The Distributed Propulsion Wing(DPW)presents prominent advantages in terms of energy conservation during flight,but the intense integration of propulsive internal flow with aerodynamic external flow brings significant...The Distributed Propulsion Wing(DPW)presents prominent advantages in terms of energy conservation during flight,but the intense integration of propulsive internal flow with aerodynamic external flow brings significant design challenges.To tackle this issue,this paper undertakes a comprehensive investigation of the aero-propulsive coupling performance of the DPW under both hovering and cruising conditions,and subsequently proposes a multi-level collaboration optimization design method based on the decomposition principle.Specifically,the complex 3D surfaces of DPW are systematically dissociated into simple 2D curves with inherent relationships for design.The decomposition is achieved based on the analysis results of the aero-propulsive coupling characteristics.And a DPW design case is conducted and subsequently analyzed in order to further validate the effectiveness and feasibility of the proposed design method.It is shown that a 115.75%drag reduction of DPW can be achieved at cruise under a specified thrust level.Furthermore,the DPW exhibits inherent characteristics of consistent lift-to-drag ratio with the thrust-drag balance constraint,regardless of variations in incoming flow velocity or total thrust.展开更多
A high performance liquid chromatography coupled with electrospray ionization-tandem mass spectrome try（HPLC-ESI-MS/MS） method was developed for the analysis and identification of ginsenosides in the extracts of raw...A high performance liquid chromatography coupled with electrospray ionization-tandem mass spectrome try（HPLC-ESI-MS/MS） method was developed for the analysis and identification of ginsenosides in the extracts of raw Panax ginseng（RPG） and steamed Panax ginseng at high temperatures（SPGHT）. A total of 25 ginsenosides were extracted include of which 10 low-polar ginsenosides, such as ginsenosides F4, Rk3, Rh4, 20S-Rg3, 20R-Rg3 and so on, were identified according to their HPLC retention time and MS/MS data. The results indicated that the low polar ginsenosides were seldom found in RPG. For the exploration of the transformation pattern of the ginsenosides in steam processing, the standards of ginsenosides Re, Rg1, Rb1, Rc, Rb2, Rb3 and Rd were selected and hydrolyzed at a temperature of 120 oC. The results show that these polar ginsenosides can be converted to low-polar ginsenosides such as Rg2, Rg6, F4, Rk3 and Rg5 by hydrolyzing the sugar chains.展开更多
We investigated the antidepressant-like activity of Hemerocallis citrine Baroni extract(HCE)in a simulated microgravity(SMG)-induced rat model of depression using a metabolomics method.A rat model,generated via 14 d o...We investigated the antidepressant-like activity of Hemerocallis citrine Baroni extract(HCE)in a simulated microgravity(SMG)-induced rat model of depression using a metabolomics method.A rat model,generated via 14 d of SMG induction,was validated from the reduced sucrose preference and the enhanced immobility time in the forced swimming test.HCE and paroxetine reversed certain metabolite profiles.Anti-depressant effects of HCE might involve the regulation of several metabolic pathways,such as phenylalanine,glutamic acid,and tryptophan metabolism and changes in energy metabolism.5-Hydroxytryptophan,hippuric acid,phenylacetylglycine,citric acid,3-hydroxykynurenine,cyclic AMP,and L-DOPA profiles were altered upon HCE and paroxetine administration.Furthermore,glutamic acid was only regulated in the HCE group,while xanthurenic acid and deoxyuridine were reversed in the positive group,suggesting differences in the mechanisms between the positive drugs and HCE in improving glutamic acid metabolism.This study provided a theoretical foundation for the application of HCE in depression therapy.展开更多
In this study, seven alkaloids were detected in Wu-tou decoction using ultra performance liquid chromatography coupled with tandem mass spectrometry （UPLC-MSn）. The aim of this study was to investigate the effect of...In this study, seven alkaloids were detected in Wu-tou decoction using ultra performance liquid chromatography coupled with tandem mass spectrometry （UPLC-MSn）. The aim of this study was to investigate the effect of Fritillariae Cirrhosae Bulbus, Fritillariae Thunbergii Bulbus, Pinelliae Rhizoma in different ratios with Wu-tou decoction （2：1, 1：1, 1：2） by measuring the therapeutic effects in Wu-tou decoction of main seven alkaloids including benzoylaconitine （BA）, benzoylmesaconitine （BM）, benzoylhypaconitine （BH）, hypaconitine （HA）, fuziline （FU）, niaolin （NE） and deoxyaconitine （DA）. The permeability of aconitum alkaloids extract through a Caco-2 cell monolayer was analyzed in the absence and presence of Fritillariae Cirrhosae Bulbus, Fritillariae Thunbergii Bulbus, and Pinelliae Rhizoma, respectively. The results showed that Pinelliae Rhizoma could reduce the absorption of the alkaloids and increase the excretion of the alkaloids, which would attenuate the therapeutic effects of Wu-tou decoction. Therefore, Pinelliae Rhizoma is an incompatible herb of Wu-tou decoction because of the inhibition of the absorption of alkaloids in the intestine. And that Fritillariae Cirrhosae Bulbus and Fritillariae rhunbergii Bulbus showed the effects to improve the permeability of the alkaloids in Wu-tou decoction. These effects of these two herbs were similar, but the former was stronger than the latter, which most likely is due to the fact that the compositions of these two traditional Chinese medicines are similar. The in vitro data suggests that the compounds such as fritillary presented in alkaloids in the formula maybe improve the therapeutic function caused by the increased bioavailability of alkaloids in intestine.展开更多
