A 'Human-Imitating Intelligent Control Theory' with 'generalized reduction' and 'Human Imitating' concepts as its kernel is proposed. And a world puzzlein the control circles is solved successf...A 'Human-Imitating Intelligent Control Theory' with 'generalized reduction' and 'Human Imitating' concepts as its kernel is proposed. And a world puzzlein the control circles is solved successfully based on this theory. The puzzle is thewell-known 'triple inverted pendulum control' using a SINGLE motor. A human-imitating intelligent technique to control inverted pendulum is here described. The success. ful experimental results show that our control objective can be achieved without a precise mathematical model of the plant. Finally, general principles of designing complexautomatic control systems based on the human-imitating intelligent control theory areconcluded.展开更多
An analytical model is presented for seismic analysis of triple friction pendulum bearings and validated using 81 bearing tests, each subjected to three cycles, with a duration of 12 seconds and using 250, 200 and 100...An analytical model is presented for seismic analysis of triple friction pendulum bearings and validated using 81 bearing tests, each subjected to three cycles, with a duration of 12 seconds and using 250, 200 and 100 tons vertical loads. The main objective is to develop formulas for bilinear behavior using maximum, average and minimum friction coefficients to check which is the closest to the real behavior in the laboratory tests and comparatives curves plotting to observe the standard derivation. Parameters such as friction coefficients, effective stiffness, damping factor and vibration periods are analyzed to understand the structural behavior of the TPF bearings.展开更多
The inverted pendulum is a classic problem in dynamics and control theory and is widely used as a benchmark for testing control algorithms. This paper studies the use of fuzzy control method to study the stability con...The inverted pendulum is a classic problem in dynamics and control theory and is widely used as a benchmark for testing control algorithms. This paper studies the use of fuzzy control method to study the stability control problem of a triple inverted pendulum system. By the linear model of the system, the feedback weight matrix of the LQR optimal control and the feedback parameters of the linear optimal control are designed to determine the parameters of the fuzzy controller. The simulation results show that the proposed method can achieve the stability control of the three stage inverted pendulum, and has good dynamic performance with simple parameter selection.展开更多
The incidence and mortality rate of lung cancer rank among the highest worldwide,severely endangering human health and life.Metformin,an anti-diabetes drug,has been shown to elicit anticancer activities in various tum...The incidence and mortality rate of lung cancer rank among the highest worldwide,severely endangering human health and life.Metformin,an anti-diabetes drug,has been shown to elicit anticancer activities in various tumors.However,its underlying mechanisms remain elusive.In this work,we explore the role of receptor-interacting protein 1(RIP1)which plays a crucial role in the process of cell death,in metformin-induced anticancer activities in lung cancer.Metformin inhibits lung cancer cell proliferation in a dose-dependent manner and promotes apoptotic cell death,as evidenced by metformin-induced PARP and caspase cleavage.Furthermore,the pan-caspase inhibitor z-VAD-fmk reverses metformin-induced cell death.Western blot and qPCR results suggest that metformin markedly downregulates RIP1 expression without affecting its mRNA and ubiquitination levels(0 vs 80 mmol/L,100%vs 20%,100%vs 15%).Additionally,co-immunoprecipitation and immunofluorescence results reveal that metformin may suppress RIP1 expression in an Hsp70-dependent manner,as metformin promotes Hsp70 degradation,and Hsp70 endogenously interacts with RIP1.Subsequent CCK-8,flow cytometry,and Western blot analyses suggest that metformin decreases Hsp70/RIP1 expression through AMPK/PKA/GSK-3βaxis.Consistently,results from a subcutaneous transplant tumor model indicate that metformin retards tumor growth without affecting mouse body weight.Collectively,these data highlight the part of RIP1 in metformin-induced anticancer activities in lung cancer in vitro and in vivo,providing novel strategy for lung cancer administration.展开更多
