针对三维激光标靶球定位模型中的系数矩阵存在随机元素和非随机元素以及考虑到观测向量与系数矩阵存在相关的情况,引入基于Partial EIV模型的相关观测加权总体最小二乘(Weighted Total Least Squares,WTLS)方法进行求解。模拟实验结果表...针对三维激光标靶球定位模型中的系数矩阵存在随机元素和非随机元素以及考虑到观测向量与系数矩阵存在相关的情况,引入基于Partial EIV模型的相关观测加权总体最小二乘(Weighted Total Least Squares,WTLS)方法进行求解。模拟实验结果表明,在顾及观测向量与系数矩阵存在相关性时,基于Partial EIV模型的相关观测加权总体最小二乘方法解算的参数结果更加接近真值,且精度更高。进一步将该方法应用于实际案例数据中,结果表明,在实际计算时有必要考虑到观测向量与系数矩阵之间的相关性,以提高参数解算精度。本文可补充和完善三维激光扫描标靶球定位技术方法。展开更多
Proxy Mobile IPv6 (PMIPv6) is a network based mobility management protocol. It is proposed by the Internet Engineering Task Force. In PMIPv6 the Mobile Node (MN) need not participate in signalling of mobility. PMIPv6 ...Proxy Mobile IPv6 (PMIPv6) is a network based mobility management protocol. It is proposed by the Internet Engineering Task Force. In PMIPv6 the Mobile Node (MN) need not participate in signalling of mobility. PMIPv6 is a layer 3 protocol. In this paper the issue of layer 3 mobility is resolved by the Enhanced Open Flow Technique (EOFT). Generally, the open flow protocol makes functions on network devices, routers, switches. Open flow controller act as server for network devices to make communication between them. In the proposed EOFT-PMIPv6, the control signalling and mobility is managed by EOFT controller. In PMIPv6, the Mobility Access gateway (MAG) has the responsibility of the control signalling. But in the EOFT-PMIPv6, the responsibility of MAG is done by the EOFT-Controller. In the proposed technique, the mobility management function is isolated from PMIPv6 mechanisms. These isolated mechanisms are combined in the EOFT-Con- troller. This EOFT-Controller satisfies the responsibility of the mechanisms which are separated from PMIPv6. The eminent mobile environment must provide the efficient multi-homing protocols. The proposed technique overcomes the problem of multihoming in PMIPv6. The EOFT-Controller takeover the responsibility of Layer 3 functions. Also, the proposed technique combines with Modified Mobility Access Gateway (M_MAG) and it handles the handover session dynamically. This paper provides the extended architecture of EOFT-PMIPv6 and provide unbeaten handover scheme for multi-homing. The result is provided by systematic analysis based on comparison with PMIPv6 and EOFT-PMIPv6 is obtained.展开更多
Liver regeneration(LR)following partial hepatectomy(PH)is a unique and complex physiological response that restores hepatic mass and function through tightly orchestrated cellular and molecular events.Traditionally vi...Liver regeneration(LR)following partial hepatectomy(PH)is a unique and complex physiological response that restores hepatic mass and function through tightly orchestrated cellular and molecular events.Traditionally viewed as a proliferation-driven process,LR is now understood to involve both hepatocyte hyperplasia and hypertrophy,triggered primarily by hemodynamic alterations such as increased portal pressure and shear stress.These promote LR through endothelial–hepatocyte communication via activation of Piezo1-a mechanosensitive ion channel highly expressed in vascular endothelial cells.This channel is considered one of the potential upstream activators of molecular cascades including the interleukin(IL)-6/signal transducer and activator of transcription 3,tumour necrosis factor-alpha/nuclear factor-kappa B,Wnt/β-catenin,Hippo/YAP,transforming growth factor-beta,and Notch pathways,which contribute variably to the proliferation,differentiation,or suppression of hepatic cells.Novel insights into the IL-22 and IL-33 signaling axes,bile acid and glutamine metabolism,and the role of intestinal microbiota are also presented as promising emerging targets.This review synthesizes current insights into the interplay between mechanical cues,key signaling pathways,and metabolic reprogramming that govern early regenerative responses.We explore the mechanisms dictating the balance between hyperplasia and hypertrophy,noting that hypertrophy predominates after minor resections,while proliferation is dominant in larger resections.Polyploidization emerges as a significant adaptive mechanism,contributing to hepatocyte survival and tissue remodeling.The importance of ductular reactions,microvascular adjustments,and extracellular matrix dynamics in lobular architecture remodeling is also highlighted.The study explores the occurrence of ductular reactions in both minor and major resections,particularly within the granulation tissue near dissection areas.The paper also examines structural remodeling in regenerated liver tissue,demonstrating ongoing transformations in hepatocyte morphology and sinusoidal architecture even months after PH,and emphasizing that the termination of liver mass regrowth does not equate to the cessation of LR.展开更多
By introducing noncanonical vortex pairs to partially coherent beams, spatial correlation singularity (SCS) and orbital angular momenta (OAM) of the resulting beams are studied using the Fraunhofer diffraction integra...By introducing noncanonical vortex pairs to partially coherent beams, spatial correlation singularity (SCS) and orbital angular momenta (OAM) of the resulting beams are studied using the Fraunhofer diffraction integral. The effect of noncanonical strength, off-axis distance and vortex sign on spatial correlation singularities in far field is stressed. Furthermore, far-field OAM spectra and densities are also investigated, and the OAM detection and crosstalk probabilities are discussed. The results show that the number of dislocations of SCS always equals the sum of absolute values of topological charges for canonical or noncanonical vortex pairs. Although the sum of the product of each OAM mode and its power weight equals the algebraic sum of topological charges for canonical vortex pairs, the relationship no longer holds in the noncanonical case except for opposite-charge vortex pairs. The changes of off-axis distance, noncanonical strength or coherence length can lead to a more dominant power in adjacent mode than that in center detection mode, which also indicates that crosstalk probabilities of adjacent modes exceed the center detection probability. This work may provide potential applications in OAM-based optical communication, imaging, sensing and computing.展开更多
