Objective Helicobacter pylori(HP)infection is associated with non-alcoholic fatty liver disease(NAFLD)and insulin resistance;however,the correlation between HP eradication and NAFLD remains controversial.This systemat...Objective Helicobacter pylori(HP)infection is associated with non-alcoholic fatty liver disease(NAFLD)and insulin resistance;however,the correlation between HP eradication and NAFLD remains controversial.This systematic review and meta-analysis examined the effect of HP treatment on clinical and laboratory parameters in NAFLD patients.Methods We conducted a literature search of the PubMed,Embase,Scopus,and Web of Science databases through Septem-ber 2023 for randomized controlled trials(RCTs)examining the effect of HP treatment on NAFLD patients versus lifestyle changes alone.The primary outcome was the change in steatosis parameters.The secondary endpoints were changes in anthropometric parameters,inflammatory markers(TNF-α),and metabolic parameters(fasting blood glucose,homeostasis model assessment of insulin resistance,AST/ALT,and lipid profile).The random effects model was used to calculate the standardized mean difference(SMD)with associated 95%confidence intervals(CIs)for our desired outcome.Results Four RCTs met our inclusion criteria.A total of 453 patients were included(mean age 42.8 years,58.5%males),228(50.3%)of whom were in the HP eradication group and 225(49.7%)of whom were in the lifestyle modification group.Compared with lifestyle modification alone,HP eradication had a significant effect on reducing liver steatosis and TNF-αlevels(SMD:-0.9;95%CI-14.67,-3.82,I^(2)=0%and SMD:-6.3;95%CI-9.04,-3.56,I^(2)=0%,respectively).No sig-nificant effect on other metabolic parameters was found.Conclusions HP eradication significantly reduced liver steatosis and TNF-αlevels in NAFLD patients.However,HP eradi-cation did not significantly affect other metabolic indices compared to lifestyle changes alone.展开更多
Coffee wilt represents one of the most devastating diseases of Arabica coffee(Coffea arabica L.)plantations in the primary coffee-producing regions.In this study,coffee trees manifesting wilt symptoms accompanied by t...Coffee wilt represents one of the most devastating diseases of Arabica coffee(Coffea arabica L.)plantations in the primary coffee-producing regions.In this study,coffee trees manifesting wilt symptoms accompanied by the defoliation and drying of the whole tree were observed in the Jazan,El Baha,Najran,and Asir regions.The purpose of this investigation was to isolate and identify the Fusarium species recovered from symptomatic coffee trees.The developed fungi were initially characterized based on their morphological features followed by molecular phylogenetic multi-locus analysis of the combined sequences of ITS,TEF1-α,RPB2,and CaM.Twenty-five isolates were recovered from 28 samples.All fungal isolates were categorized morphologically under the genus Fusarium.Phylogenetic analysis positioned all the representative 15 isolates into one cluster grouping together with Neocosmospora falciformis(formerly F.falciforme)confirming their taxonomic position.Pathogenicity tests of the N.falciformis isolates were subsequently conducted on coffee seedlings,and the results revealed that all isolates induced wilt symptoms resembling those recorded in the field,and the incidence was 100%.The fungicide sensitivity test of seven investigated fungicides revealed that Maxim XL^(®) followed by Moncut^(®) exhibited the highest inhibitory effect against N.falciformis KSA 24-14,reaching 93.33%and 91.67%,respectively.To our knowledge,N.falciformis is a new causal pathogen of coffee wilt in Saudi Arabia.Remarkably,these results offer important insights for devising effective approaches to monitor and control such diseases.展开更多
Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital...Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital life processes such as cell proliferation,differentiation,immune responses,and redox balance.In response to various physiological signals or external stimuli,a sophisticated mitochondrial quality control(MQC)mechanism has evolved,encompassing key processes like mitochondrial biogenesis,mitochondrial dynamics,and mitophagy,which have garnered increasing attention from researchers to unveil their specific molecular mechanisms.In this review,we present a comprehensive summary of the primary mechanisms and functions of key regulators involved in major components of MQC.Furthermore,the critical physiological functions regulated by MQC and its diverse roles in the progression of various systemic diseases have been described in detail.We also discuss agonists or antagonists targeting MQC,aiming to explore potential therapeutic and research prospects by enhancing MQC to stabilize mitochondrial function.展开更多
Activeow control technology is a technique that controls the internaloweld of aircraft engines or theoweld around wings by means of disturbances induced by actuators,and adjusts the aerodynamic force and attitude of t...Activeow control technology is a technique that controls the internaloweld of aircraft engines or theoweld around wings by means of disturbances induced by actuators,and adjusts the aerodynamic force and attitude of the aircraft,so as to achieve the purposes of increasing lift,reducing drag,suppressing vibration and reducing noise.Hailed as an important source of innovative development for aircraft,this technology provides a new technical approach to solve the aerodynamic problems of aircraft,signicantly improve their comprehensive performance,break throughight boundaries,and promote disruptive innovation in the next generation of aircraft.展开更多
