Respiratory infections are associated with high morbidity and mortality and are a major global health problem[1].Acute respiratory infections are caused by multiple respiratory pathogens,including viruses and bacteria...Respiratory infections are associated with high morbidity and mortality and are a major global health problem[1].Acute respiratory infections are caused by multiple respiratory pathogens,including viruses and bacteria.Viral-bacterial co-infections,which have become increasingly common and a global concern,can lead to substantial complications,causing higher morbidity and adverse prognosis[2].Previous studies have reported low positive detection rates of targeted pathogens related to acute respiratory infections,owing to the limited number of detected pathogens and variations in the sensitivity of diagnostic methods[3-4].Low positive detection rates may impede our understanding of respiratory pathogen characteristics and hamper the development of precise treatment and prevention strategies.展开更多
Chronic bacterial infections present a significant clinical challenge due to microbial persistence within host cells and the formation of biofilm structures.1 Intracellular pathogens,including Staphylococcus aureus(S....Chronic bacterial infections present a significant clinical challenge due to microbial persistence within host cells and the formation of biofilm structures.1 Intracellular pathogens,including Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli),have developed immune escape mechanisms that hinder phagolysosomal killing.By shielding themselves from humoral immune factors and limiting exposure to antibiotics,these pathogens can establish long-term reservoirs and sustain recurrent infections.展开更多
基金supported by the Beijing Science and Technology Planning Project of the Beijing Science and Technology Commission(Z241100009024047)the High-Level Public Health Technical Talent Training Plan(lingjunrencai-01-02).
文摘Respiratory infections are associated with high morbidity and mortality and are a major global health problem[1].Acute respiratory infections are caused by multiple respiratory pathogens,including viruses and bacteria.Viral-bacterial co-infections,which have become increasingly common and a global concern,can lead to substantial complications,causing higher morbidity and adverse prognosis[2].Previous studies have reported low positive detection rates of targeted pathogens related to acute respiratory infections,owing to the limited number of detected pathogens and variations in the sensitivity of diagnostic methods[3-4].Low positive detection rates may impede our understanding of respiratory pathogen characteristics and hamper the development of precise treatment and prevention strategies.
文摘Chronic bacterial infections present a significant clinical challenge due to microbial persistence within host cells and the formation of biofilm structures.1 Intracellular pathogens,including Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli),have developed immune escape mechanisms that hinder phagolysosomal killing.By shielding themselves from humoral immune factors and limiting exposure to antibiotics,these pathogens can establish long-term reservoirs and sustain recurrent infections.
