The Infrared Hyperspectral Atmospheric SounderⅡ(HIRAS-Ⅱ)is the key equipment on FengYun-3E(FY-3E)satellite,which can realize vertical atmospheric detection,featuring hyper spectral,high sensitivity and high precisio...The Infrared Hyperspectral Atmospheric SounderⅡ(HIRAS-Ⅱ)is the key equipment on FengYun-3E(FY-3E)satellite,which can realize vertical atmospheric detection,featuring hyper spectral,high sensitivity and high precision.To ensure its accuracy of detection,it is necessary to correlate their thermal models to in-orbit da⁃ta.In this work,an investigation of intelligent correlation method named Intelligent Correlation Platform for Ther⁃mal Model(ICP-TM)was established,the advanced Kriging surrogate model and efficient adaptive region opti⁃mization algorithm were introduced.After the correlation with this method for FY-3E/HIRAS-Ⅱ,the results indi⁃cate that compared with the data in orbit,the error of the thermal model has decreased from 5 K to within±1 K in cold case(10℃).Then,the correlated model is validated in hot case(20℃),and the correlated model exhibits good universality.This correlation precision is also much superiors to the general ones like 3 K in other similar lit⁃erature.Furthermore,the process is finished in 8 days using ICP-TM,the efficiency is much better than 3 months based on manual.The results show that the proposed approach significantly enhances the accuracy and efficiency of thermal model,this contributes to the precise thermal control of subsequent infrared optical payloads.展开更多
A robust attitude control methodology is proposed for satellite system with double rotary payloads. The dynamic model is built by the Newton-Euler method and then the dynamic interconneetion between satellite＇s main ...A robust attitude control methodology is proposed for satellite system with double rotary payloads. The dynamic model is built by the Newton-Euler method and then the dynamic interconneetion between satellite＇s main body and payloads is described precisely. A nonlinear disturbance observer is designed for satellite＇s main body to estimate disturbance torque acted by motion of payloads. Meanwhile, the adaptive fast nonsingular terminal sliding-mode attitude stabilization controller is proposed for satellite＇s main body to quicken convergence speed of state variables. Similarly, the adaptive fast nonsingular terminal sliding-mode attitude maneuver controller is designed for each payload to weaken the disturbance effect of motion of satellite＇s main body. Simulation results verify the effectiveness of the proposed method.展开更多
China’s first Mars exploration mission is scheduled to be launched in 2020.It aims not only to conduct global and comprehensive exploration of Mars by use of an orbiter but also to carry out in situ observation of ke...China’s first Mars exploration mission is scheduled to be launched in 2020.It aims not only to conduct global and comprehensive exploration of Mars by use of an orbiter but also to carry out in situ observation of key sites on Mars with a rover.This mission focuses on the following studies:topography,geomorphology,geological structure,soil characteristics,water-ice distribution,material composition,atmosphere and ionosphere,surface climate,environmental characteristics,Mars internal structure,and Martian magnetic field.It is comprised of an orbiter,a lander,and a rover equipped with 13 scientific payloads.This article will give an introduction to the mission including mission plan,scientific objectives,scientific payloads,and its recent development progress.展开更多
Large unmanned underwater vehicles can carry big payloads for varied missions and it is desirable for them to possess an upright orientation during payload release.Their attitude can hardly be maintained during and af...Large unmanned underwater vehicles can carry big payloads for varied missions and it is desirable for them to possess an upright orientation during payload release.Their attitude can hardly be maintained during and after the phase of payload release.Releasing a payload from the vehicle induces uncertainties not only in rigid-body parameters,e.g,the moment of inertia tensor due to the varying distribution of the masses on board the vehicle,but also in the hydrodynamic derivatives due to the vehicle’s varying geometric profile.A nonlinear attitude stabilizer that is robust to these time-varying model uncertainties is proposed in this paper.Stability is guaranteed via Lyapunov stability theory.The simulation results verify the effectiveness of the proposed approach.展开更多
In this paper, robust control problem is addressed for quad-rotor delivering unknown time-varying payloads. Firstly, the model of a quad-rotor carrying payloads is built. Dynamics of the payloads are treated as distur...In this paper, robust control problem is addressed for quad-rotor delivering unknown time-varying payloads. Firstly, the model of a quad-rotor carrying payloads is built. Dynamics of the payloads are treated as disturbances and added into the model of the quad-rotor. Secondly, to enhance system robust-ness, the extended state observer (ESO) is applied to estimate the disturbances from the payloads for feedback compensation. Then a type of predictive controller targeting multiple-input-multiple-output (MIMO) system is developed to degrade the influences caused by sudden changes from load-ing/dropping of the payloads. Finally, by making comparison with the con-ventional cascade proportional-integral-derivative (CPID) and the sliding mode control (SMC) approaches, superiority of the scheme developed is va-lidated. The simulation results indicate that the CPID method shows poor performance on attitude stabilization and the SMC shows input chattering phenomenon even it can achieve satisfied control performances.展开更多
