Since the establishment of the Collaboratory for the Study of Earthquake Predictability,China(CSEP-CN)center,no comprehensive study has been conducted on the parameter models of the Pattern Informatics(PI)method withi...Since the establishment of the Collaboratory for the Study of Earthquake Predictability,China(CSEP-CN)center,no comprehensive study has been conducted on the parameter models of the Pattern Informatics(PI)method within the China Seismic Experimental Site(CSES)region.Additionally,the boundary issues of the study area have been a subject of ongoing debate.Tian et al.(2024)indicates that variations in seismic activity within the region impact the predictive efficacy of the PI method.展开更多
In 2022,four earthquakes with M_(S)≥6.0 including the Menyuan M_(S)6.9 and Luding M_(S)6.8 earthquakes occurred in the North-South Seismic Zone(NSSZ),which demonstrated high and strong seismicity.Pattern Informatics(...In 2022,four earthquakes with M_(S)≥6.0 including the Menyuan M_(S)6.9 and Luding M_(S)6.8 earthquakes occurred in the North-South Seismic Zone(NSSZ),which demonstrated high and strong seismicity.Pattern Informatics(PI)method,as an effective long and medium term earthquake forecasting method,has been applied to the strong earthquake forecasting in Chinese mainland and results have shown the positive performance.The earthquake catalog with magnitude above M_(S)3.0 since 1970 provided by China Earthquake Networks Center was employed in this study and the Receiver Operating Characteristic(ROC)method was applied to test the forecasting efficiency of the PI method in each selected region related to the North-South Seismic Zone systematically.Based on this,we selected the area with the best ROC testing result and analyzed the evolution process of the PI hotspot map reflecting the small seismic activity pattern prior to the Menyuan M_(S)6.9 and Luding M_(S)6.8 earthquakes.A“forward”forecast for the area was carried out to assess seismic risk.The study shows the following.1)PI forecasting has higher forecasting efficiency in the selected study region where the difference of seismicity in any place of the region is smaller.2)In areas with smaller differences of seismicity,the activity pattern of small earthquakes prior to the Menyuan M_(S)6.9 and Luding M_(S)6.8 earthquakes can be obtained by analyzing the spatio-temporal evolution process of the PI hotspot map.3)The hotspot evolution in and around the southern Tazang fault in the study area is similar to that prior to the strong earthquakes,which suggests the possible seismic hazard in the future.This study could provide some ideas to the seismic hazard assessment in other regions with high seismicity,such as Japan,Californi,Turkey,and Indonesia.展开更多
Since the initial international cooperation in the framework of Collaboratory for the Study of Earthquake Predictability(CSEP)in 2007,a lot of forecast models have been developed and served for the earthquake forecast...Since the initial international cooperation in the framework of Collaboratory for the Study of Earthquake Predictability(CSEP)in 2007,a lot of forecast models have been developed and served for the earthquake forecasting experiment in different CSEP testing centers(Schorlemmer et al.,2018).展开更多
Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to chemotherapy.However,the relation between the...Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to chemotherapy.However,the relation between the growth phenotypes and chemo-resistance of SCLC remains largely unclear.Through comprehensive bioinformatic analyses,we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to chemotherapy.Adherent or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly chemoresistant.Mechanistically,activation of the PI3K/Akt/mTOR pathway promotes the phenotypic transition from suspension to adhesion growth pattern and confers SCLC cells with chemo-resistance.Such chemo-resistance could be largely overcome by combining chemotherapy with PI3K/Akt/mTOR pathway inhibitors.Our findings support that the PI3K/Akt/mTOR pathway plays an important role in SCLC phenotype transition and chemo-resistance,which holds important clinical implications for improving SCLC treatment.展开更多
基金supported by the Joint Funds of the National Natural Science Foundation of China(Grant No.U2039207).
文摘Since the establishment of the Collaboratory for the Study of Earthquake Predictability,China(CSEP-CN)center,no comprehensive study has been conducted on the parameter models of the Pattern Informatics(PI)method within the China Seismic Experimental Site(CSES)region.Additionally,the boundary issues of the study area have been a subject of ongoing debate.Tian et al.(2024)indicates that variations in seismic activity within the region impact the predictive efficacy of the PI method.