Perceived control plays a critical role in improving psychosocial health outcomes following a cardiac event.However,a comprehensive analysis and synthesis of the current research on the association between perceived c...Perceived control plays a critical role in improving psychosocial health outcomes following a cardiac event.However,a comprehensive analysis and synthesis of the current research on the association between perceived control and heart disease are lacking.We conducted this scoping review following the methodological framework of Arksey and O’Malley.A comprehensive literature search was performed up to April 15,2025.Covering five English language databases(Web of Science,PubMed,Scopus,CINAHL,and Embase)and four Chinese databases(WanFang,WeiPu,CNKI,and Chinese Biomedical Literature Database).The review included 22 studies.Our analysis organized the associations between perceived control and heart disease into four key domains:demographic characteristics,psychological factors,disease-related factors,and health behaviors.In addition,we examined aspects of study design,data analysis approaches,and the strengths and limitations of the measurement tools employed in the literature.Healthcare professionals should consider the identified factors connecting perceived control and heart disease when designing personalized health management plans.Digital health technologies could substantially advance psychological recovery and self-management support.Future research progress depends on implementing more varied study designs to detect finer associations,alongside three critical improvements:utilizing sophisticated statistical techniques,refining specialized assessment tools,and creating well-defined grading systems to enhance the precision and applicability of future evidence.展开更多
Mitochondria play a crucial role in maintaining the normal physiological state of cells.Hence,ensuring mitochondrial quality control is imperative for the prevention and treatment of numerous diseases.Previous reviews...Mitochondria play a crucial role in maintaining the normal physiological state of cells.Hence,ensuring mitochondrial quality control is imperative for the prevention and treatment of numerous diseases.Previous reviews on this topic have however been inconsistencies and lack of systematic organization.Therefore,this review aims to provide a comprehensive and systematic overview of mitochondrial quality control and explore the possibility of targeting the same for the treatment of major diseases.This review systematically summarizes three fundamental characteristics of mitochondrial quality control,including mitochondrial morphology and dynamics,function and metabolism,and protein expression and regulation.It also extensively examines how imbalances in mitochondrial quality are linked to major diseases,such as ischemia-hypoxia,inflammatory disorders,viral infections,metabolic dysregulations,degenerative conditions,and tumors.Additionally,the review explores innovative approaches to target mitochondrial quality control,including using small molecule drugs that regulate critical steps in maintaining mitochondrial quality,nanomolecular materials designed for precise targeting of mitochondria,and novel cellular therapies,such as vesicle therapy and mitochondrial transplantation.This review offers a novel perspective on comprehending the shared mechanisms underlying the occurrence and progression of major diseases and provides theoretical support and practical guidance for the clinical implementation of innovative therapeutic strategies that target mitochondrial quality control for treating major diseases.展开更多
BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease characterized by combinations of insulin resistance and insulin deficiency.Non-alcoholic fatty liver disease(NAFLD)is emerging as a public health...BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease characterized by combinations of insulin resistance and insulin deficiency.Non-alcoholic fatty liver disease(NAFLD)is emerging as a public health problem worldwide and affects up to 70%of patients with T2DM.Although patients with T2DM have an increased risk of developing advanced liver disease compared to healthy individuals,varying prevalence rates of NAFLD among patients with T2DM,ranging from 34%to 94%,have been reported.AIM To determine prevalence and identify associated factors of NAFLD among Limbe patients with T2DM and evaluate correlation with glycemic control.METHODS A cross-sectional study was carried out from February to June 2024 among patients with T2DM.Gamma-glutamyl transferase(GGT)activity and serum triglycerides(TGs)were measured by spectrophotometry.NAFLD was diagnosed using the fatty liver index score.Data were analyzed using SPSS version 26.0 for Windows.Student’s t-test was used to compare the means of two groups.The χ^(2) test was applied to determine the association of NAFLD and T2DM.Logistic regression analysis was performed to identify predictors of NAFLD.P<0.05 was considered statistically significant.RESULTS Of the 150 patients with T2DM recruited for this study,63(58%)were females and the majority(84.7%)had good glycemic control(glycated hemoglobin<7%).Prevalence of NAFLD among patients with T2DM was 19%.Patients with NAFLD had significantly elevated levels of TGs,GGT,and increased body mass index and waist circumference compared to those without NAFLD.There was a significant association between NAFLD and glycemic control.Predictive factors of NAFLD among patients with T2DM were vegetable intake of less than three times per week[adjusted odds ratio(aOR):0.131,95%CI:0.020-0.839;P=0.032],central obesity(aOR:0.167,95%CI:0.037-0.748;P=0.019),and metformin treatment for T2DM(aOR:0.167,95%CI:0.037-0.718;P<0.001).CONCLUSION The prevalence of NAFLD in patients with T2DM in Limbe Regional Hospital was 19%.Age,central obesity,metformin use,and infrequent consumption of vegetables were important predictors of NAFLD.展开更多
The outbreak of COVID-19 pneumonia has had a serious impact on the world and has led to a greater awareness of the importance of infectious disease prevention and control.Biology is closely related to life sciences an...The outbreak of COVID-19 pneumonia has had a serious impact on the world and has led to a greater awareness of the importance of infectious disease prevention and control.Biology is closely related to life sciences and is an ideal discipline to penetrate infectious disease education.Conducting infectious disease prevention and control education can help increase students’knowledge of infectious disease prevention and control and prompt them to form good living habits.展开更多