In this paper,a statistical second-order twoscale（SSOTS） method is developed to simulate the dynamic thcrmo-mechanical performances of the statistically inhomogeneous materials.For this kind of composite material,th...In this paper,a statistical second-order twoscale（SSOTS） method is developed to simulate the dynamic thcrmo-mechanical performances of the statistically inhomogeneous materials.For this kind of composite material,the random distribution characteristics of particles,including the shape,size,orientation,spatial location,and volume fractions,are all considered.Firstly,the repre.sentation for the microscopic configuration of the statistically inhomogeneous materials is described.Secondly,the SSOTS formulation for the dynamic thermo-mechanical coupled problem is proposed in a constructive way,including the cell problems,effective thermal and mechanical parameters,homogenized problems,and the SSOTS formulas of the temperatures,displacements,heat flux densities and stresses.And then the algorithm procedure corresponding to the SSOTS method is brought forward.The numerical results obtained by using the SSOTS algorithm are compared with those by classical methods.In addition,the thermo-mechanical coupling effect is studied by comparing the results of coupled case with those of uncoupled case.It demonstrates that the coupling effect on the temperatures,heat flux densities,displacements,and stresses is very distinct.The results show that the SSOTS method is valid to predict the dynamic thermo-mechanical coupled performances of statistically inhomogeneous materials.展开更多
Recently, the spar platform concept develops quickly in the offshore oil and gas exploitations, especially in deep and ultra-deep water, owing to its benign motion performance, excellent stability and adaptation to wi...Recently, the spar platform concept develops quickly in the offshore oil and gas exploitations, especially in deep and ultra-deep water, owing to its benign motion performance, excellent stability and adaptation to wide range of water depth. Many new spar concepts have been put forward with the purpose of reducing fabrication difficulty and cost, while meeting the requirements of exploitation in the meantime Based on the aims mentioned above, a new spar concept was presented in this article and its hydrodynamics both in operating and survival conditions was studied by means of numerical simulation. Basic model tests were also conducted to calibrate the numerical approach. Following aspects are highlighted： （1） new spar concept, （2） global performance of the spar concept and （3） mooring line analysis.展开更多
Complicated global climate problems trigger researchers from different scientific disciplines to link multiphysics simulations called models for integrated modeling of climate changes by using a software framework cal...Complicated global climate problems trigger researchers from different scientific disciplines to link multiphysics simulations called models for integrated modeling of climate changes by using a software framework called earth system modeling （ESM）. As its critical component, coupler is in charge of connections and interactions among models. With the advance of next-generation models, greater data transfer volume and higher coupling frequency are expected to put heavy performance burden on coupler. High efficient coupling techniques are required. In this paper, we propose the sub-domain mapping method to improve the parallel coupling consisted of data transfer and data transformation. By using one specific interpolation oriented communication routing, the communication operations that are originally decentralized in various steps can be combined together for execution. This can reduce the redundant communications and the entailed synchronization costs. The tests on the Tianhe-lA （TH-1A） supercomputer show that our method can achieve 1.1 to 4.9 fold performance improve- ments. We also present further optimization solution for the multi-interpolation cases. The test results show that our method can achieve up to 3.4 fold speedup over the original coupling execution of the current climate system.展开更多