When a coin is tossed to a gravity well,it will spiral instead of falling directly to the center.Inspired by this phenomenon,a gravity well-inspired double friction pendulum system(GW-DFPS)is developed to extend the l...When a coin is tossed to a gravity well,it will spiral instead of falling directly to the center.Inspired by this phenomenon,a gravity well-inspired double friction pendulum system(GW-DFPS)is developed to extend the length of sliding trajectories of bridge superstructures during pulse-like near-fault earthquakes.As a result,a greater amount of energy will be dissipated due to the frictional sliding of the isolators.The GW-DFPS consists of a spherical surface and an outer surface described by a 1/x or logarithmic function to build gravity well.Full-scale isolators were fabricated and their response was characterized considering various parameters such as the friction material of slider,surface roughness of sliding surfaces,and applied vertical loads.Additionally,a finite element model of the isolator was created using the experimental test data.Numerical simulations were performed on a case-study bridge structure isolated using both a conventional DFPS system and the proposed GW-DFPS systems.The experimental results reveal that the proposed isolators exhibit stable response under vertical loads varying from 200 kN to 1000 kN with a negative stiffness response when the isolator slides at the outer sliding surface.The numerical simulations of the selected bridge structure demonstrate that the GW-DFPS significantly extends the sliding trajectory lengths of the superstructure during half of the earthquake pulses,resulting in increased energy dissipation during this interval.The kinetic energies of the bridge isolated by GW-DFPS are consistently lower than those of the bridge isolated by the other two kinds of isolators,resulting lower shear forces on the bridge.展开更多
Accurate thrust assessment is crucial for characterizing the performance of micro-thrusters.This paper presents a comprehensive evaluation of the thrust generated by a needle-type indium field emission electric propul...Accurate thrust assessment is crucial for characterizing the performance of micro-thrusters.This paper presents a comprehensive evaluation of the thrust generated by a needle-type indium field emission electric propulsion(In-FEEP)micro-thruster using three methods based on a pendulum:direct thrust measurement,indirect plume momentum transfer and beam current diagnostics.The experimental setup utilized capacitive displacement sensors for force detection and a voice coil motor as a feedback actuator,achieving a resolution better than 0.1μN.Key performance factors such as ionization and plume divergence of ejected charged particles were also examined.The study reveals that the high applied voltage induces significant electrostatic interference,becoming the dominant source of error in direct thrust measurements.Beam current diagnostics and indirect plume momentum measurements were conducted simultaneously,showing strong agreement within a deviation of less than 0.2N across the operational thrust range.The results from all three methods are consistent within the error margins,verifying the reliability of the indirect measurement approach and the theoretical thrust model based on the electrical parameters of In-FEEP.展开更多
Rip currents are a significant threat to swimmers worldwide,responsible for numerous drowning incidents each year.In Vietnam,Bai Dai Beach in Cam Ranh Bay,Khanh Hoa Province,has experienced an increase in drowning eve...Rip currents are a significant threat to swimmers worldwide,responsible for numerous drowning incidents each year.In Vietnam,Bai Dai Beach in Cam Ranh Bay,Khanh Hoa Province,has experienced an increase in drowning events due to rip currents in recent years.To address this issue,a comprehensive study was conducted based on developing a depth-averaged 2D hydrodynamic model to simulate rip currents in the Bai Dai-Cam Ranh coast.The HYDIST-2D numerical model was applied to simulate the rip current evolution in space and time for the study area.The results showed that the HYDIST-2D numerical model can accurately predict the location,magnitude,and microstructure of rip currents,including rip current speed,width,and length.The simulation results revealed that the rip current speed is greater during the low tide phase,with an average speed of 0.5 m s^(-1),while during high tide,the rip current speed is lower,around 0.1–0.8 m s^(-1).The width and length of the rip current also vary with the tide phase,with a wider and longer rip current observed during the low tide phase.The results also showed that the rip current speed and microstructure are influenced by the wave features,tide current,and bathymetry of the study area.The present study provides valuable insights into the dynamics of rip currents in the Bai Dai-Cam Ranh coast.The findings can be used to support the management of bathing activities and provide early warnings for potential risks associated with rip currents.展开更多