With the reduction of sequencing costs,optimization of algorithms,and improvement of multi-omics integration capabilities,transcriptomics,as a core technology for analyzing gene expression dynamics and discovering key...With the reduction of sequencing costs,optimization of algorithms,and improvement of multi-omics integration capabilities,transcriptomics,as a core technology for analyzing gene expression dynamics and discovering key functional molecules,has shown great potential in the field of disease prevention and control[1,2].The multi-continental transcriptomics study of tick-borne poxvirus not only provides a new perspective for understanding the evolution and transmission of vector-mediated viruses,but also reflects the trend of transcriptomics research and highlights its key role in disease prevention and control[3].展开更多
Coffee black fruit disease causes great harm to the yield and quality of coffee. Multiple factors, such as climate factors, insect pests, pathogen infection, physiological disorders, improper planting density, etc. , ...Coffee black fruit disease causes great harm to the yield and quality of coffee. Multiple factors, such as climate factors, insect pests, pathogen infection, physiological disorders, improper planting density, etc. , can cause coffee black fruit disease, which can be categorized into three types: pathogen infection type, physiological disorder type and insect pest type. Through the analysis of pathogenesis, the prevention and control methods and techniques of the disease corresponding to different types are put forward.展开更多
[ Objective ] The paper was to grasp the incidence characteristic of kiwifruit bacterial canker disease （Pseudomonas syrirtgate pv. actinidiae Takikawa） in Guanzhong area of Shanxi province, and to screen the endoph...[ Objective ] The paper was to grasp the incidence characteristic of kiwifruit bacterial canker disease （Pseudomonas syrirtgate pv. actinidiae Takikawa） in Guanzhong area of Shanxi province, and to screen the endophytic actinomycetes with control effect against kiwifruit bacterial canker. [ Method] The incidence characteristics of kiwifruit bacterial canker disease in 65 orchards of 13 villages in guanzhong area of Shanxi province （Yangling, Zhouzhi, Meixian） were investiga- ted and analyzed. The antagonistic strains against Pseudomonas syringae were simultaneously screened from 242 endophytic actinomycetes, and carried out field dis- ease control test. [ Result] The average incidence rate of kiwifruit bacterial canker disease in guan^ong area of Shanxi province was 7.95% ; the variety of kiwifruit had dose relationship with incidence rate. 76 strains bad inhibition activity agmnst P. syringae, while the inhibition zone diameters of fermentation broths of 35 strains against P. syr/ngae were greater than 20 nun. TIASA5 strain had inhibition activity against four target bacteria; gCLA4 strain not only had inhibition activity against four target bacteria, but also had strong inhibition activity against 10 species of plant pathogenic fungi. Field test showed that the fermentation broth of gCLA4 strain had obvious control effect against kiwifruit bacterial canker disease, and the relative control effect at 21 d could reach 66.7%. [ Conclusion] The an- tibacterial spectrum of fermentation broth of gCLA4 strain is broad, so gCLA4 strain has the potential to be developed into a broad-spectrum agricultural fungicide. Key words Kiwifruit bacterial canker disease; Endophytic actinomycetes; Biological control; Field test展开更多
Foodborne disease is a worldwide il ness and over 1 bil ion people get diseased every year. In China, thousands of foodborne diseases occur every year. It is proved that prevention is the most crucial for control ing ...Foodborne disease is a worldwide il ness and over 1 bil ion people get diseased every year. In China, thousands of foodborne diseases occur every year. It is proved that prevention is the most crucial for control ing foodborne disease. In the research, food safety monitoring system, laws and early warning system in the US and EU were introduced to explore the successful experience and monitoring or control mode suitable for China.展开更多
[Objective] Study on control efficacy and inhibitory effect of Bacillus cereus strain JK14^·against wheat take-all disease, investigating its antifungal mechanism. [Method] B. cereus JK14^· was isolated from...[Objective] Study on control efficacy and inhibitory effect of Bacillus cereus strain JK14^·against wheat take-all disease, investigating its antifungal mechanism. [Method] B. cereus JK14^· was isolated from soil in the rhizosphere of wheat, inhibitory effects of whose nutrient solution form against Gaeumannomyces graminis var tritici strains 9862 and 9812 were measured in laboratory and then for its antifungal mechanism. The strain JK14^· with rifampicin and wheat take-all disease resistance was screened by increasing concentration of the two substrates, and colonization of JK14^·was studied. [Result] In pot experiment, the control effects of JK14^·, against 9862 and 9812 are 63% and 59%, respectively, which are higher than that of chemical fungicides, with 55% and 51% , respectively. JK14^· could deform mycelium and causes degradation of cell wall. And there are also dynamic change of JK14^· in root system. JK14^· on seed could extend to root along with seed germination and rooting, but per unit tissue mycelium number decreased gradually. [Conclusion] The results indicate some control efficacy of B. cereus strain JK14^· against wheat take-all disease.展开更多
[ Objective ] The research aimed to discuss the occurrence regularity of apple early defoliation disease and control effects of fungicides in west Sichuan plateau. [ Method ] Apple early defoliation disease in west Si...[ Objective ] The research aimed to discuss the occurrence regularity of apple early defoliation disease and control effects of fungicides in west Sichuan plateau. [ Method ] Apple early defoliation disease in west Sichuan plateau was systematically investigated during 2009 and 2011, and the control effects of different fungicides during different spraying periods were studied. [ Result] The species of pathogen mainly was Marssonina ma/i （ P. Henn）, accounting for 32.5%, Phyl-losticta Pirina Sa accounted for 29.9%, and Alternaria mali Roberts accounted for 25.7%. The field fluctuation regularity was as follows ： the disease generally be- gan in the mid-May and ended in early and middle October with only one damage peak during the whole year, the fluctuation had positive correlation with rainfall （ R2 =0.891 8 ＊ ＊ ）. Control test showed that 40% flusilazole had the best control effect （86.5%）, which was best to apply after anthesis. [ Conclusion ] The paper provided theoretical basis for the effective control against apple early defoliation disease.展开更多