Highlights●CRISPR/Cas9 RNP complex-based strategy demonstrates robustness and accuracy in generating gene-edited sheep.●Sheep horn development remains unaffected by partial RXFP2 knockout.●Partial RXFP2 knockout re...Highlights●CRISPR/Cas9 RNP complex-based strategy demonstrates robustness and accuracy in generating gene-edited sheep.●Sheep horn development remains unaffected by partial RXFP2 knockout.●Partial RXFP2 knockout results in unilateral cryptorchidism in sheep.展开更多
Aiming at the problem that infrared small target detection faces low contrast between the background and the target and insufficient noise suppression ability under the complex cloud background,an infrared small targe...Aiming at the problem that infrared small target detection faces low contrast between the background and the target and insufficient noise suppression ability under the complex cloud background,an infrared small target detection method based on the tensor nuclear norm and direction residual weighting was proposed.Based on converting the infrared image into an infrared patch tensor model,from the perspective of the low-rank nature of the background tensor,and taking advantage of the difference in contrast between the background and the target in different directions,we designed a double-neighborhood local contrast based on direction residual weighting method(DNLCDRW)combined with the partial sum of tensor nuclear norm(PSTNN)to achieve effective background suppression and recovery of infrared small targets.Experiments show that the algorithm is effective in suppressing the background and improving the detection ability of the target.展开更多
To explore the impact of partial centralization on supply chain performance,this study constructs a two-period game model of a closed-loop supply chain involving a manufacturer and an online retail platform participat...To explore the impact of partial centralization on supply chain performance,this study constructs a two-period game model of a closed-loop supply chain involving a manufacturer and an online retail platform participating in the trade-in strategy.Through mathematical modeling and numerical simulation methods,the optimal decisions were analyzed under conditions where the manufacturer partially owns the retail platform’s partial equity.This study finds that partial centralization yields the highest profits,followed by full centralization,with decentralized decisions yielding the lowest profits.Moderate centralization enhances overall profits by optimizing incentive mechanisms,whereas excessive ownership concentration reduces the flexibility of the retail platform,leading to a decline in profits.Additionally,product durability and trade-in subsidy significantly influence supply chain profitability:high-durability products reduce renewal frequency,while trade-in subsidy effectively stimulates consumer demand and increase overall profits.This study provides theoretical support and practical guidance for companies implementing the trade-in strategy.展开更多
In this paper,we mainly investigate the forms of entire solutions for certain Fermattype partial differential-difference equations in C^(2)by using Nevanlinna’s theory of several complex variables.
Based on the first-order correlation function of light,we propose analogous optical coherent states(AOCSs)sourced by partially coherent beams,which can nondiffractively propagate with sinusoidal oscillation in the har...Based on the first-order correlation function of light,we propose analogous optical coherent states(AOCSs)sourced by partially coherent beams,which can nondiffractively propagate with sinusoidal oscillation in the harmonic potential when the nondiffraction propagation matching condition(NPMC)is met.Unlike the traditional quantum coherent state,the minimum uncertainty of AOCS is related to the coherence of light,and only when the NPMC is met,its uncertainty is the least.Furthermore,based on the mathematical similarity between the Schrödinger and the Helmholtz equations,we find that our proposed AOCSs correspond to the partially coherent steady states of the harmonic oscillator.Our research not only increases the understanding of the coherence of light and enriches the types of nondiffraction beams but also increases the understanding of the quantum coherence regulating the evolution of probability waves.展开更多
Introduction:Radical cystectomy with pelvic node dissection remains the standard of care for muscle-invasive bladder carcinoma(MIBC);however,there is a growing interest in bladder preservation alternatives among the e...Introduction:Radical cystectomy with pelvic node dissection remains the standard of care for muscle-invasive bladder carcinoma(MIBC);however,there is a growing interest in bladder preservation alternatives among the elderly population.Guidelines indicate that partial cystectomy(PC)combined with pelvic node dissection(LND)can be considered as an alternative in carefully selected individuals.Using the National Cancer Database,we analyzed the overall survival(OS)between PC with and without LND among octogenarians.Methods:We identified octogenarians with localized muscle-invasive bladder carcinoma(cT2-3N0M0)and urothelial histology who underwent PC with or without LND between 2004 and 2018.Based on the number of lymph nodes removed(LNR),the LND group was further subdivided into<10 and>=10 lymph node groups.A propensity-matched Kaplan-Meier survival analysis was performed to compare OS between these groups.Results:Among 2573 patients who underwent PC,492 octogenarians met our selection criteria.208(42.2%)had LND,while 284(57.8%)had no LND.Within the LND group,53(25.5%)had<10 LNR,and 155(74.5%)had>=10 LNR.The median OS for the matched LND and non-LND groups was 36.9 and 33.4 months(p=0.96),respectively.Similarly,<10 LNR and>=10 LNR had 36.9 and 43.5 months(p=0.42),respectively.Multivariate Cox regression analysis revealed no difference in the risk of mortality.Conclusion:Among octogenarians who underwent PC,there was no significant difference in OS between those with or without LND,and between<10 or>=10 LNR groups.Therefore,the role and extent of LND after PC need further exploration in this subset of the population.展开更多
