Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical applicati...Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical application of multi-omics parameters is still restricted by the expensive and less accessible assays,although they accurately reflect immune status.A comprehensive evaluation framework based on“easy-to-obtain”multi-model clinical parameters is urgently required,incorporating clinical features to establish baseline patient profiles and disease staging;routine blood tests assessing systemic metabolic and functional status;immune cell subsets quantifying subcluster dynamics;imaging features delineating tumor morphology,spatial configuration,and perilesional anatomical relationships;immunohistochemical markers positioning qualitative and quantitative detection of tumor antigens from the cellular and molecular level.This integrated phenomic approach aims to improve prognostic stratification and clinical decision-making in hepatocellular carcinoma management conveniently and practically.展开更多
Presented in this study is a novel method for estimating the depth of single underwater source in shallow water,utilizing vector sensors.The approach leverages the depth distribution of the broadband Stokes parameters...Presented in this study is a novel method for estimating the depth of single underwater source in shallow water,utilizing vector sensors.The approach leverages the depth distribution of the broadband Stokes parameters to estimate source depth accurately.Unlike traditional matched field processing(MFP)and matched mode processing(MMP),the proposed approach can estimate source depth directly from the data received by sensors without requiring complete environmental information.Firstly,the broadband Stokes parameters(BSP)are established using the normal mode theory.Then the nonstationary phase approximation is used to simplify the theoretical derivation,which is necessary when dealing with broadband integrals.Additionally,range terms of the BSP are eliminated by normalization.By analyzing the depth distribution of the normalized broadband Stokes parameters(NBSP),it is found that the NBSP exhibit extreme values at the source depth,which can be used for source depth estimation.So the proposed depth estimation method is based on searching the peaks of the NBSP.Simulations show that this method is effective in relatively simple shallow water environments.Finally,the effect of source range,frequency bandwidth,sound speed profile(SSP),water depth,and signal-to-noise ratio(SNR)are studied.The findings indicate that the proposed method can accurately estimate the source depth when the SNR is greater than-5 d B and does not need to consider model mismatch issues.Additionally,variations in environmental parameters have minimal impact on estimation accuracy.Compared to MFP,the proposed method requires a higher SNR,but demonstrates superior robustness against fluctuations in environmental parameters.展开更多
As binary geological media,soil-rock mixtures(SRMs)exhibit a distinct gradational composition,leading to their unique mechanical behaviors.To appraise the stability of SRM slopes,it is essential to determine equivalen...As binary geological media,soil-rock mixtures(SRMs)exhibit a distinct gradational composition,leading to their unique mechanical behaviors.To appraise the stability of SRM slopes,it is essential to determine equivalent parameters of SRMs,which are typically obtained through experimental and numerical methods.In contrasted to other numerical methods,the numerical manifold method(NMM)is more effective in addressing SRM problems.This is because the high-precision regular mathematical meshes in NMM can be used without aligning with the soil-rock interfaces and boundaries of SRMs.In the current research,the equivalent strength parameters of SRMs,i.e.the equivalent cohesion ce and internal friction angleϕ_(e),are determined using NMM.Initially,an NMM triaxial numerical model is established and validated based on triaxial experiments.Subsequently,the soil and rock parameters are derived through parameter inversion.Moreover,the impacts of rock content,size,shape and rock blocks'major-axis orientation on ce andϕ_(e) of SRMs are thoroughly examined using the NMM triaxial numerical model.Additionally,a fitting function is proposed to linkϕ_(e) to the rock content and size of SRMs.When other influencing factors are fixed,the above fitting model leads to the following conclusions:(1)the predictedϕ_(e) of SRMs increase with the increase of rock content;and(2)SRM samples with smaller rocks display a higher predictedϕ_(e).展开更多
To investigate the long-term stability of soft-hard interbedded rock masses with initial damage induced by earthquakes and periodic drying and wetting,this study prepared samples with different initial damage through ...To investigate the long-term stability of soft-hard interbedded rock masses with initial damage induced by earthquakes and periodic drying and wetting,this study prepared samples with different initial damage through cyclic loading and unloading(CLU)experiments followed by cyclic drying and wetting(CDW)experiments,and finally conducted creep experiments.The study analyzed the effects of initial damage on creep mechanical behavior,crack evolution,and explored failure precursor information,revealing the damage failure mechanisms.The results show that the structural characteristics of the rock mass control its macroscopic failure mode.Initial damage promotes microcrack development,influences the fracture mode,and increases the proportion of high-frequency(200−280 kHz)acoustic emission events during creep.Meanwhile,initial damage exacerbates creep characteristics,increasing the creep rate,shortening total creep failure time,and reducing long-term strength.The damage failure is attributed to:the generation of internal cracks and pores in the rock caused by CLU;mineral hydrolysis and expansion-contraction due to CDW,resulting in weakened intergranular cementation;and full development of cracks and pores under creep stress.Additionally,the deformation difference coefficient and the coefficient of variation of RA/AF values can serve as precursor indicators for creep failure.展开更多