In this study, the pathogen causing skin ulcer disease in Cynoglossus semilaevis Gunther was isolated for morphological observation, physiological and bio- chemical identification. According to the result, the isolate...In this study, the pathogen causing skin ulcer disease in Cynoglossus semilaevis Gunther was isolated for morphological observation, physiological and bio- chemical identification. According to the result, the isolated pathogen was identified as Vibrio harveyi. The results of recurrent infection of C. semilaevis Gonther showed that the pathogen was strongly pathogenic to C. semilaevis Gunther. In or- der to explore the pathogenesis, outer membrane protein （OMP） gene of C. semi- laevis Gunther was detected by PCR. The results showed that all the three repre- sentative strains harbored OMP gene. According to the results of sensitivity test of the pathogen to Chinese herbal medicine, Galla Chinensis, Fructus Mume, Fructus Hippophae and Lignum Sappan exerted strong antibacterial effects against V. harveyr, Pericarpium Granati exhibited slight antibacterial effect against V. harveyi; Pericarpium Citri Reticulatae, Rhizoma Acori GramineL Herba Houttuyniae, Herba Portulacae, Herba Andrographis, Eucalyptus globulus Labill. and Herba Menthae Heplocalycis had little effect on V. harveyi. Galla Chinensis, Fructus Mume, Fructus Hippophae and Lignum Sappan were prepared into three prescriptions, among which prescription 1 （Galla Chinensis ＋ Fructus Mume） exhibited the strongest antibacterial effect.展开更多
Comparisons were performed between self-propelled boom sprayer and traditional mechanis, such as knapsack sprayer and sprayer-duster, stretcher-type powered sprayer, as well as single rotor unmanned sprayer and multi-...Comparisons were performed between self-propelled boom sprayer and traditional mechanis, such as knapsack sprayer and sprayer-duster, stretcher-type powered sprayer, as well as single rotor unmanned sprayer and multi-rotor un- manned sprayer. The effects on rice injury, lodging, and rehabilitation were conclud- ed and drug uniform distribution, sedimentation and prevention effects were ana- lyzed. The results showed that the self-propelled boom sprayer is characterized by high degree of automation, convenient operation, high adaptability, and high work efficiency. What＇s more, the sprayed fog quality is better, and fog distribution is more uniform. During the work process, fog loss would be diminished substantially, improving work efficiency and cutting down drug and water. It is notable that the underpart of the sprayer can be widely applied to plant protection in large-scale ar- eas in Jiangsu Province, significantly advancing whole-process mechanization of rice production.展开更多
[ Objective] This study aimed to investigate the effective prevention and control of maize rough dwarf disease in different areas with varying epidemic inten-sity in Shandong Province. [Method] Control effects of sing...[ Objective] This study aimed to investigate the effective prevention and control of maize rough dwarf disease in different areas with varying epidemic inten-sity in Shandong Province. [Method] Control effects of single application of virus in-hibitors and composite application of virus inhibitors with seed dressing agents and pesticides on maize rough dwarf disease in different areas with varying epidemic intensity were investigated. [Result] The same treatment possessed entirely different effects in severely affected areas and slightly affected areas. To be specific, single application of virus inhibitors in slightly affected areas exhibited good control effects, with a control efficiency of 76.59% and yield increment rate of 158.21%; in severely affected areas, single application of virus inhibitors led to low control efficiency and yield increment rate. The highest control efficiency of composite application of virus inhibitors with seed dressing agents and pesticides in severely affected areas was 71.38%, and experimental plots changed from total crop failure to have certain eco-nomic output. [Conclusion] ln different areas with varying epidemic intensity of maize rough dwarf disease, different application modes should be adopted according to lo-cal conditions, thereby saving cost and improving control efficiency.展开更多
The root rot is a major disease affecting yield of Gentiana macrophyl a pal , reducing yield or even causing total crop failure. This research introduced the occurrence characteristics and various control techniques o...The root rot is a major disease affecting yield of Gentiana macrophyl a pal , reducing yield or even causing total crop failure. This research introduced the occurrence characteristics and various control techniques of root rot of Gentiana macrophyl a pal , in order to provide references for farmers.展开更多
[ Objective ] The paper was to confirm the current major diseases of pepper in Hainan Province and their corresponding pathogens. [ Method ] The pep- per gardens in 13 main cultivation regions of pepper in Hainan Prov...[ Objective ] The paper was to confirm the current major diseases of pepper in Hainan Province and their corresponding pathogens. [ Method ] The pep- per gardens in 13 main cultivation regions of pepper in Hainan Province were systematically investigated, and the pathogens of the obtained specimens were isolated and identified. [ Result] Seven fungal diseases in pepper were totally investigated, including blast, anthracnose, blight, slow wilt, root rot, basal rot and scleretin- ia disease. Currently, the diseases with serious damage on pepper include blast, anthracnese, blight and slow wilt. [ Conclusion] The result provides the theoreti- cal basis for the integrated control of diseases in pepper, and is also benefit for scientific research workers to master the latest dynamic of diseases.展开更多
