Distribution of plant roots in a red soil derived from granite was investigated to study the effect of plantroots on intensifying soil penetrability and anti-scouribility by the double-cutting-ring and the undisturbed...Distribution of plant roots in a red soil derived from granite was investigated to study the effect of plantroots on intensifying soil penetrability and anti-scouribility by the double-cutting-ring and the undisturbedsoil-flume methods, respectively. The plant roots system consisting mostly of fibrils, < 1 mm in diameter,was mainly distributed in the upper surface soil 30 cm in depth. It can remarhably increase the penetrabilityand anti-scouribility of the red soil derived from granite. When the root density was > 0.35 root cm-2, theintensifying effect of roots on both the penetrability and the anti-scouribility could be described by exponentequations, △ Ks = 0.0021RD1.4826 (R2 = 0.9313) and △ As = 0.0003RD1.8478 (R2 = O.9619), where △ Ks isthe value of intensified soil penetrability, a As the value of intensified soil anti-scouribility and RD the rootdensity, especially in the top soils within 30 cm in depth where plant roots were conceotrated.展开更多
OBJECTIVE Hypericin,a powerful naturally photosensitizer in photodynamic therapy(PDT),is suitable for treating skin diseases involving excess capillary proliferation.In the present study,we aimed to evaluate the skin ...OBJECTIVE Hypericin,a powerful naturally photosensitizer in photodynamic therapy(PDT),is suitable for treating skin diseases involving excess capillary proliferation.In the present study,we aimed to evaluate the skin penetrability of a topically applied hypericin,expecting reducing the risk of prolonged skin photosensitivity,which often occurs after systemic administration.METHODS The Franz diffusion cell assay was performed to evaluate different penetration enhancers.In vivo studies,fluorescence microscopy was performed to examine the distribution of hypericin in the skin,macroscopic and microscopic analyses were also carried out to detect pathological changes in the skin after topical hypericin-PDT treatment.Immunohistochemistry was used to determine the expression of PECAM-1 in the treated skin.RESULTS 5% menthol facilitated hypericin penetrate the skin of nude mice most.The results of in vivo assays revealed that hypericin penetrated nude mice skin,spread to the dermis,and resulted in obvious photosensitivity reaction on the dermal capillaries.Moreover,skin injured by the photosensitive reaction induced by hypericin was replaced by normal skin 7 d after hypericin-PDT treatment.CONCLUSION Topical hypericin could penetrate nude mouse skin well and be great potential in PDT treatment of skin diseases.展开更多
Four kinds of polymer coated urea(PCU)were put in distilled water at 30℃ to determine the variation of coating penetrability and give a precise description of the urea release kinetics. The urea release from PCU coul...Four kinds of polymer coated urea(PCU)were put in distilled water at 30℃ to determine the variation of coating penetrability and give a precise description of the urea release kinetics. The urea release from PCU could be divided into four stages: lag stage, swell stage, steady stage and decay stage. The release rate coefficient K, a measure of coating penetrability, was linearly increased at swell stage, but almost not variable at steady stage. At decay stage, the relation of X to time t could be described by the equation K= mtn-1where m and n are the coefficients). When n>1, the coating penetrability was gradually increased, and the urea release from PCU was accelerated; when n=1, the coating penetrability was steady, and the urea release from PCU obeyed the first-order kinetics; and when n<1.the coating penetrability was gradually decreased, and the urea release from PCU was delayed, resulting in a significant 'tailing effect'.展开更多
We develop a new fully quantum method for determination of widths for nuclear decay by proton emission where multiple internal reflections of wave packet describing tunneling process inside proton-nucleus radial barri...We develop a new fully quantum method for determination of widths for nuclear decay by proton emission where multiple internal reflections of wave packet describing tunneling process inside proton-nucleus radial barrier are taken into account. Exact solutions for amplitudes of wave function, penetrability T and reflection R (estimated for the first time for decay problem) are found for n -step barrier (at arbitrary n) which approximates the realistic barrier. In contrast to semiclassical approach and two-potential approach, we establish by this method essential dependence of the penetrability on the starting point Rform in the internal well where proton starts to move outside (for example, for Ta the penetrability is changed up to 200 times;accuracy is T+R-1|-15 ). We impose a new condition: in the beginning of the proton decay the proton starts to move outside from minimum of the well. Such a condition provides minimal calculated half-life and gives stable basis for predictions. However, the half-lives calculated by such an approach turn out to be a little closer to experimental data in comparison with the semiclassical half-lives. Estimated influence of the external barrier region is up to 1.5 times for changed penetrability.展开更多
This article details how forest soil moisture content (MC) and subsequent resistances to cone penetration (referred below as Cone Index, CI) vary by daily weather, season, topography, site and soil properties across e...This article details how forest soil moisture content (MC) and subsequent resistances to cone penetration (referred below as Cone Index, CI) vary by daily weather, season, topography, site and soil properties across eleven harvest blocks in northwestern New Brunswick. The MC- and CI-affecting soil variables refer to density, texture, organic matter content, coarse fragment content, and topographic position (i.e., elevation, and the seasonally affected cartographic depth-to-water (DTW) pattern). The harvest blocks were transect-sampled inside and outside their wood-forwarding tracks at varying times throughout the year. In detail, 61% of the pore-filled moisture content (MCPS) determinations inside and outside the tracks could be related to topographic position, coarse fragments, bulk density, and forest cover type specifications. In addition, 40% of the CI variations could be related to soil depth, MCPS, and block-specific cover type. Actual versus model-projected uncertainties amounted to ΔMCPS ≤ ± 15% and ΔCI ≤ ± 0.5 MPa, 8 times out of 10. Block-centered MC and CI projections were obtained through: 1) daily hydrological modelling using daily precipitation and air temperature weather-station records nearest each block, and 2) digitally mapped variations in soil properties, elevation, DTW and forest cover type, done at 10 m resolution.展开更多