Combining with empirical method, laboratory test and numerical simulation, a comprehensive system was presented to determine the mechanical parameters of jointed rock masses. The system has the following four function...Combining with empirical method, laboratory test and numerical simulation, a comprehensive system was presented to determine the mechanical parameters of jointed rock masses. The system has the following four functions: (1) Based on the field investigation of joints, the system can consider rock mass structures, by using network simulation technology. (2) Rock samples are conducted by numerical simulation with the input engineering mechanical parameters of rocks and joints obtained from laboratory tests. (3) The whole stress-strain curve of jointed rock masses under certain normal stress can be plotted from numerical simulation, and then the shear strength parameters of jointed rock masses can be obtained from the whole stress-strain curves under different normal stresses. (4) The statistical values of mechanical parameters of jointed rock masses can be determined according to numerical simulation. Based on the statistical values, combining with engineering experiences and geological investigations, the comprehensive mechanical parameters of jointed rock masses can be achieved finally. Several cases are presented to prove the engineering feasibility and suitability of this system.展开更多
According to the characteristic of elastic waves propagation in medium and the application of elastic waves method in rock mass engineering, the cranny mass with random crannies was regarded as quasi-isotropic cranny ...According to the characteristic of elastic waves propagation in medium and the application of elastic waves method in rock mass engineering, the cranny mass with random crannies was regarded as quasi-isotropic cranny mass. In accordance with the rock rupture mechanics, principle of energy balance and Castiglano＇s theorem, the relationship of effective dynamic parameters of elasticity （E, v, G） and cranny density parameters or porosity was put forward. On this basis, through the theory of elastic waves propagation in isotropic medium, the relationship between the elastic wave velocity and cranny density parameters and porosity was set up. The theoretical research results show that, in this kind of cranny rock masses, there is nonlinear relationships between the effective dynamic parameters of elasticity and wave velocities and the cranny density parameter or porosity; and with the increase of cranny density parameter or porosity of cranny rock masses, the effective dynamic modulus and the elastic wave velocities of cranny rock masses will decrease; and at the same time, when the cranny density parameter or porosity is very small, the effective dynamic modulus of elasticity and the elastic wave velocities change with the cranny density parameter, which can explain the sensitivity of effective elastic parameters and elastic wave velocities to cranny rock masses.展开更多
This paper proposes a new continuity model for engineering in rock masses and a new schematic method for reporting the engineering of rock continuity. This method can be used to evaluate the mechanics of every kind of...This paper proposes a new continuity model for engineering in rock masses and a new schematic method for reporting the engineering of rock continuity. This method can be used to evaluate the mechanics of every kind of medium;and is a new way to determine the mechanical parameters used in engineering design in rock masses. In the numerical simulation, the experimental parameters of intact rock were combined with the structural properties of field rock. Theexperimental results for orthogonally-jointed rock are given. The results included the curves of the stress-strain relationship of some rock masses, the curve of the relationship between the dimension Δ and the uniaxial pressure-resistant strength σc of these rock masses, and pictures of the destructive procedure of some rock masses in uniaxial or triaxial tests, etc. Application of the method to engineering design in rock masses showed the potential of its application to engineering practice.展开更多
The gears of new energy vehicles are required to withstand higher rotational speeds and greater loads,which puts forward higher precision essentials for gear manufacturing.However,machining process parameters can caus...The gears of new energy vehicles are required to withstand higher rotational speeds and greater loads,which puts forward higher precision essentials for gear manufacturing.However,machining process parameters can cause changes in cutting force/heat,resulting in affecting gear machining precision.Therefore,this paper studies the effect of different process parameters on gear machining precision.A multi-objective optimization model is established for the relationship between process parameters and tooth surface deviations,tooth profile deviations,and tooth lead deviations through the cutting speed,feed rate,and cutting depth of the worm wheel gear grinding machine.The response surface method(RSM)is used for experimental design,and the corresponding experimental results and optimal process parameters are obtained.Subsequently,gray relational analysis-principal component analysis(GRA-PCA),particle swarm optimization(PSO),and genetic algorithm-particle swarm optimization(GA-PSO)methods are used to analyze the experimental results and obtain different optimal process parameters.The results show that optimal process parameters obtained by the GRA-PCA,PSO,and GA-PSO methods improve the gear machining precision.Moreover,the gear machining precision obtained by GA-PSO is superior to other methods.展开更多