[Objective] Disease analysis and pathogen identification of black spot disease of Chinese cabbage [Alternaria brassicae（Berk.） Sace.] in Bijie City of Guizhou Province was carried out,so as to raise the correspondin...[Objective] Disease analysis and pathogen identification of black spot disease of Chinese cabbage [Alternaria brassicae（Berk.） Sace.] in Bijie City of Guizhou Province was carried out,so as to raise the corresponding prevention measures.[Method] Pathogen was isolated from diseased leaves using tissue surface separation method for cultivation,microscopic examination,spore size determination and pathogen identification.[Result] Microscopic examination showed that the disease was caused by Alternaria sp.,the size of its spores was（15.0-38.5） μm×（7.5-13.5） μm.Combining with the characteristics of host and pathogen,the pathogen caused black spot disease of Chinese cabbage was identified to be Alternaria brassicicola.[Conclusion] A.brassicicola was the pathogenic fungi of black spot disease of Chinese cabbage in Bijie City of Guizhou Province,and damage caused by the disease could be reduced through agricultural measures and chemical control.展开更多
文摘Objective Helicobacter pylori(HP)infection is associated with non-alcoholic fatty liver disease(NAFLD)and insulin resistance;however,the correlation between HP eradication and NAFLD remains controversial.This systematic review and meta-analysis examined the effect of HP treatment on clinical and laboratory parameters in NAFLD patients.Methods We conducted a literature search of the PubMed,Embase,Scopus,and Web of Science databases through Septem-ber 2023 for randomized controlled trials(RCTs)examining the effect of HP treatment on NAFLD patients versus lifestyle changes alone.The primary outcome was the change in steatosis parameters.The secondary endpoints were changes in anthropometric parameters,inflammatory markers(TNF-α),and metabolic parameters(fasting blood glucose,homeostasis model assessment of insulin resistance,AST/ALT,and lipid profile).The random effects model was used to calculate the standardized mean difference(SMD)with associated 95%confidence intervals(CIs)for our desired outcome.Results Four RCTs met our inclusion criteria.A total of 453 patients were included(mean age 42.8 years,58.5%males),228(50.3%)of whom were in the HP eradication group and 225(49.7%)of whom were in the lifestyle modification group.Compared with lifestyle modification alone,HP eradication had a significant effect on reducing liver steatosis and TNF-αlevels(SMD:-0.9;95%CI-14.67,-3.82,I^(2)=0%and SMD:-6.3;95%CI-9.04,-3.56,I^(2)=0%,respectively).No sig-nificant effect on other metabolic parameters was found.Conclusions HP eradication significantly reduced liver steatosis and TNF-αlevels in NAFLD patients.However,HP eradi-cation did not significantly affect other metabolic indices compared to lifestyle changes alone.
基金funded by the Deanship of Scientific Research,Vice Presidency for Graduate Studies and Scientific Research,King Faisal University,Saudi Arabia,for supporting this work for work through grant number KFU242134.
文摘Coffee wilt represents one of the most devastating diseases of Arabica coffee(Coffea arabica L.)plantations in the primary coffee-producing regions.In this study,coffee trees manifesting wilt symptoms accompanied by the defoliation and drying of the whole tree were observed in the Jazan,El Baha,Najran,and Asir regions.The purpose of this investigation was to isolate and identify the Fusarium species recovered from symptomatic coffee trees.The developed fungi were initially characterized based on their morphological features followed by molecular phylogenetic multi-locus analysis of the combined sequences of ITS,TEF1-α,RPB2,and CaM.Twenty-five isolates were recovered from 28 samples.All fungal isolates were categorized morphologically under the genus Fusarium.Phylogenetic analysis positioned all the representative 15 isolates into one cluster grouping together with Neocosmospora falciformis(formerly F.falciforme)confirming their taxonomic position.Pathogenicity tests of the N.falciformis isolates were subsequently conducted on coffee seedlings,and the results revealed that all isolates induced wilt symptoms resembling those recorded in the field,and the incidence was 100%.The fungicide sensitivity test of seven investigated fungicides revealed that Maxim XL^(®) followed by Moncut^(®) exhibited the highest inhibitory effect against N.falciformis KSA 24-14,reaching 93.33%and 91.67%,respectively.To our knowledge,N.falciformis is a new causal pathogen of coffee wilt in Saudi Arabia.Remarkably,these results offer important insights for devising effective approaches to monitor and control such diseases.
基金supported by the National Natural Science Foundation of China(8210082163,81800343)the Fundamental Research Fund for the Central Universities(2042021kf0081)+1 种基金the Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(2020CFA027)the Doctor of Excellence Program of the First Hospital of Jilin University(JDYY-DEP-2023043).
文摘Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital life processes such as cell proliferation,differentiation,immune responses,and redox balance.In response to various physiological signals or external stimuli,a sophisticated mitochondrial quality control(MQC)mechanism has evolved,encompassing key processes like mitochondrial biogenesis,mitochondrial dynamics,and mitophagy,which have garnered increasing attention from researchers to unveil their specific molecular mechanisms.In this review,we present a comprehensive summary of the primary mechanisms and functions of key regulators involved in major components of MQC.Furthermore,the critical physiological functions regulated by MQC and its diverse roles in the progression of various systemic diseases have been described in detail.We also discuss agonists or antagonists targeting MQC,aiming to explore potential therapeutic and research prospects by enhancing MQC to stabilize mitochondrial function.
文摘Activeow control technology is a technique that controls the internaloweld of aircraft engines or theoweld around wings by means of disturbances induced by actuators,and adjusts the aerodynamic force and attitude of the aircraft,so as to achieve the purposes of increasing lift,reducing drag,suppressing vibration and reducing noise.Hailed as an important source of innovative development for aircraft,this technology provides a new technical approach to solve the aerodynamic problems of aircraft,signicantly improve their comprehensive performance,break throughight boundaries,and promote disruptive innovation in the next generation of aircraft.