Curcumin,a safe natural yellow pigment with a wide range of pharmacological activities,is used both in herbal drugs and as a food coloring agents.Studies have shown that curcumin would suffer from extensive metabolism...Curcumin,a safe natural yellow pigment with a wide range of pharmacological activities,is used both in herbal drugs and as a food coloring agents.Studies have shown that curcumin would suffer from extensive metabolism in vivoand the predominant metabolic pathways are reduction and conjugation.In order to comprehensively study the metabolism and enrich the metabolic profile of cxurcumin in vivo,we carried out this research.A systematic method with highly sensitive UPLC-Q/TOF-MS was established to analyze different biological samples of rats after展开更多
Gestational diabetes mellitus(GDM)is a high-prevalence disease and diagnosed in middle pregnancy.Acylcarnitines are a series of fatty acid esters of carnitine and play important roles in fatty acid and carbohydrate me...Gestational diabetes mellitus(GDM)is a high-prevalence disease and diagnosed in middle pregnancy.Acylcarnitines are a series of fatty acid esters of carnitine and play important roles in fatty acid and carbohydrate metabolism.However,the role of acylcarnitine on the development of GDM remains unclear.This case-control study involving 214 study participants(107 GDM cases and 107 matched controls)was conducted in a cohort,in China,from 2013 to 2015.The levels of carnitine and 36 acylcarnitines in serum samples collected at the early stage of pregnancy were determined by using ultra-high performance liquid chromatography coupled with tandem mass spectrometry.The associations of the levels of the 37 targeted compounds with GDM risk were investigated by using binary conditional logistic regression models.Alterations in acylcarnitine levels were observed 9–17 weeks before GDM diagnosis.The increases in levels of propionyl-carnitine,malonyl-carnitine,isovaleryl-carnitine,palmitoyl-carnitine and linoleoyl-carnitine were associated with GDM risk with odds ratios(ORs)per standard deviation(SD)increment greater than 1(p<0.05),after adjustment for potential confounding factors(pre-pregnancy body mass index and parity).On the contrary,the increases of decanoyl-carnitine,decenoyl-carnitine,tetradecenoyl-carnitine,tetradecandienoylcarnitine levels were associated with the reduced risk for GDM(ORs per SD<1,p<0.05).To our knowledge,the present study is the largest case-control study to investigate the association between early-pregnancy acylcarnitine levels in serum and GDM risk.The findings add to the evidence for the association between acylcarnitine levels and GDM risk.展开更多
基金co-supported by the Equipment Advance Research Project of China(No.50911040803)the National Defense Pre-research Foundation of China(No.2021-JCJQJJ-0805)the Aeronautical Science Foundation of China(No.2024Z006053001)。
文摘The Distributed Propulsion Wing(DPW)presents prominent advantages in terms of energy conservation during flight,but the intense integration of propulsive internal flow with aerodynamic external flow brings significant design challenges.To tackle this issue,this paper undertakes a comprehensive investigation of the aero-propulsive coupling performance of the DPW under both hovering and cruising conditions,and subsequently proposes a multi-level collaboration optimization design method based on the decomposition principle.Specifically,the complex 3D surfaces of DPW are systematically dissociated into simple 2D curves with inherent relationships for design.The decomposition is achieved based on the analysis results of the aero-propulsive coupling characteristics.And a DPW design case is conducted and subsequently analyzed in order to further validate the effectiveness and feasibility of the proposed design method.It is shown that a 115.75%drag reduction of DPW can be achieved at cruise under a specified thrust level.Furthermore,the DPW exhibits inherent characteristics of consistent lift-to-drag ratio with the thrust-drag balance constraint,regardless of variations in incoming flow velocity or total thrust.
基金Supported by the Key Project of Jilin Provincial Science and Technology Department, China(No.20090908)the Project of Changchun Science and Technology Bureau, China(No.2008256)the Special Cooperative Project for Hitech Industrializa-tion of Jilin Provincial Science and Chinese Academy of Sciences, China(No.2009SYHZ0026)
文摘A high performance liquid chromatography coupled with electrospray ionization-tandem mass spectrome try（HPLC-ESI-MS/MS） method was developed for the analysis and identification of ginsenosides in the extracts of raw Panax ginseng（RPG） and steamed Panax ginseng at high temperatures（SPGHT）. A total of 25 ginsenosides were extracted include of which 10 low-polar ginsenosides, such as ginsenosides F4, Rk3, Rh4, 20S-Rg3, 20R-Rg3 and so on, were identified according to their HPLC retention time and MS/MS data. The results indicated that the low polar ginsenosides were seldom found in RPG. For the exploration of the transformation pattern of the ginsenosides in steam processing, the standards of ginsenosides Re, Rg1, Rb1, Rc, Rb2, Rb3 and Rd were selected and hydrolyzed at a temperature of 120 oC. The results show that these polar ginsenosides can be converted to low-polar ginsenosides such as Rg2, Rg6, F4, Rk3 and Rg5 by hydrolyzing the sugar chains.