This study investigated whether liposomes could enhance the permeation and penetration of diclofenac diethylammonium. For this, a 1.16% diclofenac diethylammonium liposome gel formulation was developed (Grupo Leti, S....This study investigated whether liposomes could enhance the permeation and penetration of diclofenac diethylammonium. For this, a 1.16% diclofenac diethylammonium liposome gel formulation was developed (Grupo Leti, S.A.V.). In vitro and ex vivo tests were conducted to analyze the diffusion and penetration profiles of the formulation. The profiles obtained were compared with a commercially available product, DiAnalper gel (Pharmetique Labs). The in vitro test was assessed in a Franz diffusion cell system using a dialysis membrane. The cumulative amount of drug permeated after 24 h demonstrated a significantly (p 2, whereas the commercial formulation yielded values of 371.00 ± 3.54 μg/cm2. These findings were further supported by consistent results in the percentage of drug release, flux, and permeability coefficient, all indicating a notable improvement in diffusion associated with the liposomal gel formulation. The tape stripping assay performed on pig ear skin demonstrates a statistically significant difference (p < 0.05) between the penetration transport of the diclofenac from liposome gel formulation (1413.95 ± 250.51 μg) and the conventional product (202.36 ± 18.07 μg) the liposomal formulation was able to cross de stratum corneum and deliver a high amount of drug to the skin. These findings demonstrated that incorporating diclofenac into a liposomal system significantly improved the drug delivery, which could confer an advantage for clinical uses.展开更多
Installing internal bulkheads in a composite bucket foundation alters the rotational symmetry characteristic of a single-compartment bucket foundation,consequently influencing the stress distribution within the bucket...Installing internal bulkheads in a composite bucket foundation alters the rotational symmetry characteristic of a single-compartment bucket foundation,consequently influencing the stress distribution within the bucket and surrounding soil.During the seabed penetration of a spudcan from a jack-up wind turbine installation vessel,an angle may form between the spudcan’s axis and the axis of symmetry of the adjacent composite bucket foundation in the horizontal plane.Such a misalignment may affect load distribution and the non-uniform interaction between the foundation,soil,and spudcan,ultimately influencing the foundation’s stability.This study employs physical model tests to ascertain the trends in end resistance during spudcan penetration in sand,the extent of soil disturbance,and the backflow condition.The finite element coupled Eulerian-Lagrangian method is validated and utilized to determine the range of penetration angles that induce alterations in the maximum vertical displacement and tilt rate of the composite bucket foundation in sand.The differential contact stress distribution at the base of the bucket is analyzed,with qualitative criteria for sand backflow provided.Findings demonstrate that the maximum vertical displacement and tilt rate of the composite bucket foundation display a“wave-like”variation with the increasing spudcan penetration angle,peaking when the angle between the spudcan and bulkhead is the smallest.Stress distribution is predominantly concentrated at the base and apex of the bucket,becoming increasingly uneven as the penetration angle deviates from the foundation’s symmetry axis.The maximum stress gradually shifts to the junction of the bulkhead and bucket bottom on the side with the shortest net distance from the spudcan.Considering the in-place stability and stress state of the composite bucket foundation is therefore imperative,and particular attention should be paid to the foundation’s state when the angle between the spudcan and bulkhead is small.展开更多
The utilization of discarded coral debris in cementitious material is a prominent research area for island construction projects.The aim of this study is to explore the use of environment-friendly cement and waste cor...The utilization of discarded coral debris in cementitious material is a prominent research area for island construction projects.The aim of this study is to explore the use of environment-friendly cement and waste coral sand in the preparation of coral mortar,while investigating its performance when exposed to a chloride environment.Three types of low-carbon cements were employed,such as rapid hardening sulphoaluminate(RCSA)cement,high belite sulphoaluminate(HBCSA)cement,and slag sulphoaluminate cement(SSC).The coulomb electric flux,mechanical properties,free chloride content,and mass change of the cement mortar under exposed to 3.5 wt%NaCl solution were examined at various time intervals.X-ray diffraction analysis was conducted to identify the mineral phases present in the mortar samples.The results demonstrate that the flexural and compressive strength of the mortar consistently increase throughout the 360 days chloride exposure period.Incorporating coral sand into SSC-based mortars enhances their compressive strength from day 28 up until day 360.However,it adversely affects the strength of HBCSA-based mortars.The behavior of mortars exposed to a chloride-rich environment is closely associated with the amount of C-S-H gel present within them.SSC generates a significant quantity of C-S-H gel which possesses a large specific surface area capable of absorbing more chloride ions thereby reducing their concentration within the mortar matrix as well as increasing its mass and improving resistance against chloride ion penetration.展开更多
This paper develops a semi-analytical solution for pile penetration in natural soft clays using the strain path method(SPM).The stress-strain behavior of soils is characterized by the S-CLAY1S model,which can capture ...This paper develops a semi-analytical solution for pile penetration in natural soft clays using the strain path method(SPM).The stress-strain behavior of soils is characterized by the S-CLAY1S model,which can capture the anisotropic evolution and destructuring nature of soft clays.By integrating the S-CLAY1S model into the theoretical framework of the SPM,a set of ordinary differential equations is formulated with respect to the vertical coordinate of soil particles.The distribution of excess pore water pressure(EPWP)following pile installation is approximated through one-dimensional(1D)radial integration around the pile shaft.The distribution of stresses and EPWP,along with the evolution of fabric anisotropy within the soil surrounding the pile,is presented to illustrate the response of pile penetration in natural soft clays.The proposed solution is validated against existing theoretical solutions using the SPM and cavity expansion method(CEM),along with experimental data.The findings demonstrate that the SPM reveals lower radial effective stresses and EPWP at the pile shaft than that of CEM.Pile penetration alters the soil's anisotropic properties,inducing rotational hardening and affecting post-installation stress distribution.Soil destructuration eliminates bonding among particles near the pile,resulting in a complete disruption of soil structure at the pile surface,which is particularly pronounced for higher initial soil structure ratios.Minimal variation was observed in the three principal stresses and shear stress on the cone side surface as the angle increased from 18°to 60°,except for a slight reduction in EPWP.展开更多
Photothermal therapy(PTT)triggered by second near-infrared(NIR-II)light(1000–1400 nm)has shown great potential in tumor ablation because of its good tissue penetrability.However,NIR-II PTT still cannot treat tumors u...Photothermal therapy(PTT)triggered by second near-infrared(NIR-II)light(1000–1400 nm)has shown great potential in tumor ablation because of its good tissue penetrability.However,NIR-II PTT still cannot treat tumors underneath skin because of the light scattering effect of skin components.This research aims to promote the NIR-II penetrability of skin tissue by weakening the light scattering effect from the refractive index inhomogeneity among skin constituents.展开更多