A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that th...A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that the loading parameters(initial normal stress,normal stiffness,and shear velocity)determine propagation paths of the wing and secondary cracks in rock bridges during the initial shear cycle,creating different morphologies of macroscopic step-path rupture surfaces and asperities on them.The differences in stress state and rupture surface induce different cyclic shear responses.It shows that high initial normal stress accelerates asperity degradation,raises shear resistance,and promotes compression of intermittent joints.In addition,high normal stiffness provides higher normal stress and shear resistance during the initial cycles and inhibits the dilation and compression of intermittent joints.High shear velocity results in a higher shear resistance,greater dilation,and greater compression.Finally,shear strength is most sensitive to initial normal stress,followed by shear velocity and normal stiffness.Moreover,average dilation angle is most sensitive to initial normal stress,followed by normal stiffness and shear velocity.During the shear cycles,frictional coefficient is affected by asperity degradation,backfilling of rock debris,and frictional area,exhibiting a non-monotonic behavior.展开更多
Accurate measurement of helicopter rotor motion parameters(flap,lead-lag,torsion,and azimuth angles)is essential for rotor blade design,helicopter dynamics modeling,and flight safety and health monitoring.However,the ...Accurate measurement of helicopter rotor motion parameters(flap,lead-lag,torsion,and azimuth angles)is essential for rotor blade design,helicopter dynamics modeling,and flight safety and health monitoring.However,the existing methods face challenges in testing equipment installation,calibration,and data transmission,resulting in limited reports on real-time in-flight measurements of blade motion parameters.This paper proposes a non-contact optoelectronic method based on two-dimensional position-sensitive detectors for in-flight measurement and a ground calibration system to obtain real-time rotor motion parameters during helicopter flight.The proposed method establishes the time evolution relationship of rotor motion parameters and verifies the performance of the in-flight measurement system regarding measurement resolution and accuracy through the construction of a blade motion posture experimental platform.The proposed method has been applied to the flight measurement of a medium-sized single-rotor helicopter,and the obtained results have been compared with theoretical analysis outcomes.Furthermore,this paper examines the characteristics of blade motion parameters during flight and discusses the challenges and potential solutions for measuring rotor motion parameters during helicopter flight using the proposed method.展开更多
Cystic lesions of the anterior mediastinum in children suggest a well-known group of benign lesions that are comparatively frequent.Thymic cysts(TCs)are mostly positioned in the anterior mediastinum and some patients ...Cystic lesions of the anterior mediastinum in children suggest a well-known group of benign lesions that are comparatively frequent.Thymic cysts(TCs)are mostly positioned in the anterior mediastinum and some patients in the neck.Benign TCs classified as congenital intra-thoracic mesothelial cysts are commonly asymptomatic and have slight clinical significance.Multilocular TC,which can mimic another anterior mediastinal cystic tumor and is seen in adults,is more clinically important.It is a sporadic mediastinal lesion thought to arise in the course of acquired inflammation.Congenital mediastinal cysts represent 3%-6%of all mediastinal tumors and 10%-18%of radiologically reported mediastinal masses.Mediastinal TCs are uncommon and it is hard to know their true incidence.About 60%of cases with mediastinal TCs are asymptomatic,and the remainder of patients complains of nonspecific symptoms(e.g.,chest pain,dyspnea,or cough).The literature suggests that most cysts are benign,but an indefinite percentage may have a neoplastic process and result in significant compressive symptoms over time.Clinical symptoms of TCs vary depending on the location.In addition,frequent symptoms at the appearance of enlarged benign thymic and mediastinal cysts generally contain compressive symptoms(e.g.,respiratory distress,thymic pain,and symptoms related to Horner syndrome,hoarseness,dysphonia,dyspnea,orthopnea,wheezing,and fever).Many TCs have cystic density and a neat border and are simple to diagnose with radiological imaging.However,some TCs are hard to identify before surgery and may be misidentified as thymomas depending on their site and computed tomography results.Excision by thoracotomy,median sternotomy,or video-assisted techniques is essential for conclusive diagnosis,management,and abolition of relapse of anterior mediastinal masses and TCs.Histopathologic examination may be required after surgery.Considering the extent of the mass and the preliminary inability to make a definitive diagnosis,en bloc excision of the cyst was thought to be preferred to circumvent likely complications(e.g.,perforation,spillage of the contents,or incomplete excision).展开更多
