Objective： To quantitatively identify and grade trigeminal sensory functions after 3 major surgical procedures of trigeminal neuralgia using a newly developed quantitative sensory testing technique, current perceptio...Objective： To quantitatively identify and grade trigeminal sensory functions after 3 major surgical procedures of trigeminal neuralgia using a newly developed quantitative sensory testing technique, current perception threshold measurement （CPTM）. Methods： In the current study, there were 48 trigeminal neuralgia patients without history of prior surgical treatment. These patients received one of the following 3 surgical procedures, microvascular decompression （MVD）, peripheral nerve block with alcohol （PNB）, or percutaneous radiofrequency thermocoagulation （PRFT）. The quantitative sensory testing measurement, CPTM, and conventional qualitative sensory testing measurements were performed preoperatively and postoperatively to evaluate and grade the trigeminal sensory functions All 3 major cutaneous sensory fiber types, large myelinated fibers （A beta）, small myelinated fibers （A delta） and unmyelinated fibers（C） were allowed to quantitatively evaluate and grade by CPTM. The results of the measurements were statistically analyzed using a one-way analysis of variance （single factor）. Each subject was his/her own control for comparison of the preoperative to postoperative state on the asymptomatic and symptomatic sides. Subjects were tested 48 h preoperatively and 4 weeks postoperatively. Results： PNB with alcohol and PRFT caused significant sensory dysfunction postoperatively in every fiber type, indicating damage to all fibers. On the contrary, the sensory function in all 3 fiber types was unchanged after MVD management. Conclusion： Among the 3 major surgical procedures tested, only MVD preserves sensory function in trigeminal system. CPTM is of quantitative nature on the evaluation of sensory functions of nerve fibers展开更多
<strong>Objectives: </strong>To investigate influence of metabolic syndrome on vibration perception threshold in first-degree relatives of type 2 diabetes who were not diagnosed with diabets before. <st...<strong>Objectives: </strong>To investigate influence of metabolic syndrome on vibration perception threshold in first-degree relatives of type 2 diabetes who were not diagnosed with diabets before. <strong>Material and Methods:</strong> First-degree relatives of type 2 diabetes at the age of 40 - 60 s who had not been diagnosed with diabetes before were enrolled. Height, weight, waist circumference, hip circumference, blood pressure (systolic and diastolic blood pressure), body fat percentage, fasting plasma lipid, fasting plasma glucose, 2-hour blood glucose after 75 g oral glucose and vibration perception threshold were measured. <strong>Results:</strong> 58 subjects were diagnosed with the level of vibration perception threshold ≥ 16 V. Vibration perception threshold in the metabolic syndrome group was significantly higher than that in the non-metabolic syndrome group (<em>P</em> < 0.05). Vibration perception threshold increased with the increase of metabolic syndrome component. The group with ≥3 components of metabolic syndrome had a significantly higher level of vibration perception, as compared with that of group with 0 component, group with 1 component of metabolic syndrome (<em>p</em> < 0.01). Group with 2 components of metabolic syndrome had a significantly higher level of vibration perception threshold when comparing with group with 0 component (<em>P</em> < 0.05). Vibration perception threshold was positively correlated with weight, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose and 2-hour blood glucose. Stepwise multiple regression analysis showed that there was a positive correlation between waist circumference, systolic blood pressure and vibration perception threshold. <strong>Conclusion:</strong> Some first-degree relatives of type 2 diabetes who have not been diagnosed with diabetes have high risk of peripheral neuropathy, especially those with metabolic syndrome. Waist circumference and blood pressure are the main factors affecting Vibration perception threshold levels. Early detection of vibration perception threshold should be performed in first-degree relatives of type 2 diabetes with metabolic syndrome. Waist circumference and blood pressure may be important risk factors of peripheral neuropathy for them.展开更多
A generalized mathematical model of human body current threshold for perception was established and the current flowing through human body could be arbitrary cyclical waveforms.The relationship between human body curr...A generalized mathematical model of human body current threshold for perception was established and the current flowing through human body could be arbitrary cyclical waveforms.The relationship between human body current threshold for perception and current frequency, true root mean square(RMS) value and influence factor was described.A test system was established based on electroencephalogram(EEG) to study the relationship between human body current threshold for perception and current waveform, frequency ...展开更多