Mars is not only our nearby but also the most Earth-like planetary neighbor.Scientific exploration of Mars is thus of crucial value to our understanding of the solar system.The existence of abundant evidence for the f...Mars is not only our nearby but also the most Earth-like planetary neighbor.Scientific exploration of Mars is thus of crucial value to our understanding of the solar system.The existence of abundant evidence for the former presence of water on Mars demands further exploration for signs of life on our sister planet,and investigations that could shed light on conditions favorable to the origin of life.For nearly 60 years,humans have conducted orbitally-based remote sensing and in-situ surface exploration of Mars,leading to many significant scientific discoveries.But much remains to be done before we can be sure that we truly and fully understand Mars.Key research topics include the history of water on Mars and how that history relates to the planet’s habitable environment-past,present,and future;the distribution and evolution of waterbearing and evaporative salt minerals on the planet’s surface;the history of volcanic activity on Mars;the Martian magnetic field and its effect on the escape of water and atmosphere from the planet;interactions between the solar wind and the Martian atmosphere and ionosphere;atmospheric characteristics and climate change on Mars;and so on(Li CL et al.,2018;Liu JJ et al.,2018).Based on the above scientific questions about life,climate,and geology on Mars,the international planetary science community has formulated ambitious Mars exploration programs.展开更多
Antibody-drug conjugates(ADCs),which combine the advantages of monoclonal antibodies with precise targeting and payloads with efficient killing,show great clinical therapeutic value.The ADCs’payloads play a key role ...Antibody-drug conjugates(ADCs),which combine the advantages of monoclonal antibodies with precise targeting and payloads with efficient killing,show great clinical therapeutic value.The ADCs’payloads play a key role in determining the efficacy of ADC drugs and thus have attracted great attention in the field.An ideal ADC payload should possess sufficient toxicity,low immunogenicity,high stability,and modifiable functional groups.Common ADC payloads include tubulin inhibitors and DNA damaging agents,with tubulin inhibitors accounting for more than half of the ADC drugs in clinical development.However,due to clinical limitations of traditional ADC payloads,such as inadequate efficacy and the development of acquired drug resistance,novel highly efficient payloads with diverse targets and reduced side effects are being developed.This perspective summarizes the recent research advances of traditional and novel ADC payloads with main focuses on the structure-activity relationship studies,co-crystal structures,and designing strategies,and further discusses the future research directions of ADC payloads.This review also aims to provide valuable references and future directions for the development of novel ADC payloads that will have high efficacy,low toxicity,adequate stability,and abilities to overcome drug resistance.展开更多
Ganzi Tibetan Autonomous Prefecture(hereafter referred to as Ganzi),Sichuan Province,China,is situated at the southeastern edge of the Qinghai-Tibet Plateau,adjacent to the Sichuan Basin.The region has a high-elevatio...Ganzi Tibetan Autonomous Prefecture(hereafter referred to as Ganzi),Sichuan Province,China,is situated at the southeastern edge of the Qinghai-Tibet Plateau,adjacent to the Sichuan Basin.The region has a high-elevation mountainous terrain covered by dense forests.On March 15,2024,awildfire broke out in Ganzi due to hot work.展开更多
Statistics show that more than 80 applications are installed on each android smartphone.Vulnerability research on Android applications is of critical importance.Recently,academic researchers mainly focus on single bug...Statistics show that more than 80 applications are installed on each android smartphone.Vulnerability research on Android applications is of critical importance.Recently,academic researchers mainly focus on single bug patterns,while few of them investigate the relations between multiple bugs.Industrial researchers proposed a series of logic exploit chains leveraging multiple logic bugs.However,there is no general model to evaluate the chaining abilities between bugs.This paper presents a formal model to elucidate the relations between multiple bugs in Android applications.To prove the effectiveness of the model,we design and implement a prototype system named AppChainer.AppChainer automatically identifies attack surfaces of Android applications and investigates whether the payloads entering these attack surfaces are“chainable”.Experimental results on 2138 popular Android applications show that AppChainer is effective in identifying and chaining attacker-controllable payloads.It identifies 14467 chainable payloads and constructs 5458 chains both inside a single application and among various applications.The time cost and resource consumption of AppChainer are also acceptable.For each application,the average analysis time is 317 s,and the average memory consumed is 2368 MB.Compared with the most relevant work Jandroid,the experiment results on our custom DroidChainBench show that AppChainer outperforms Jandroid at the precision rate and performs equally with Jandroid at the recall rate.展开更多
The evolution of cancer therapies has highlighted the limitations of traditional chemotherapy,particularly its lack of specificity and off-target toxicities,driving the development of targeted treatments like small mo...The evolution of cancer therapies has highlighted the limitations of traditional chemotherapy,particularly its lack of specificity and off-target toxicities,driving the development of targeted treatments like small molecule-drug conjugates(SMDCs).SMDCs offer distinct advantages over antibody-drug conjugates(ADCs),including simpler synthesis,lower production costs,and improved solid tumor penetration due to their smaller size.However,challenges remain,such as a limited variety of targeting ligands and the complexity of optimizing selectivity and efficacy within the tumor microenvironment.This review focuses on key aspects such as mechanisms of action,biomarker selection,and the optimization of each component of SMDCs.It also covers SMDCs that have been approved or are currently under active clinical trials,while providing insights into future developments in this promising field of targeted cancer therapies.展开更多
