Pathogen spread and infection represent paramount global challenges,their intricate transmission pathways fundamentally shaped by human behavior and anthropogenic influences.Here,we elucidate pathogen transmission net...Pathogen spread and infection represent paramount global challenges,their intricate transmission pathways fundamentally shaped by human behavior and anthropogenic influences.Here,we elucidate pathogen transmission networks in the environment and identify the increasing risks resulting from mutant viruses and resistant bacteria.展开更多
Introduction:Most current research on Salmonella has targeted prevalent serotypes,such as S.Typhimurium and S.Enteritidis,but the epidemiology and molecular characteristics of less prevalent serotypes remain insuffici...Introduction:Most current research on Salmonella has targeted prevalent serotypes,such as S.Typhimurium and S.Enteritidis,but the epidemiology and molecular characteristics of less prevalent serotypes remain insufficiently characterized.This study focused on S.Give,a less common serotype,to elucidate its genomic characteristics and antimicrobial resistance gene(ARG)profiles in China.Methods:The whole-genome sequences of 185 isolates of S.Give were extracted from the Chinese Pathogen Identification Network database from 2017 to 2024 and subjected to ARG detection and phylogenetic analysis.Results:Two major sequence types(STs)were identified among the S.Give isolates,with ST516 being the predominant ST(92.43%)in China—consistent with the global ST distribution,except in the U.S.,where ST654 prevailed(82.70%).The multidrug resistance(concurrent carriage of≥3 ARGs)rate was 3.51%.All 185 isolates harbored the T57S point mutation in the parC gene on the chromosome,and an increasing trend was observed in the quinolone resistance gene qnrB19 prevalence in China from 2020 to 2024.In the major sublineage,80%of the isolates contained the qnrB19 gene,and 86.41%of the isolates carried the small mobilizable plasmid Col(pHAD28)harboring the qnrB19 gene.Six clusters were detected,indicating several potential outbreaks within China.Moreover a close phylogenetic relationship with European strains was exhibited.Conclusion:This study shows that S.Give predominates in China and is characterized by clonal expansion and the widespread presence of qnrB19-harboring plasmids.S.Give’s sporadic outbreaks and multidrug resistance represent emerging public health threats.Moreover,the ongoing genomic surveillance of uncommon serotypes is essential to identify and mitigate concealed risks to public health.展开更多
基金supported by the National Key R&D Program of China(grants 2022YFC3205400 and 2022YFC3204703)the National Natural Science Foundation of China(grant 52200079)the UKRI Horizon Europe Guarantee funding of Marie Skłodowska-Curie Actions Postdoctoral Fellowship(grant EP/X022730/1).
文摘Pathogen spread and infection represent paramount global challenges,their intricate transmission pathways fundamentally shaped by human behavior and anthropogenic influences.Here,we elucidate pathogen transmission networks in the environment and identify the increasing risks resulting from mutant viruses and resistant bacteria.
文摘Introduction:Most current research on Salmonella has targeted prevalent serotypes,such as S.Typhimurium and S.Enteritidis,but the epidemiology and molecular characteristics of less prevalent serotypes remain insufficiently characterized.This study focused on S.Give,a less common serotype,to elucidate its genomic characteristics and antimicrobial resistance gene(ARG)profiles in China.Methods:The whole-genome sequences of 185 isolates of S.Give were extracted from the Chinese Pathogen Identification Network database from 2017 to 2024 and subjected to ARG detection and phylogenetic analysis.Results:Two major sequence types(STs)were identified among the S.Give isolates,with ST516 being the predominant ST(92.43%)in China—consistent with the global ST distribution,except in the U.S.,where ST654 prevailed(82.70%).The multidrug resistance(concurrent carriage of≥3 ARGs)rate was 3.51%.All 185 isolates harbored the T57S point mutation in the parC gene on the chromosome,and an increasing trend was observed in the quinolone resistance gene qnrB19 prevalence in China from 2020 to 2024.In the major sublineage,80%of the isolates contained the qnrB19 gene,and 86.41%of the isolates carried the small mobilizable plasmid Col(pHAD28)harboring the qnrB19 gene.Six clusters were detected,indicating several potential outbreaks within China.Moreover a close phylogenetic relationship with European strains was exhibited.Conclusion:This study shows that S.Give predominates in China and is characterized by clonal expansion and the widespread presence of qnrB19-harboring plasmids.S.Give’s sporadic outbreaks and multidrug resistance represent emerging public health threats.Moreover,the ongoing genomic surveillance of uncommon serotypes is essential to identify and mitigate concealed risks to public health.
