Presented here are the Generalized BCS Equations incorporating Fermi Energy for the study of the {Δ, Tc, jc(T)} values of both elemental and composite superconductors (SCs) for all T ≤ Tc, where Δ, Tc and jc(T) den...Presented here are the Generalized BCS Equations incorporating Fermi Energy for the study of the {Δ, Tc, jc(T)} values of both elemental and composite superconductors (SCs) for all T ≤ Tc, where Δ, Tc and jc(T) denote, respectively, one of the gap values, the critical temperature and the T-dependent critical current density. This framework, which extends our earlier study that dealt with the {Δ0, Tc, jc(0)} values of an SC, is also shown to lead to T-dependent values of several other related parameters such as the effective mass of electrons, their number density, critical velocity, Fermi velocity (VF), coherence length and the London penetration depth. The extended framework is applied to the jc(T) data reported by Romijn et al. for superconducting Aluminium strips and is shown not only to provide an alternative to the explanation given by them, but also to some novel features such as the role of the Sommerfeld coefficient γ(T) in the context of jc(T) and the role of VF(T) in the context of a recent finding by Plumb et al. about the superconductivity of Bi-2212.展开更多
The 18 crude drugs in Bofutsushosan (BOF: Pulvis ledebouriellae compositae: 防風通聖散) are separated into 6 groups such as diaphoretic, cathartic, antidote, antipyretic, neutralizer and diuretic groups. The effects o...The 18 crude drugs in Bofutsushosan (BOF: Pulvis ledebouriellae compositae: 防風通聖散) are separated into 6 groups such as diaphoretic, cathartic, antidote, antipyretic, neutralizer and diuretic groups. The effects of single administered BOF and composed crude drugs in 6 groups were investigated on the levels of diabetic parameters (serum glucose, insulin, triglyceride and cholesterol) in streptozotocin-induced diabetic mice. The anti-hyperglycemic action of BOF was depended on Ephedrae Herba, Saposhnikoviae Radix and Schizonepetae Spica in diaphoretic group, Forsythiae Fructus, Saposhnikoviae Radix, Schizonepetae Spica and Cnidii Rhizoma in antidote group, Scutellariae Radix, Gardeniae Fructus and Gypsum Fibrosum in antipyretic group and Paeoniae Radix in neutralizer group. In these crude drugs, Ephedrae Herba, Saposhnikoviae Radix, Schizonepetae Spica, Forsythiae Fructus, Scutellariae Radix, Gypsum Fibrosum and Paeoniae Radix increased serum insulin level, but Cnidii Rhizoma and Gardeniae Fructus did not affect serum insulin level. From these results, it suggested that anti-hyperglycemic action of BOF was through insulin-dependent and insulin independent manners. The lowering effect of BOF on serum triglyceride level was dependent on actions of Platycodi Radix in antidote and diuretic groups and Gardeniae Fructus in antipyretic group. The lowering effect of Gardeniae Fructus was parallel with its anti-hyperglycemic action. The lowering effect of BOF on high serum triglyceride level also included both direct action and indirect action. The reducing effect of BOF on serum cholesterol level was observed together with the actions of Ephedrae Herba and Zingiberis Rhizoma in diaphoretic group, Schizonepetae Spica in diaphoretic and antidote groups and Paeoniae Radix in neutralizer group. The lowering effects of Ephedrae Herba, Schizonepetae Spica and Paeoniae Radix on serum cholesterol level were parallel with their anti-hyperglycemic actions. Zingiberis Rhizoma in diaphoretic group might be direct reducing effect on serum cholesterol level but no serum glucose level. The Ephedrae Herba in diaphoretic group, Schizonepetae Spica in diaphoretic and antidote groups and Paeoniae Radix in neutralizer group might have reduced serum cholesterol level by reducing blood glucose level. From these results, composed crude drugs in 6 groups show various mechanisms in the action of BOF.展开更多
A novel integrated water treatment facility, inner-recycling continuous sand filter, is discussed. The theory of micro-flocculation is applied in the sand-washing circulation system with continuous filtration and back...A novel integrated water treatment facility, inner-recycling continuous sand filter, is discussed. The theory of micro-flocculation is applied in the sand-washing circulation system with continuous filtration and backwashing. The design and operation parameters, which affect the performance of the filter, are discussed. The key design parameters are provided as follows: diameter of filter material is 0.7 to 1.0 mm, depth of filter bed is 0.6 m, filtration velocity is less than 12 m/h, ratio of gas to water is 9:11 and sand recycling rate is 2 to 4 mm/min.展开更多
The inverse problem of wave equation is the importance of study not only in seismic prospecting but also in applied mathematics. With the development of the research, the inverse methods of 1 - D wave equations have b...The inverse problem of wave equation is the importance of study not only in seismic prospecting but also in applied mathematics. With the development of the research, the inverse methods of 1 - D wave equations have been trending towards the multiple parameters inversion . We have obtained an inverse method with double -parameter, in which medium density and wave velocity can be derived simultaneously. In this paper, to increase the inverse accuracy, the method is improved as follows. Firstly, the formula in which the Green Function is omitted are derived and used. Secondly, the regularizing method is reasonable used by choosing the stable function. With the new method, we may derive elastic parameter and medium density or medium density and wave velocity. Thus, lithology parameters for seismic prospecting may be obtained.After comparing the derived values from the new method with that from previous method, we obtain the new method through which substantially improve the derived accuracy . The new method has been applied to real depths inversion for sedimentary strata and volcanic rock strata in Chaoyanggou Terrace of Songliao Basin in eastern China. According to the inverse results,the gas - bearing beds are determlned.展开更多
Objectives: The aim of this study was to investigate the effectiveness of dietary intervention with apricots, pomegranate juice or lactic acid fermented sobya on improving the plasma levels of lipid profile parameters...Objectives: The aim of this study was to investigate the effectiveness of dietary intervention with apricots, pomegranate juice or lactic acid fermented sobya on improving the plasma levels of lipid profile parameters and total plasma homocysteine (tHcy) among healthy adults. Design of the study: Thirty-five men and women (28.9 ± 3.0 years) with mean body mass index of 23.5 ± 1.2 kg/m2 were randomly assigned to a dietary intervention study. During the pre-feeding study records of 24-hour food intake, anthropometric measurements and blood sampling were collected for biochemical investigations. Thereafter the volunteers were divided into five groups: a control group (C);the other four groups received daily one of the following supplements: 200 g of deep yellow apricots (Prunus armeniaca) (AF);250 g pomegranate (Punica granatum) juice (PJ);mixture of 100 g (PJ) and 150 g of fermented sobya (FS), (PJ-FS) or 165 g (FS). After completing the three-week dietary intervention, blood