Rubbery waste at the end of the cycle often constitutes a threat for the environment because of their encumbrance and low biodeterioration.The purpose of the research presented is to develop the rubber fine powder as ...Rubbery waste at the end of the cycle often constitutes a threat for the environment because of their encumbrance and low biodeterioration.The purpose of the research presented is to develop the rubber fine powder as a pavement.It is interested primarily in the behavior of two types of bitumen 40/50 modified by the addition of two varieties of rubber fine powders of different grading,resulting from the crushing of the rubbery products intended for the clothes industry of soles of shoes.The objective of the experimentation is to study the influence of the added polymer on the physical properties of the ordinary road bitumen with the incorporation of the fine powder.The experimental approach is carried out using the two tests of characterization of the bitumen i.e.the softening point test and the penetration test which remain the most used to define and classify the road bitumen.It will be noted however,that the experimental investigation which is based on several tests according to the type and the content of fine powders,leads on a whole of interesting correlations.展开更多
In this paper,the failure caused by HRAM loads which were generated by high-speed projectile penetration,and protection technology of the fluid-filled structure were explored.A bubble was preset on the projectile traj...In this paper,the failure caused by HRAM loads which were generated by high-speed projectile penetration,and protection technology of the fluid-filled structure were explored.A bubble was preset on the projectile trajectory in a fluid-filled structure.Based on the reflection and transmission phenomena of pressure waves at the gas-liquid interface and the compressibility characteristics of gases,a numerical analysis was conducted on the influence of preset bubble on projectile penetration and structural failure characteristics.The results indicate that the secondary water-entry impact phenomenon occurs when a preset bubble exists on the projectile trajectory,leading to the secondary water entry impact loads.The rarefaction waves reflected on the surface of the preset bubble cause the attenuation ratio of the initial impact pressure peak to reach 68.8%and the total specific impulse attenuation ratio to reach 48.6%.Furthermore,the larger the bubble,the faster the projectile,and the more obvious the attenuation effect.Moreover,due to the compressibility of the bubble,the global deformation attenuation ratio of the front and rear walls can reach over 80%.However,the larger the bubble size,the faster the projectile velocity,the smaller the local deformation attenuation effect of the rear wall,and the more severe the failure at the perforation of the rear wall.展开更多
Titanium alloy has the advantages of high strength,strong corrosion resistance,excellent high and low temperature mechanical properties,etc.,and is widely used in aerospace,shipbuilding,weapons and equipment,and other...Titanium alloy has the advantages of high strength,strong corrosion resistance,excellent high and low temperature mechanical properties,etc.,and is widely used in aerospace,shipbuilding,weapons and equipment,and other fields.In recent years,with the continuous increase in demand for medium-thick plate titanium alloys,corresponding welding technologies have also continued to develop.Therefore,this article reviews the research progress of deep penetration welding technology for medium-thick plate titanium alloys,mainly covering traditional arc welding,high-energy beam welding,and other welding technologies.Among many methods,narrow gap welding,hybrid welding,and external energy field assistance welding all contribute to improving the welding efficiency and quality of medium-thick plate titanium alloys.Finally,the development trend of deep penetration welding technology for mediumthick plate titanium alloys is prospected.展开更多
The penetration-deflagration coupling damage performance of rod-like reactive shaped charge pene-trator(RRSCP)impacting thick steel plates is investigated by theoretical analysis and experiments.A penetration-deflagra...The penetration-deflagration coupling damage performance of rod-like reactive shaped charge pene-trator(RRSCP)impacting thick steel plates is investigated by theoretical analysis and experiments.A penetration-deflagration coupling damage model is developed to predict the penetration depth and cratering diameter.Four type of aluminum-polytetrafluoroethylene-copper(Al-PTFE-Cu)reactive liners with densities of 2.3,2.7,3.5,and 4.5 g·cm^(-3) are selected to conduct the penetration experiments.The comparison results show that model predictions are in good agreement with the experimental data.By comparing the penetration depth and cratering diameter in the inert penetration mode and the penetration-deflagration coupling mode,the influence mechanism that the penetration-induced chemical response is unfavorable to penetration but has an enhanced cratering effect is revealed.From the formation characteristics,penetration effect and penetration-induced chemical reaction be-haviors,the influence of reactive liner density on the penetration-deflagration performance is further analyzed.The results show that increasing the density of reactive liner significantly increases both the kinetic energy and length of the reactive penetrator,meanwhile effectively reduces the weakened effect of penetration-induced chemical response,resulting in an enhanced penetration capability.However,due to the decreased diameter and potential energy content of reactive penetrator,the cratering capa-bility is weakened significantly.展开更多
The study aims to explore the damage characteristics and protection technologies of liquid-filled structures under high-speed projectile impact.A series of penetration impact experiments were conducted by focusing on ...The study aims to explore the damage characteristics and protection technologies of liquid-filled structures under high-speed projectile impact.A series of penetration impact experiments were conducted by focusing on different air layer configurations.By using high-speed camera and dynamic measurement systems,the effects of air layers on the projectile penetration,pressure wave propagation,cavitation evolution,and structural dynamic responses were analyzed.The results showed that the rarefaction wave reflected from the air-liquid interface significantly reduced the peak and specific impulse of the initial pressure wave,thereby diminishing the impact load on the structure.Additionally,the compressibility of air layers also attenuated the cavitation extrusion load.Both front and rear plates exhibited superimposed deformation modes,i.e.,local deformation or petal fracture with global deformation.Air layers effectively mitigated global deformation.However,when the air layer was positioned on the projectile's trajectory,it split the water-entry process and velocity attenuation of the projectile into two relatively independent phases.And the secondary water entry pressure wave caused more severe local deformation and petal fractures on the rear plate.展开更多