The Standard Model of particle physics assumes that fundamental fermions are point particles with zero radius, no spatial dimensions, and infinite matter density. This alternative model treats the nine charged fundame...The Standard Model of particle physics assumes that fundamental fermions are point particles with zero radius, no spatial dimensions, and infinite matter density. This alternative model treats the nine charged fundamental fermions (three leptons and nine quarks) as spheres with non-zero holographic radius. Holographic analysis (based on quantum mechanics, general relativity, thermodynamics, and Shannon information theory) specifies electron mass by five fundamental constants: Planck’s constant ℏ, gravitational constant G, fine structure constant α, cosmological constant Λ, and vacuum energy fraction ΩΛ. Protons and neutrons are composite systems of up and down quarks. Describing forces between quark constituents confined within nucleons as inverse square attractive forces, this alternative model identifies composition factors Cpand Cnto relate proton and neutron masses to electron mass and thus to fundamental constants. An appendix summarizes holographic analyses characterizing astronomical masses at the opposite end of the mass scale for objects in the universe.展开更多
To guarantee safe and efficient tunneling of a tunnel boring machine(TBM),rapid and accurate judgment of the rock mass condition is essential.Based on fuzzy C-means clustering,this paper proposes a grouped machine lea...To guarantee safe and efficient tunneling of a tunnel boring machine(TBM),rapid and accurate judgment of the rock mass condition is essential.Based on fuzzy C-means clustering,this paper proposes a grouped machine learning method for predicting rock mass parameters.An elaborate data set on field rock mass is collected,which also matches field TBM tunneling.Meanwhile,target stratum samples are divided into several clusters by fuzzy C-means clustering,and multiple submodels are trained by samples in different clusters with the input of pretreated TBM tunneling data and the output of rock mass parameter data.Each testing sample or newly encountered tunneling condition can be predicted by multiple submodels with the weight of the membership degree of the sample to each cluster.The proposed method has been realized by 100 training samples and verified by 30 testing samples collected from the C1 part of the Pearl Delta water resources allocation project.The average percentage error of uniaxial compressive strength and joint frequency(Jf)of the 30 testing samples predicted by the pure back propagation(BP)neural network is 13.62%and 12.38%,while that predicted by the BP neural network combined with fuzzy C-means is 7.66%and6.40%,respectively.In addition,by combining fuzzy C-means clustering,the prediction accuracies of support vector regression and random forest are also improved to different degrees,which demonstrates that fuzzy C-means clustering is helpful for improving the prediction accuracy of machine learning and thus has good applicability.Accordingly,the proposed method is valuable for predicting rock mass parameters during TBM tunneling.展开更多
In complex systems,there is a kind of parameters having only a minor impact on the outputs in most cases,but their accurate values are still critical for the operation of systems.In this paper,the authors focus on the...In complex systems,there is a kind of parameters having only a minor impact on the outputs in most cases,but their accurate values are still critical for the operation of systems.In this paper,the authors focus on the identification of these weak influence parameters in the complex systems and propose a identification model based on the parameter recursion.As an application,three parameters of the steam generator are identified,that is,the valve opening,the valve CV value,and the reference water level,in which the valve opening and the reference water level are weak influence parameters under most operating conditions.Numerical simulation results show that,in comparison with the multi-layer perceptron(MLP),the identification error rate is decreased.Actually,the average identification error rate for the valve opening decreases by 0.96%,for the valve CV decreases by 0.002%,and for the reference water level decreases by 12%after one recursion.After two recursions,the average identification error rate for the valve opening decreases by 11.07%,for the valve CV decreases by 2.601%,and for the reference water level decreases by 95.79%.This method can help to improve the control of the steam generator.展开更多