文摘Perceived control plays a critical role in improving psychosocial health outcomes following a cardiac event.However,a comprehensive analysis and synthesis of the current research on the association between perceived control and heart disease are lacking.We conducted this scoping review following the methodological framework of Arksey and O’Malley.A comprehensive literature search was performed up to April 15,2025.Covering five English language databases(Web of Science,PubMed,Scopus,CINAHL,and Embase)and four Chinese databases(WanFang,WeiPu,CNKI,and Chinese Biomedical Literature Database).The review included 22 studies.Our analysis organized the associations between perceived control and heart disease into four key domains:demographic characteristics,psychological factors,disease-related factors,and health behaviors.In addition,we examined aspects of study design,data analysis approaches,and the strengths and limitations of the measurement tools employed in the literature.Healthcare professionals should consider the identified factors connecting perceived control and heart disease when designing personalized health management plans.Digital health technologies could substantially advance psychological recovery and self-management support.Future research progress depends on implementing more varied study designs to detect finer associations,alongside three critical improvements:utilizing sophisticated statistical techniques,refining specialized assessment tools,and creating well-defined grading systems to enhance the precision and applicability of future evidence.
基金supported by the National Natural Science Foundation of China (82272252 and 82372192)the Senior Medical Talents Program of Chongqing for Young and Middle-AgedKuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University
文摘Mitochondria play a crucial role in maintaining the normal physiological state of cells.Hence,ensuring mitochondrial quality control is imperative for the prevention and treatment of numerous diseases.Previous reviews on this topic have however been inconsistencies and lack of systematic organization.Therefore,this review aims to provide a comprehensive and systematic overview of mitochondrial quality control and explore the possibility of targeting the same for the treatment of major diseases.This review systematically summarizes three fundamental characteristics of mitochondrial quality control,including mitochondrial morphology and dynamics,function and metabolism,and protein expression and regulation.It also extensively examines how imbalances in mitochondrial quality are linked to major diseases,such as ischemia-hypoxia,inflammatory disorders,viral infections,metabolic dysregulations,degenerative conditions,and tumors.Additionally,the review explores innovative approaches to target mitochondrial quality control,including using small molecule drugs that regulate critical steps in maintaining mitochondrial quality,nanomolecular materials designed for precise targeting of mitochondria,and novel cellular therapies,such as vesicle therapy and mitochondrial transplantation.This review offers a novel perspective on comprehending the shared mechanisms underlying the occurrence and progression of major diseases and provides theoretical support and practical guidance for the clinical implementation of innovative therapeutic strategies that target mitochondrial quality control for treating major diseases.
文摘BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease characterized by combinations of insulin resistance and insulin deficiency.Non-alcoholic fatty liver disease(NAFLD)is emerging as a public health problem worldwide and affects up to 70%of patients with T2DM.Although patients with T2DM have an increased risk of developing advanced liver disease compared to healthy individuals,varying prevalence rates of NAFLD among patients with T2DM,ranging from 34%to 94%,have been reported.AIM To determine prevalence and identify associated factors of NAFLD among Limbe patients with T2DM and evaluate correlation with glycemic control.METHODS A cross-sectional study was carried out from February to June 2024 among patients with T2DM.Gamma-glutamyl transferase(GGT)activity and serum triglycerides(TGs)were measured by spectrophotometry.NAFLD was diagnosed using the fatty liver index score.Data were analyzed using SPSS version 26.0 for Windows.Student’s t-test was used to compare the means of two groups.The χ^(2) test was applied to determine the association of NAFLD and T2DM.Logistic regression analysis was performed to identify predictors of NAFLD.P<0.05 was considered statistically significant.RESULTS Of the 150 patients with T2DM recruited for this study,63(58%)were females and the majority(84.7%)had good glycemic control(glycated hemoglobin<7%).Prevalence of NAFLD among patients with T2DM was 19%.Patients with NAFLD had significantly elevated levels of TGs,GGT,and increased body mass index and waist circumference compared to those without NAFLD.There was a significant association between NAFLD and glycemic control.Predictive factors of NAFLD among patients with T2DM were vegetable intake of less than three times per week[adjusted odds ratio(aOR):0.131,95%CI:0.020-0.839;P=0.032],central obesity(aOR:0.167,95%CI:0.037-0.748;P=0.019),and metformin treatment for T2DM(aOR:0.167,95%CI:0.037-0.718;P<0.001).CONCLUSION The prevalence of NAFLD in patients with T2DM in Limbe Regional Hospital was 19%.Age,central obesity,metformin use,and infrequent consumption of vegetables were important predictors of NAFLD.
基金Anqing Normal University School-Level Teaching and Research Project(2022aqnujyxm32)Anqing Normal University Provincial Graduate Online CourseAnhui Province Graduate Student Online Course on Animal Ecology。
文摘The outbreak of COVID-19 pneumonia has had a serious impact on the world and has led to a greater awareness of the importance of infectious disease prevention and control.Biology is closely related to life sciences and is an ideal discipline to penetrate infectious disease education.Conducting infectious disease prevention and control education can help increase students’knowledge of infectious disease prevention and control and prompt them to form good living habits.