The motion characteristics of projectile during oblique penetration into concrete were studied using a three-dimensional meso-scale model.The finite element model validation and parameter chosen were conducted by comp...The motion characteristics of projectile during oblique penetration into concrete were studied using a three-dimensional meso-scale model.The finite element model validation and parameter chosen were conducted by comparing the experimental data,with computational efficiency enhanced through improved mesh refinement.Penetration simulations involving deformable projectiles at various incident angles analyzed the effects of aggregate volume fraction and particle size on ballistic trajectory and terminal deflection.Sensitivity analysis reveals a strong power-law relationship between aggregate content and the projectile's deflection angle.The increase in aggregate content will enhance the confinement effect,shorten the intrusion distance of the projectile,and lead to a decrease in the deflection angle of the projectile.The effect of aggregate particle size on the projectile deflection angle follows a Gaussian distribution.The maximum deflection angle occurs when the aggregate particle size is between 2.7 and 3.1 times the projectile diameter.An increase in particle size reduces the number of aggregate-mortar interfaces at the same aggregate volume fraction,leading to an enlargement of the damage zone in concrete,a decrease in the number of cracks,and an increase in crack length.These findings enhance the understanding of concrete penetration mechanisms and offers valuable insights for engineering structure protection.展开更多
Nanoemulsions have garnered significant attention in the cosmetic industry due to their ability to enhance ingredient dispersion,improve topical absorption,and enable targeted delivery of active compounds within the s...Nanoemulsions have garnered significant attention in the cosmetic industry due to their ability to enhance ingredient dispersion,improve topical absorption,and enable targeted delivery of active compounds within the skin layers.These nano-sized emulsions allow skincare products,like moisturizers,anti-aging creams,and sunscreens,to penetrate the skin more deeply and be absorbed better.They can also release their active ingredients gradually,which enhances the product's effectiveness.Additionally,nanoemulsions are more stable,meaning they protect ingredients from breaking down or losing their effectiveness,which helps extend the shelf life of the products.However,despite their advantages,nanoemulsions come with challenges,such as difficulties in producing them on a large scale,meeting safety regulations,and ensuring they remain stable over time.Future research will likely focus on improving how these formulations are made,making sure they are safe to use,and exploring more environmentally friendly and personalized solutions for skincare.As this technology develops,nanoemulsions have the potential to transform cosmetic formulations by offering more innovative and effective skincare options.展开更多
Shaped charge has been widely used for penetrating concrete.However,due to the obvious difference between the propagation of shock waves and explosion products in water and air,the theory governing the formation of sh...Shaped charge has been widely used for penetrating concrete.However,due to the obvious difference between the propagation of shock waves and explosion products in water and air,the theory governing the formation of shaped charge jets in water as well as the underwater penetration effect of concrete need to be studied.In this paper,we introduced a modified forming theory of an underwater hemispherical shaped charge,and investigated the behavior of jet formation and concrete penetration in both air and water experimentally and numerically.The results show that the modified jet forming theory predicts the jet velocity of the hemispherical liner with an error of less than 10%.The underwater jets exhibit at least 3%faster and 11%longer than those in air.Concrete shows different failure modes after penetration in air and water.The depth of penetration deepens at least 18.75%after underwater penetration,accompanied by deeper crater with 65%smaller radius.Moreover,cracks throughout the entire target are formed,whereas cracks exist only near the penetration hole in air.This comprehensive study provides guidance for optimizing the structure of shaped charge and improves the understanding of the permeability effect of concrete in water.展开更多
The chloride penetration resistance of cement-based grout materials was improved by nano-silica emulsion.Specimens of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride so...The chloride penetration resistance of cement-based grout materials was improved by nano-silica emulsion.Specimens of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test ages.Hardened properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and microstructure.The results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion penetration.This improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.展开更多
Currently,there is a lack of in-situ or model test results for cone penetration tests(CPTs)conducted in deep,dense sand layers under high overburden stresses,restricting the development of empirical relationships betw...Currently,there is a lack of in-situ or model test results for cone penetration tests(CPTs)conducted in deep,dense sand layers under high overburden stresses,restricting the development of empirical relationships between CPT results and the characteristics of such deep,dense sand layers.This study addresses this gap by proposing an empirical relationship to predict the relative density of dense silica sand based on stress level and cone tip resistance.The relationship was developed through CPTs performed in a calibration chamber using dense sand specimens(with relative densities of 74%-91%)subjected to high stresses(under overburden stresses of 0.5-2.0 MPa)and numerical simulations employing the large deformation finite element method.The Arbitrary Lagrangian Eulerian method was used to regularly regenerate the mesh to prevent soil element distortion around the cone tip.Additionally,the modified Mohr-Coulomb model was integrated to capture the stress-strain behavior of dense silica sand under high stresses.A reasonable agreement was achieved between the numerical and experimental penetration profiles,which verifies the reliability of the numerical model.A sufficient number of parametric analyses were carried out,and then an empirical equation was proposed to establish the relationship between the relative density of dense sand,stress level and cone resistance.The empirical equation provides predictions with acceptable accuracy,as the discrepancies between the predicted and measured relative density values fall within±30%.展开更多
文摘Distribution of plant roots in a red soil derived from granite was investigated to study the effect of plantroots on intensifying soil penetrability and anti-scouribility by the double-cutting-ring and the undisturbedsoil-flume methods, respectively. The plant roots system consisting mostly of fibrils, < 1 mm in diameter,was mainly distributed in the upper surface soil 30 cm in depth. It can remarhably increase the penetrabilityand anti-scouribility of the red soil derived from granite. When the root density was > 0.35 root cm-2, theintensifying effect of roots on both the penetrability and the anti-scouribility could be described by exponentequations, △ Ks = 0.0021RD1.4826 (R2 = 0.9313) and △ As = 0.0003RD1.8478 (R2 = O.9619), where △ Ks isthe value of intensified soil penetrability, a As the value of intensified soil anti-scouribility and RD the rootdensity, especially in the top soils within 30 cm in depth where plant roots were conceotrated.