samples were collected and blood indices were again evaluated. Biochemical analysis of total lipids (TL), total glycerides (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) and tHcy were completed. The low density lipoprotein-cholesterol level and three indices of risk factors were calculated using the appropriate equations. Results: Three-week dietary intervention improved the levels of lipid profile parameters TG, TC, HDL-C and LDL-C as compared to the respective baseline levels and the response of the control group that did not receive any supplement. Consuming (PJ-FS) had a synergistic beneficially added value on some of the above mentioned lipid profile parameters. The mean plasma tHcy concentrations;a marker for occlusive vascular disease was reduced significantly following the three week consumption of (PJ) or (FS), compared with the respective pre-feeding levels. Conclusion: Pomegranate juice (PJ) or lactic acid fermented sobya (FS) or mixture of both are potential natural agents in lowering the plasma levels of lipid profile parameters and tHcy among apparently healthy young women and men, without dyslipidemic symptoms.展开更多
On the basis of a three-dimensional non stationary model of a convective cloud with detailed description of dynamic, thermodynamic and microphysical processes, numerical experiments were conducted to study the formati...On the basis of a three-dimensional non stationary model of a convective cloud with detailed description of dynamic, thermodynamic and microphysical processes, numerical experiments were conducted to study the formation of parameters of convective clouds under unstable stratification of the atmosphere. Numerical experiments have been carried out to study the formation of convective processes in the atmosphere. The thermo hydrodynamic parameters in the zone of a thunderstorm cloud are determined, and regions with a vortex motion of air are identified. The main flows feeding the convective cloud in the mature stage are determined. Due to the means of visualization, the areas of formation and growth of precipitation particles are identified. In a three-dimensional form, the interaction of dynamic and thermodynamic processes is analyzed. The interaction of fields is manifested in the form of deformation of fields of thermodynamic parameters under the influence of dynamic processes. Trajectories of air streams around a cloud and the trajectories of drops in a cloud are determined. The results of numerical experiments confirm that dynamic processes significantly influence the formation of fields of thermodynamic parameters in the cloud, which also determine the course of microphysical processes and the nature of the growth of precipitation particles.展开更多
OBJECTIVE: To observe the effect of Modified Erchen Decoction on cervical spondylotic vertebral arteriopathy with stagnation and blockade of phlegm-dampness syndrome and effects on cerebral blood flow parameters. METH...OBJECTIVE: To observe the effect of Modified Erchen Decoction on cervical spondylotic vertebral arteriopathy with stagnation and blockade of phlegm-dampness syndrome and effects on cerebral blood flow parameters. METHODS: A total of 80 cervical spondylotic vertebral arteriopathy(CSA) patients with stagnation and blockade of phlegmdampness syndrome admitted to our hospital from October 2016 to April 2017 were selected and randomly divided into observation group and control group, with 40 cases in each group. The observation group was treated with Modified Erchen Decoction and the control group was given conventional treatment with Western medicine. After 4 weeks of treatment, the main clinical symptoms and signs(vertigo, neck and shoulder pain, headache, psychological and social adjustment, daily life and work) and cerebral blood flow parameters [the peak values of intracranial vertebral-basal artery diastolic blood flow velocity(Vd) and systolic blood flow velocity(Vp)] were compared between the 2 groups. The total clinical effective rate and adverse reactions during treatment were also compared. RESULTS: After treatment, the total effective rate of the observation group was 90.0%, which was significantly higher than that of the control group(77.5%). The difference between the two groups was statistically significant(P < 0.05). After treatment, The scores of vertigo, neck and shoulder pain, headache, psychology and society adaptation, daily life and work were significantly increased(P < 0.05), and the above scores of the observation group were increased more obviously. The difference between the groups was statistically significant(P < 0.05). After treatment, the levels of Vd and Vp were significantly increased(P < 0.05), and the increase of the above indexes was more obvious in the observation group. The difference between the 2 groups was statistically significant(P < 0.05). There were no significant abnormalities in blood routine, urine routine, liver function and renal function. There was no significant difference in the incidence of adverse reactions between the 2 groups.(P > 0.05). CONCLUSION: The treatment of vertebral artery type cervical spondylopathy with stagnation and blockade of phlegm-dampness syndrome by Modified Erchen Decoction can effectively relieve the main clinical symptoms and signs, improve cerebral blood flow parameters, and improve the peak values of vertebral-basal artery diastolic blood flow velocity(Vd) and systolic blood flow velocity(Vp), which is safe and effective, and helps to promote the recovery of cervical function.展开更多
Waterlogging is one of the most factors limiting wheat production in the middle and lower reaches of the Yangtze River Plain of China,especially in the middle and late stages of wheat.Wheat varieties‘Jingmai102’(JM1...Waterlogging is one of the most factors limiting wheat production in the middle and lower reaches of the Yangtze River Plain of China,especially in the middle and late stages of wheat.Wheat varieties‘Jingmai102’(JM102)and‘Yangmai158’(YM158)were planted to study the dynamic changes of photosynthetic characteristics in flag leaf and the influence of waterlogging at anthesis on the yield and components and dry matter accumulation and remobilization of winter wheat in above ground.The results showed that the SPAD values slightly increased at 1 day after anthesis(d),and then kept decreasing with the increase of waterlogging time.The decrease in SPAD value was more remarkably in YM158 than that in JM102.As for the chlorophyll fluorescence parameters,the photochemical efficiency(Fv/Fm),potential activity(Fv/Fo)of photosystem II,and electronic transmission(Fm/Fo)on photosystem II increased first and then decreased with the increase of waterlogging days after anthesis.The quantum ratio of heat dissipation(Fo/Fm)had a tendency opposite to that of Fv/Fm,and the change range of JM102 was lower than that of YM158.For the grain yield and components,waterlogging at anthesis decreased the dry weight of single stem,grain yield,1 000-kernel weight,spikelet per panicle,and harvest index,and the reduction of JM102 was smaller than that of YM158.As for the accumulation and remobilization of dry matter,the accumulation of dry matter after anthesis decreased significantly under waterlogging condition(WL),and the reduction of JM102 was smaller than that of YM158.In conclusion,waterlogging at anthesis significantly affected the photosynthetic characteristics,yield and components in both varieties,but different varieties exhibited different tolerances to waterlogging stress and YM158 was more sensitive to water stress than JM102.展开更多
Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on ...Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on performance of Forced Swimming Test (FST), blood biochemical parameters related to fatigue and thyroid functions. Therefore, Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), and Total Protein (TP), triiodothyronine T3, thyroxin T4 and TSH tests were investigated. Thirty five male adult mice were randomly divided into five groups: three NS-fed groups, one fluoxetine treated group and one control group. Three NS experimental groups received hydro-alcoholic extract of NS at doses of 50, 100 and 200 mg/kg orally for two weeks. Immobility time decreased in all NS groups compared with control group. Administration of NS significantly increased the concentration of T3 and T4 of the treatment groups. On the contrary, the amount of BUN, CK, LDH, TP and TSH decreased. In conclusion, black seed extract at the experimented doses showed anti-depressant, anti-fatigue and hyperthyroid effects.展开更多
Stress-induced failure is among the most common causes of instability in Canadian deep underground mines.Open stoping is the most widely practiced underground excavation method in these mines,and creates large stopes ...Stress-induced failure is among the most common causes of instability in Canadian deep underground mines.Open stoping is the most widely practiced underground excavation method in these mines,and creates large stopes which are subjected to stress-induced failure.The probability of failure(POF)depends on many factors,of which the geometry of an open stope is especially important.In this study,a methodology is proposed to assess the effect of stope geometrical parameters on the POF,using numerical modelling.Different ranges for each input parameter are defined according to previous surveys on open stope geometry in a number of Canadian underground mines.A Monte-Carlo simulation technique is combined with the finite difference code FLAC3D,to generate model realizations containing stopes with different geometrical features.The probability of failure(POF)for different categories of stope geometry,is calculated by considering two modes of failure;relaxation-related gravity driven(tensile)failure and rock mass brittle failure.The individual and interactive effects of stope geometrical parameters on the POF,are analyzed using a general multi-level factorial design.Finally,mathematical optimization techniques are employed to estimate the most stable stope conditions,by determining the optimal ranges for each stope’s geometrical parameter.展开更多
A neural network model of key process parameters and forming quality is developed based on training samples which are obtained from the orthogonal experiment and the finite element numerical simulation. Optimization o...A neural network model of key process parameters and forming quality is developed based on training samples which are obtained from the orthogonal experiment and the finite element numerical simulation. Optimization of the process parameters is conducted using the genetic algorithm (GA). The experimental results have shown that a surface model of the neural network can describe the nonlinear implicit relationship between the parameters of the power spinning process:the wall margin and amount of expansion. It has been found that the process of determining spinning technological parameters can be accelerated using the optimization method developed based on the BP neural network and the genetic algorithm used for the process parameters of power spinning formation. It is undoubtedly beneficial towards engineering applications.展开更多
Excitation parameter preferences are key factors a ecting the performance of magnetic frequency mixing detection.A uniform experimental design method was used to analyze this influence.Using fuzzy theory,a comprehensi...Excitation parameter preferences are key factors a ecting the performance of magnetic frequency mixing detection.A uniform experimental design method was used to analyze this influence.Using fuzzy theory,a comprehensive model is established for evaluating the e ect of magnetic frequency mixing.A polynomial is selected as the regression function to express explicitly the correlation between the excitation parameters and the frequency-mixing e ect.The excitation parameters were then optimized using genetic algorithm.Magnetic frequency mixing experiments were conducted to measure the surface hardness of some ferromagnetic materials.Frequency mixing is further enhanced under the optimal settings,resulting in an improvement in the measurement sensitivity.The results of this study support the application of the magnetic frequency mixing technique in non-destructive testing.展开更多
The process of wear process expedient considering as set of special cases wear. For each special case wear were received settlement with reference to some certain conditions of experimental researches realisation, uni...The process of wear process expedient considering as set of special cases wear. For each special case wear were received settlement with reference to some certain conditions of experimental researches realisation, uniting in self SLOP. For successful application deduced dependence at forecasting wear-resistance the mechanism of reduction is developed which allows to distribute deduced dependencies to any conditions of wear process.展开更多
This manuscript provides a comparison of the Hypersphere World-Universe Model (WUM) with the prevailing Big Bang Model (BBM) of the Standard Cosmology. The performed analysis of BBM shows that the Four Pillars of the ...This manuscript provides a comparison of the Hypersphere World-Universe Model (WUM) with the prevailing Big Bang Model (BBM) of the Standard Cosmology. The performed analysis of BBM shows that the Four Pillars of the Standard Cosmology are model-dependent and not strong enough to support the model. The angular momentum problem is one of the most critical problems in BBM. Standard Cosmology cannot explain how Galaxies and Extra Solar systems obtained their substantial orbital and rotational angular momenta, and why the orbital momentum of Jupiter is considerably larger than the rotational momentum of the Sun. WUM is the only cosmological model in existence that is consistent with the Law of Conservation of Angular Momentum. To be consistent with this Fundamental Law, WUM discusses in detail the Beginning of the World. The Model introduces Dark Epoch (spanning from the Beginning of the World for 0.4 billion years) when only Dark Matter Particles (DMPs) existed, and Luminous Epoch (ever since for 13.8 billion years). Big Bang discussed in Standard Cosmology is, in our view, transition from Dark Epoch to Luminous Epoch due to Rotational Fission of Overspinning Dark Matter (DM) Supercluster’s Cores. WUM envisions Matter carried from the Universe into the World from the fourth spatial dimension by DMPs. Ordinary Matter is a byproduct of DM annihilation. WUM solves a number of physical problems in contemporary Cosmology and Astrophysics through DMPs and their interactions: Angular Momentum problem in birth and subsequent evolution of Galaxies and Extrasolar systems—how do they obtain it;Fermi Bubbles—two large structures in gamma-rays and X-rays above and below Galactic center;Diversity of Gravitationally-Rounded Objects in Solar system;some problems in Solar and Geophysics [1]. WUM reveals Inter-Connectivity of Primary Cosmological Parameters and calculates their values, which are in good agreement with the latest results of their measurements.展开更多