Global warming has made the regular operation of Arctic routes possible.This study selects hub ports based on infrastructure conditions and sea ice status,and then designs two pendulum route solutions for the Northeas...Global warming has made the regular operation of Arctic routes possible.This study selects hub ports based on infrastructure conditions and sea ice status,and then designs two pendulum route solutions for the Northeast Passage according to the distance between hub ports and ice-covered areas.We employ an evaluation framework combining annual profit metrics with discounted net present value(NPV)analysis,conducting probabilistic economic assessments through Monte Carlo simulations(20,000 iterations).Key findings indicate that(1)both solutions demonstrate>90%probability of economic viability and(2)Solution I′,with hub ports closer to ice-covered areas than those in Solution II,yields 5.02%higher mean annual profit and 4.69%greater NPV.The results indicate that pendulum routes in the Northeast Passage can achieve economic benefits by enabling year-round regular operations.Moreover,shorter shipping distances between hub ports and ice-covered areas enhance economic viability.展开更多
路由信息协议(Routing Information Protocol,RIP)是中小型计算机网络常用的路由协议,也是一种重要的基于距离矢量(Distance-Vector)算法的路由协议。本文利用华三HCL(H3C Cloud Lab)网络仿真软件,设计环状拓扑结构实验网络,配置网络路...路由信息协议(Routing Information Protocol,RIP)是中小型计算机网络常用的路由协议,也是一种重要的基于距离矢量(Distance-Vector)算法的路由协议。本文利用华三HCL(H3C Cloud Lab)网络仿真软件,设计环状拓扑结构实验网络,配置网络路由协议RIP,抓取RIP数据报文,跟踪分析网络路由环路生成。通过实验及协议数据报分析,观察路由环路动态变化,有助于深入理解RIP防止路由环路机制,提高路由故障排查能力。展开更多
In this study,a dynamic model for an inverted pendulum system(IPS)attached to a car is created,and two different control methods are applied to control the system.The designed control algorithms aim to stabilize the p...In this study,a dynamic model for an inverted pendulum system(IPS)attached to a car is created,and two different control methods are applied to control the system.The designed control algorithms aim to stabilize the pendulum arms in the upright position and the car to reach the equilibrium position.Grey Wolf Optimization-based Linear Quadratic Regulator(GWO-LQR)and GWO-based Fuzzy LQR(FLQR)control algorithms are used in the control process.To improve the performance of the LQR and FLQR methods,the optimum values of the coefficients corresponding to the foot points of the membership functions are determined by the GWO algorithm.Both a graphic and a numerical analysis of the outcomes are provided.In the comparative analysis,it is observed that the GWO-based FLQR method reduces the settling time by 22.58% and the maximum peak value by 18.2% when evaluated in terms of the angular response of the pendulum arm.Furthermore,this approach outperformed comparable research in the literature with a settling time of 2.4 s.These findings demonstrate that the suggested GWO-based FLQR controlmethod outperforms existing literature in terms of the time required for the pendulum arm to reach equilibrium.展开更多
The shear pin of the friction pendulum bearing(FPB)can be made of 40Cr steel.In conceptual design,the optimal cut-off point of the shear pin is predetermined,guiding the design of bridges isolated by FPBs to maximize ...The shear pin of the friction pendulum bearing(FPB)can be made of 40Cr steel.In conceptual design,the optimal cut-off point of the shear pin is predetermined,guiding the design of bridges isolated by FPBs to maximize their isolation performance.Current researches on the shear pins are mainly based on linear elastic models,neglecting their plasticity,damage,and fracture mechanical properties.To accurately predict its cutoff behavior,the elastic-plastic degradationmodel of 40Cr steel is indeed calibrated.For this purpose,the Ramberg-Osgoodmodel,the Bao-Wierzbicki damage initiation criterion,and the linear damage evolution criterion were selected to develop the elastic-plastic