This study aimed to evaluate the wake effect on the electric field detector(EFD) onboard the China Seismo-Electromagnetic Satellite(CSES-01). Through a series of experiments and analyses, we confirmed that the disturb...This study aimed to evaluate the wake effect on the electric field detector(EFD) onboard the China Seismo-Electromagnetic Satellite(CSES-01). Through a series of experiments and analyses, we confirmed that the disturbance phenomenon from probe B of the EFD is not caused by the boom layout. To validate and determine whether it is influenced by the wake effect, we conducted two experiments. In the first experiment, the entire satellite platform underwent a 90° counterclockwise yaw maneuver to allow probe B to avoid the plasma wake region. We then verified whether the disturbance was improved. In the second experiment, the satellite platform performed a 180° counterclockwise yaw maneuver, positioning probe B on the ram side of the satellite and completely avoiding all satellite wakes. The plasma wake effect of the satellite did not significantly influence the spherical probes of the EFD because the measurement accuracy stayed relatively stable under the two experiments, despite the observed abnormalities in the operating state of spherical probe B. This consistency in performance is important for electric field detection missions because the spatial electric field vector data obtained from these probes continue to effectively reflect information on spatial electromagnetic disturbances. These two experimental results showed that probe B consistently exhibited data jump phenomena under various maneuver states, whereas probes A, C, and D did not display such phenomena in any maneuver state.展开更多
About this issue:Radar astronomy is a science that utilizes radar electromagnetic waves to study celestial bodies within and beyond the solar system,focusing mainly on planets,satellites and small bodies such as the M...About this issue:Radar astronomy is a science that utilizes radar electromagnetic waves to study celestial bodies within and beyond the solar system,focusing mainly on planets,satellites and small bodies such as the Moon,Mars,Venus and Saturn.Through radar electromagnetic wave detection,we are able to gain an in-depth understanding of these celestial bodies'internal structures,composition,distribution of water resources,magnetic fields,atmospheres,and other physical properties.This is of great significance for human beings to find a habitable environment in the solar system.At present,the observation methods of radar astronomy mainly rely on ground-based radio telescopes that actively emit electromagnetic waves.In recent years,with the continuous advancement of international deep space exploration,in-situ radar detection technology has gradually become an indispensable new tool for lunar and planetary radar astronomical observations.For example,China's Chang'e3,4,5 and 6 missions,as well as the Tianwen-1 mission to Mars and the United States'Perseverance rover,are equipped with radar payloads.These deep space exploration missions have expanded radar astronomy techniques to lunar and planetary surface observations,greatly enriching and promoting the scientific content and development of radar astronomy.For this reason,the editorial office invited Dr.Chunyu Ding from Shenzhen University and Dr.Yan Su from the National Astronomical Observatories,Chinese Academy of Sciences to co edit a special issue of radar astronomy.展开更多
The rocket sled system is not only a high-speed dynamic ground test system,but also one of the future aerospace horizontal launch schemes.The winged load,as a common type of payload,has greater vibration and noise int...The rocket sled system is not only a high-speed dynamic ground test system,but also one of the future aerospace horizontal launch schemes.The winged load,as a common type of payload,has greater vibration and noise intensity than the wingless load.Due to the severe aerodynamic instability prior to separation,the head-up or head-down phenomena are more evident and the test accuracy significantly decreases.The high-precision computer fluid dynamics and aeroacoustic analysis are employed to explore the multifield coupling mechanism of a rocket sled with the winged payload in the wide speed range(Ma=0.5–2).The results show that as the incoming velocity increases,the cone angle of the shock wave of the rocket sled decreases,the shock pressure increases quickly,and the vortex between the slippers splits and gradually shrinks in size.The velocity of the rocket sled exerts little influence on the modal resonance frequency.The wing has a significant impact on aerodynamic noise,and as the sound pressure level rises,the propagation direction gradually shifts towards the rear and upper regions of the wing.展开更多
Traditional weather observation methods have limitations in detecting low-altitude,small-scale areas and sudden weather events.They often have insufficient coverage,slow response,or high costs.Multi-rotor unmanned aer...Traditional weather observation methods have limitations in detecting low-altitude,small-scale areas and sudden weather events.They often have insufficient coverage,slow response,or high costs.Multi-rotor unmanned aerial vehicles(UAVs),with their strong vertical take-off and landing ability,precise hovering,flexible movement,and ability to carry various small sensors,are gradually becoming key tools to fill these gaps and build three-dimensional weather observation networks.They show important value in medium-and small-scale weather monitoring and emergency weather support.This paper reviews the main sensors for multi-rotor weather drones,their operating modes,and key supporting technologies,summarizes the current state of technology,and provides references for future development.展开更多
Gamma-ray spectrometer （GRS） is one of the main payloads on the Chang＇E-1 （CE-1） lunar probe, mainly aimed to detect the elemental abundances and distributions on the lunar surface. At 03：58 on 28 November 2007,...Gamma-ray spectrometer （GRS） is one of the main payloads on the Chang＇E-1 （CE-1） lunar probe, mainly aimed to detect the elemental abundances and distributions on the lunar surface. At 03：58 on 28 November 2007, it performed the first observation of the lunar gamma rays. As of 24 October 2008, 2105 h of effective gamma rays spectra had been acquired by CE-1 GRS, which covers the whole surface of the moon. This paper mainly describes the data processing procedures and methods of deriving the elemental abundances by using the CE-1 GRS time series corrected spectra： first, to bin data into pixels for mapping; then, to perform a background deduction of the cumulative spectra and obtain a peak area of the elements; and finally, to use the elemental abundances inversion model to produce the elemental abundances. Based on these processing methods, the global abundance maps of U, K, and Th at a 5°×5° equal-area pixel are acquired by CE-1 GRS data. The paper gives a preliminary analysis of the uncertainties of the elemental abundances.展开更多