We present a quantum ranging protocol that overcomes photon-loss limitations using optimized partially frequencyentangled states.By establishing the fundamental relationship between the degree of entanglement,channel ...We present a quantum ranging protocol that overcomes photon-loss limitations using optimized partially frequencyentangled states.By establishing the fundamental relationship between the degree of entanglement,channel transmission efficiency and measurement precision,we demonstrate superclassical timing resolution in both lossless and lossy regimes.Theoretical analysis and numerical simulations reveal that,under a lossless channel,the precision gain increases with the degree of entanglement,approaching the Heisenberg limit.Importantly,in lossy channels,the precision gain is significantly influenced by both the channel transmission efficiency and the degree of entanglement.For transmission efficiencies above50%,the proposed method provides up to 1.5 times the precision gain of classical methods when entanglement parameters are optimized.Moreover,by optimizing intra-group and inter-group covariances in the multi-structured entangled state,we achieve substantial precision gains even at low transmission efficiencies(~30%),demonstrating its robustness against loss.This study resolves the critical trade-off between entanglement-enhanced precision and loss-induced information degradation.Future implementation could extend to satellite-based quantum positioning,remote sensing,quantum illumination,and other fields that require high-precision ranging in lossy environments.The protocol establishes a universal framework for loss-tolerant quantum metrology,advancing the practical deployment of quantum-enhanced sensing in real-world applications.展开更多
Objective:Nowadays robot-assisted partial nephrectomy(RAPN)represents the standard of care for clinical T1(cT1)renal masses,providing similar oncological outcomes when compared to open or laparoscopic PN with advantag...Objective:Nowadays robot-assisted partial nephrectomy(RAPN)represents the standard of care for clinical T1(cT1)renal masses,providing similar oncological outcomes when compared to open or laparoscopic PN with advantages in terms of functional outcomes and lower perioperative comorbidity,when compared to radical nephrectomy.Methods:We performed an extensive literature review of studies regarding RAPN,its evolution,technical aspects and applications,and new technological tools using different combinations of Medical Subject Headings terms“RAPN”,“partial nephrectomy”,“robot-assisted”,“nephron-sparing surgery”,“renal cell carcinoma”,“complex renal masses”,“endophytic renal masses”,and“bilateral renal tumors”.Results:A consistent body of evidence was selected,including original articles,systematic reviews,meta-analyses,and clinical trials having RAPN as the central focus in adult patients,with all its technical nuances.We started our narrative review with a background on PN and its evolution toward the robotic era with a special spotlight on the extending indications for PN in large and highly complex renal masses.Our review continued with an overview of nephron-sparing surgery in bilateral and recurrent masses.RAPN for bilateral synchronous renal masses represents a challenging scenario with no formal recommendations provided by international guidelines and controversial management and decision-making.Additionally,we reported evidence on redo RAPN which seems to be safe and effective.A final overview of the available technological tools,and in particular on three-dimensional reconstruction was provided.Conclusion:RAPN has been established as the standard of care for cT1 renal masses with an expanding spectrum of applications in different scenarios,including large(cT2),highly complex,and bilateral renal masses,as well as the surgical treatment of local recurrences after nephron-sparing surgery with acknowledged advantages in terms of functional outcomes and perioperative risk profiles while maintaining similar oncological outcomes when compared to open or laparoscopic PN and radical treatment.展开更多
Quantum link models(QLMs)serve as experimentally accessible platforms for studying lattice gauge theories with finite-dimensional Hilbert spaces.In this work,we investigate information scrambling in the partially conf...Quantum link models(QLMs)serve as experimentally accessible platforms for studying lattice gauge theories with finite-dimensional Hilbert spaces.In this work,we investigate information scrambling in the partially confined phase of a spin-1 quantum link model by calculating the dynamics of out-of-time-ordered correlators(OTOCs)and entanglement entropy.We observe that,in the partially confined phase,information scrambling exhibits significant asymmetry,manifested as the unidirectional propagation of both OTOCs and entanglement entropy.This phenomenon stands in stark contrast to the isotropic spreading observed in the deconfined phase and the localization characteristic of the confined phase.Furthermore,the simultaneous occurrence of the unidirectional propagation of both OTOCs and entanglement entropy,together with the q-induced asymmetric excitation propagation,reveals a direct connection between information scrambling and charge confinement.展开更多
Dear Editor,This letter investigates the optimal transmission scheduling problem in remote state estimation systems over an unknown wireless channel.We propose a partially observable Markov decision Process(POMDP)fram...Dear Editor,This letter investigates the optimal transmission scheduling problem in remote state estimation systems over an unknown wireless channel.We propose a partially observable Markov decision Process(POMDP)framework to model the sensor scheduling problem.By truncating and simplifying the POMDP problem,we have established the properties of the optimal solution under the POMDP model,through a fixed-point contraction method,and have shown that the threshold structure of the POMDP solution is not easily attainable.Subsequently,we obtained a suboptimal solution via Qlearning.Numerical simulations are used to demonstrate the efficacy of the proposed Q-learning approach.展开更多