Driving simulators involve the capability of simulating critical and dangerous driving situations up to the limits of active safety. They are employed for investigating the interactions of the driver-vehicle system un...Driving simulators involve the capability of simulating critical and dangerous driving situations up to the limits of active safety. They are employed for investigating the interactions of the driver-vehicle system under reproducible and non-dangerous conditions. Because of their flexibility they are well established in scientific research. They are mainly used in current automotive fields of research like driver assistance and autonomous driving systems. The development of assistance systems makes the human being as the directly concerned component irreplaceable in the development process. Here the use of driving simulators has become an essential element, because they offer the possibility to integrate the human being as a real part into the simulation environment. It must be considered that the circuit of information has to be the same as under real driving conditions. Otherwise the results are not transferable. This paper deals with the possibilities of presenting all information to the driver, which are necessary to give him a realistic impression of driving. A main subject is the sensation of yaw-movements, which could be of interest when novel kinds of moving base systems are designed.展开更多
Objective:To investigate the prevalence of diabetic at-risk foot and its associated factors.Methods:A total of 838 hospitalized patients with type 2 diabetes were screened for at-risk foot.Neural and vascular disorder...Objective:To investigate the prevalence of diabetic at-risk foot and its associated factors.Methods:A total of 838 hospitalized patients with type 2 diabetes were screened for at-risk foot.Neural and vascular disorders were evaluated by assessing vibration perception thresholds and ankle brachial indexes (ABIs).After excluding 12 patients with abnormally high ABIs,remaining individuals with neural and/or vascular disorder were identified as at-risk patients and further classified into three subtypes:isolated neural disorder,isolated vascular disorder and mixed disorder.Potential associated factors were examined using Logistic regression models.Results:In the final sample of 826 individuals,the prevalence of diabetic at-risk foot was 30.6％.Among all at-risk patients,isolated neural disorders (69.6％) were more common than mixed (16.2％) or isolated vascular disorders (14.2％).Isolated neural and vascular disorders shared specific risk factors,including age per 20-year increment (odds ratio [95％ CI],3.73 [2.59-5.37] and 4.01 [1.98-8.11]),diabetic duration ≥10 years (1.69 11.13-2.54] and 3.29 [1.49-7.24]) and systolic blood pressure ≥140 mmHg (1.96 [1.31-2.93] and 2.90 [1.38-6.10]) respectively.In addition,isolated neural disorders were associated with a heavy smoking history (95％CI 2.69 [1.15-6.31]),increased high-sensitivity C-reactive protein levels (95％CI 1.30 [1.04-1.62]) and mild obesity (95％CI 0.49 [0.20-1.241).Isolated vascular disorders were linked with decreased high density lipoprotein (HDL) cholesterol levels (95％CI 3.42 [1.31-8.96]) and increased triglycerides levels (95％CI 2.74 [1.26-5.97]).Conclusions:Diabetic at-risk foot is epidemic among hospitalized patients with type 2 diabetes.Aging,long-term diabetes,hypertension,smoking,inflammatory response and dyslipidemia may be associated with the prevalence of diabetic at-risk foot.展开更多
文摘Objective： To quantitatively identify and grade trigeminal sensory functions after 3 major surgical procedures of trigeminal neuralgia using a newly developed quantitative sensory testing technique, current perception threshold measurement （CPTM）. Methods： In the current study, there were 48 trigeminal neuralgia patients without history of prior surgical treatment. These patients received one of the following 3 surgical procedures, microvascular decompression （MVD）, peripheral nerve block with alcohol （PNB）, or percutaneous radiofrequency thermocoagulation （PRFT）. The quantitative sensory testing measurement, CPTM, and conventional qualitative sensory testing measurements were performed preoperatively and postoperatively to evaluate and grade the trigeminal sensory functions All 3 major cutaneous sensory fiber types, large myelinated fibers （A beta）, small myelinated fibers （A delta） and unmyelinated fibers（C） were allowed to quantitatively evaluate and grade by CPTM. The results of the measurements were statistically analyzed using a one-way analysis of variance （single factor）. Each subject was his/her own control for comparison of the preoperative to postoperative state on the asymptomatic and symptomatic sides. Subjects were tested 48 h preoperatively and 4 weeks postoperatively. Results： PNB with alcohol and PRFT caused significant sensory dysfunction postoperatively in every fiber type, indicating damage to all fibers. On the contrary, the sensory function in all 3 fiber types was unchanged after MVD management. Conclusion： Among the 3 major surgical procedures tested, only MVD preserves sensory function in trigeminal system. CPTM is of quantitative nature on the evaluation of sensory functions of nerve fibers