Among the methods used for evaluating the potential hydraulic erodibility of rock,the most common methods are those based on the correlation between the force of flowing water and the capacity of a rock to resist eros...Among the methods used for evaluating the potential hydraulic erodibility of rock,the most common methods are those based on the correlation between the force of flowing water and the capacity of a rock to resist erosion,such as Annandale’s and Pells’methods.The capacity of a rock to resist erosion is evaluated based on erodibility indices that are determined from specific geomechanical parameters of a rock mass.These indices include unconfined compressive strength(UCS)of rock,rock block size,joint shear strength,a block’s shape and orientation relative to the direction of flow,joint openings,and the nature of the surface to be potentially eroded.However,it is difficult to determine the relevant geomechanical parameters for evaluating the hydraulic erodibility of rock.The assessment of eroded unlined spillways of dams has shown that the capacity of a rock to resist erosion is not accurately evaluated.Using more than 100 case studies,we develop a method to determine the relevant geomechanical parameters for evaluating the hydraulic erodibility of rock in unlined spillways.The UCS of rock is found not to be a relevant parameter for evaluating the hydraulic erodibility of rock.On the other hand,we find that the use of three-dimensional(3D)block volume measurements,instead of the block size factor used in Annandale’s method,improves the rock block size estimation.Furthermore,the parameter representing the effect of a rock block’s shape and orientation relative to the direction of flow,as considered in Pells’method,is more accurate than the parameter adopted by Annandale’s method.展开更多
The aim of this work is mathematical education through the knowledge system and mathematical modeling. A net model of formation of mathematical knowledge as a deductive theory is suggested here. Within this model the ...The aim of this work is mathematical education through the knowledge system and mathematical modeling. A net model of formation of mathematical knowledge as a deductive theory is suggested here. Within this model the formation of deductive theory is represented as the development of a certain informational space, the elements of which are structured in the form of the orientated semantic net. This net is properly metrized and characterized by a certain system of coverings. It allows injecting net optimization parameters, regulating qualitative aspects of knowledge system under consideration. To regulate the creative processes of the formation and realization of mathematical know- edge, stochastic model of formation deductive theory is suggested here in the form of branching Markovian process, which is realized in the corresponding informational space as a semantic net. According to this stochastic model we can get correct foundation of criterion of optimization creative processes that leads to “great main points” strategy (GMP-strategy) in the process of realization of the effective control in the research work in the sphere of mathematics and its applications.展开更多
Compared with conventional well, herringbone-like laterals wells can increase the area of oil release, and can reduce the number of wellhead slots of platforms,?and?also can greatly improve the development efficiency....Compared with conventional well, herringbone-like laterals wells can increase the area of oil release, and can reduce the number of wellhead slots of platforms,?and?also can greatly improve the development efficiency. Based on threshold pressure gradient in heavy oil reservoir,?and?the applied principle of mirror reflection and superposition, the pressure distribution equation of herringbone-like laterals wells is obtained in heavy oil reservoir. Productivity model of herringbone-like laterals wells is proposed by reservoir-wellbore steady seepage. The example shows that the productivity model is great accuracy?to?predict the productivity of herringbone-like laterals wells. The model is used to analyze the branching length, branching angle, branching symmetry, branching position and spacing and their effects on productivity of herringbone-like laterals wells. The principle of optimizing the well shape of herringbone-like laterals wells is proposed.展开更多
Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical applicati...Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical application of multi-omics parameters is still restricted by the expensive and less accessible assays,although they accurately reflect immune status.A comprehensive evaluation framework based on“easy-to-obtain”multi-model clinical parameters is urgently required,incorporating clinical features to establish baseline patient profiles and disease staging;routine blood tests assessing systemic metabolic and functional status;immune cell subsets quantifying subcluster dynamics;imaging features delineating tumor morphology,spatial configuration,and perilesional anatomical relationships;immunohistochemical markers positioning qualitative and quantitative detection of tumor antigens from the cellular and molecular level.This integrated phenomic approach aims to improve prognostic stratification and clinical decision-making in hepatocellular carcinoma management conveniently and practically.展开更多
The S38C railway axle undergoes induction hardening,resulting in a gradient-distributed microstructure and mechanical properties.The accurate identification of gradient-distributed plastic parameters for the S38C axle...The S38C railway axle undergoes induction hardening,resulting in a gradient-distributed microstructure and mechanical properties.The accurate identification of gradient-distributed plastic parameters for the S38C axle remains a challenging task.To tackle this challenge,the present study proposes a novel approach for identifying the gradient-distributed plastic parameters for the S38C axle by integrating nano-indentation techniques with the machine learning method.Firstly,nano-indentation tests are conducted along the radial direction of the S38C axle to obtain the gradient-distributed load-displacement curves,nano-hardness,and elastic modulus.Subsequently,the dimensionless analysis is performed to obtain the representative stress,strain,and yield stress from load-displacement curves.These parameters are then incorporated into the machine learning method as physical information to identify the gradient-distributed plastic parameters of the S38C axle.The results indicate that the proposed method based on the physics-informed neural network and multi-fidelity neural network successfully identifies the gradient-distributed plastic parameters of the S38C axles and demonstrates superior prediction accuracy and generalization compared with the purely data-driven machine learning method.展开更多