With the popularity of the Internet of Vehicles(IoV),a large amount of data is being generated every day.How to securely share data between the IoV operator and various value-added service providers becomes one of the...With the popularity of the Internet of Vehicles(IoV),a large amount of data is being generated every day.How to securely share data between the IoV operator and various value-added service providers becomes one of the critical issues.Due to its flexible and efficient fine-grained access control feature,Ciphertext-Policy Attribute-Based Encryption(CP-ABE)is suitable for data sharing in IoV.However,there are many flaws in most existing CP-ABE schemes,such as attribute privacy leakage and key misuse.This paper proposes a Traceable and Revocable CP-ABE-based Data Sharing with Partially hidden policy for IoV(TRE-DSP).A partially hidden access structure is adopted to hide sensitive user attribute values,and attribute categories are sent along with the ciphertext to effectively avoid privacy exposure.In addition,key tracking and malicious user revocation are introduced with broadcast encryption to prevent key misuse.Since the main computation task is outsourced to the cloud,the burden of the user side is relatively low.Analysis of security and performance demonstrates that TRE-DSP is more secure and practical for data sharing in IoV.展开更多
As an energy and carbon saving process for nitrogen removal from wastewater,the partial nitrification and denitrification process(PN/D)has been extensively researched.However,achieving stable PNinmunicipalwastewater h...As an energy and carbon saving process for nitrogen removal from wastewater,the partial nitrification and denitrification process(PN/D)has been extensively researched.However,achieving stable PNinmunicipalwastewater has always been challenging.In this study,a gel immobilized PN/D nitrogen removal process(GI-PN/D)was established.A 94 days pilot-scale experiment was conducted using real municipal wastewater with an ammonia concentration of 43.5±5.3mg N/L at a temperature range of 11.3–28.7◦C.The nitrogen removal performance and associated pathways,shifts in the microbial community as well as sludge yield were investigated.The results were as follows:the effluent TN and COD were 0.6±0.4mg/L and 31.1±3.8 mg/L respectively,and the NAR exceeding 95%.GI-PN/D achieved deep nitrogen removal ofmunicipalwastewater through stable PN without taking any othermeasures.The primary pathways for nitrogen removal were identified as denitrification,simultaneous nitrification-denitrification,and aerobic denitrification.High-throughput sequencing analysis revealed that the immobilized fillers facilitated the autonomous enrichment of functional bacteria in each reactor,effectively promoting the dominance and stability of the microbial communities.In addition,GI-PN/D had the characteristic of low sludge yield,with an average sludge yield of 0.029 kg SS/kg COD.This study provides an effective technical for nitrogen removal from municipal wastewater through PN.展开更多
Public-key encryption is essential for secure communications,eliminating the need for pre-shared keys.However,traditional schemes such as RSA(Rivest-Shamir-Adleman)and elliptic curve cryptography rely on computational...Public-key encryption is essential for secure communications,eliminating the need for pre-shared keys.However,traditional schemes such as RSA(Rivest-Shamir-Adleman)and elliptic curve cryptography rely on computational complexity,making them increasingly susceptible to advances in computing power and algorithms.Physical-layer encryption,which leverages the intrinsic properties of physical systems,offers a promising alternative with security rooted in physics.Despite progress in this field,public-key encryption at the optical layer remains largely unexplored.Here,we propose a novel optical public-key encryption scheme based on partially coherent light sources.The cryptographic keys are encoded in the incoherent optical transmission matrix of an on-chip Mach-Zehnder interferometer mesh,providing high complexity and resilience to computational attacks.We experimentally demonstrate encrypted image transmission over 40 km of optical fiber with high decryption fidelity and achieve a 10 Gbit/s optical encryption rate using a lithium niobate photonic chip.This represents the first implementation of public-key encryption at the physical optical layer.The approach offers key advantages in security,cost,energy efficiency,and compatibility with commercial optical communication systems.By integrating public-key encryption into photonic hardware,this work opens a new direction for secure and high-speed optical communications in next-generation networks.展开更多
This article reviews a paper in the World Journal of Diabetes.The study uncovers the link between PPARG gene mutations and metabolic disorders,such as insulin resistance,diabetes,and hypertriglyceridemia,and emphasize...This article reviews a paper in the World Journal of Diabetes.The study uncovers the link between PPARG gene mutations and metabolic disorders,such as insulin resistance,diabetes,and hypertriglyceridemia,and emphasizes the crucial role of genetic testing in precise diagnosis and personalized treatment.This article further points out that in-depth investigation into the clinical heterogeneity of PPARG mutations and their underlying mechanisms can contribute to optimizing management strategies.Meanwhile,the development of more effective targeted therapies and the conduct of extensive genomic research are of great significance for understanding familial partial lipodystrophy type 3 and related metabolic syndromes.展开更多
The fracture behavior of natural fracture in the geological reservoir subjected to filling property,affects the crack initiation and propagation under stress perturbation.Partial filling flaws were intermediate betwee...The fracture behavior of natural fracture in the geological reservoir subjected to filling property,affects the crack initiation and propagation under stress perturbation.Partial filling flaws were intermediate between open fractures and filled fractures,the fracture response may be worth exploring.In this work,the effect of the filling property of sandstone with partial filling flaws on the fracture behavior was systematically investigated based on three-point bending tests and the numerical approach of discrete element method(DEM).In the laboratory,semi-circular three-point bending tests were carried out with partial filling flaws of various filling strengths.Based on this,numerical simulations were used to further investigate the effect of the filling ratio and the inclination of the partial filling flaw on the mechanical and fracture responses,and the effect of the partial filling flaw under mixed-mode loading on the fracture mechanism was elucidated coupled with acoustic emission(AE)characteristics.The obtained results showed that the increase in filling strength and filling ratio of partial filling flaw led to an increase in peak strength,with a decreasing trend in peak strength with the inclination of partial filling flaw.In terms of crack propagation pattern,the increasing filling strength of the partial filling flaw induced the transformation of the fracture mechanism toward deflection,with a tortuosity path,while the filling ratio and inclination of partial filling flaw led to fracture mechanism change from deflection to penetration and attraction,accompanied with a larger AE event source in filler.Accordingly,the b-value based on the Gutenberg-Richter equation fluctuated between 5 and 4 at low filling ratio and inclination and remained around 5 at high filling ratio and inclination of partial filling flaw.Related results may provide an application prospective for reservoir stimulation using the natural fracture system.展开更多