Multiple images steganography refers to hiding secret messages in multiple natural images to minimize the leakage of secret messages during transmission.Currently,the main multiple images steganography algorithms main...Multiple images steganography refers to hiding secret messages in multiple natural images to minimize the leakage of secret messages during transmission.Currently,the main multiple images steganography algorithms mainly distribute the payloads as sparsely as possible inmultiple cover images to improve the detection error rate of stego images.In order to enable the payloads to be accurately and efficiently distributed in each cover image,this paper proposes a multiple images steganography for JPEG images based on optimal payload redistribution.Firstly,the algorithm uses the principle of dynamic programming to redistribute the payloads of the cover images to reduce the time required in the process of payloads distribution.Then,by reducing the difference between the features of the cover images and the stego images to increase the detection error rate of the stego images.Secondly,this paper uses a data decomposition mechanism based on Vandermonde matrix.Even if part of the data is lost during the transmission of the secret messages,as long as the data loss rate is less than the data redundancy rate,the original secret messages can be recovered.Experimental results show that the method proposed in this paper improves the efficiency of payloads distribution compared with existing multiple images steganography.At the same time,the algorithm can achieve the optimal payload distribution of multiple images steganography to improve the anti-statistical detection performance of stego images.展开更多
China’s Chang’E-4 probe successfully landed on 3 January 2019 in Von Kármán crater within the South Pole-Aitken(SPA)basin on the lunar far side.Based on the data acquired by the scientific payloads onboard...China’s Chang’E-4 probe successfully landed on 3 January 2019 in Von Kármán crater within the South Pole-Aitken(SPA)basin on the lunar far side.Based on the data acquired by the scientific payloads onboard the lander and the rover,the researchers obtained the related information such as the geologic and tectonic setting of the landing area,compositional characteristics of the landing surface materials,dielectric permittivity and density of the lunar soil.The experiments confirmed the existence of materials dominated by olivine and low-calcium pyroxene in the SPA basin on the lunar far side,which preliminary revealed the geological evolution history of the SPA basin and even that of the early time lunar crust,as well as the tectonic setting and formation mechanism of the materials in the lunar interior.The researchers also investigated the particle radiation,Linear Energy Transaction(LET)spectrum,and so forth on the lunar surface.The low-frequency radio observations were carried out on the lunar far side for the first time as well.This article summarizes the latest scientific results in the past years,focusing on the Chang’E-4 mission.展开更多
The variation of mass, and moment of inertia of a spin-stabilized spacecraft leads to concern about the nutation instability. Here a careful analysis on the nutation instability is performed on a spacecraft propelled ...The variation of mass, and moment of inertia of a spin-stabilized spacecraft leads to concern about the nutation instability. Here a careful analysis on the nutation instability is performed on a spacecraft propelled by solid rocket booster（SRB）. The influences of specific solid propellant designs on transversal angular velocity are discussed. The results show that the typical SRB of End Burn suppresses the non-principal axial angular velocity. On the contrary, the frequently used SRB of Radial Burn could amplify the transversal angular velocity. The nutation instability caused by a design of Radial Burn could be remedied by the addition of End Burn at the same time based on the study of the combination design of both End Burn and Radial Burn.The analysis of the results proposes the design conception of how to control the nutation motion.The method is suitable to resolve the nutation instability of solid rocket motor with complex propellant patterns.展开更多
基金Supported by the National Key Research and Development Program of China(2022YFB3904803)。
文摘The Infrared Hyperspectral Atmospheric SounderⅡ(HIRAS-Ⅱ)is the key equipment on FengYun-3E(FY-3E)satellite,which can realize vertical atmospheric detection,featuring hyper spectral,high sensitivity and high precision.To ensure its accuracy of detection,it is necessary to correlate their thermal models to in-orbit da⁃ta.In this work,an investigation of intelligent correlation method named Intelligent Correlation Platform for Ther⁃mal Model(ICP-TM)was established,the advanced Kriging surrogate model and efficient adaptive region opti⁃mization algorithm were introduced.After the correlation with this method for FY-3E/HIRAS-Ⅱ,the results indi⁃cate that compared with the data in orbit,the error of the thermal model has decreased from 5 K to within±1 K in cold case(10℃).Then,the correlated model is validated in hot case(20℃),and the correlated model exhibits good universality.This correlation precision is also much superiors to the general ones like 3 K in other similar lit⁃erature.Furthermore,the process is finished in 8 days using ICP-TM,the efficiency is much better than 3 months based on manual.The results show that the proposed approach significantly enhances the accuracy and efficiency of thermal model,this contributes to the precise thermal control of subsequent infrared optical payloads.