文摘With the reduction of sequencing costs,optimization of algorithms,and improvement of multi-omics integration capabilities,transcriptomics,as a core technology for analyzing gene expression dynamics and discovering key functional molecules,has shown great potential in the field of disease prevention and control[1,2].The multi-continental transcriptomics study of tick-borne poxvirus not only provides a new perspective for understanding the evolution and transmission of vector-mediated viruses,but also reflects the trend of transcriptomics research and highlights its key role in disease prevention and control[3].
基金Supported by Undergraduate Innovation and Enterpreneurship Training Program of Guangdong Province(S202110580043).
文摘Coffee black fruit disease causes great harm to the yield and quality of coffee. Multiple factors, such as climate factors, insect pests, pathogen infection, physiological disorders, improper planting density, etc. , can cause coffee black fruit disease, which can be categorized into three types: pathogen infection type, physiological disorder type and insect pest type. Through the analysis of pathogenesis, the prevention and control methods and techniques of the disease corresponding to different types are put forward.
基金Supported by"Changjiang Scholars and Innovative Research Team"SupportPlan of Ministry of Education(200558)Research Fund for the DoctoralProgram of Three Gorges University(KJ2008B015)~~
文摘[ Objective ] The paper was to grasp the incidence characteristic of kiwifruit bacterial canker disease （Pseudomonas syrirtgate pv. actinidiae Takikawa） in Guanzhong area of Shanxi province, and to screen the endophytic actinomycetes with control effect against kiwifruit bacterial canker. [ Method] The incidence characteristics of kiwifruit bacterial canker disease in 65 orchards of 13 villages in guanzhong area of Shanxi province （Yangling, Zhouzhi, Meixian） were investiga- ted and analyzed. The antagonistic strains against Pseudomonas syringae were simultaneously screened from 242 endophytic actinomycetes, and carried out field dis- ease control test. [ Result] The average incidence rate of kiwifruit bacterial canker disease in guan^ong area of Shanxi province was 7.95% ; the variety of kiwifruit had dose relationship with incidence rate. 76 strains bad inhibition activity agmnst P. syringae, while the inhibition zone diameters of fermentation broths of 35 strains against P. syr/ngae were greater than 20 nun. TIASA5 strain had inhibition activity against four target bacteria; gCLA4 strain not only had inhibition activity against four target bacteria, but also had strong inhibition activity against 10 species of plant pathogenic fungi. Field test showed that the fermentation broth of gCLA4 strain had obvious control effect against kiwifruit bacterial canker disease, and the relative control effect at 21 d could reach 66.7%. [ Conclusion] The an- tibacterial spectrum of fermentation broth of gCLA4 strain is broad, so gCLA4 strain has the potential to be developed into a broad-spectrum agricultural fungicide. Key words Kiwifruit bacterial canker disease; Endophytic actinomycetes; Biological control; Field test
文摘Foodborne disease is a worldwide il ness and over 1 bil ion people get diseased every year. In China, thousands of foodborne diseases occur every year. It is proved that prevention is the most crucial for control ing foodborne disease. In the research, food safety monitoring system, laws and early warning system in the US and EU were introduced to explore the successful experience and monitoring or control mode suitable for China.
文摘[Objective] Study on control efficacy and inhibitory effect of Bacillus cereus strain JK14^·against wheat take-all disease, investigating its antifungal mechanism. [Method] B. cereus JK14^· was isolated from soil in the rhizosphere of wheat, inhibitory effects of whose nutrient solution form against Gaeumannomyces graminis var tritici strains 9862 and 9812 were measured in laboratory and then for its antifungal mechanism. The strain JK14^· with rifampicin and wheat take-all disease resistance was screened by increasing concentration of the two substrates, and colonization of JK14^·was studied. [Result] In pot experiment, the control effects of JK14^·, against 9862 and 9812 are 63% and 59%, respectively, which are higher than that of chemical fungicides, with 55% and 51% , respectively. JK14^· could deform mycelium and causes degradation of cell wall. And there are also dynamic change of JK14^· in root system. JK14^· on seed could extend to root along with seed germination and rooting, but per unit tissue mycelium number decreased gradually. [Conclusion] The results indicate some control efficacy of B. cereus strain JK14^· against wheat take-all disease.
基金Supported by Comprehensive Test Station in West Sichuan Plateau for National Apple's Industrial Technology System ( CARS-28)~~
文摘[ Objective ] The research aimed to discuss the occurrence regularity of apple early defoliation disease and control effects of fungicides in west Sichuan plateau. [ Method ] Apple early defoliation disease in west Sichuan plateau was systematically investigated during 2009 and 2011, and the control effects of different fungicides during different spraying periods were studied. [ Result] The species of pathogen mainly was Marssonina ma/i （ P. Henn）, accounting for 32.5%, Phyl-losticta Pirina Sa accounted for 29.9%, and Alternaria mali Roberts accounted for 25.7%. The field fluctuation regularity was as follows ： the disease generally be- gan in the mid-May and ended in early and middle October with only one damage peak during the whole year, the fluctuation had positive correlation with rainfall （ R2 =0.891 8 ＊ ＊ ）. Control test showed that 40% flusilazole had the best control effect （86.5%）, which was best to apply after anthesis. [ Conclusion ] The paper provided theoretical basis for the effective control against apple early defoliation disease.