文摘针对三维激光标靶球定位模型中的系数矩阵存在随机元素和非随机元素以及考虑到观测向量与系数矩阵存在相关的情况,引入基于Partial EIV模型的相关观测加权总体最小二乘(Weighted Total Least Squares,WTLS)方法进行求解。模拟实验结果表明,在顾及观测向量与系数矩阵存在相关性时,基于Partial EIV模型的相关观测加权总体最小二乘方法解算的参数结果更加接近真值,且精度更高。进一步将该方法应用于实际案例数据中,结果表明,在实际计算时有必要考虑到观测向量与系数矩阵之间的相关性,以提高参数解算精度。本文可补充和完善三维激光扫描标靶球定位技术方法。
文摘Proxy Mobile IPv6 (PMIPv6) is a network based mobility management protocol. It is proposed by the Internet Engineering Task Force. In PMIPv6 the Mobile Node (MN) need not participate in signalling of mobility. PMIPv6 is a layer 3 protocol. In this paper the issue of layer 3 mobility is resolved by the Enhanced Open Flow Technique (EOFT). Generally, the open flow protocol makes functions on network devices, routers, switches. Open flow controller act as server for network devices to make communication between them. In the proposed EOFT-PMIPv6, the control signalling and mobility is managed by EOFT controller. In PMIPv6, the Mobility Access gateway (MAG) has the responsibility of the control signalling. But in the EOFT-PMIPv6, the responsibility of MAG is done by the EOFT-Controller. In the proposed technique, the mobility management function is isolated from PMIPv6 mechanisms. These isolated mechanisms are combined in the EOFT-Con- troller. This EOFT-Controller satisfies the responsibility of the mechanisms which are separated from PMIPv6. The eminent mobile environment must provide the efficient multi-homing protocols. The proposed technique overcomes the problem of multihoming in PMIPv6. The EOFT-Controller takeover the responsibility of Layer 3 functions. Also, the proposed technique combines with Modified Mobility Access Gateway (M_MAG) and it handles the handover session dynamically. This paper provides the extended architecture of EOFT-PMIPv6 and provide unbeaten handover scheme for multi-homing. The result is provided by systematic analysis based on comparison with PMIPv6 and EOFT-PMIPv6 is obtained.
文摘Liver regeneration(LR)following partial hepatectomy(PH)is a unique and complex physiological response that restores hepatic mass and function through tightly orchestrated cellular and molecular events.Traditionally viewed as a proliferation-driven process,LR is now understood to involve both hepatocyte hyperplasia and hypertrophy,triggered primarily by hemodynamic alterations such as increased portal pressure and shear stress.These promote LR through endothelial–hepatocyte communication via activation of Piezo1-a mechanosensitive ion channel highly expressed in vascular endothelial cells.This channel is considered one of the potential upstream activators of molecular cascades including the interleukin(IL)-6/signal transducer and activator of transcription 3,tumour necrosis factor-alpha/nuclear factor-kappa B,Wnt/β-catenin,Hippo/YAP,transforming growth factor-beta,and Notch pathways,which contribute variably to the proliferation,differentiation,or suppression of hepatic cells.Novel insights into the IL-22 and IL-33 signaling axes,bile acid and glutamine metabolism,and the role of intestinal microbiota are also presented as promising emerging targets.This review synthesizes current insights into the interplay between mechanical cues,key signaling pathways,and metabolic reprogramming that govern early regenerative responses.We explore the mechanisms dictating the balance between hyperplasia and hypertrophy,noting that hypertrophy predominates after minor resections,while proliferation is dominant in larger resections.Polyploidization emerges as a significant adaptive mechanism,contributing to hepatocyte survival and tissue remodeling.The importance of ductular reactions,microvascular adjustments,and extracellular matrix dynamics in lobular architecture remodeling is also highlighted.The study explores the occurrence of ductular reactions in both minor and major resections,particularly within the granulation tissue near dissection areas.The paper also examines structural remodeling in regenerated liver tissue,demonstrating ongoing transformations in hepatocyte morphology and sinusoidal architecture even months after PH,and emphasizing that the termination of liver mass regrowth does not equate to the cessation of LR.
文摘By introducing noncanonical vortex pairs to partially coherent beams, spatial correlation singularity (SCS) and orbital angular momenta (OAM) of the resulting beams are studied using the Fraunhofer diffraction integral. The effect of noncanonical strength, off-axis distance and vortex sign on spatial correlation singularities in far field is stressed. Furthermore, far-field OAM spectra and densities are also investigated, and the OAM detection and crosstalk probabilities are discussed. The results show that the number of dislocations of SCS always equals the sum of absolute values of topological charges for canonical or noncanonical vortex pairs. Although the sum of the product of each OAM mode and its power weight equals the algebraic sum of topological charges for canonical vortex pairs, the relationship no longer holds in the noncanonical case except for opposite-charge vortex pairs. The changes of off-axis distance, noncanonical strength or coherence length can lead to a more dominant power in adjacent mode than that in center detection mode, which also indicates that crosstalk probabilities of adjacent modes exceed the center detection probability. This work may provide potential applications in OAM-based optical communication, imaging, sensing and computing.