基金supported by the National Natural Science Foundation of China(No.91016017)the Funding of Jiangsu Innovation Program for Graduate Education (No. CXZZ12_0160)+1 种基金the Natural Science Foundation of Jiangsu Province of China(No.BK20130234)the Changzhou Sci.& Tech.Program (CE20145056)
文摘A robust attitude control methodology is proposed for satellite system with double rotary payloads. The dynamic model is built by the Newton-Euler method and then the dynamic interconneetion between satellite＇s main body and payloads is described precisely. A nonlinear disturbance observer is designed for satellite＇s main body to estimate disturbance torque acted by motion of payloads. Meanwhile, the adaptive fast nonsingular terminal sliding-mode attitude stabilization controller is proposed for satellite＇s main body to quicken convergence speed of state variables. Similarly, the adaptive fast nonsingular terminal sliding-mode attitude maneuver controller is designed for each payload to weaken the disturbance effect of motion of satellite＇s main body. Simulation results verify the effectiveness of the proposed method.
基金Supported by the Major Program of the National Science Foundation of China(41590851)the Beijing Municipal Science and Technology Commission(Z181100002918003)。
文摘China’s first Mars exploration mission is scheduled to be launched in 2020.It aims not only to conduct global and comprehensive exploration of Mars by use of an orbiter but also to carry out in situ observation of key sites on Mars with a rover.This mission focuses on the following studies:topography,geomorphology,geological structure,soil characteristics,water-ice distribution,material composition,atmosphere and ionosphere,surface climate,environmental characteristics,Mars internal structure,and Martian magnetic field.It is comprised of an orbiter,a lander,and a rover equipped with 13 scientific payloads.This article will give an introduction to the mission including mission plan,scientific objectives,scientific payloads,and its recent development progress.
文摘Large unmanned underwater vehicles can carry big payloads for varied missions and it is desirable for them to possess an upright orientation during payload release.Their attitude can hardly be maintained during and after the phase of payload release.Releasing a payload from the vehicle induces uncertainties not only in rigid-body parameters,e.g,the moment of inertia tensor due to the varying distribution of the masses on board the vehicle,but also in the hydrodynamic derivatives due to the vehicle’s varying geometric profile.A nonlinear attitude stabilizer that is robust to these time-varying model uncertainties is proposed in this paper.Stability is guaranteed via Lyapunov stability theory.The simulation results verify the effectiveness of the proposed approach.
文摘In this paper, robust control problem is addressed for quad-rotor delivering unknown time-varying payloads. Firstly, the model of a quad-rotor carrying payloads is built. Dynamics of the payloads are treated as disturbances and added into the model of the quad-rotor. Secondly, to enhance system robust-ness, the extended state observer (ESO) is applied to estimate the disturbances from the payloads for feedback compensation. Then a type of predictive controller targeting multiple-input-multiple-output (MIMO) system is developed to degrade the influences caused by sudden changes from load-ing/dropping of the payloads. Finally, by making comparison with the con-ventional cascade proportional-integral-derivative (CPID) and the sliding mode control (SMC) approaches, superiority of the scheme developed is va-lidated. The simulation results indicate that the CPID method shows poor performance on attitude stabilization and the SMC shows input chattering phenomenon even it can achieve satisfied control performances.
