The generation of reactive oxygen species(ROS)is often limited by the overexpression of glutathione(GSH)in the tumor microenvironment(TME)and the penetration depth of visible light.In view of this,we designed biodegra...The generation of reactive oxygen species(ROS)is often limited by the overexpression of glutathione(GSH)in the tumor microenvironment(TME)and the penetration depth of visible light.In view of this,we designed biodegradable Cu/ZIF-8 shell-coated lanthanide-doped nanoparticles and loaded with a photosensitizer(Rose Bengal),and fabricated a NIR-triggered nanocomposite NaYF_(4):20%Yb,2%Er@Cu/ZIF-8/RB@F127(UCZRF)for the synergistic treatment of CDT and PDT.Interestingly,the UCZRF nanostructures can specifically release RB and Cu^(2+)in the acidic tumor microenvironment(TME).Cu^(2+)depletes GSH to effectively change the amount of ROS produced by RB under 980 nm laser irradiation,and Cu+from the reduction reaction of GSH reacts with excess hydrogen peroxide(H_(2)O_(2))in the TME to generate hydroxyl radicals(·OH)with high oxidation activity.In such a simple nanosystem,we enhance the anti-tumor effect of CDT and PDT by improving the efficiency of ROS generation.展开更多
基金supported by the National Natural Science Foundation of China(grant no.NSFC 51720105015,51672269,51929201,51922097,51772124 and 51872282)the Science and Technology Cooperation Project between Chinese and Australian Governments(2017YFE0132300)+5 种基金the Jiangmen Innovative Research Team Program(2017)the Major Program of Basic Research and Applied Research of Guangdong Province(2017KZDXM083)the Key Research Program of Frontier Sciences,CAS(YZDYSSW-JSC018)the Youth Innovation Promotion Association of CAS(grant no.2017273)the Overseas,Hong Kong&Macao Scholars Collaborated Researching Fund(grant no.21728101)the CAS-Croucher Funding Scheme for Joint Laboratories(grant no.CAS18204).
文摘The generation of reactive oxygen species(ROS)is often limited by the overexpression of glutathione(GSH)in the tumor microenvironment(TME)and the penetration depth of visible light.In view of this,we designed biodegradable Cu/ZIF-8 shell-coated lanthanide-doped nanoparticles and loaded with a photosensitizer(Rose Bengal),and fabricated a NIR-triggered nanocomposite NaYF_(4):20%Yb,2%Er@Cu/ZIF-8/RB@F127(UCZRF)for the synergistic treatment of CDT and PDT.Interestingly,the UCZRF nanostructures can specifically release RB and Cu^(2+)in the acidic tumor microenvironment(TME).Cu^(2+)depletes GSH to effectively change the amount of ROS produced by RB under 980 nm laser irradiation,and Cu+from the reduction reaction of GSH reacts with excess hydrogen peroxide(H_(2)O_(2))in the TME to generate hydroxyl radicals(·OH)with high oxidation activity.In such a simple nanosystem,we enhance the anti-tumor effect of CDT and PDT by improving the efficiency of ROS generation.