基金supported by the National Key Research and Development Program of China(2022YFD1300200)the National Natural Science Foundation of China(32161143010,32202646,and 32272848)+2 种基金the China Agriculture Research System(CARS-39)the Key Special Project of Ningxia Science and Technology Department,China(2021BEF02024)the local grants,China(NXTS2021-001,2022GD-TSLD-46,NK2022010207,and NXTS2022-001)。
文摘Highlights●CRISPR/Cas9 RNP complex-based strategy demonstrates robustness and accuracy in generating gene-edited sheep.●Sheep horn development remains unaffected by partial RXFP2 knockout.●Partial RXFP2 knockout results in unilateral cryptorchidism in sheep.
基金Supported by the Key Laboratory Fund for Equipment Pre-Research(6142207210202)。
文摘Aiming at the problem that infrared small target detection faces low contrast between the background and the target and insufficient noise suppression ability under the complex cloud background,an infrared small target detection method based on the tensor nuclear norm and direction residual weighting was proposed.Based on converting the infrared image into an infrared patch tensor model,from the perspective of the low-rank nature of the background tensor,and taking advantage of the difference in contrast between the background and the target in different directions,we designed a double-neighborhood local contrast based on direction residual weighting method(DNLCDRW)combined with the partial sum of tensor nuclear norm(PSTNN)to achieve effective background suppression and recovery of infrared small targets.Experiments show that the algorithm is effective in suppressing the background and improving the detection ability of the target.
文摘To explore the impact of partial centralization on supply chain performance,this study constructs a two-period game model of a closed-loop supply chain involving a manufacturer and an online retail platform participating in the trade-in strategy.Through mathematical modeling and numerical simulation methods,the optimal decisions were analyzed under conditions where the manufacturer partially owns the retail platform’s partial equity.This study finds that partial centralization yields the highest profits,followed by full centralization,with decentralized decisions yielding the lowest profits.Moderate centralization enhances overall profits by optimizing incentive mechanisms,whereas excessive ownership concentration reduces the flexibility of the retail platform,leading to a decline in profits.Additionally,product durability and trade-in subsidy significantly influence supply chain profitability:high-durability products reduce renewal frequency,while trade-in subsidy effectively stimulates consumer demand and increase overall profits.This study provides theoretical support and practical guidance for companies implementing the trade-in strategy.
基金Supported by the National Natural Science Foundation of China(Grant No.11971344).
文摘In this paper,we mainly investigate the forms of entire solutions for certain Fermattype partial differential-difference equations in C^(2)by using Nevanlinna’s theory of several complex variables.
基金supported by the Ministry of Science and Technology of the People’s Republic of China(Grant No.2022YFC2808203)the National Natural Science Foundation of China(Grant Nos.11474254 and 11804298).
文摘Based on the first-order correlation function of light,we propose analogous optical coherent states(AOCSs)sourced by partially coherent beams,which can nondiffractively propagate with sinusoidal oscillation in the harmonic potential when the nondiffraction propagation matching condition(NPMC)is met.Unlike the traditional quantum coherent state,the minimum uncertainty of AOCS is related to the coherence of light,and only when the NPMC is met,its uncertainty is the least.Furthermore,based on the mathematical similarity between the Schrödinger and the Helmholtz equations,we find that our proposed AOCSs correspond to the partially coherent steady states of the harmonic oscillator.Our research not only increases the understanding of the coherence of light and enriches the types of nondiffraction beams but also increases the understanding of the quantum coherence regulating the evolution of probability waves.
文摘Introduction:Radical cystectomy with pelvic node dissection remains the standard of care for muscle-invasive bladder carcinoma(MIBC);however,there is a growing interest in bladder preservation alternatives among the elderly population.Guidelines indicate that partial cystectomy(PC)combined with pelvic node dissection(LND)can be considered as an alternative in carefully selected individuals.Using the National Cancer Database,we analyzed the overall survival(OS)between PC with and without LND among octogenarians.Methods:We identified octogenarians with localized muscle-invasive bladder carcinoma(cT2-3N0M0)and urothelial histology who underwent PC with or without LND between 2004 and 2018.Based on the number of lymph nodes removed(LNR),the LND group was further subdivided into<10 and>=10 lymph node groups.A propensity-matched Kaplan-Meier survival analysis was performed to compare OS between these groups.Results:Among 2573 patients who underwent PC,492 octogenarians met our selection criteria.208(42.2%)had LND,while 284(57.8%)had no LND.Within the LND group,53(25.5%)had<10 LNR,and 155(74.5%)had>=10 LNR.The median OS for the matched LND and non-LND groups was 36.9 and 33.4 months(p=0.96),respectively.Similarly,<10 LNR and>=10 LNR had 36.9 and 43.5 months(p=0.42),respectively.Multivariate Cox regression analysis revealed no difference in the risk of mortality.Conclusion:Among octogenarians who underwent PC,there was no significant difference in OS between those with or without LND,and between<10 or>=10 LNR groups.Therefore,the role and extent of LND after PC need further exploration in this subset of the population.