文摘Mars is not only our nearby but also the most Earth-like planetary neighbor.Scientific exploration of Mars is thus of crucial value to our understanding of the solar system.The existence of abundant evidence for the former presence of water on Mars demands further exploration for signs of life on our sister planet,and investigations that could shed light on conditions favorable to the origin of life.For nearly 60 years,humans have conducted orbitally-based remote sensing and in-situ surface exploration of Mars,leading to many significant scientific discoveries.But much remains to be done before we can be sure that we truly and fully understand Mars.Key research topics include the history of water on Mars and how that history relates to the planet’s habitable environment-past,present,and future;the distribution and evolution of waterbearing and evaporative salt minerals on the planet’s surface;the history of volcanic activity on Mars;the Martian magnetic field and its effect on the escape of water and atmosphere from the planet;interactions between the solar wind and the Martian atmosphere and ionosphere;atmospheric characteristics and climate change on Mars;and so on(Li CL et al.,2018;Liu JJ et al.,2018).Based on the above scientific questions about life,climate,and geology on Mars,the international planetary science community has formulated ambitious Mars exploration programs.
基金provided by the National Natural Science Foundation of China(82073318)the Fundamental Research Funds for the Central Universities(SCU2022D025,0082604151345,China)+1 种基金Sichuan Science and Technology Program Projects(2019YFS0003,China)to Yuxi Wangprovided by the University of Tennessee College of Pharmacy Drug Discovery Center to Wei Li。
文摘Antibody-drug conjugates(ADCs),which combine the advantages of monoclonal antibodies with precise targeting and payloads with efficient killing,show great clinical therapeutic value.The ADCs’payloads play a key role in determining the efficacy of ADC drugs and thus have attracted great attention in the field.An ideal ADC payload should possess sufficient toxicity,low immunogenicity,high stability,and modifiable functional groups.Common ADC payloads include tubulin inhibitors and DNA damaging agents,with tubulin inhibitors accounting for more than half of the ADC drugs in clinical development.However,due to clinical limitations of traditional ADC payloads,such as inadequate efficacy and the development of acquired drug resistance,novel highly efficient payloads with diverse targets and reduced side effects are being developed.This perspective summarizes the recent research advances of traditional and novel ADC payloads with main focuses on the structure-activity relationship studies,co-crystal structures,and designing strategies,and further discusses the future research directions of ADC payloads.This review also aims to provide valuable references and future directions for the development of novel ADC payloads that will have high efficacy,low toxicity,adequate stability,and abilities to overcome drug resistance.
基金supported by the Space Technologies for Sustainable Development Goals International Partnership Program of the Chinese Academy of Sciences for Big Science(313GJHZ2022040BS)the SDG Report Sub-Project of International Research Center of Big Data for Sustainable Development Goals(CBAS)(CBAS2024SDG009).
文摘Ganzi Tibetan Autonomous Prefecture(hereafter referred to as Ganzi),Sichuan Province,China,is situated at the southeastern edge of the Qinghai-Tibet Plateau,adjacent to the Sichuan Basin.The region has a high-elevation mountainous terrain covered by dense forests.On March 15,2024,awildfire broke out in Ganzi due to hot work.
基金This work was supported by the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDC02040100).
文摘Statistics show that more than 80 applications are installed on each android smartphone.Vulnerability research on Android applications is of critical importance.Recently,academic researchers mainly focus on single bug patterns,while few of them investigate the relations between multiple bugs.Industrial researchers proposed a series of logic exploit chains leveraging multiple logic bugs.However,there is no general model to evaluate the chaining abilities between bugs.This paper presents a formal model to elucidate the relations between multiple bugs in Android applications.To prove the effectiveness of the model,we design and implement a prototype system named AppChainer.AppChainer automatically identifies attack surfaces of Android applications and investigates whether the payloads entering these attack surfaces are“chainable”.Experimental results on 2138 popular Android applications show that AppChainer is effective in identifying and chaining attacker-controllable payloads.It identifies 14467 chainable payloads and constructs 5458 chains both inside a single application and among various applications.The time cost and resource consumption of AppChainer are also acceptable.For each application,the average analysis time is 317 s,and the average memory consumed is 2368 MB.Compared with the most relevant work Jandroid,the experiment results on our custom DroidChainBench show that AppChainer outperforms Jandroid at the precision rate and performs equally with Jandroid at the recall rate.
基金the financial support from the National Natural Science Foundation of China(Nos.82473781,82173652 and 81872728)the Natural Science Foundation of Jiangsu Province(No.BK20221522)Support from Jiangsu“333 High Level Talents Cultivation”Leading Talents(No.2022–3–16–203)。
文摘The evolution of cancer therapies has highlighted the limitations of traditional chemotherapy,particularly its lack of specificity and off-target toxicities,driving the development of targeted treatments like small molecule-drug conjugates(SMDCs).SMDCs offer distinct advantages over antibody-drug conjugates(ADCs),including simpler synthesis,lower production costs,and improved solid tumor penetration due to their smaller size.However,challenges remain,such as a limited variety of targeting ligands and the complexity of optimizing selectivity and efficacy within the tumor microenvironment.This review focuses on key aspects such as mechanisms of action,biomarker selection,and the optimization of each component of SMDCs.It also covers SMDCs that have been approved or are currently under active clinical trials,while providing insights into future developments in this promising field of targeted cancer therapies.