Joints are widely distributed structural defects in rock masses,and their geometric characteristics play a decisive role in the overall stability of rocks under complex stress conditions.To clarify the influence of jo...Joints are widely distributed structural defects in rock masses,and their geometric characteristics play a decisive role in the overall stability of rocks under complex stress conditions.To clarify the influence of joint geometry on the mechanical behavior of jointed rock under such conditions,this study investigated the mechanical properties and failure mechanisms of composite jointed rock specimens with varying joint roughness and joint dip angles.Three typical failure modes under triaxial loading were identified,and a mechanical analysis model incorporating joint roughness and dip angle was established.The failure mechanism was revealed,and a discrete element model was developed to analyze the micro-damage evolution process of the specimens.The results show that the mechanical parameters of the specimens exhibit pronounced anisotropy.Both the elastic modulus and peak strength reach their minimum values at a joint dip angle of 60°.Increasing joint roughness significantly reduces the degree of anisotropy and enhances the energy storage capacity of the specimens.A strong linear relationship is observed between the elastic strain energy and the peak deviatoric stress,confirming the applicability of the linear energy storage law in composite jointed rocks.Discrete element simulations revealed the evolution path and dominant types of microcracks between the joint and matrix.The joint dip angle governs the transition of dominant crack types from tensile to shear and then back to tensile.Increased joint roughness significantly suppresses damage localization along the joint and results in an approximately 20%increase in the proportion of shear microcracks within the matrix.These findings clarify the regulatory role of joint geometrical parameters in the damage evolution process.展开更多
In this paper,we propose a neural network approach to learn the parameters of a class of stochastic Lotka-Volterra systems.Approximations of the mean and covariance matrix of the observational variables are obtained f...In this paper,we propose a neural network approach to learn the parameters of a class of stochastic Lotka-Volterra systems.Approximations of the mean and covariance matrix of the observational variables are obtained from the Euler-Maruyama discretization of the underlying stochastic differential equations(SDEs),based on which the loss function is built.The stochastic gradient descent method is applied in the neural network training.Numerical experiments demonstrate the effectiveness of our method.展开更多
To overcome the shortage of complex equipment,large volume,and high energy consumption in space capsule manufacturing,a novel sliding pressure Joule heat fuse additive manufacturing technique with reduced volume and l...To overcome the shortage of complex equipment,large volume,and high energy consumption in space capsule manufacturing,a novel sliding pressure Joule heat fuse additive manufacturing technique with reduced volume and low energy consumption was proposed.But the unreasonable process parameters may lead to the inferior consistency of the forming quality of single-channel multilayer in Joule heat additive manufacturing process,and it is difficult to reach the condition for forming thinwalled parts.Orthogonal experiments were designed to fabricate single-channel multilayer samples with varying numbers of layers,and their forming quality was evaluated.The influence of printing current,forming speed,and contact pressure on the forming quality of the single-channel multilayer was analyzed.The optimal process parameters were obtained and the quality characterization of the experiment results was conducted.Results show that the printing current has the most significant influence on the forming quality of the single-channel multilayer.Under the optimal process parameters,the forming section is well fused and the surface is continuously smooth.The surface roughness of a single-channel 3-layer sample is 0.16μm,and the average Vickers hardness of cross section fusion zone is 317 HV,which lays a foundation for the subsequent use of Joule heat additive manufacturing technique to form thinwall parts.展开更多
BACKGROUND Sagittal spinopelvic alignment(SSA)is essential for preserving a stable and effective upright posture and locomotion.Although alterations in the SSA are recognised to induce compensatory modifications in th...BACKGROUND Sagittal spinopelvic alignment(SSA)is essential for preserving a stable and effective upright posture and locomotion.Although alterations in the SSA are recognised to induce compensatory modifications in the pelvis,hips,and knees,the inverse relationship concerning knee pathology undergoing total knee arthroplasty(TKA)has been examined by a limited number of studies,yielding inconclusive results.AIM To generate evidence of the effect of TKA on the SSA from existing literature.METHODS Databases like PubMed,EMBASE,and Scopus were used to identify articles related to the“knee spine syndrome”phenomenon using a combination of subject terms and keywords such as“spinopelvic parameters”,“sagittal spinal balance”,and“total knee arthroplasty”were used with appropriate Boolean operators.Studies measuring the SSA following TKA were included,and research was conducted as per preferred reporting items for systematic review and metaanalysis guidelines.RESULTS A total of 475 participants had undergone TKA,and six studies measuring SSA were analysed.Following TKA,pelvic tilt was the only parameter that showed significant changes,while lumbar lordosis(LL),pelvic incidence,and sacral slope were non-significant,as evident from the forest plots.CONCLUSION The body's sagittal alignment is a complex balance between pelvic,spine,and lower extremity parameters.TKA,while having the potential to correct the flexion contracture,can also correct it.Still,the primary SSA for spinal pathology,i.e.,LL,may not be corrected in patients with co-existent spinal degenerative disease.展开更多
