Ulcerative colitis(UC)and Crohn’s disease(CD)are chronic inflammatory bowel diseases(IBDs)with largely unclear etiologies and complex pathogeneses.The pathogenesis of UC has been linked to an imbalance in the gut mic...Ulcerative colitis(UC)and Crohn’s disease(CD)are chronic inflammatory bowel diseases(IBDs)with largely unclear etiologies and complex pathogeneses.The pathogenesis of UC has been linked to an imbalance in the gut microbiota,including in the prevalence of Enterobacteriaceae,especially pathogenic Escherichia coli(E.coli).[1]The UC diagnosis and assessment primarily rely on colonoscopy and mucosal biopsy pathology,which are limited by their invasiveness,constraints on medical resources,and potential risks and complications.Several biomarkers,such as serum C-reactive protein(CRP),fecal calprotectin,and fecal lactoferrin,are currently recommended for assessing UC disease activity.However,these markers are primarily inflammation-related factors produced by the host,not specific to IBD,and are influenced by other inflammatory states.Microbiome-related biomarkers are used as direct indicators of the gut microecosystem and have considerable potential for disease assessment and therapeutic guidance in IBD.However,current analyses of gut microbiota,such as 16S rRNA or metagenomic sequencing,are often time-consuming and costly.Siderophore,a low-molecularweight protein secreted extracellularly to chelate ferric iron,is a crucial virulence factor in iron acquisition of bacteria and fungi.The presence of siderophores can indirectly reflect bacterial abundance and activity.[2]展开更多
文摘Ulcerative colitis(UC)and Crohn’s disease(CD)are chronic inflammatory bowel diseases(IBDs)with largely unclear etiologies and complex pathogeneses.The pathogenesis of UC has been linked to an imbalance in the gut microbiota,including in the prevalence of Enterobacteriaceae,especially pathogenic Escherichia coli(E.coli).[1]The UC diagnosis and assessment primarily rely on colonoscopy and mucosal biopsy pathology,which are limited by their invasiveness,constraints on medical resources,and potential risks and complications.Several biomarkers,such as serum C-reactive protein(CRP),fecal calprotectin,and fecal lactoferrin,are currently recommended for assessing UC disease activity.However,these markers are primarily inflammation-related factors produced by the host,not specific to IBD,and are influenced by other inflammatory states.Microbiome-related biomarkers are used as direct indicators of the gut microecosystem and have considerable potential for disease assessment and therapeutic guidance in IBD.However,current analyses of gut microbiota,such as 16S rRNA or metagenomic sequencing,are often time-consuming and costly.Siderophore,a low-molecularweight protein secreted extracellularly to chelate ferric iron,is a crucial virulence factor in iron acquisition of bacteria and fungi.The presence of siderophores can indirectly reflect bacterial abundance and activity.[2]