基金a project funded by the China National Space Administration (CNSA) and China Earthquake Administration (CEA)supported by the National Key R&D Program of Intergovernmental Cooperation in Science and Technology (Grant No. 2023YFE0117300)+3 种基金the International Space Science Institute (ISSI in Bern, Switzerland, and ISSI-BJ in Beijing, China)supporting International Team 23-583 led by Dedalo Marchetti and Essam Ghamrythe Hebei Province Graduate Professional Degree Excellent Teaching Case (Library) Construction Project (Grant No. KCJPZ2023060)the Open Fund for the Key Laboratory of Seismic Disaster Instruments and Monitoring Technology in Hebei Province (Grant No. FZ224104)。
文摘This study aimed to evaluate the wake effect on the electric field detector(EFD) onboard the China Seismo-Electromagnetic Satellite(CSES-01). Through a series of experiments and analyses, we confirmed that the disturbance phenomenon from probe B of the EFD is not caused by the boom layout. To validate and determine whether it is influenced by the wake effect, we conducted two experiments. In the first experiment, the entire satellite platform underwent a 90° counterclockwise yaw maneuver to allow probe B to avoid the plasma wake region. We then verified whether the disturbance was improved. In the second experiment, the satellite platform performed a 180° counterclockwise yaw maneuver, positioning probe B on the ram side of the satellite and completely avoiding all satellite wakes. The plasma wake effect of the satellite did not significantly influence the spherical probes of the EFD because the measurement accuracy stayed relatively stable under the two experiments, despite the observed abnormalities in the operating state of spherical probe B. This consistency in performance is important for electric field detection missions because the spatial electric field vector data obtained from these probes continue to effectively reflect information on spatial electromagnetic disturbances. These two experimental results showed that probe B consistently exhibited data jump phenomena under various maneuver states, whereas probes A, C, and D did not display such phenomena in any maneuver state.
文摘About this issue:Radar astronomy is a science that utilizes radar electromagnetic waves to study celestial bodies within and beyond the solar system,focusing mainly on planets,satellites and small bodies such as the Moon,Mars,Venus and Saturn.Through radar electromagnetic wave detection,we are able to gain an in-depth understanding of these celestial bodies'internal structures,composition,distribution of water resources,magnetic fields,atmospheres,and other physical properties.This is of great significance for human beings to find a habitable environment in the solar system.At present,the observation methods of radar astronomy mainly rely on ground-based radio telescopes that actively emit electromagnetic waves.In recent years,with the continuous advancement of international deep space exploration,in-situ radar detection technology has gradually become an indispensable new tool for lunar and planetary radar astronomical observations.For example,China's Chang'e3,4,5 and 6 missions,as well as the Tianwen-1 mission to Mars and the United States'Perseverance rover,are equipped with radar payloads.These deep space exploration missions have expanded radar astronomy techniques to lunar and planetary surface observations,greatly enriching and promoting the scientific content and development of radar astronomy.For this reason,the editorial office invited Dr.Chunyu Ding from Shenzhen University and Dr.Yan Su from the National Astronomical Observatories,Chinese Academy of Sciences to co edit a special issue of radar astronomy.
基金supported by the National Natural Science Foundation of China(No.12104047)。
文摘The rocket sled system is not only a high-speed dynamic ground test system,but also one of the future aerospace horizontal launch schemes.The winged load,as a common type of payload,has greater vibration and noise intensity than the wingless load.Due to the severe aerodynamic instability prior to separation,the head-up or head-down phenomena are more evident and the test accuracy significantly decreases.The high-precision computer fluid dynamics and aeroacoustic analysis are employed to explore the multifield coupling mechanism of a rocket sled with the winged payload in the wide speed range(Ma=0.5–2).The results show that as the incoming velocity increases,the cone angle of the shock wave of the rocket sled decreases,the shock pressure increases quickly,and the vortex between the slippers splits and gradually shrinks in size.The velocity of the rocket sled exerts little influence on the modal resonance frequency.The wing has a significant impact on aerodynamic noise,and as the sound pressure level rises,the propagation direction gradually shifts towards the rear and upper regions of the wing.
基金supported by the High-Level Talent Foundation of Natural Science Research Funding Project for Ordinary Universities in Jiangsu Province(grant number.25KJD520004)Jinling Institute of Technology(grant number.JIT-B-202413).