The study of the morphometric parameters of the three most abundant species in the lower course of the Kouilou River (Chrysichthys auratus, Liza falcipinnis and Pellonula vorax) was carried out. The standard length of...The study of the morphometric parameters of the three most abundant species in the lower course of the Kouilou River (Chrysichthys auratus, Liza falcipinnis and Pellonula vorax) was carried out. The standard length of Chrysichthys auratus varies between 43.57 and 210 mm, for an average of 96.70 ± 28.63 mm;the weight varies between 2.92 and 140.83 mg, an average of 73.03 ± 21.62 mg. The condition coefficient is equal to 4.42 ± 1.52. Liza falcipinnis has a standard length which varies between 59.9 mm and 158.08 mm for an average of 88.15 ± 29.74 mm;its weight varies between 4.77 and 76.21 mg, an average of 18.61 ± 11.82 mg. The condition coefficient is equal to 2.47 ± 1.57. Pellonula vorax has a standard length which varies between 60.33 mm and 117.72 mm;for an average of 80.48 ± 17.75 mm;the weight varies between 3.61 and 25.17 mg, an average of 9.03 ± 3.61 mg. The condition coefficient is equal to 2.17 ± 0.57. These three species have a minor allometric growth.展开更多
The current investigation focuses on intertwined relationships of ecology and aquaculture for the benefit of farmers involved in fish farming practices.The study evaluated glucosinolate reduction in black,brown,and wh...The current investigation focuses on intertwined relationships of ecology and aquaculture for the benefit of farmers involved in fish farming practices.The study evaluated glucosinolate reduction in black,brown,and white mustard meals as fish feed ingredients for Indian Major Carps.Fish were fed with 10%mustard meal-supplemented diets in three forms:Raw(R),Anti-nutritional Rich(AR),and Anti-nutritional Lowered(AL),alongside a control group using floating feed.The three-month indoor experiment(September-November 2023)was conducted in FRP tanks with triplicate treatments.Blood analysis revealed compromised health in AR-fed carps,with reduced hemoglobin levels in rohu,catla and mrigal and elevated total leukocyte counts indicating inflammation in all the three carps studied here.Liver function was impaired in AR-fed fish,shown by increased alanine transaminase levels,highest in rohu followed by mrigal and catla.Histopathological examination of AR-fed carps liver tissue revealed necrotic spots,deformed hepatocytes,and significant vacuolation.In contrast,AL-fed fish demonstrated improved health parameters through Complete Blood Count analysis,liver function tests,and histo-pathological observations,suggesting successful reduction of anti-nutritional factors in the processed mustard meals.In near future,replacement of unprocessed seed meal with processed seed meal will lead to economic gains in fish farming.展开更多
文摘Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical application of multi-omics parameters is still restricted by the expensive and less accessible assays,although they accurately reflect immune status.A comprehensive evaluation framework based on“easy-to-obtain”multi-model clinical parameters is urgently required,incorporating clinical features to establish baseline patient profiles and disease staging;routine blood tests assessing systemic metabolic and functional status;immune cell subsets quantifying subcluster dynamics;imaging features delineating tumor morphology,spatial configuration,and perilesional anatomical relationships;immunohistochemical markers positioning qualitative and quantitative detection of tumor antigens from the cellular and molecular level.This integrated phenomic approach aims to improve prognostic stratification and clinical decision-making in hepatocellular carcinoma management conveniently and practically.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12274348 and 12004335)the National Key Research and Development Program of China(Grant No.2024YFC2813800)。
文摘Presented in this study is a novel method for estimating the depth of single underwater source in shallow water,utilizing vector sensors.The approach leverages the depth distribution of the broadband Stokes parameters to estimate source depth accurately.Unlike traditional matched field processing(MFP)and matched mode processing(MMP),the proposed approach can estimate source depth directly from the data received by sensors without requiring complete environmental information.Firstly,the broadband Stokes parameters(BSP)are established using the normal mode theory.Then the nonstationary phase approximation is used to simplify the theoretical derivation,which is necessary when dealing with broadband integrals.Additionally,range terms of the BSP are eliminated by normalization.By analyzing the depth distribution of the normalized broadband Stokes parameters(NBSP),it is found that the NBSP exhibit extreme values at the source depth,which can be used for source depth estimation.So the proposed depth estimation method is based on searching the peaks of the NBSP.Simulations show that this method is effective in relatively simple shallow water environments.Finally,the effect of source range,frequency bandwidth,sound speed profile(SSP),water depth,and signal-to-noise ratio(SNR)are studied.The findings indicate that the proposed method can accurately estimate the source depth when the SNR is greater than-5 d B and does not need to consider model mismatch issues.Additionally,variations in environmental parameters have minimal impact on estimation accuracy.Compared to MFP,the proposed method requires a higher SNR,but demonstrates superior robustness against fluctuations in environmental parameters.