文摘OBJECTIVE Hypericin,a powerful naturally photosensitizer in photodynamic therapy(PDT),is suitable for treating skin diseases involving excess capillary proliferation.In the present study,we aimed to evaluate the skin penetrability of a topically applied hypericin,expecting reducing the risk of prolonged skin photosensitivity,which often occurs after systemic administration.METHODS The Franz diffusion cell assay was performed to evaluate different penetration enhancers.In vivo studies,fluorescence microscopy was performed to examine the distribution of hypericin in the skin,macroscopic and microscopic analyses were also carried out to detect pathological changes in the skin after topical hypericin-PDT treatment.Immunohistochemistry was used to determine the expression of PECAM-1 in the treated skin.RESULTS 5% menthol facilitated hypericin penetrate the skin of nude mice most.The results of in vivo assays revealed that hypericin penetrated nude mice skin,spread to the dermis,and resulted in obvious photosensitivity reaction on the dermal capillaries.Moreover,skin injured by the photosensitive reaction induced by hypericin was replaced by normal skin 7 d after hypericin-PDT treatment.CONCLUSION Topical hypericin could penetrate nude mouse skin well and be great potential in PDT treatment of skin diseases.
基金supported by the National 863 Program,Ministry of Science and Technology of China(2001AA246021)the Knowledge Innovation Engineering of the Chinese Academy of Sciences(KZCX2-402).
文摘Four kinds of polymer coated urea(PCU)were put in distilled water at 30℃ to determine the variation of coating penetrability and give a precise description of the urea release kinetics. The urea release from PCU could be divided into four stages: lag stage, swell stage, steady stage and decay stage. The release rate coefficient K, a measure of coating penetrability, was linearly increased at swell stage, but almost not variable at steady stage. At decay stage, the relation of X to time t could be described by the equation K= mtn-1where m and n are the coefficients). When n>1, the coating penetrability was gradually increased, and the urea release from PCU was accelerated; when n=1, the coating penetrability was steady, and the urea release from PCU obeyed the first-order kinetics; and when n<1.the coating penetrability was gradually decreased, and the urea release from PCU was delayed, resulting in a significant 'tailing effect'.
文摘We develop a new fully quantum method for determination of widths for nuclear decay by proton emission where multiple internal reflections of wave packet describing tunneling process inside proton-nucleus radial barrier are taken into account. Exact solutions for amplitudes of wave function, penetrability T and reflection R (estimated for the first time for decay problem) are found for n -step barrier (at arbitrary n) which approximates the realistic barrier. In contrast to semiclassical approach and two-potential approach, we establish by this method essential dependence of the penetrability on the starting point Rform in the internal well where proton starts to move outside (for example, for Ta the penetrability is changed up to 200 times;accuracy is T+R-1|-15 ). We impose a new condition: in the beginning of the proton decay the proton starts to move outside from minimum of the well. Such a condition provides minimal calculated half-life and gives stable basis for predictions. However, the half-lives calculated by such an approach turn out to be a little closer to experimental data in comparison with the semiclassical half-lives. Estimated influence of the external barrier region is up to 1.5 times for changed penetrability.
文摘This article details how forest soil moisture content (MC) and subsequent resistances to cone penetration (referred below as Cone Index, CI) vary by daily weather, season, topography, site and soil properties across eleven harvest blocks in northwestern New Brunswick. The MC- and CI-affecting soil variables refer to density, texture, organic matter content, coarse fragment content, and topographic position (i.e., elevation, and the seasonally affected cartographic depth-to-water (DTW) pattern). The harvest blocks were transect-sampled inside and outside their wood-forwarding tracks at varying times throughout the year. In detail, 61% of the pore-filled moisture content (MCPS) determinations inside and outside the tracks could be related to topographic position, coarse fragments, bulk density, and forest cover type specifications. In addition, 40% of the CI variations could be related to soil depth, MCPS, and block-specific cover type. Actual versus model-projected uncertainties amounted to ΔMCPS ≤ ± 15% and ΔCI ≤ ± 0.5 MPa, 8 times out of 10. Block-centered MC and CI projections were obtained through: 1) daily hydrological modelling using daily precipitation and air temperature weather-station records nearest each block, and 2) digitally mapped variations in soil properties, elevation, DTW and forest cover type, done at 10 m resolution.