基金Chinese Academy of Agricultural Sciences(Grant No.125161015000150013)the grants from the China Agriculture Research System(Grant No.CARS-21).
文摘We investigated the antidepressant-like activity of Hemerocallis citrine Baroni extract(HCE)in a simulated microgravity(SMG)-induced rat model of depression using a metabolomics method.A rat model,generated via 14 d of SMG induction,was validated from the reduced sucrose preference and the enhanced immobility time in the forced swimming test.HCE and paroxetine reversed certain metabolite profiles.Anti-depressant effects of HCE might involve the regulation of several metabolic pathways,such as phenylalanine,glutamic acid,and tryptophan metabolism and changes in energy metabolism.5-Hydroxytryptophan,hippuric acid,phenylacetylglycine,citric acid,3-hydroxykynurenine,cyclic AMP,and L-DOPA profiles were altered upon HCE and paroxetine administration.Furthermore,glutamic acid was only regulated in the HCE group,while xanthurenic acid and deoxyuridine were reversed in the positive group,suggesting differences in the mechanisms between the positive drugs and HCE in improving glutamic acid metabolism.This study provided a theoretical foundation for the application of HCE in depression therapy.
基金supported by the National Natural Sciences Foundation of China(No.81274046)National Basic Research Program of China("973 Program")(Nos.2011CB505300, 2011CB505305)
文摘In this study, seven alkaloids were detected in Wu-tou decoction using ultra performance liquid chromatography coupled with tandem mass spectrometry （UPLC-MSn）. The aim of this study was to investigate the effect of Fritillariae Cirrhosae Bulbus, Fritillariae Thunbergii Bulbus, Pinelliae Rhizoma in different ratios with Wu-tou decoction （2：1, 1：1, 1：2） by measuring the therapeutic effects in Wu-tou decoction of main seven alkaloids including benzoylaconitine （BA）, benzoylmesaconitine （BM）, benzoylhypaconitine （BH）, hypaconitine （HA）, fuziline （FU）, niaolin （NE） and deoxyaconitine （DA）. The permeability of aconitum alkaloids extract through a Caco-2 cell monolayer was analyzed in the absence and presence of Fritillariae Cirrhosae Bulbus, Fritillariae Thunbergii Bulbus, and Pinelliae Rhizoma, respectively. The results showed that Pinelliae Rhizoma could reduce the absorption of the alkaloids and increase the excretion of the alkaloids, which would attenuate the therapeutic effects of Wu-tou decoction. Therefore, Pinelliae Rhizoma is an incompatible herb of Wu-tou decoction because of the inhibition of the absorption of alkaloids in the intestine. And that Fritillariae Cirrhosae Bulbus and Fritillariae rhunbergii Bulbus showed the effects to improve the permeability of the alkaloids in Wu-tou decoction. These effects of these two herbs were similar, but the former was stronger than the latter, which most likely is due to the fact that the compositions of these two traditional Chinese medicines are similar. The in vitro data suggests that the compounds such as fritillary presented in alkaloids in the formula maybe improve the therapeutic function caused by the increased bioavailability of alkaloids in intestine.
基金supported by the National Natural Science Foundation of China(Grants 11471262,11202032)the Basic Research Project of National Defense(Grant B 1520132013)supported by the State Key Laboratory of Science and Engineering Computing and Center for high performance computing of Northwestem Polytechnical University
文摘In this paper,a statistical second-order twoscale（SSOTS） method is developed to simulate the dynamic thcrmo-mechanical performances of the statistically inhomogeneous materials.For this kind of composite material,the random distribution characteristics of particles,including the shape,size,orientation,spatial location,and volume fractions,are all considered.Firstly,the repre.sentation for the microscopic configuration of the statistically inhomogeneous materials is described.Secondly,the SSOTS formulation for the dynamic thermo-mechanical coupled problem is proposed in a constructive way,including the cell problems,effective thermal and mechanical parameters,homogenized problems,and the SSOTS formulas of the temperatures,displacements,heat flux densities and stresses.And then the algorithm procedure corresponding to the SSOTS method is brought forward.The numerical results obtained by using the SSOTS algorithm are compared with those by classical methods.In addition,the thermo-mechanical coupling effect is studied by comparing the results of coupled case with those of uncoupled case.It demonstrates that the coupling effect on the temperatures,heat flux densities,displacements,and stresses is very distinct.The results show that the SSOTS method is valid to predict the dynamic thermo-mechanical coupled performances of statistically inhomogeneous materials.