degradation model of 40Cr.Subsequently,parameter calibration of this model was performed through uniaxial tensile tests on two sets of six smooth,round bars with different diameters.Following this,finite element simulations were conducted for the pure shear test of grade 10.9 high-strength bolts made of 40Cr steel,aiming to verify the elasticplastic degradation model.The results showed that the failure modes and force-displacement curves simulated by the finite element method were in good agreement with the test results.Moreover,the error between the primary characteristic parameters(initial stiffness,peak load,fracture displacement,and absorbed energy)obtained by finite element calculation and the test values was within 15%.These results demonstrated that the calibration elastic-plastic degradation model of 40Cr steel can predict the cutoff of the shear pin.展开更多
文摘A 'Human-Imitating Intelligent Control Theory' with 'generalized reduction' and 'Human Imitating' concepts as its kernel is proposed. And a world puzzlein the control circles is solved successfully based on this theory. The puzzle is thewell-known 'triple inverted pendulum control' using a SINGLE motor. A human-imitating intelligent technique to control inverted pendulum is here described. The success. ful experimental results show that our control objective can be achieved without a precise mathematical model of the plant. Finally, general principles of designing complexautomatic control systems based on the human-imitating intelligent control theory areconcluded.
文摘An analytical model is presented for seismic analysis of triple friction pendulum bearings and validated using 81 bearing tests, each subjected to three cycles, with a duration of 12 seconds and using 250, 200 and 100 tons vertical loads. The main objective is to develop formulas for bilinear behavior using maximum, average and minimum friction coefficients to check which is the closest to the real behavior in the laboratory tests and comparatives curves plotting to observe the standard derivation. Parameters such as friction coefficients, effective stiffness, damping factor and vibration periods are analyzed to understand the structural behavior of the TPF bearings.
文摘The inverted pendulum is a classic problem in dynamics and control theory and is widely used as a benchmark for testing control algorithms. This paper studies the use of fuzzy control method to study the stability control problem of a triple inverted pendulum system. By the linear model of the system, the feedback weight matrix of the LQR optimal control and the feedback parameters of the linear optimal control are designed to determine the parameters of the fuzzy controller. The simulation results show that the proposed method can achieve the stability control of the three stage inverted pendulum, and has good dynamic performance with simple parameter selection.
文摘The incidence and mortality rate of lung cancer rank among the highest worldwide,severely endangering human health and life.Metformin,an anti-diabetes drug,has been shown to elicit anticancer activities in various tumors.However,its underlying mechanisms remain elusive.In this work,we explore the role of receptor-interacting protein 1(RIP1)which plays a crucial role in the process of cell death,in metformin-induced anticancer activities in lung cancer.Metformin inhibits lung cancer cell proliferation in a dose-dependent manner and promotes apoptotic cell death,as evidenced by metformin-induced PARP and caspase cleavage.Furthermore,the pan-caspase inhibitor z-VAD-fmk reverses metformin-induced cell death.Western blot and qPCR results suggest that metformin markedly downregulates RIP1 expression without affecting its mRNA and ubiquitination levels(0 vs 80 mmol/L,100%vs 20%,100%vs 15%).Additionally,co-immunoprecipitation and immunofluorescence results reveal that metformin may suppress RIP1 expression in an Hsp70-dependent manner,as metformin promotes Hsp70 degradation,and Hsp70 endogenously interacts with RIP1.Subsequent CCK-8,flow cytometry,and Western blot analyses suggest that metformin decreases Hsp70/RIP1 expression through AMPK/PKA/GSK-3βaxis.Consistently,results from a subcutaneous transplant tumor model indicate that metformin retards tumor growth without affecting mouse body weight.Collectively,these data highlight the part of RIP1 in metformin-induced anticancer activities in lung cancer in vitro and in vivo,providing novel strategy for lung cancer administration.