文摘This study investigated whether liposomes could enhance the permeation and penetration of diclofenac diethylammonium. For this, a 1.16% diclofenac diethylammonium liposome gel formulation was developed (Grupo Leti, S.A.V.). In vitro and ex vivo tests were conducted to analyze the diffusion and penetration profiles of the formulation. The profiles obtained were compared with a commercially available product, DiAnalper gel (Pharmetique Labs). The in vitro test was assessed in a Franz diffusion cell system using a dialysis membrane. The cumulative amount of drug permeated after 24 h demonstrated a significantly (p 2, whereas the commercial formulation yielded values of 371.00 ± 3.54 μg/cm2. These findings were further supported by consistent results in the percentage of drug release, flux, and permeability coefficient, all indicating a notable improvement in diffusion associated with the liposomal gel formulation. The tape stripping assay performed on pig ear skin demonstrates a statistically significant difference (p < 0.05) between the penetration transport of the diclofenac from liposome gel formulation (1413.95 ± 250.51 μg) and the conventional product (202.36 ± 18.07 μg) the liposomal formulation was able to cross de stratum corneum and deliver a high amount of drug to the skin. These findings demonstrated that incorporating diclofenac into a liposomal system significantly improved the drug delivery, which could confer an advantage for clinical uses.
文摘Installing internal bulkheads in a composite bucket foundation alters the rotational symmetry characteristic of a single-compartment bucket foundation,consequently influencing the stress distribution within the bucket and surrounding soil.During the seabed penetration of a spudcan from a jack-up wind turbine installation vessel,an angle may form between the spudcan’s axis and the axis of symmetry of the adjacent composite bucket foundation in the horizontal plane.Such a misalignment may affect load distribution and the non-uniform interaction between the foundation,soil,and spudcan,ultimately influencing the foundation’s stability.This study employs physical model tests to ascertain the trends in end resistance during spudcan penetration in sand,the extent of soil disturbance,and the backflow condition.The finite element coupled Eulerian-Lagrangian method is validated and utilized to determine the range of penetration angles that induce alterations in the maximum vertical displacement and tilt rate of the composite bucket foundation in sand.The differential contact stress distribution at the base of the bucket is analyzed,with qualitative criteria for sand backflow provided.Findings demonstrate that the maximum vertical displacement and tilt rate of the composite bucket foundation display a“wave-like”variation with the increasing spudcan penetration angle,peaking when the angle between the spudcan and bulkhead is the smallest.Stress distribution is predominantly concentrated at the base and apex of the bucket,becoming increasingly uneven as the penetration angle deviates from the foundation’s symmetry axis.The maximum stress gradually shifts to the junction of the bulkhead and bucket bottom on the side with the shortest net distance from the spudcan.Considering the in-place stability and stress state of the composite bucket foundation is therefore imperative,and particular attention should be paid to the foundation’s state when the angle between the spudcan and bulkhead is small.
基金Funded by the National Natural Science Foundation of China(No.51708290)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘The utilization of discarded coral debris in cementitious material is a prominent research area for island construction projects.The aim of this study is to explore the use of environment-friendly cement and waste coral sand in the preparation of coral mortar,while investigating its performance when exposed to a chloride environment.Three types of low-carbon cements were employed,such as rapid hardening sulphoaluminate(RCSA)cement,high belite sulphoaluminate(HBCSA)cement,and slag sulphoaluminate cement(SSC).The coulomb electric flux,mechanical properties,free chloride content,and mass change of the cement mortar under exposed to 3.5 wt%NaCl solution were examined at various time intervals.X-ray diffraction analysis was conducted to identify the mineral phases present in the mortar samples.The results demonstrate that the flexural and compressive strength of the mortar consistently increase throughout the 360 days chloride exposure period.Incorporating coral sand into SSC-based mortars enhances their compressive strength from day 28 up until day 360.However,it adversely affects the strength of HBCSA-based mortars.The behavior of mortars exposed to a chloride-rich environment is closely associated with the amount of C-S-H gel present within them.SSC generates a significant quantity of C-S-H gel which possesses a large specific surface area capable of absorbing more chloride ions thereby reducing their concentration within the mortar matrix as well as increasing its mass and improving resistance against chloride ion penetration.
基金support from the National Natural Science Foundation of China(Grant No.42407256)the State Key Laboratory of Hydraulics and Mountain River Engineering,China(Grant No.SKHL2113)the Sichuan Science and Technology Program(Grant No.2024YFHZ0341).
文摘This paper develops a semi-analytical solution for pile penetration in natural soft clays using the strain path method(SPM).The stress-strain behavior of soils is characterized by the S-CLAY1S model,which can capture the anisotropic evolution and destructuring nature of soft clays.By integrating the S-CLAY1S model into the theoretical framework of the SPM,a set of ordinary differential equations is formulated with respect to the vertical coordinate of soil particles.The distribution of excess pore water pressure(EPWP)following pile installation is approximated through one-dimensional(1D)radial integration around the pile shaft.The distribution of stresses and EPWP,along with the evolution of fabric anisotropy within the soil surrounding the pile,is presented to illustrate the response of pile penetration in natural soft clays.The proposed solution is validated against existing theoretical solutions using the SPM and cavity expansion method(CEM),along with experimental data.The findings demonstrate that the SPM reveals lower radial effective stresses and EPWP at the pile shaft than that of CEM.Pile penetration alters the soil's anisotropic properties,inducing rotational hardening and affecting post-installation stress distribution.Soil destructuration eliminates bonding among particles near the pile,resulting in a complete disruption of soil structure at the pile surface,which is particularly pronounced for higher initial soil structure ratios.Minimal variation was observed in the three principal stresses and shear stress on the cone side surface as the angle increased from 18°to 60°,except for a slight reduction in EPWP.