Objective: To investigate effect of aerobic exercise training combined with conventional drug on red blood cell parameters, vascular endothelial function and cardiac function in elderly patients with coronary heart di...Objective: To investigate effect of aerobic exercise training combined with conventional drug on red blood cell parameters, vascular endothelial function and cardiac function in elderly patients with coronary heart disease complicated with chronic heart failure. Methods: A total of 110 elderly patients with coronary heart disease and chronic heart failure according to random data table were divided into control group (n=54) and observation group (n=56). The patients in control group were treated with conventional drug, and patients in the observation group received conventional drug combined with aerobic exercise training. Before and after treatment, levels of red blood cell parameters, vascular endothelial function and cardiac function indexes were compared between the two groups. Results: Before treatment, the difference of HCT, RDW, RBC, NO, ET-1, LVEF, LVEDD and LVESD levels in the two groups were not significantly. After treatment, HCT and RBC levels in two groups were no statistically significant difference;The levels of RDW, ET-1, LVEDD and LVESD in observation group were significantly lower than those in this group before treatment, and significantly lower than those in the control group after treatment;The levels of NO and LVEF in two groups were significantly higher than those in the group before treatment, and levels of NO and LVEF in the observation group were significantly higher than those in control group after treatment. Conclusion: The clinical effect of aerobic exercise training combined with conventional drug in treatment of senile coronary heart disease with chronic heart failure was significant, which can effectively increase the RDW level of patients, improve vascular endothelial function and heart function, it has important clinical value.展开更多
文摘Presented here are the Generalized BCS Equations incorporating Fermi Energy for the study of the {Δ, Tc, jc(T)} values of both elemental and composite superconductors (SCs) for all T ≤ Tc, where Δ, Tc and jc(T) denote, respectively, one of the gap values, the critical temperature and the T-dependent critical current density. This framework, which extends our earlier study that dealt with the {Δ0, Tc, jc(0)} values of an SC, is also shown to lead to T-dependent values of several other related parameters such as the effective mass of electrons, their number density, critical velocity, Fermi velocity (VF), coherence length and the London penetration depth. The extended framework is applied to the jc(T) data reported by Romijn et al. for superconducting Aluminium strips and is shown not only to provide an alternative to the explanation given by them, but also to some novel features such as the role of the Sommerfeld coefficient γ(T) in the context of jc(T) and the role of VF(T) in the context of a recent finding by Plumb et al. about the superconductivity of Bi-2212.
文摘The 18 crude drugs in Bofutsushosan (BOF: Pulvis ledebouriellae compositae: 防風通聖散) are separated into 6 groups such as diaphoretic, cathartic, antidote, antipyretic, neutralizer and diuretic groups. The effects of single administered BOF and composed crude drugs in 6 groups were investigated on the levels of diabetic parameters (serum glucose, insulin, triglyceride and cholesterol) in streptozotocin-induced diabetic mice. The anti-hyperglycemic action of BOF was depended on Ephedrae Herba, Saposhnikoviae Radix and Schizonepetae Spica in diaphoretic group, Forsythiae Fructus, Saposhnikoviae Radix, Schizonepetae Spica and Cnidii Rhizoma in antidote group, Scutellariae Radix, Gardeniae Fructus and Gypsum Fibrosum in antipyretic group and Paeoniae Radix in neutralizer group. In these crude drugs, Ephedrae Herba, Saposhnikoviae Radix, Schizonepetae Spica, Forsythiae Fructus, Scutellariae Radix, Gypsum Fibrosum and Paeoniae Radix increased serum insulin level, but Cnidii Rhizoma and Gardeniae Fructus did not affect serum insulin level. From these results, it suggested that anti-hyperglycemic action of BOF was through insulin-dependent and insulin independent manners. The lowering effect of BOF on serum triglyceride level was dependent on actions of Platycodi Radix in antidote and diuretic groups and Gardeniae Fructus in antipyretic group. The lowering effect of Gardeniae Fructus was parallel with its anti-hyperglycemic action. The lowering effect of BOF on high serum triglyceride level also included both direct action and indirect action. The reducing effect of BOF on serum cholesterol level was observed together with the actions of Ephedrae Herba and Zingiberis Rhizoma in diaphoretic group, Schizonepetae Spica in diaphoretic and antidote groups and Paeoniae Radix in neutralizer group. The lowering effects of Ephedrae Herba, Schizonepetae Spica and Paeoniae Radix on serum cholesterol level were parallel with their anti-hyperglycemic actions. Zingiberis Rhizoma in diaphoretic group might be direct reducing effect on serum cholesterol level but no serum glucose level. The Ephedrae Herba in diaphoretic group, Schizonepetae Spica in diaphoretic and antidote groups and Paeoniae Radix in neutralizer group might have reduced serum cholesterol level by reducing blood glucose level. From these results, composed crude drugs in 6 groups show various mechanisms in the action of BOF.
文摘A novel integrated water treatment facility, inner-recycling continuous sand filter, is discussed. The theory of micro-flocculation is applied in the sand-washing circulation system with continuous filtration and backwashing. The design and operation parameters, which affect the performance of the filter, are discussed. The key design parameters are provided as follows: diameter of filter material is 0.7 to 1.0 mm, depth of filter bed is 0.6 m, filtration velocity is less than 12 m/h, ratio of gas to water is 9:11 and sand recycling rate is 2 to 4 mm/min.
文摘The inverse problem of wave equation is the importance of study not only in seismic prospecting but also in applied mathematics. With the development of the research, the inverse methods of 1 - D wave equations have been trending towards the multiple parameters inversion . We have obtained an inverse method with double -parameter, in which medium density and wave velocity can be derived simultaneously. In this paper, to increase the inverse accuracy, the method is improved as follows. Firstly, the formula in which the Green Function is omitted are derived and used. Secondly, the regularizing method is reasonable used by choosing the stable function. With the new method, we may derive elastic parameter and medium density or medium density and wave velocity. Thus, lithology parameters for seismic prospecting may be obtained.After comparing the derived values from the new method with that from previous method, we obtain the new method through which substantially improve the derived accuracy . The new method has been applied to real depths inversion for sedimentary strata and volcanic rock strata in Chaoyanggou Terrace of Songliao Basin in eastern China. According to the inverse results,the gas - bearing beds are determlned.