基金Project supported by the National Natural Science Foundation of China(Grant No.62071363)the Key Research and Development Projects of Shaanxi Province,China(Grant No.2021LLRH-06)。
文摘We present a quantum ranging protocol that overcomes photon-loss limitations using optimized partially frequencyentangled states.By establishing the fundamental relationship between the degree of entanglement,channel transmission efficiency and measurement precision,we demonstrate superclassical timing resolution in both lossless and lossy regimes.Theoretical analysis and numerical simulations reveal that,under a lossless channel,the precision gain increases with the degree of entanglement,approaching the Heisenberg limit.Importantly,in lossy channels,the precision gain is significantly influenced by both the channel transmission efficiency and the degree of entanglement.For transmission efficiencies above50%,the proposed method provides up to 1.5 times the precision gain of classical methods when entanglement parameters are optimized.Moreover,by optimizing intra-group and inter-group covariances in the multi-structured entangled state,we achieve substantial precision gains even at low transmission efficiencies(~30%),demonstrating its robustness against loss.This study resolves the critical trade-off between entanglement-enhanced precision and loss-induced information degradation.Future implementation could extend to satellite-based quantum positioning,remote sensing,quantum illumination,and other fields that require high-precision ranging in lossy environments.The protocol establishes a universal framework for loss-tolerant quantum metrology,advancing the practical deployment of quantum-enhanced sensing in real-world applications.
文摘Objective:Nowadays robot-assisted partial nephrectomy(RAPN)represents the standard of care for clinical T1(cT1)renal masses,providing similar oncological outcomes when compared to open or laparoscopic PN with advantages in terms of functional outcomes and lower perioperative comorbidity,when compared to radical nephrectomy.Methods:We performed an extensive literature review of studies regarding RAPN,its evolution,technical aspects and applications,and new technological tools using different combinations of Medical Subject Headings terms“RAPN”,“partial nephrectomy”,“robot-assisted”,“nephron-sparing surgery”,“renal cell carcinoma”,“complex renal masses”,“endophytic renal masses”,and“bilateral renal tumors”.Results:A consistent body of evidence was selected,including original articles,systematic reviews,meta-analyses,and clinical trials having RAPN as the central focus in adult patients,with all its technical nuances.We started our narrative review with a background on PN and its evolution toward the robotic era with a special spotlight on the extending indications for PN in large and highly complex renal masses.Our review continued with an overview of nephron-sparing surgery in bilateral and recurrent masses.RAPN for bilateral synchronous renal masses represents a challenging scenario with no formal recommendations provided by international guidelines and controversial management and decision-making.Additionally,we reported evidence on redo RAPN which seems to be safe and effective.A final overview of the available technological tools,and in particular on three-dimensional reconstruction was provided.Conclusion:RAPN has been established as the standard of care for cT1 renal masses with an expanding spectrum of applications in different scenarios,including large(cT2),highly complex,and bilateral renal masses,as well as the surgical treatment of local recurrences after nephron-sparing surgery with acknowledged advantages in terms of functional outcomes and perioperative risk profiles while maintaining similar oncological outcomes when compared to open or laparoscopic PN and radical treatment.
基金supported by the National Natural Science Foundation of China(Grant Nos.GG2030007011 and GG2030040453)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0302004)+1 种基金support from the National Natural Science Foundation of China(Grant No.12174236)the fund for the Shanxi 1331 Project.
文摘Quantum link models(QLMs)serve as experimentally accessible platforms for studying lattice gauge theories with finite-dimensional Hilbert spaces.In this work,we investigate information scrambling in the partially confined phase of a spin-1 quantum link model by calculating the dynamics of out-of-time-ordered correlators(OTOCs)and entanglement entropy.We observe that,in the partially confined phase,information scrambling exhibits significant asymmetry,manifested as the unidirectional propagation of both OTOCs and entanglement entropy.This phenomenon stands in stark contrast to the isotropic spreading observed in the deconfined phase and the localization characteristic of the confined phase.Furthermore,the simultaneous occurrence of the unidirectional propagation of both OTOCs and entanglement entropy,together with the q-induced asymmetric excitation propagation,reveals a direct connection between information scrambling and charge confinement.
基金supported in part by the Frontier Technology R&D Plan of Jiangsu Province(BF2024065)the Shenzhen Science and Technology Program(JCYJ20230807114609019)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_0236).
文摘Dear Editor,This letter investigates the optimal transmission scheduling problem in remote state estimation systems over an unknown wireless channel.We propose a partially observable Markov decision Process(POMDP)framework to model the sensor scheduling problem.By truncating and simplifying the POMDP problem,we have established the properties of the optimal solution under the POMDP model,through a fixed-point contraction method,and have shown that the threshold structure of the POMDP solution is not easily attainable.Subsequently,we obtained a suboptimal solution via Qlearning.Numerical simulations are used to demonstrate the efficacy of the proposed Q-learning approach.