文摘Traditional weather observation methods have limitations in detecting low-altitude,small-scale areas and sudden weather events.They often have insufficient coverage,slow response,or high costs.Multi-rotor unmanned aerial vehicles(UAVs),with their strong vertical take-off and landing ability,precise hovering,flexible movement,and ability to carry various small sensors,are gradually becoming key tools to fill these gaps and build three-dimensional weather observation networks.They show important value in medium-and small-scale weather monitoring and emergency weather support.This paper reviews the main sensors for multi-rotor weather drones,their operating modes,and key supporting technologies,summarizes the current state of technology,and provides references for future development.
基金supported by the National High Technology Research and Development Program of China(Nos2008AA12A212 and 2010AA122202)the National Natural Science Foundation of China(Nos41040031 and 40904024)
文摘Gamma-ray spectrometer （GRS） is one of the main payloads on the Chang＇E-1 （CE-1） lunar probe, mainly aimed to detect the elemental abundances and distributions on the lunar surface. At 03：58 on 28 November 2007, it performed the first observation of the lunar gamma rays. As of 24 October 2008, 2105 h of effective gamma rays spectra had been acquired by CE-1 GRS, which covers the whole surface of the moon. This paper mainly describes the data processing procedures and methods of deriving the elemental abundances by using the CE-1 GRS time series corrected spectra： first, to bin data into pixels for mapping; then, to perform a background deduction of the cumulative spectra and obtain a peak area of the elements; and finally, to use the elemental abundances inversion model to produce the elemental abundances. Based on these processing methods, the global abundance maps of U, K, and Th at a 5°×5° equal-area pixel are acquired by CE-1 GRS data. The paper gives a preliminary analysis of the uncertainties of the elemental abundances.
基金This work was supported by the National Natural Science Foundation of China(Nos.U1736214,U1804263,U1636219,61772281,61772549,and 61872448)the National Key R&D Program of China(Nos.2016YFB0801303,2016QY01W0105)the Science and Technology Innovation Talent Project of Henan Province(No.184200510018).
文摘Multiple images steganography refers to hiding secret messages in multiple natural images to minimize the leakage of secret messages during transmission.Currently,the main multiple images steganography algorithms mainly distribute the payloads as sparsely as possible inmultiple cover images to improve the detection error rate of stego images.In order to enable the payloads to be accurately and efficiently distributed in each cover image,this paper proposes a multiple images steganography for JPEG images based on optimal payload redistribution.Firstly,the algorithm uses the principle of dynamic programming to redistribute the payloads of the cover images to reduce the time required in the process of payloads distribution.Then,by reducing the difference between the features of the cover images and the stego images to increase the detection error rate of the stego images.Secondly,this paper uses a data decomposition mechanism based on Vandermonde matrix.Even if part of the data is lost during the transmission of the secret messages,as long as the data loss rate is less than the data redundancy rate,the original secret messages can be recovered.Experimental results show that the method proposed in this paper improves the efficiency of payloads distribution compared with existing multiple images steganography.At the same time,the algorithm can achieve the optimal payload distribution of multiple images steganography to improve the anti-statistical detection performance of stego images.
基金Supported by National Key R&D Program of China(2020YFE0202100)Beijing Municipal Science and Technology Commission(Z181100002918003)。
文摘China’s Chang’E-4 probe successfully landed on 3 January 2019 in Von Kármán crater within the South Pole-Aitken(SPA)basin on the lunar far side.Based on the data acquired by the scientific payloads onboard the lander and the rover,the researchers obtained the related information such as the geologic and tectonic setting of the landing area,compositional characteristics of the landing surface materials,dielectric permittivity and density of the lunar soil.The experiments confirmed the existence of materials dominated by olivine and low-calcium pyroxene in the SPA basin on the lunar far side,which preliminary revealed the geological evolution history of the SPA basin and even that of the early time lunar crust,as well as the tectonic setting and formation mechanism of the materials in the lunar interior.The researchers also investigated the particle radiation,Linear Energy Transaction(LET)spectrum,and so forth on the lunar surface.The low-frequency radio observations were carried out on the lunar far side for the first time as well.This article summarizes the latest scientific results in the past years,focusing on the Chang’E-4 mission.
基金supported by the National Natural Science Foundation of China (Nos. 11502086 and 11502087)
文摘The variation of mass, and moment of inertia of a spin-stabilized spacecraft leads to concern about the nutation instability. Here a careful analysis on the nutation instability is performed on a spacecraft propelled by solid rocket booster（SRB）. The influences of specific solid propellant designs on transversal angular velocity are discussed. The results show that the typical SRB of End Burn suppresses the non-principal axial angular velocity. On the contrary, the frequently used SRB of Radial Burn could amplify the transversal angular velocity. The nutation instability caused by a design of Radial Burn could be remedied by the addition of End Burn at the same time based on the study of the combination design of both End Burn and Radial Burn.The analysis of the results proposes the design conception of how to control the nutation motion.The method is suitable to resolve the nutation instability of solid rocket motor with complex propellant patterns.