文摘Objectives: The aim of this study was to investigate the effectiveness of dietary intervention with apricots, pomegranate juice or lactic acid fermented sobya on improving the plasma levels of lipid profile parameters and total plasma homocysteine (tHcy) among healthy adults. Design of the study: Thirty-five men and women (28.9 ± 3.0 years) with mean body mass index of 23.5 ± 1.2 kg/m2 were randomly assigned to a dietary intervention study. During the pre-feeding study records of 24-hour food intake, anthropometric measurements and blood sampling were collected for biochemical investigations. Thereafter the volunteers were divided into five groups: a control group (C);the other four groups received daily one of the following supplements: 200 g of deep yellow apricots (Prunus armeniaca) (AF);250 g pomegranate (Punica granatum) juice (PJ);mixture of 100 g (PJ) and 150 g of fermented sobya (FS), (PJ-FS) or 165 g (FS). After completing the three-week dietary intervention, blood samples were collected and blood indices were again evaluated. Biochemical analysis of total lipids (TL), total glycerides (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) and tHcy were completed. The low density lipoprotein-cholesterol level and three indices of risk factors were calculated using the appropriate equations. Results: Three-week dietary intervention improved the levels of lipid profile parameters TG, TC, HDL-C and LDL-C as compared to the respective baseline levels and the response of the control group that did not receive any supplement. Consuming (PJ-FS) had a synergistic beneficially added value on some of the above mentioned lipid profile parameters. The mean plasma tHcy concentrations;a marker for occlusive vascular disease was reduced significantly following the three week consumption of (PJ) or (FS), compared with the respective pre-feeding levels. Conclusion: Pomegranate juice (PJ) or lactic acid fermented sobya (FS) or mixture of both are potential natural agents in lowering the plasma levels of lipid profile parameters and tHcy among apparently healthy young women and men, without dyslipidemic symptoms.
文摘On the basis of a three-dimensional non stationary model of a convective cloud with detailed description of dynamic, thermodynamic and microphysical processes, numerical experiments were conducted to study the formation of parameters of convective clouds under unstable stratification of the atmosphere. Numerical experiments have been carried out to study the formation of convective processes in the atmosphere. The thermo hydrodynamic parameters in the zone of a thunderstorm cloud are determined, and regions with a vortex motion of air are identified. The main flows feeding the convective cloud in the mature stage are determined. Due to the means of visualization, the areas of formation and growth of precipitation particles are identified. In a three-dimensional form, the interaction of dynamic and thermodynamic processes is analyzed. The interaction of fields is manifested in the form of deformation of fields of thermodynamic parameters under the influence of dynamic processes. Trajectories of air streams around a cloud and the trajectories of drops in a cloud are determined. The results of numerical experiments confirm that dynamic processes significantly influence the formation of fields of thermodynamic parameters in the cloud, which also determine the course of microphysical processes and the nature of the growth of precipitation particles.
文摘OBJECTIVE: To observe the effect of Modified Erchen Decoction on cervical spondylotic vertebral arteriopathy with stagnation and blockade of phlegm-dampness syndrome and effects on cerebral blood flow parameters. METHODS: A total of 80 cervical spondylotic vertebral arteriopathy(CSA) patients with stagnation and blockade of phlegmdampness syndrome admitted to our hospital from October 2016 to April 2017 were selected and randomly divided into observation group and control group, with 40 cases in each group. The observation group was treated with Modified Erchen Decoction and the control group was given conventional treatment with Western medicine. After 4 weeks of treatment, the main clinical symptoms and signs(vertigo, neck and shoulder pain, headache, psychological and social adjustment, daily life and work) and cerebral blood flow parameters [the peak values of intracranial vertebral-basal artery diastolic blood flow velocity(Vd) and systolic blood flow velocity(Vp)] were compared between the 2 groups. The total clinical effective rate and adverse reactions during treatment were also compared. RESULTS: After treatment, the total effective rate of the observation group was 90.0%, which was significantly higher than that of the control group(77.5%). The difference between the two groups was statistically significant(P < 0.05). After treatment, The scores of vertigo, neck and shoulder pain, headache, psychology and society adaptation, daily life and work were significantly increased(P < 0.05), and the above scores of the observation group were increased more obviously. The difference between the groups was statistically significant(P < 0.05). After treatment, the levels of Vd and Vp were significantly increased(P < 0.05), and the increase of the above indexes was more obvious in the observation group. The difference between the 2 groups was statistically significant(P < 0.05). There were no significant abnormalities in blood routine, urine routine, liver function and renal function. There was no significant difference in the incidence of adverse reactions between the 2 groups.(P > 0.05). CONCLUSION: The treatment of vertebral artery type cervical spondylopathy with stagnation and blockade of phlegm-dampness syndrome by Modified Erchen Decoction can effectively relieve the main clinical symptoms and signs, improve cerebral blood flow parameters, and improve the peak values of vertebral-basal artery diastolic blood flow velocity(Vd) and systolic blood flow velocity(Vp), which is safe and effective, and helps to promote the recovery of cervical function.
基金Supported by the National Key Research and Development Program of China(2016YFD0300107,2017YFD0300202-3)National Natural Science Foundation of China(31371580,31871578)
文摘Waterlogging is one of the most factors limiting wheat production in the middle and lower reaches of the Yangtze River Plain of China,especially in the middle and late stages of wheat.Wheat varieties‘Jingmai102’(JM102)and‘Yangmai158’(YM158)were planted to study the dynamic changes of photosynthetic characteristics in flag leaf and the influence of waterlogging at anthesis on the yield and components and dry matter accumulation and remobilization of winter wheat in above ground.The results showed that the SPAD values slightly increased at 1 day after anthesis(d),and then kept decreasing with the increase of waterlogging time.The decrease in SPAD value was more remarkably in YM158 than that in JM102.As for the chlorophyll fluorescence parameters,the photochemical efficiency(Fv/Fm),potential activity(Fv/Fo)of photosystem II,and electronic transmission(Fm/Fo)on photosystem II increased first and then decreased with the increase of waterlogging days after anthesis.The quantum ratio of heat dissipation(Fo/Fm)had a tendency opposite to that of Fv/Fm,and the change range of JM102 was lower than that of YM158.For the grain yield and components,waterlogging at anthesis decreased the dry weight of single stem,grain yield,1 000-kernel weight,spikelet per panicle,and harvest index,and the reduction of JM102 was smaller than that of YM158.As for the accumulation and remobilization of dry matter,the accumulation of dry matter after anthesis decreased significantly under waterlogging condition(WL),and the reduction of JM102 was smaller than that of YM158.In conclusion,waterlogging at anthesis significantly affected the photosynthetic characteristics,yield and components in both varieties,but different varieties exhibited different tolerances to waterlogging stress and YM158 was more sensitive to water stress than JM102.