基金financially supported by the National Natural Science Foundation of China(Grants 52178124,52478151).
文摘When a coin is tossed to a gravity well,it will spiral instead of falling directly to the center.Inspired by this phenomenon,a gravity well-inspired double friction pendulum system(GW-DFPS)is developed to extend the length of sliding trajectories of bridge superstructures during pulse-like near-fault earthquakes.As a result,a greater amount of energy will be dissipated due to the frictional sliding of the isolators.The GW-DFPS consists of a spherical surface and an outer surface described by a 1/x or logarithmic function to build gravity well.Full-scale isolators were fabricated and their response was characterized considering various parameters such as the friction material of slider,surface roughness of sliding surfaces,and applied vertical loads.Additionally,a finite element model of the isolator was created using the experimental test data.Numerical simulations were performed on a case-study bridge structure isolated using both a conventional DFPS system and the proposed GW-DFPS systems.The experimental results reveal that the proposed isolators exhibit stable response under vertical loads varying from 200 kN to 1000 kN with a negative stiffness response when the isolator slides at the outer sliding surface.The numerical simulations of the selected bridge structure demonstrate that the GW-DFPS significantly extends the sliding trajectory lengths of the superstructure during half of the earthquake pulses,resulting in increased energy dissipation during this interval.The kinetic energies of the bridge isolated by GW-DFPS are consistently lower than those of the bridge isolated by the other two kinds of isolators,resulting lower shear forces on the bridge.
基金Project supported by the National Key Research and Development Program of China(Grant No.2020YFC2201001)the Guangdong Major Project of Basic and Applied Basic Research(Grant No.2019B030302001)+1 种基金the National Natural Science Foundation of China(Grant Nos.12105373,12105374,and 11927812)the Science and Technology Research Project of Jiangxi Provincial Department of Education(Grant No.GJJ2402105).
文摘Accurate thrust assessment is crucial for characterizing the performance of micro-thrusters.This paper presents a comprehensive evaluation of the thrust generated by a needle-type indium field emission electric propulsion(In-FEEP)micro-thruster using three methods based on a pendulum:direct thrust measurement,indirect plume momentum transfer and beam current diagnostics.The experimental setup utilized capacitive displacement sensors for force detection and a voice coil motor as a feedback actuator,achieving a resolution better than 0.1μN.Key performance factors such as ionization and plume divergence of ejected charged particles were also examined.The study reveals that the high applied voltage induces significant electrostatic interference,becoming the dominant source of error in direct thrust measurements.Beam current diagnostics and indirect plume momentum measurements were conducted simultaneously,showing strong agreement within a deviation of less than 0.2N across the operational thrust range.The results from all three methods are consistent within the error margins,verifying the reliability of the indirect measurement approach and the theoretical thrust model based on the electrical parameters of In-FEEP.
文摘Rip currents are a significant threat to swimmers worldwide,responsible for numerous drowning incidents each year.In Vietnam,Bai Dai Beach in Cam Ranh Bay,Khanh Hoa Province,has experienced an increase in drowning events due to rip currents in recent years.To address this issue,a comprehensive study was conducted based on developing a depth-averaged 2D hydrodynamic model to simulate rip currents in the Bai Dai-Cam Ranh coast.The HYDIST-2D numerical model was applied to simulate the rip current evolution in space and time for the study area.The results showed that the HYDIST-2D numerical model can accurately predict the location,magnitude,and microstructure of rip currents,including rip current speed,width,and length.The simulation results revealed that the rip current speed is greater during the low tide phase,with an average speed of 0.5 m s^(-1),while during high tide,the rip current speed is lower,around 0.1–0.8 m s^(-1).The width and length of the rip current also vary with the tide phase,with a wider and longer rip current observed during the low tide phase.The results also showed that the rip current speed and microstructure are influenced by the wave features,tide current,and bathymetry of the study area.The present study provides valuable insights into the dynamics of rip currents in the Bai Dai-Cam Ranh coast.The findings can be used to support the management of bathing activities and provide early warnings for potential risks associated with rip currents.