基金supported by the National Natural Science Foundation of China(No.62272076)。
文摘With the popularity of the Internet of Vehicles(IoV),a large amount of data is being generated every day.How to securely share data between the IoV operator and various value-added service providers becomes one of the critical issues.Due to its flexible and efficient fine-grained access control feature,Ciphertext-Policy Attribute-Based Encryption(CP-ABE)is suitable for data sharing in IoV.However,there are many flaws in most existing CP-ABE schemes,such as attribute privacy leakage and key misuse.This paper proposes a Traceable and Revocable CP-ABE-based Data Sharing with Partially hidden policy for IoV(TRE-DSP).A partially hidden access structure is adopted to hide sensitive user attribute values,and attribute categories are sent along with the ciphertext to effectively avoid privacy exposure.In addition,key tracking and malicious user revocation are introduced with broadcast encryption to prevent key misuse.Since the main computation task is outsourced to the cloud,the burden of the user side is relatively low.Analysis of security and performance demonstrates that TRE-DSP is more secure and practical for data sharing in IoV.
基金supported by Beijing Municipal Commission of Education(No.Z161100004516015)the Open Project Program of Hebei Center for Ecological and Environmental Geology Research(No.JSYF-202304).
文摘As an energy and carbon saving process for nitrogen removal from wastewater,the partial nitrification and denitrification process(PN/D)has been extensively researched.However,achieving stable PNinmunicipalwastewater has always been challenging.In this study,a gel immobilized PN/D nitrogen removal process(GI-PN/D)was established.A 94 days pilot-scale experiment was conducted using real municipal wastewater with an ammonia concentration of 43.5±5.3mg N/L at a temperature range of 11.3–28.7◦C.The nitrogen removal performance and associated pathways,shifts in the microbial community as well as sludge yield were investigated.The results were as follows:the effluent TN and COD were 0.6±0.4mg/L and 31.1±3.8 mg/L respectively,and the NAR exceeding 95%.GI-PN/D achieved deep nitrogen removal ofmunicipalwastewater through stable PN without taking any othermeasures.The primary pathways for nitrogen removal were identified as denitrification,simultaneous nitrification-denitrification,and aerobic denitrification.High-throughput sequencing analysis revealed that the immobilized fillers facilitated the autonomous enrichment of functional bacteria in each reactor,effectively promoting the dominance and stability of the microbial communities.In addition,GI-PN/D had the characteristic of low sludge yield,with an average sludge yield of 0.029 kg SS/kg COD.This study provides an effective technical for nitrogen removal from municipal wastewater through PN.
基金supported by the Fundamental Research Funds for the Central Universities.National Natural Science Foundation of China(62425504,U21A20511,62275088).
文摘Public-key encryption is essential for secure communications,eliminating the need for pre-shared keys.However,traditional schemes such as RSA(Rivest-Shamir-Adleman)and elliptic curve cryptography rely on computational complexity,making them increasingly susceptible to advances in computing power and algorithms.Physical-layer encryption,which leverages the intrinsic properties of physical systems,offers a promising alternative with security rooted in physics.Despite progress in this field,public-key encryption at the optical layer remains largely unexplored.Here,we propose a novel optical public-key encryption scheme based on partially coherent light sources.The cryptographic keys are encoded in the incoherent optical transmission matrix of an on-chip Mach-Zehnder interferometer mesh,providing high complexity and resilience to computational attacks.We experimentally demonstrate encrypted image transmission over 40 km of optical fiber with high decryption fidelity and achieve a 10 Gbit/s optical encryption rate using a lithium niobate photonic chip.This represents the first implementation of public-key encryption at the physical optical layer.The approach offers key advantages in security,cost,energy efficiency,and compatibility with commercial optical communication systems.By integrating public-key encryption into photonic hardware,this work opens a new direction for secure and high-speed optical communications in next-generation networks.
文摘This article reviews a paper in the World Journal of Diabetes.The study uncovers the link between PPARG gene mutations and metabolic disorders,such as insulin resistance,diabetes,and hypertriglyceridemia,and emphasizes the crucial role of genetic testing in precise diagnosis and personalized treatment.This article further points out that in-depth investigation into the clinical heterogeneity of PPARG mutations and their underlying mechanisms can contribute to optimizing management strategies.Meanwhile,the development of more effective targeted therapies and the conduct of extensive genomic research are of great significance for understanding familial partial lipodystrophy type 3 and related metabolic syndromes.
基金supported by the National Key R&D Program of China(Grant No.2022YFE0128300).
文摘The fracture behavior of natural fracture in the geological reservoir subjected to filling property,affects the crack initiation and propagation under stress perturbation.Partial filling flaws were intermediate between open fractures and filled fractures,the fracture response may be worth exploring.In this work,the effect of the filling property of sandstone with partial filling flaws on the fracture behavior was systematically investigated based on three-point bending tests and the numerical approach of discrete element method(DEM).In the laboratory,semi-circular three-point bending tests were carried out with partial filling flaws of various filling strengths.Based on this,numerical simulations were used to further investigate the effect of the filling ratio and the inclination of the partial filling flaw on the mechanical and fracture responses,and the effect of the partial filling flaw under mixed-mode loading on the fracture mechanism was elucidated coupled with acoustic emission(AE)characteristics.The obtained results showed that the increase in filling strength and filling ratio of partial filling flaw led to an increase in peak strength,with a decreasing trend in peak strength with the inclination of partial filling flaw.In terms of crack propagation pattern,the increasing filling strength of the partial filling flaw induced the transformation of the fracture mechanism toward deflection,with a tortuosity path,while the filling ratio and inclination of partial filling flaw led to fracture mechanism change from deflection to penetration and attraction,accompanied with a larger AE event source in filler.Accordingly,the b-value based on the Gutenberg-Richter equation fluctuated between 5 and 4 at low filling ratio and inclination and remained around 5 at high filling ratio and inclination of partial filling flaw.Related results may provide an application prospective for reservoir stimulation using the natural fracture system.