基金supported by the National Natural Science Foundation of China(Grant Nos.12272393 and 52130905).
文摘As binary geological media,soil-rock mixtures(SRMs)exhibit a distinct gradational composition,leading to their unique mechanical behaviors.To appraise the stability of SRM slopes,it is essential to determine equivalent parameters of SRMs,which are typically obtained through experimental and numerical methods.In contrasted to other numerical methods,the numerical manifold method(NMM)is more effective in addressing SRM problems.This is because the high-precision regular mathematical meshes in NMM can be used without aligning with the soil-rock interfaces and boundaries of SRMs.In the current research,the equivalent strength parameters of SRMs,i.e.the equivalent cohesion ce and internal friction angleϕ_(e),are determined using NMM.Initially,an NMM triaxial numerical model is established and validated based on triaxial experiments.Subsequently,the soil and rock parameters are derived through parameter inversion.Moreover,the impacts of rock content,size,shape and rock blocks'major-axis orientation on ce andϕ_(e) of SRMs are thoroughly examined using the NMM triaxial numerical model.Additionally,a fitting function is proposed to linkϕ_(e) to the rock content and size of SRMs.When other influencing factors are fixed,the above fitting model leads to the following conclusions:(1)the predictedϕ_(e) of SRMs increase with the increase of rock content;and(2)SRM samples with smaller rocks display a higher predictedϕ_(e).
基金Project(U22A20603)supported by the National Natural Science Foundation of ChinaProject(2023YFC3008300)supported by the National Key Research and Development Program of China。
文摘To investigate the long-term stability of soft-hard interbedded rock masses with initial damage induced by earthquakes and periodic drying and wetting,this study prepared samples with different initial damage through cyclic loading and unloading(CLU)experiments followed by cyclic drying and wetting(CDW)experiments,and finally conducted creep experiments.The study analyzed the effects of initial damage on creep mechanical behavior,crack evolution,and explored failure precursor information,revealing the damage failure mechanisms.The results show that the structural characteristics of the rock mass control its macroscopic failure mode.Initial damage promotes microcrack development,influences the fracture mode,and increases the proportion of high-frequency(200−280 kHz)acoustic emission events during creep.Meanwhile,initial damage exacerbates creep characteristics,increasing the creep rate,shortening total creep failure time,and reducing long-term strength.The damage failure is attributed to:the generation of internal cracks and pores in the rock caused by CLU;mineral hydrolysis and expansion-contraction due to CDW,resulting in weakened intergranular cementation;and full development of cracks and pores under creep stress.Additionally,the deformation difference coefficient and the coefficient of variation of RA/AF values can serve as precursor indicators for creep failure.
基金Supported by the National Basic Research Program of China (973 Program) (2011CB013502)the National Natural Science Foundation of China (51179210)
文摘Combining with empirical method, laboratory test and numerical simulation, a comprehensive system was presented to determine the mechanical parameters of jointed rock masses. The system has the following four functions: (1) Based on the field investigation of joints, the system can consider rock mass structures, by using network simulation technology. (2) Rock samples are conducted by numerical simulation with the input engineering mechanical parameters of rocks and joints obtained from laboratory tests. (3) The whole stress-strain curve of jointed rock masses under certain normal stress can be plotted from numerical simulation, and then the shear strength parameters of jointed rock masses can be obtained from the whole stress-strain curves under different normal stresses. (4) The statistical values of mechanical parameters of jointed rock masses can be determined according to numerical simulation. Based on the statistical values, combining with engineering experiences and geological investigations, the comprehensive mechanical parameters of jointed rock masses can be achieved finally. Several cases are presented to prove the engineering feasibility and suitability of this system.
基金Projects(50334060 50474025) supported by the National Natural Science Foundation of China project(2005CB221502)supported by the National Key Fundamental Research and Development Programof China
文摘According to the characteristic of elastic waves propagation in medium and the application of elastic waves method in rock mass engineering, the cranny mass with random crannies was regarded as quasi-isotropic cranny mass. In accordance with the rock rupture mechanics, principle of energy balance and Castiglano＇s theorem, the relationship of effective dynamic parameters of elasticity （E, v, G） and cranny density parameters or porosity was put forward. On this basis, through the theory of elastic waves propagation in isotropic medium, the relationship between the elastic wave velocity and cranny density parameters and porosity was set up. The theoretical research results show that, in this kind of cranny rock masses, there is nonlinear relationships between the effective dynamic parameters of elasticity and wave velocities and the cranny density parameter or porosity; and with the increase of cranny density parameter or porosity of cranny rock masses, the effective dynamic modulus and the elastic wave velocities of cranny rock masses will decrease; and at the same time, when the cranny density parameter or porosity is very small, the effective dynamic modulus of elasticity and the elastic wave velocities change with the cranny density parameter, which can explain the sensitivity of effective elastic parameters and elastic wave velocities to cranny rock masses.