基金the National Natural Science Foundation of China Study on the Theory and Methods of Deterministic-Probabilistic(No.U2039207)the National Key Research and Development Program of China‘CSEP China in the Context of China Seismic Experimental Site’(No.2018YFE0109700).
文摘In 2022,four earthquakes with M_(S)≥6.0 including the Menyuan M_(S)6.9 and Luding M_(S)6.8 earthquakes occurred in the North-South Seismic Zone(NSSZ),which demonstrated high and strong seismicity.Pattern Informatics(PI)method,as an effective long and medium term earthquake forecasting method,has been applied to the strong earthquake forecasting in Chinese mainland and results have shown the positive performance.The earthquake catalog with magnitude above M_(S)3.0 since 1970 provided by China Earthquake Networks Center was employed in this study and the Receiver Operating Characteristic(ROC)method was applied to test the forecasting efficiency of the PI method in each selected region related to the North-South Seismic Zone systematically.Based on this,we selected the area with the best ROC testing result and analyzed the evolution process of the PI hotspot map reflecting the small seismic activity pattern prior to the Menyuan M_(S)6.9 and Luding M_(S)6.8 earthquakes.A“forward”forecast for the area was carried out to assess seismic risk.The study shows the following.1)PI forecasting has higher forecasting efficiency in the selected study region where the difference of seismicity in any place of the region is smaller.2)In areas with smaller differences of seismicity,the activity pattern of small earthquakes prior to the Menyuan M_(S)6.9 and Luding M_(S)6.8 earthquakes can be obtained by analyzing the spatio-temporal evolution process of the PI hotspot map.3)The hotspot evolution in and around the southern Tazang fault in the study area is similar to that prior to the strong earthquakes,which suggests the possible seismic hazard in the future.This study could provide some ideas to the seismic hazard assessment in other regions with high seismicity,such as Japan,Californi,Turkey,and Indonesia.
基金granted by the National Key Research and Development Program of China(Grant No.2018YFE0109700)National Natural Science Foundation of China(Grant No.42004038)the Special Fund of the Institute of Earthquake Forecasting,China Earthquake Administration(Grant No.2020IEF0501)
文摘Since the initial international cooperation in the framework of Collaboratory for the Study of Earthquake Predictability(CSEP)in 2007,a lot of forecast models have been developed and served for the earthquake forecasting experiment in different CSEP testing centers(Schorlemmer et al.,2018).
基金supported by the National Natural Science Foundation of China(82030083 to H.J.,81871875 to L.H.)the National Basic Research Program of China(2017YFA0505501 to H.J.+8 种基金2020YFA0803300 to H.J.)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19020201 to H.J.)the National Natural Science Foundation of China(81872312 to H.J.,82011540007 to H.J.,31621003 to H.J.,81402371 to Y.J.,81802279 to H.H.,81902326 to X.W.,81602443 to X.L.)the Basic Frontier Scientific Research Program of Chinese Academy of Science(ZDBSLY-SM006 to H.J.)the International Cooperation Project of Chinese Academy of Sciences(153D31KYSB20190035 to H.J.)the Youth Innovation Promotion Association CAS(Y919S31371 to X.W.)the Natural Science Foundation of Hunan Province,China(2019JJ50550 to X.L.)Clinical Medical Technology Innovation Guide Project of Hunan(2020SK51827 to X.L.)Project of Scientific Research Plan of Hunan Provincial Health Commission(202103100127 to X.L.)。
文摘Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to chemotherapy.However,the relation between the growth phenotypes and chemo-resistance of SCLC remains largely unclear.Through comprehensive bioinformatic analyses,we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to chemotherapy.Adherent or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly chemoresistant.Mechanistically,activation of the PI3K/Akt/mTOR pathway promotes the phenotypic transition from suspension to adhesion growth pattern and confers SCLC cells with chemo-resistance.Such chemo-resistance could be largely overcome by combining chemotherapy with PI3K/Akt/mTOR pathway inhibitors.Our findings support that the PI3K/Akt/mTOR pathway plays an important role in SCLC phenotype transition and chemo-resistance,which holds important clinical implications for improving SCLC treatment.