基金the Major Fundamental Research Program of Science and Technology Commission of Shanghai Municipality (Grant No. 05DJ14001)the National High Technology Research and Development Program of China (863 Program, Grant No. 2006AA09A107).
文摘Recently, the spar platform concept develops quickly in the offshore oil and gas exploitations, especially in deep and ultra-deep water, owing to its benign motion performance, excellent stability and adaptation to wide range of water depth. Many new spar concepts have been put forward with the purpose of reducing fabrication difficulty and cost, while meeting the requirements of exploitation in the meantime Based on the aims mentioned above, a new spar concept was presented in this article and its hydrodynamics both in operating and survival conditions was studied by means of numerical simulation. Basic model tests were also conducted to calibrate the numerical approach. Following aspects are highlighted： （1） new spar concept, （2） global performance of the spar concept and （3） mooring line analysis.
文摘Complicated global climate problems trigger researchers from different scientific disciplines to link multiphysics simulations called models for integrated modeling of climate changes by using a software framework called earth system modeling （ESM）. As its critical component, coupler is in charge of connections and interactions among models. With the advance of next-generation models, greater data transfer volume and higher coupling frequency are expected to put heavy performance burden on coupler. High efficient coupling techniques are required. In this paper, we propose the sub-domain mapping method to improve the parallel coupling consisted of data transfer and data transformation. By using one specific interpolation oriented communication routing, the communication operations that are originally decentralized in various steps can be combined together for execution. This can reduce the redundant communications and the entailed synchronization costs. The tests on the Tianhe-lA （TH-1A） supercomputer show that our method can achieve 1.1 to 4.9 fold performance improve- ments. We also present further optimization solution for the multi-interpolation cases. The test results show that our method can achieve up to 3.4 fold speedup over the original coupling execution of the current climate system.
基金partly supported by National Natural Science Foundation of China(No.81430095)also by Special National Program on Key Basic Research Project(No.2014CB560706)
文摘Curcumin,a safe natural yellow pigment with a wide range of pharmacological activities,is used both in herbal drugs and as a food coloring agents.Studies have shown that curcumin would suffer from extensive metabolism in vivoand the predominant metabolic pathways are reduction and conjugation.In order to comprehensively study the metabolism and enrich the metabolic profile of cxurcumin in vivo,we carried out this research.A systematic method with highly sensitive UPLC-Q/TOF-MS was established to analyze different biological samples of rats after
基金supported by the National Natural Science Foundation of China(21437002)the General Research Fund(12319716)from Research Grants Council of Hong Kong
文摘Gestational diabetes mellitus(GDM)is a high-prevalence disease and diagnosed in middle pregnancy.Acylcarnitines are a series of fatty acid esters of carnitine and play important roles in fatty acid and carbohydrate metabolism.However,the role of acylcarnitine on the development of GDM remains unclear.This case-control study involving 214 study participants(107 GDM cases and 107 matched controls)was conducted in a cohort,in China,from 2013 to 2015.The levels of carnitine and 36 acylcarnitines in serum samples collected at the early stage of pregnancy were determined by using ultra-high performance liquid chromatography coupled with tandem mass spectrometry.The associations of the levels of the 37 targeted compounds with GDM risk were investigated by using binary conditional logistic regression models.Alterations in acylcarnitine levels were observed 9–17 weeks before GDM diagnosis.The increases in levels of propionyl-carnitine,malonyl-carnitine,isovaleryl-carnitine,palmitoyl-carnitine and linoleoyl-carnitine were associated with GDM risk with odds ratios(ORs)per standard deviation(SD)increment greater than 1(p<0.05),after adjustment for potential confounding factors(pre-pregnancy body mass index and parity).On the contrary,the increases of decanoyl-carnitine,decenoyl-carnitine,tetradecenoyl-carnitine,tetradecandienoylcarnitine levels were associated with the reduced risk for GDM(ORs per SD<1,p<0.05).To our knowledge,the present study is the largest case-control study to investigate the association between early-pregnancy acylcarnitine levels in serum and GDM risk.The findings add to the evidence for the association between acylcarnitine levels and GDM risk.
