performance and biological integration.Additive manufacturing technologies further allow the fabrication of geometrically complex,customized impla nts that meet individual anatomical and pathological needs.In parallel,multiscale evaluation techniques—from mechanical testing to in vitro and in vivo models—provide comprehensive insights into implant performance and safety.Looking ahead,the field is poised to benefit from several transformative trends:the development of smart and multifunctional biomaterials;Al-driven design frameworks that leverage patient-specific data and computational modeling;predictive additive manufacturing with real-time quality control;and advanced biological testing platforms for preclinical evaluation.Together,these advances form the foundation of a data-informed,translational pipeline from bench to bedside.Realizing the full potential of nextgene ration CMFIs will require close interdisciplina ry collaboration across mate rials science,computational engineering,and clinical medicine.
基金supported by National Key R&D Program of China(2021YFD2100700).
文摘Both linoleic acid(18:2 n-6,LA)andα-linolenic acid(18:3 n-3,ALA)are essential fatty acids for infants.The contents of LA and ALA,and their ratio exhibited significant changes in human milk over the past 4 decades,which were not well summarized.Here,we summarized these values in 9898 human breast milk samples of 6664 mothers from 50 countries in 81 studies.A literature search was conducted using PubMed,Embase,and Web of Science between January 1980 and October 2023.The 95%confidence interval of LA/ALA ratio across lactation and gestation ranged from 14.24 to 31.26.The LA content was higher in China and Turkey(>20%)whereas the ALA content was below 1%in Africa.The LA/ALA ratio in countries along the Mediterranean coast exceeded 20 or even 30.LA and ALA contents increased significantly(P<0.01)while the ratio remained stable over the last 40 years.Multivariate meta-regression results showed that regions significantly(P<0.01)determined the LA,ALA,and LA/ALA ratio.Especially,maternal diet could definitely explain the variation while the effects of gestational age,lactation period was not significant.Clinical trials demonstrated that decreasing the LA/ALA ratio increased docosahexaenoic acid(22:6 n-3,DHA)status,reduced arachidonic acid(20:4 n-6,AA)contents,exerted no effect on the visual function of infants,and reached no consensus on growth.The current review aims to provide an overview on the LA and ALA contents and their ratio in human breast milk to raise concern in infant formula.
文摘Circumferentially non-uniform tip clearances induced by rotor eccentricity significantly affect the overall performance of axial compressors,particularly the stability margin.Currently,Computational Fluid Dynamics(CFD)plays a crucial role in the aerodynamic analysis of eccentric compressors.However,conventional full-annulus Unsteady Reynolds-Averaged Navier-Stokes(URANS)simulations are prohibitively expensive for routine design and analysis purposes.To address this issue,the paper presents a novel Fourier-based method,called the Time-Space Collocation(TSC)method,for efficient simulations of eccentric compressors.This method coherently treats temporal and spatial harmonics,making it well-suited to tackle the rotor eccentricity problem,as the perturbation waves induced by eccentricity are time-periodic with respect to the rotor and space-periodic with respect to the stator.Three numerical cases,including NASA Rotor 67,original Stage 67,and Stage 67 with a reduced rotor-stator axial gap,were conducted to verify the effectiveness of the TSC method.The results indicate that,for the rotor eccentricity levels studied in this paper,the influence of weak rotor-stator interactions can be disregarded in the original Stage 67.In this situation,applying three harmonics can accurately capture both the performance variations and the non-uniformly distributed flowfields of eccentric compressors,while achieving a reduction in run time by two orders of magnitude compared to full-annulus URANS simulations.However,in Stage 67 with a reduced rotor-stator axial gap,the results that include rotor-stator interactions align much more closely with the URANS results.Nevertheless,the TSC simulations can still achieve speed-ups of several dozen times.Overall,the TSC method shows promising potential for application within the engineering community.