文摘<strong>Objectives: </strong>To investigate influence of metabolic syndrome on vibration perception threshold in first-degree relatives of type 2 diabetes who were not diagnosed with diabets before. <strong>Material and Methods:</strong> First-degree relatives of type 2 diabetes at the age of 40 - 60 s who had not been diagnosed with diabetes before were enrolled. Height, weight, waist circumference, hip circumference, blood pressure (systolic and diastolic blood pressure), body fat percentage, fasting plasma lipid, fasting plasma glucose, 2-hour blood glucose after 75 g oral glucose and vibration perception threshold were measured. <strong>Results:</strong> 58 subjects were diagnosed with the level of vibration perception threshold ≥ 16 V. Vibration perception threshold in the metabolic syndrome group was significantly higher than that in the non-metabolic syndrome group (<em>P</em> < 0.05). Vibration perception threshold increased with the increase of metabolic syndrome component. The group with ≥3 components of metabolic syndrome had a significantly higher level of vibration perception, as compared with that of group with 0 component, group with 1 component of metabolic syndrome (<em>p</em> < 0.01). Group with 2 components of metabolic syndrome had a significantly higher level of vibration perception threshold when comparing with group with 0 component (<em>P</em> < 0.05). Vibration perception threshold was positively correlated with weight, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose and 2-hour blood glucose. Stepwise multiple regression analysis showed that there was a positive correlation between waist circumference, systolic blood pressure and vibration perception threshold. <strong>Conclusion:</strong> Some first-degree relatives of type 2 diabetes who have not been diagnosed with diabetes have high risk of peripheral neuropathy, especially those with metabolic syndrome. Waist circumference and blood pressure are the main factors affecting Vibration perception threshold levels. Early detection of vibration perception threshold should be performed in first-degree relatives of type 2 diabetes with metabolic syndrome. Waist circumference and blood pressure may be important risk factors of peripheral neuropathy for them.
基金Supported by the Ministry of Science and Technology of China (No. NCSTE-2006-JKZX-167)Beijing Key Laboratory (Measurement and Control of Electro-mechanical Systems) (No. 82063005)
文摘A generalized mathematical model of human body current threshold for perception was established and the current flowing through human body could be arbitrary cyclical waveforms.The relationship between human body current threshold for perception and current frequency, true root mean square(RMS) value and influence factor was described.A test system was established based on electroencephalogram(EEG) to study the relationship between human body current threshold for perception and current waveform, frequency ...
文摘Driving simulators involve the capability of simulating critical and dangerous driving situations up to the limits of active safety. They are employed for investigating the interactions of the driver-vehicle system under reproducible and non-dangerous conditions. Because of their flexibility they are well established in scientific research. They are mainly used in current automotive fields of research like driver assistance and autonomous driving systems. The development of assistance systems makes the human being as the directly concerned component irreplaceable in the development process. Here the use of driving simulators has become an essential element, because they offer the possibility to integrate the human being as a real part into the simulation environment. It must be considered that the circuit of information has to be the same as under real driving conditions. Otherwise the results are not transferable. This paper deals with the possibilities of presenting all information to the driver, which are necessary to give him a realistic impression of driving. A main subject is the sensation of yaw-movements, which could be of interest when novel kinds of moving base systems are designed.
文摘Objective:To investigate the prevalence of diabetic at-risk foot and its associated factors.Methods:A total of 838 hospitalized patients with type 2 diabetes were screened for at-risk foot.Neural and vascular disorders were evaluated by assessing vibration perception thresholds and ankle brachial indexes (ABIs).After excluding 12 patients with abnormally high ABIs,remaining individuals with neural and/or vascular disorder were identified as at-risk patients and further classified into three subtypes:isolated neural disorder,isolated vascular disorder and mixed disorder.Potential associated factors were examined using Logistic regression models.Results:In the final sample of 826 individuals,the prevalence of diabetic at-risk foot was 30.6％.Among all at-risk patients,isolated neural disorders (69.6％) were more common than mixed (16.2％) or isolated vascular disorders (14.2％).Isolated neural and vascular disorders shared specific risk factors,including age per 20-year increment (odds ratio [95％ CI],3.73 [2.59-5.37] and 4.01 [1.98-8.11]),diabetic duration ≥10 years (1.69 11.13-2.54] and 3.29 [1.49-7.24]) and systolic blood pressure ≥140 mmHg (1.96 [1.31-2.93] and 2.90 [1.38-6.10]) respectively.In addition,isolated neural disorders were associated with a heavy smoking history (95％CI 2.69 [1.15-6.31]),increased high-sensitivity C-reactive protein levels (95％CI 1.30 [1.04-1.62]) and mild obesity (95％CI 0.49 [0.20-1.241).Isolated vascular disorders were linked with decreased high density lipoprotein (HDL) cholesterol levels (95％CI 3.42 [1.31-8.96]) and increased triglycerides levels (95％CI 2.74 [1.26-5.97]).Conclusions:Diabetic at-risk foot is epidemic among hospitalized patients with type 2 diabetes.Aging,long-term diabetes,hypertension,smoking,inflammatory response and dyslipidemia may be associated with the prevalence of diabetic at-risk foot.