基金Supported by Post-award Grants Program of Science and Technology Department of Hebei Province(15926620H)Science and Technology Support Program of Qinhuangdao Municipal Bureau of Science and Technology(201401A067,201402B043)~~
文摘In this study, the pathogen causing skin ulcer disease in Cynoglossus semilaevis Gunther was isolated for morphological observation, physiological and bio- chemical identification. According to the result, the isolated pathogen was identified as Vibrio harveyi. The results of recurrent infection of C. semilaevis Gonther showed that the pathogen was strongly pathogenic to C. semilaevis Gunther. In or- der to explore the pathogenesis, outer membrane protein （OMP） gene of C. semi- laevis Gunther was detected by PCR. The results showed that all the three repre- sentative strains harbored OMP gene. According to the results of sensitivity test of the pathogen to Chinese herbal medicine, Galla Chinensis, Fructus Mume, Fructus Hippophae and Lignum Sappan exerted strong antibacterial effects against V. harveyr, Pericarpium Granati exhibited slight antibacterial effect against V. harveyi; Pericarpium Citri Reticulatae, Rhizoma Acori GramineL Herba Houttuyniae, Herba Portulacae, Herba Andrographis, Eucalyptus globulus Labill. and Herba Menthae Heplocalycis had little effect on V. harveyi. Galla Chinensis, Fructus Mume, Fructus Hippophae and Lignum Sappan were prepared into three prescriptions, among which prescription 1 （Galla Chinensis ＋ Fructus Mume） exhibited the strongest antibacterial effect.
基金Supported by National Natural Science Foundation of China(31401296)Independent Innovation Foundation of Science and Technology in Jiangsu Province(CX(14)2101)
文摘Comparisons were performed between self-propelled boom sprayer and traditional mechanis, such as knapsack sprayer and sprayer-duster, stretcher-type powered sprayer, as well as single rotor unmanned sprayer and multi-rotor un- manned sprayer. The effects on rice injury, lodging, and rehabilitation were conclud- ed and drug uniform distribution, sedimentation and prevention effects were ana- lyzed. The results showed that the self-propelled boom sprayer is characterized by high degree of automation, convenient operation, high adaptability, and high work efficiency. What＇s more, the sprayed fog quality is better, and fog distribution is more uniform. During the work process, fog loss would be diminished substantially, improving work efficiency and cutting down drug and water. It is notable that the underpart of the sprayer can be widely applied to plant protection in large-scale ar- eas in Jiangsu Province, significantly advancing whole-process mechanization of rice production.
基金Supported by National Public Welfare Industry Research Project of China(201003031)Science and Technology Development Program of Shandong Province(2009GG10009015)Agricultural Science and Technology Innovation Program of Jinan City(201302637-1)~~
文摘[ Objective] This study aimed to investigate the effective prevention and control of maize rough dwarf disease in different areas with varying epidemic inten-sity in Shandong Province. [Method] Control effects of single application of virus in-hibitors and composite application of virus inhibitors with seed dressing agents and pesticides on maize rough dwarf disease in different areas with varying epidemic intensity were investigated. [Result] The same treatment possessed entirely different effects in severely affected areas and slightly affected areas. To be specific, single application of virus inhibitors in slightly affected areas exhibited good control effects, with a control efficiency of 76.59% and yield increment rate of 158.21%; in severely affected areas, single application of virus inhibitors led to low control efficiency and yield increment rate. The highest control efficiency of composite application of virus inhibitors with seed dressing agents and pesticides in severely affected areas was 71.38%, and experimental plots changed from total crop failure to have certain eco-nomic output. [Conclusion] ln different areas with varying epidemic intensity of maize rough dwarf disease, different application modes should be adopted according to lo-cal conditions, thereby saving cost and improving control efficiency.
文摘The root rot is a major disease affecting yield of Gentiana macrophyl a pal , reducing yield or even causing total crop failure. This research introduced the occurrence characteristics and various control techniques of root rot of Gentiana macrophyl a pal , in order to provide references for farmers.
基金Supported by Natural Science Foundation of Hainan Province (309016)~~
文摘[ Objective ] The paper was to confirm the current major diseases of pepper in Hainan Province and their corresponding pathogens. [ Method ] The pep- per gardens in 13 main cultivation regions of pepper in Hainan Province were systematically investigated, and the pathogens of the obtained specimens were isolated and identified. [ Result] Seven fungal diseases in pepper were totally investigated, including blast, anthracnose, blight, slow wilt, root rot, basal rot and scleretin- ia disease. Currently, the diseases with serious damage on pepper include blast, anthracnese, blight and slow wilt. [ Conclusion] The result provides the theoreti- cal basis for the integrated control of diseases in pepper, and is also benefit for scientific research workers to master the latest dynamic of diseases.
文摘[Objective] Disease analysis and pathogen identification of black spot disease of Chinese cabbage [Alternaria brassicae（Berk.） Sace.] in Bijie City of Guizhou Province was carried out,so as to raise the corresponding prevention measures.[Method] Pathogen was isolated from diseased leaves using tissue surface separation method for cultivation,microscopic examination,spore size determination and pathogen identification.[Result] Microscopic examination showed that the disease was caused by Alternaria sp.,the size of its spores was（15.0-38.5） μm×（7.5-13.5） μm.Combining with the characteristics of host and pathogen,the pathogen caused black spot disease of Chinese cabbage was identified to be Alternaria brassicicola.[Conclusion] A.brassicicola was the pathogenic fungi of black spot disease of Chinese cabbage in Bijie City of Guizhou Province,and damage caused by the disease could be reduced through agricultural measures and chemical control.
