Microtia,a congenital malformation affecting the external and middle ear,arises from disruptions during the development of embryonic branchial arches and cranial neural crest cells(CNCCs),making it the second most pre...Microtia,a congenital malformation affecting the external and middle ear,arises from disruptions during the development of embryonic branchial arches and cranial neural crest cells(CNCCs),making it the second most prevalent maxillofacial birth defect and a leading cause of conductive hearing loss.1 Aberrant gene expression is pivotal in microtia pathogenesis by influencing chondrocyte activities.Homeobox(HOX)genes stand out as regulators for proper skeletal patterning,and mutations within the HOX family have been implicated in microtia.2 Our transcriptomic microarray analysis of microtia revealed a substantial reduction in HOXB6 expression in auricle cartilage.展开更多
基金supported by the National Natural Science Foundation of China(No.82271889,82371173)the National Key Research and Development Program of China(No.2021YFC2701000)+1 种基金the Natural Science Foundation Project of Shanghai Science and Technology Innovation Action Plan(China)(No.23ZR1409400)Shanghai Science and Technology Commission of China(No.21DZ2200700).
文摘Microtia,a congenital malformation affecting the external and middle ear,arises from disruptions during the development of embryonic branchial arches and cranial neural crest cells(CNCCs),making it the second most prevalent maxillofacial birth defect and a leading cause of conductive hearing loss.1 Aberrant gene expression is pivotal in microtia pathogenesis by influencing chondrocyte activities.Homeobox(HOX)genes stand out as regulators for proper skeletal patterning,and mutations within the HOX family have been implicated in microtia.2 Our transcriptomic microarray analysis of microtia revealed a substantial reduction in HOXB6 expression in auricle cartilage.