基金from the National Natural Science Foundation of China(grant no.21825503).
文摘Photothermal therapy(PTT)triggered by second near-infrared(NIR-II)light(1000–1400 nm)has shown great potential in tumor ablation because of its good tissue penetrability.However,NIR-II PTT still cannot treat tumors underneath skin because of the light scattering effect of skin components.This research aims to promote the NIR-II penetrability of skin tissue by weakening the light scattering effect from the refractive index inhomogeneity among skin constituents.
文摘Rubbery waste at the end of the cycle often constitutes a threat for the environment because of their encumbrance and low biodeterioration.The purpose of the research presented is to develop the rubber fine powder as a pavement.It is interested primarily in the behavior of two types of bitumen 40/50 modified by the addition of two varieties of rubber fine powders of different grading,resulting from the crushing of the rubbery products intended for the clothes industry of soles of shoes.The objective of the experimentation is to study the influence of the added polymer on the physical properties of the ordinary road bitumen with the incorporation of the fine powder.The experimental approach is carried out using the two tests of characterization of the bitumen i.e.the softening point test and the penetration test which remain the most used to define and classify the road bitumen.It will be noted however,that the experimental investigation which is based on several tests according to the type and the content of fine powders,leads on a whole of interesting correlations.
文摘In this paper,the failure caused by HRAM loads which were generated by high-speed projectile penetration,and protection technology of the fluid-filled structure were explored.A bubble was preset on the projectile trajectory in a fluid-filled structure.Based on the reflection and transmission phenomena of pressure waves at the gas-liquid interface and the compressibility characteristics of gases,a numerical analysis was conducted on the influence of preset bubble on projectile penetration and structural failure characteristics.The results indicate that the secondary water-entry impact phenomenon occurs when a preset bubble exists on the projectile trajectory,leading to the secondary water entry impact loads.The rarefaction waves reflected on the surface of the preset bubble cause the attenuation ratio of the initial impact pressure peak to reach 68.8%and the total specific impulse attenuation ratio to reach 48.6%.Furthermore,the larger the bubble,the faster the projectile,and the more obvious the attenuation effect.Moreover,due to the compressibility of the bubble,the global deformation attenuation ratio of the front and rear walls can reach over 80%.However,the larger the bubble size,the faster the projectile velocity,the smaller the local deformation attenuation effect of the rear wall,and the more severe the failure at the perforation of the rear wall.
基金financially supported by the Key Research and Development Program of Ningbo(Grant No.2023Z098)Natural Science Foundation of Inner Mongolia(Grant No.2023MS05040)+1 种基金Shenyang Collaborative Innovation Center Project for Multiple Energy Fields Composite Processing of Special Materials(Grant No.JG210027)Shenyang Key Technology Special Project of The Open Competition Mechanism to Select the Best Solution(Grant Nos.2022210101000827,2022-0-43-048).
文摘Titanium alloy has the advantages of high strength,strong corrosion resistance,excellent high and low temperature mechanical properties,etc.,and is widely used in aerospace,shipbuilding,weapons and equipment,and other fields.In recent years,with the continuous increase in demand for medium-thick plate titanium alloys,corresponding welding technologies have also continued to develop.Therefore,this article reviews the research progress of deep penetration welding technology for medium-thick plate titanium alloys,mainly covering traditional arc welding,high-energy beam welding,and other welding technologies.Among many methods,narrow gap welding,hybrid welding,and external energy field assistance welding all contribute to improving the welding efficiency and quality of medium-thick plate titanium alloys.Finally,the development trend of deep penetration welding technology for mediumthick plate titanium alloys is prospected.
基金supported by the National Natural Science Foundation of China(Grant No.12172052)the Foundation of State Key Laboratory of Explosion Science and Safety Protection(Grant No.QKKT24-02).
文摘The penetration-deflagration coupling damage performance of rod-like reactive shaped charge pene-trator(RRSCP)impacting thick steel plates is investigated by theoretical analysis and experiments.A penetration-deflagration coupling damage model is developed to predict the penetration depth and cratering diameter.Four type of aluminum-polytetrafluoroethylene-copper(Al-PTFE-Cu)reactive liners with densities of 2.3,2.7,3.5,and 4.5 g·cm^(-3) are selected to conduct the penetration experiments.The comparison results show that model predictions are in good agreement with the experimental data.By comparing the penetration depth and cratering diameter in the inert penetration mode and the penetration-deflagration coupling mode,the influence mechanism that the penetration-induced chemical response is unfavorable to penetration but has an enhanced cratering effect is revealed.From the formation characteristics,penetration effect and penetration-induced chemical reaction be-haviors,the influence of reactive liner density on the penetration-deflagration performance is further analyzed.The results show that increasing the density of reactive liner significantly increases both the kinetic energy and length of the reactive penetrator,meanwhile effectively reduces the weakened effect of penetration-induced chemical response,resulting in an enhanced penetration capability.However,due to the decreased diameter and potential energy content of reactive penetrator,the cratering capa-bility is weakened significantly.
基金the financial support provided by National Natural Science Foundation of China(Grant Nos.52271338,52371342 and 51979277).
