The rarity of Francisella novicida infection in humans is well-known,and the F.novicida cases occur in immunocompromised patients or those with underlying health problems.Herein,we report the case of a patient with lo...The rarity of Francisella novicida infection in humans is well-known,and the F.novicida cases occur in immunocompromised patients or those with underlying health problems.Herein,we report the case of a patient with long-term diabetes who died following F.novicida infection that caused multiple organ failure,although F.novicida was effectively eliminated using antimicrobial therapy.Microbiological confirmation of F.novicida infection relies on metagenomic next-generation sequencing(mNGS)and pdpD-2 gene-specific identification.This study highlights the importance of early pathogen diagnosis in severely infected patients,particularly in cases of F.novicida,and indicates that mNGS is a useful tool for early diagnosis.展开更多
基金supported by National key R&D projects(2022YFC2302701)Science and Technology Planning Project of Guangdong Province(2021B1212040017)Sun Yat-sen University Founded Program(2022_76220_B21127).
文摘The rarity of Francisella novicida infection in humans is well-known,and the F.novicida cases occur in immunocompromised patients or those with underlying health problems.Herein,we report the case of a patient with long-term diabetes who died following F.novicida infection that caused multiple organ failure,although F.novicida was effectively eliminated using antimicrobial therapy.Microbiological confirmation of F.novicida infection relies on metagenomic next-generation sequencing(mNGS)and pdpD-2 gene-specific identification.This study highlights the importance of early pathogen diagnosis in severely infected patients,particularly in cases of F.novicida,and indicates that mNGS is a useful tool for early diagnosis.
