AIM： To determine if brain-derived neurotrophic factor （BDNF） could offer protention to retinal ganglion cells following a superior colliculus （SC） lesion in mice using pattern electroretinogram （PERG） and opti...AIM： To determine if brain-derived neurotrophic factor （BDNF） could offer protention to retinal ganglion cells following a superior colliculus （SC） lesion in mice using pattern electroretinogram （PERG） and optical coherence tomography （OCT） as a measures of ganglion cell response and retinal health. METHODS： Seven C57BIJ6J mice with BDNF protection were tested with PERG and OCT before and after SC lesions, RESULTS： Compared with baseline PERG, the amplitude of PERG decreased 11.7% after SC lesions, but not significantly（P〉0.05）. Through fast Fourier transform （FFT） analysis of the PERGs before and after SC lesions, it was found that dominant frequency of PERGs stayed unchanged, suggesting that the ganglion cells of the retina remained relatively healthy inspite of damage to the ends of the ganglion cell axons. Also, OCT showed no changes in retinal thickness after lesions. CONCLUSION： It was concluded that BDNF is essential component of normal retinal and helps retina keeping normal function. While retina lack of BDNF, ex vivo resource of BDNF provides protection to the sick retina. It implies that BDNF is a kind therapeutic neurotrophic factor to retina neurodegeneration diseases, such as glaucoma, age related macular degeneration.展开更多
AIM: To explore changes and possible communication relationship of local potential signals recorded simultaneously from retina and visual cortex I(V1).·METHODS: Fourteen C57BL/6J mice were measured with pattern e...AIM: To explore changes and possible communication relationship of local potential signals recorded simultaneously from retina and visual cortex I(V1).·METHODS: Fourteen C57BL/6J mice were measured with pattern electroretinogram(PERG) and pattern visually evoked potential(PVEP) and fast Fourier transform has been used to analyze the frequency components of those signals.· RESULTS: The amplitude of PERG and PVEP was measured at about 36.7 μV and 112.5 μV respectively and the dominant frequency of PERG and PVEP, however,stay unchanged and both signals do not have second, or otherwise, harmonic generation.· CONCLUSION: The results suggested that retina encodes visual information in the way of frequency spectrum and then transfers it to primary visual cortex.The primary visual cortex accepts and deciphers the input visual information coded from retina. Frequency spectrum may act as communication code between retina and V1.展开更多
文摘AIM： To determine if brain-derived neurotrophic factor （BDNF） could offer protention to retinal ganglion cells following a superior colliculus （SC） lesion in mice using pattern electroretinogram （PERG） and optical coherence tomography （OCT） as a measures of ganglion cell response and retinal health. METHODS： Seven C57BIJ6J mice with BDNF protection were tested with PERG and OCT before and after SC lesions, RESULTS： Compared with baseline PERG, the amplitude of PERG decreased 11.7% after SC lesions, but not significantly（P〉0.05）. Through fast Fourier transform （FFT） analysis of the PERGs before and after SC lesions, it was found that dominant frequency of PERGs stayed unchanged, suggesting that the ganglion cells of the retina remained relatively healthy inspite of damage to the ends of the ganglion cell axons. Also, OCT showed no changes in retinal thickness after lesions. CONCLUSION： It was concluded that BDNF is essential component of normal retinal and helps retina keeping normal function. While retina lack of BDNF, ex vivo resource of BDNF provides protection to the sick retina. It implies that BDNF is a kind therapeutic neurotrophic factor to retina neurodegeneration diseases, such as glaucoma, age related macular degeneration.
基金Supported by 973 Program of the Ministry of Science and Technology of China (No.2013CB967101)Shanghai Science Committee Foundation (No.13PJ1433200)
文摘AIM: To explore changes and possible communication relationship of local potential signals recorded simultaneously from retina and visual cortex I(V1).·METHODS: Fourteen C57BL/6J mice were measured with pattern electroretinogram(PERG) and pattern visually evoked potential(PVEP) and fast Fourier transform has been used to analyze the frequency components of those signals.· RESULTS: The amplitude of PERG and PVEP was measured at about 36.7 μV and 112.5 μV respectively and the dominant frequency of PERG and PVEP, however,stay unchanged and both signals do not have second, or otherwise, harmonic generation.· CONCLUSION: The results suggested that retina encodes visual information in the way of frequency spectrum and then transfers it to primary visual cortex.The primary visual cortex accepts and deciphers the input visual information coded from retina. Frequency spectrum may act as communication code between retina and V1.
