1 Introduction The process of complex diseases is closely linked to the disruption of key biological pathways,it is crucial to identify the dysfunctional pathways and quantify the degree of dysregulation at the indivi...1 Introduction The process of complex diseases is closely linked to the disruption of key biological pathways,it is crucial to identify the dysfunctional pathways and quantify the degree of dysregulation at the individual sample level[1].展开更多
基金supported in part by the National Natural Science Foundation of China(Grant No.62202383)Guangdong Basic and Applied Basic Research Foundation(No.2024A1515012602)the National Key Research and Development Program of China(No.2022YFD1801200).
文摘1 Introduction The process of complex diseases is closely linked to the disruption of key biological pathways,it is crucial to identify the dysfunctional pathways and quantify the degree of dysregulation at the individual sample level[1].