Background We aim to comprehensively assess and compare the predictive performance of haematoma expansion(HE)scores in a homogeneous cohort of acute intracerebral haemorrhage(ICH)patients.Methods Existing scores for p...Background We aim to comprehensively assess and compare the predictive performance of haematoma expansion(HE)scores in a homogeneous cohort of acute intracerebral haemorrhage(ICH)patients.Methods Existing scores for predicting HE in acute ICH patients were included and categorised by imaging modality:non-contrast CT(NCCT),single-phase CT angiography(sCTA)and multiphase CTA(mCTA).The predictive performance of the scores was evaluated with the c-statistic in a population of consecutive adult patients with acute ICH admitted to a tertiary care centre in Southern Alberta,Canada,between February 2012 and May 2020,investigated with a multimodal imaging protocol(NCCT,sCTA and mCTA).The primary outcome was HE(ICH volume growth≥6 mL or≥33%),and the secondary outcome was severe HE(ICH volume growth≥12.5 mL or≥66%).The DeLong test compared the best-performing scores from each imaging category.Results 16 HE scores were assessed(NCCT=8,sCTA=6 and mCTA=2)in 217 patients with a median age of 70 years(IQR=60-80),and 86(39.6%)were females.51(23.5%)patients experienced HE and 35(16.1%)had severe HE.The c-statistic for predicting HE ranged from 0.516 to 0.674 for NCCT-based scores,0.627 to 0.725 for sCTA-based scores and 0.800 to 0.814 for mCTA-based score.The c-statistic for predicting severe HE ranged from 0.505 to 0.666 for NCCT scores,0.651 to 0.740 for sCTA scores and 0.813 to 0.828 for mCTA scores.A statistically significant difference favouring mCTA over other imaging modalities in predicting both HE and severe HE was observed.Conclusions Advanced imaging demonstrated a stepwise improvement in the predictive performance of HE scores.However,no existing score achieved excellent predictive performance(c-statistics≥0.90)in our cohort,highlighting the need for further refinement.展开更多
Objective To construct a nomogram prediction model for predicting hemoglobin A_(1)c(HbA_(1)c)failure in type 2 diabetes mellitus(T2DM)patients.Methods A total of 936 inpatients with T2DM admitted to the Department of ...Objective To construct a nomogram prediction model for predicting hemoglobin A_(1)c(HbA_(1)c)failure in type 2 diabetes mellitus(T2DM)patients.Methods A total of 936 inpatients with T2DM admitted to the Department of Endocrinology of the Affiliated Hospital of Shandong Second Medical University from January 2021to January 2022 were selected as the research subjects and divided into the non-standard group(HbA_(1)c≥7%,n=801)and the standard group(HbA_(1)c<7%,n=135).展开更多
文摘Background We aim to comprehensively assess and compare the predictive performance of haematoma expansion(HE)scores in a homogeneous cohort of acute intracerebral haemorrhage(ICH)patients.Methods Existing scores for predicting HE in acute ICH patients were included and categorised by imaging modality:non-contrast CT(NCCT),single-phase CT angiography(sCTA)and multiphase CTA(mCTA).The predictive performance of the scores was evaluated with the c-statistic in a population of consecutive adult patients with acute ICH admitted to a tertiary care centre in Southern Alberta,Canada,between February 2012 and May 2020,investigated with a multimodal imaging protocol(NCCT,sCTA and mCTA).The primary outcome was HE(ICH volume growth≥6 mL or≥33%),and the secondary outcome was severe HE(ICH volume growth≥12.5 mL or≥66%).The DeLong test compared the best-performing scores from each imaging category.Results 16 HE scores were assessed(NCCT=8,sCTA=6 and mCTA=2)in 217 patients with a median age of 70 years(IQR=60-80),and 86(39.6%)were females.51(23.5%)patients experienced HE and 35(16.1%)had severe HE.The c-statistic for predicting HE ranged from 0.516 to 0.674 for NCCT-based scores,0.627 to 0.725 for sCTA-based scores and 0.800 to 0.814 for mCTA-based score.The c-statistic for predicting severe HE ranged from 0.505 to 0.666 for NCCT scores,0.651 to 0.740 for sCTA scores and 0.813 to 0.828 for mCTA scores.A statistically significant difference favouring mCTA over other imaging modalities in predicting both HE and severe HE was observed.Conclusions Advanced imaging demonstrated a stepwise improvement in the predictive performance of HE scores.However,no existing score achieved excellent predictive performance(c-statistics≥0.90)in our cohort,highlighting the need for further refinement.
文摘Objective To construct a nomogram prediction model for predicting hemoglobin A_(1)c(HbA_(1)c)failure in type 2 diabetes mellitus(T2DM)patients.Methods A total of 936 inpatients with T2DM admitted to the Department of Endocrinology of the Affiliated Hospital of Shandong Second Medical University from January 2021to January 2022 were selected as the research subjects and divided into the non-standard group(HbA_(1)c≥7%,n=801)and the standard group(HbA_(1)c<7%,n=135).