文摘Global warming has made the regular operation of Arctic routes possible.This study selects hub ports based on infrastructure conditions and sea ice status,and then designs two pendulum route solutions for the Northeast Passage according to the distance between hub ports and ice-covered areas.We employ an evaluation framework combining annual profit metrics with discounted net present value(NPV)analysis,conducting probabilistic economic assessments through Monte Carlo simulations(20,000 iterations).Key findings indicate that(1)both solutions demonstrate>90%probability of economic viability and(2)Solution I′,with hub ports closer to ice-covered areas than those in Solution II,yields 5.02%higher mean annual profit and 4.69%greater NPV.The results indicate that pendulum routes in the Northeast Passage can achieve economic benefits by enabling year-round regular operations.Moreover,shorter shipping distances between hub ports and ice-covered areas enhance economic viability.
文摘路由信息协议(Routing Information Protocol,RIP)是中小型计算机网络常用的路由协议,也是一种重要的基于距离矢量(Distance-Vector)算法的路由协议。本文利用华三HCL(H3C Cloud Lab)网络仿真软件,设计环状拓扑结构实验网络,配置网络路由协议RIP,抓取RIP数据报文,跟踪分析网络路由环路生成。通过实验及协议数据报分析,观察路由环路动态变化,有助于深入理解RIP防止路由环路机制,提高路由故障排查能力。
文摘In this study,a dynamic model for an inverted pendulum system(IPS)attached to a car is created,and two different control methods are applied to control the system.The designed control algorithms aim to stabilize the pendulum arms in the upright position and the car to reach the equilibrium position.Grey Wolf Optimization-based Linear Quadratic Regulator(GWO-LQR)and GWO-based Fuzzy LQR(FLQR)control algorithms are used in the control process.To improve the performance of the LQR and FLQR methods,the optimum values of the coefficients corresponding to the foot points of the membership functions are determined by the GWO algorithm.Both a graphic and a numerical analysis of the outcomes are provided.In the comparative analysis,it is observed that the GWO-based FLQR method reduces the settling time by 22.58% and the maximum peak value by 18.2% when evaluated in terms of the angular response of the pendulum arm.Furthermore,this approach outperformed comparable research in the literature with a settling time of 2.4 s.These findings demonstrate that the suggested GWO-based FLQR controlmethod outperforms existing literature in terms of the time required for the pendulum arm to reach equilibrium.
基金The Research Start-up Fund for Talents Introduction of Huaiyin Institute of Technology(Grant No.Z301B23517).
文摘The shear pin of the friction pendulum bearing(FPB)can be made of 40Cr steel.In conceptual design,the optimal cut-off point of the shear pin is predetermined,guiding the design of bridges isolated by FPBs to maximize their isolation performance.Current researches on the shear pins are mainly based on linear elastic models,neglecting their plasticity,damage,and fracture mechanical properties.To accurately predict its cutoff behavior,the elastic-plastic degradationmodel of 40Cr steel is indeed calibrated.For this purpose,the Ramberg-Osgoodmodel,the Bao-Wierzbicki damage initiation criterion,and the linear damage evolution criterion were selected to develop the elastic-plastic degradation model of 40Cr.Subsequently,parameter calibration of this model was performed through uniaxial tensile tests on two sets of six smooth,round bars with different diameters.Following this,finite element simulations were conducted for the pure shear test of grade 10.9 high-strength bolts made of 40Cr steel,aiming to verify the elasticplastic degradation model.The results showed that the failure modes and force-displacement curves simulated by the finite element method were in good agreement with the test results.Moreover,the error between the primary characteristic parameters(initial stiffness,peak load,fracture displacement,and absorbed energy)obtained by finite element calculation and the test values was within 15%.These results demonstrated that the calibration elastic-plastic degradation model of 40Cr steel can predict the cutoff of the shear pin.