文摘Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on performance of Forced Swimming Test (FST), blood biochemical parameters related to fatigue and thyroid functions. Therefore, Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), and Total Protein (TP), triiodothyronine T3, thyroxin T4 and TSH tests were investigated. Thirty five male adult mice were randomly divided into five groups: three NS-fed groups, one fluoxetine treated group and one control group. Three NS experimental groups received hydro-alcoholic extract of NS at doses of 50, 100 and 200 mg/kg orally for two weeks. Immobility time decreased in all NS groups compared with control group. Administration of NS significantly increased the concentration of T3 and T4 of the treatment groups. On the contrary, the amount of BUN, CK, LDH, TP and TSH decreased. In conclusion, black seed extract at the experimented doses showed anti-depressant, anti-fatigue and hyperthyroid effects.
基金funded by a grant from Natural Sciences and Engineering Research Council of Canada (NSERC)the authors would like to acknowledge the Niobec mine (Saint-Honoré, QuébecQuébec)
文摘Stress-induced failure is among the most common causes of instability in Canadian deep underground mines.Open stoping is the most widely practiced underground excavation method in these mines,and creates large stopes which are subjected to stress-induced failure.The probability of failure(POF)depends on many factors,of which the geometry of an open stope is especially important.In this study,a methodology is proposed to assess the effect of stope geometrical parameters on the POF,using numerical modelling.Different ranges for each input parameter are defined according to previous surveys on open stope geometry in a number of Canadian underground mines.A Monte-Carlo simulation technique is combined with the finite difference code FLAC3D,to generate model realizations containing stopes with different geometrical features.The probability of failure(POF)for different categories of stope geometry,is calculated by considering two modes of failure;relaxation-related gravity driven(tensile)failure and rock mass brittle failure.The individual and interactive effects of stope geometrical parameters on the POF,are analyzed using a general multi-level factorial design.Finally,mathematical optimization techniques are employed to estimate the most stable stope conditions,by determining the optimal ranges for each stope’s geometrical parameter.
基金Supported by the Natural Science Foundation of Shanxi Province Project(2012011023-2)
文摘A neural network model of key process parameters and forming quality is developed based on training samples which are obtained from the orthogonal experiment and the finite element numerical simulation. Optimization of the process parameters is conducted using the genetic algorithm (GA). The experimental results have shown that a surface model of the neural network can describe the nonlinear implicit relationship between the parameters of the power spinning process:the wall margin and amount of expansion. It has been found that the process of determining spinning technological parameters can be accelerated using the optimization method developed based on the BP neural network and the genetic algorithm used for the process parameters of power spinning formation. It is undoubtedly beneficial towards engineering applications.
基金Supported by National Key Research and Development Program of China(Grant No.2017YFF0209703)National Natural Science Foundation of China(Grant Nos.11972053,11527801).
文摘Excitation parameter preferences are key factors a ecting the performance of magnetic frequency mixing detection.A uniform experimental design method was used to analyze this influence.Using fuzzy theory,a comprehensive model is established for evaluating the e ect of magnetic frequency mixing.A polynomial is selected as the regression function to express explicitly the correlation between the excitation parameters and the frequency-mixing e ect.The excitation parameters were then optimized using genetic algorithm.Magnetic frequency mixing experiments were conducted to measure the surface hardness of some ferromagnetic materials.Frequency mixing is further enhanced under the optimal settings,resulting in an improvement in the measurement sensitivity.The results of this study support the application of the magnetic frequency mixing technique in non-destructive testing.
文摘The process of wear process expedient considering as set of special cases wear. For each special case wear were received settlement with reference to some certain conditions of experimental researches realisation, uniting in self SLOP. For successful application deduced dependence at forecasting wear-resistance the mechanism of reduction is developed which allows to distribute deduced dependencies to any conditions of wear process.
文摘This manuscript provides a comparison of the Hypersphere World-Universe Model (WUM) with the prevailing Big Bang Model (BBM) of the Standard Cosmology. The performed analysis of BBM shows that the Four Pillars of the Standard Cosmology are model-dependent and not strong enough to support the model. The angular momentum problem is one of the most critical problems in BBM. Standard Cosmology cannot explain how Galaxies and Extra Solar systems obtained their substantial orbital and rotational angular momenta, and why the orbital momentum of Jupiter is considerably larger than the rotational momentum of the Sun. WUM is the only cosmological model in existence that is consistent with the Law of Conservation of Angular Momentum. To be consistent with this Fundamental Law, WUM discusses in detail the Beginning of the World. The Model introduces Dark Epoch (spanning from the Beginning of the World for 0.4 billion years) when only Dark Matter Particles (DMPs) existed, and Luminous Epoch (ever since for 13.8 billion years). Big Bang discussed in Standard Cosmology is, in our view, transition from Dark Epoch to Luminous Epoch due to Rotational Fission of Overspinning Dark Matter (DM) Supercluster’s Cores. WUM envisions Matter carried from the Universe into the World from the fourth spatial dimension by DMPs. Ordinary Matter is a byproduct of DM annihilation. WUM solves a number of physical problems in contemporary Cosmology and Astrophysics through DMPs and their interactions: Angular Momentum problem in birth and subsequent evolution of Galaxies and Extrasolar systems—how do they obtain it;Fermi Bubbles—two large structures in gamma-rays and X-rays above and below Galactic center;Diversity of Gravitationally-Rounded Objects in Solar system;some problems in Solar and Geophysics [1]. WUM reveals Inter-Connectivity of Primary Cosmological Parameters and calculates their values, which are in good agreement with the latest results of their measurements.
