Dear Editor,Large-scale phenotyping efforts have shown that placental defects correlate strongly with embryonic lethal mouse mutants(Perez-Garcia et al.,2018).To rescue normal development of these mutant embryos,tetra...Dear Editor,Large-scale phenotyping efforts have shown that placental defects correlate strongly with embryonic lethal mouse mutants(Perez-Garcia et al.,2018).To rescue normal development of these mutant embryos,tetraploid complementation can be a reliable strategy,in which,tetraploid cells form extraembryonic lineages thus providing the embryo with a wild-type placenta(Nagy et al.,1990).展开更多
基金supported by the Genome Tagging Project and grants from the National Key Research and Development Program of China(2024YFA1800010,2020YFA0509000)the National Science and Technology Major Project of China(2023ZD0500500)+2 种基金the National Natural Science Foundation of China(32488101,32030029,32293231,32370909)partly supported by Shanghai Municipal Science and Technology Major Project(22YS1400900,23HC1401000)support of the Sanofi Scholarship Program.
文摘Dear Editor,Large-scale phenotyping efforts have shown that placental defects correlate strongly with embryonic lethal mouse mutants(Perez-Garcia et al.,2018).To rescue normal development of these mutant embryos,tetraploid complementation can be a reliable strategy,in which,tetraploid cells form extraembryonic lineages thus providing the embryo with a wild-type placenta(Nagy et al.,1990).