文摘The study aims to explore the damage characteristics and protection technologies of liquid-filled structures under high-speed projectile impact.A series of penetration impact experiments were conducted by focusing on different air layer configurations.By using high-speed camera and dynamic measurement systems,the effects of air layers on the projectile penetration,pressure wave propagation,cavitation evolution,and structural dynamic responses were analyzed.The results showed that the rarefaction wave reflected from the air-liquid interface significantly reduced the peak and specific impulse of the initial pressure wave,thereby diminishing the impact load on the structure.Additionally,the compressibility of air layers also attenuated the cavitation extrusion load.Both front and rear plates exhibited superimposed deformation modes,i.e.,local deformation or petal fracture with global deformation.Air layers effectively mitigated global deformation.However,when the air layer was positioned on the projectile's trajectory,it split the water-entry process and velocity attenuation of the projectile into two relatively independent phases.And the secondary water entry pressure wave caused more severe local deformation and petal fractures on the rear plate.
基金funded by the National Natural Science Foundation of China(Grant Nos.12472390 and 12102292)the special fund for Science and Technology Innovation Teams of Shanxi Province(Grant No.202204051002006)。
文摘The motion characteristics of projectile during oblique penetration into concrete were studied using a three-dimensional meso-scale model.The finite element model validation and parameter chosen were conducted by comparing the experimental data,with computational efficiency enhanced through improved mesh refinement.Penetration simulations involving deformable projectiles at various incident angles analyzed the effects of aggregate volume fraction and particle size on ballistic trajectory and terminal deflection.Sensitivity analysis reveals a strong power-law relationship between aggregate content and the projectile's deflection angle.The increase in aggregate content will enhance the confinement effect,shorten the intrusion distance of the projectile,and lead to a decrease in the deflection angle of the projectile.The effect of aggregate particle size on the projectile deflection angle follows a Gaussian distribution.The maximum deflection angle occurs when the aggregate particle size is between 2.7 and 3.1 times the projectile diameter.An increase in particle size reduces the number of aggregate-mortar interfaces at the same aggregate volume fraction,leading to an enlargement of the damage zone in concrete,a decrease in the number of cracks,and an increase in crack length.These findings enhance the understanding of concrete penetration mechanisms and offers valuable insights for engineering structure protection.
文摘Nanoemulsions have garnered significant attention in the cosmetic industry due to their ability to enhance ingredient dispersion,improve topical absorption,and enable targeted delivery of active compounds within the skin layers.These nano-sized emulsions allow skincare products,like moisturizers,anti-aging creams,and sunscreens,to penetrate the skin more deeply and be absorbed better.They can also release their active ingredients gradually,which enhances the product's effectiveness.Additionally,nanoemulsions are more stable,meaning they protect ingredients from breaking down or losing their effectiveness,which helps extend the shelf life of the products.However,despite their advantages,nanoemulsions come with challenges,such as difficulties in producing them on a large scale,meeting safety regulations,and ensuring they remain stable over time.Future research will likely focus on improving how these formulations are made,making sure they are safe to use,and exploring more environmentally friendly and personalized solutions for skincare.As this technology develops,nanoemulsions have the potential to transform cosmetic formulations by offering more innovative and effective skincare options.
基金supported by the National Science Foundation of China(Grant Nos.12372361,12102427,12372335 and 12102202)the Fundamental Research Funds for the Central Universities(Grant No.30923010908)Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYCX23_0520).
文摘Shaped charge has been widely used for penetrating concrete.However,due to the obvious difference between the propagation of shock waves and explosion products in water and air,the theory governing the formation of shaped charge jets in water as well as the underwater penetration effect of concrete need to be studied.In this paper,we introduced a modified forming theory of an underwater hemispherical shaped charge,and investigated the behavior of jet formation and concrete penetration in both air and water experimentally and numerically.The results show that the modified jet forming theory predicts the jet velocity of the hemispherical liner with an error of less than 10%.The underwater jets exhibit at least 3%faster and 11%longer than those in air.Concrete shows different failure modes after penetration in air and water.The depth of penetration deepens at least 18.75%after underwater penetration,accompanied by deeper crater with 65%smaller radius.Moreover,cracks throughout the entire target are formed,whereas cracks exist only near the penetration hole in air.This comprehensive study provides guidance for optimizing the structure of shaped charge and improves the understanding of the permeability effect of concrete in water.
基金Funded by a Science and Technology Project from the Ministry of Housing and Urban-Rural Development of the People’s Republic of China(No.2019-K-047)Yangzhou Government-Yangzhou University Cooperative Platform Project for Science and Technology Innovation(No.YZ2020262)。
文摘The chloride penetration resistance of cement-based grout materials was improved by nano-silica emulsion.Specimens of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test ages.Hardened properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and microstructure.The results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion penetration.This improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.
基金National Natural Science Foundation of China(Nos.42025702,52394251)。
文摘Currently,there is a lack of in-situ or model test results for cone penetration tests(CPTs)conducted in deep,dense sand layers under high overburden stresses,restricting the development of empirical relationships between CPT results and the characteristics of such deep,dense sand layers.This study addresses this gap by proposing an empirical relationship to predict the relative density of dense silica sand based on stress level and cone tip resistance.The relationship was developed through CPTs performed in a calibration chamber using dense sand specimens(with relative densities of 74%-91%)subjected to high stresses(under overburden stresses of 0.5-2.0 MPa)and numerical simulations employing the large deformation finite element method.The Arbitrary Lagrangian Eulerian method was used to regularly regenerate the mesh to prevent soil element distortion around the cone tip.Additionally,the modified Mohr-Coulomb model was integrated to capture the stress-strain behavior of dense silica sand under high stresses.A reasonable agreement was achieved between the numerical and experimental penetration profiles,which verifies the reliability of the numerical model.A sufficient number of parametric analyses were carried out,and then an empirical equation was proposed to establish the relationship between the relative density of dense sand,stress level and cone resistance.The empirical equation provides predictions with acceptable accuracy,as the discrepancies between the predicted and measured relative density values fall within±30%.