基金the Natural Sciences and Engineering Research Council of Canada(Grant No.498020-16)Hydro-Quebec(NC525700)the Mitacs Accelerate Program(Grant Ref.IT10008)
文摘Among the methods used for evaluating the potential hydraulic erodibility of rock,the most common methods are those based on the correlation between the force of flowing water and the capacity of a rock to resist erosion,such as Annandale’s and Pells’methods.The capacity of a rock to resist erosion is evaluated based on erodibility indices that are determined from specific geomechanical parameters of a rock mass.These indices include unconfined compressive strength(UCS)of rock,rock block size,joint shear strength,a block’s shape and orientation relative to the direction of flow,joint openings,and the nature of the surface to be potentially eroded.However,it is difficult to determine the relevant geomechanical parameters for evaluating the hydraulic erodibility of rock.The assessment of eroded unlined spillways of dams has shown that the capacity of a rock to resist erosion is not accurately evaluated.Using more than 100 case studies,we develop a method to determine the relevant geomechanical parameters for evaluating the hydraulic erodibility of rock in unlined spillways.The UCS of rock is found not to be a relevant parameter for evaluating the hydraulic erodibility of rock.On the other hand,we find that the use of three-dimensional(3D)block volume measurements,instead of the block size factor used in Annandale’s method,improves the rock block size estimation.Furthermore,the parameter representing the effect of a rock block’s shape and orientation relative to the direction of flow,as considered in Pells’method,is more accurate than the parameter adopted by Annandale’s method.
文摘The aim of this work is mathematical education through the knowledge system and mathematical modeling. A net model of formation of mathematical knowledge as a deductive theory is suggested here. Within this model the formation of deductive theory is represented as the development of a certain informational space, the elements of which are structured in the form of the orientated semantic net. This net is properly metrized and characterized by a certain system of coverings. It allows injecting net optimization parameters, regulating qualitative aspects of knowledge system under consideration. To regulate the creative processes of the formation and realization of mathematical know- edge, stochastic model of formation deductive theory is suggested here in the form of branching Markovian process, which is realized in the corresponding informational space as a semantic net. According to this stochastic model we can get correct foundation of criterion of optimization creative processes that leads to “great main points” strategy (GMP-strategy) in the process of realization of the effective control in the research work in the sphere of mathematics and its applications.
文摘Compared with conventional well, herringbone-like laterals wells can increase the area of oil release, and can reduce the number of wellhead slots of platforms,?and?also can greatly improve the development efficiency. Based on threshold pressure gradient in heavy oil reservoir,?and?the applied principle of mirror reflection and superposition, the pressure distribution equation of herringbone-like laterals wells is obtained in heavy oil reservoir. Productivity model of herringbone-like laterals wells is proposed by reservoir-wellbore steady seepage. The example shows that the productivity model is great accuracy?to?predict the productivity of herringbone-like laterals wells. The model is used to analyze the branching length, branching angle, branching symmetry, branching position and spacing and their effects on productivity of herringbone-like laterals wells. The principle of optimizing the well shape of herringbone-like laterals wells is proposed.
文摘Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical application of multi-omics parameters is still restricted by the expensive and less accessible assays,although they accurately reflect immune status.A comprehensive evaluation framework based on“easy-to-obtain”multi-model clinical parameters is urgently required,incorporating clinical features to establish baseline patient profiles and disease staging;routine blood tests assessing systemic metabolic and functional status;immune cell subsets quantifying subcluster dynamics;imaging features delineating tumor morphology,spatial configuration,and perilesional anatomical relationships;immunohistochemical markers positioning qualitative and quantitative detection of tumor antigens from the cellular and molecular level.This integrated phenomic approach aims to improve prognostic stratification and clinical decision-making in hepatocellular carcinoma management conveniently and practically.
基金supported by the National Key Research and Development Plan(Grant No.2022YFB3401901)the National Natural Science Foundation of China(Grant Nos.12192210,12192214,12072295,and 12222209)+1 种基金Independent Project of State Key Laboratory of Rail Transit Vehicle System(Grant No.2023TPL-T03)Fundamental Research Funds for the Central Universities(Grant No.2682023CG004).
文摘The S38C railway axle undergoes induction hardening,resulting in a gradient-distributed microstructure and mechanical properties.The accurate identification of gradient-distributed plastic parameters for the S38C axle remains a challenging task.To tackle this challenge,the present study proposes a novel approach for identifying the gradient-distributed plastic parameters for the S38C axle by integrating nano-indentation techniques with the machine learning method.Firstly,nano-indentation tests are conducted along the radial direction of the S38C axle to obtain the gradient-distributed load-displacement curves,nano-hardness,and elastic modulus.Subsequently,the dimensionless analysis is performed to obtain the representative stress,strain,and yield stress from load-displacement curves.These parameters are then incorporated into the machine learning method as physical information to identify the gradient-distributed plastic parameters of the S38C axle.The results indicate that the proposed method based on the physics-informed neural network and multi-fidelity neural network successfully identifies the gradient-distributed plastic parameters of the S38C axles and demonstrates superior prediction accuracy and generalization compared with the purely data-driven machine learning method.
文摘Objective: To investigate effect of aerobic exercise training combined with conventional drug on red blood cell parameters, vascular endothelial function and cardiac function in elderly patients with coronary heart disease complicated with chronic heart failure. Methods: A total of 110 elderly patients with coronary heart disease and chronic heart failure according to random data table were divided into control group (n=54) and observation group (n=56). The patients in control group were treated with conventional drug, and patients in the observation group received conventional drug combined with aerobic exercise training. Before and after treatment, levels of red blood cell parameters, vascular endothelial function and cardiac function indexes were compared between the two groups. Results: Before treatment, the difference of HCT, RDW, RBC, NO, ET-1, LVEF, LVEDD and LVESD levels in the two groups were not significantly. After treatment, HCT and RBC levels in two groups were no statistically significant difference;The levels of RDW, ET-1, LVEDD and LVESD in observation group were significantly lower than those in this group before treatment, and significantly lower than those in the control group after treatment;The levels of NO and LVEF in two groups were significantly higher than those in the group before treatment, and levels of NO and LVEF in the observation group were significantly higher than those in control group after treatment. Conclusion: The clinical effect of aerobic exercise training combined with conventional drug in treatment of senile coronary heart disease with chronic heart failure was significant, which can effectively increase the RDW level of patients, improve vascular endothelial function and heart function, it has important clinical value.