文摘This paper proposes a new continuity model for engineering in rock masses and a new schematic method for reporting the engineering of rock continuity. This method can be used to evaluate the mechanics of every kind of medium;and is a new way to determine the mechanical parameters used in engineering design in rock masses. In the numerical simulation, the experimental parameters of intact rock were combined with the structural properties of field rock. Theexperimental results for orthogonally-jointed rock are given. The results included the curves of the stress-strain relationship of some rock masses, the curve of the relationship between the dimension Δ and the uniaxial pressure-resistant strength σc of these rock masses, and pictures of the destructive procedure of some rock masses in uniaxial or triaxial tests, etc. Application of the method to engineering design in rock masses showed the potential of its application to engineering practice.
基金Projects(U22B2084,52275483,52075142)supported by the National Natural Science Foundation of ChinaProject(2023ZY01050)supported by the Ministry of Industry and Information Technology High Quality Development,China。
文摘The gears of new energy vehicles are required to withstand higher rotational speeds and greater loads,which puts forward higher precision essentials for gear manufacturing.However,machining process parameters can cause changes in cutting force/heat,resulting in affecting gear machining precision.Therefore,this paper studies the effect of different process parameters on gear machining precision.A multi-objective optimization model is established for the relationship between process parameters and tooth surface deviations,tooth profile deviations,and tooth lead deviations through the cutting speed,feed rate,and cutting depth of the worm wheel gear grinding machine.The response surface method(RSM)is used for experimental design,and the corresponding experimental results and optimal process parameters are obtained.Subsequently,gray relational analysis-principal component analysis(GRA-PCA),particle swarm optimization(PSO),and genetic algorithm-particle swarm optimization(GA-PSO)methods are used to analyze the experimental results and obtain different optimal process parameters.The results show that optimal process parameters obtained by the GRA-PCA,PSO,and GA-PSO methods improve the gear machining precision.Moreover,the gear machining precision obtained by GA-PSO is superior to other methods.
基金financially supported by the National Natural Science Foundation of China(Grant No.42172292)Taishan Scholars Project Special Funding,and Shandong Energy Group(Grant No.SNKJ 2022A01-R26).
文摘A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that the loading parameters(initial normal stress,normal stiffness,and shear velocity)determine propagation paths of the wing and secondary cracks in rock bridges during the initial shear cycle,creating different morphologies of macroscopic step-path rupture surfaces and asperities on them.The differences in stress state and rupture surface induce different cyclic shear responses.It shows that high initial normal stress accelerates asperity degradation,raises shear resistance,and promotes compression of intermittent joints.In addition,high normal stiffness provides higher normal stress and shear resistance during the initial cycles and inhibits the dilation and compression of intermittent joints.High shear velocity results in a higher shear resistance,greater dilation,and greater compression.Finally,shear strength is most sensitive to initial normal stress,followed by shear velocity and normal stiffness.Moreover,average dilation angle is most sensitive to initial normal stress,followed by normal stiffness and shear velocity.During the shear cycles,frictional coefficient is affected by asperity degradation,backfilling of rock debris,and frictional area,exhibiting a non-monotonic behavior.
基金the funding provided by the National Helicopter Development Project of China。
文摘Accurate measurement of helicopter rotor motion parameters(flap,lead-lag,torsion,and azimuth angles)is essential for rotor blade design,helicopter dynamics modeling,and flight safety and health monitoring.However,the existing methods face challenges in testing equipment installation,calibration,and data transmission,resulting in limited reports on real-time in-flight measurements of blade motion parameters.This paper proposes a non-contact optoelectronic method based on two-dimensional position-sensitive detectors for in-flight measurement and a ground calibration system to obtain real-time rotor motion parameters during helicopter flight.The proposed method establishes the time evolution relationship of rotor motion parameters and verifies the performance of the in-flight measurement system regarding measurement resolution and accuracy through the construction of a blade motion posture experimental platform.The proposed method has been applied to the flight measurement of a medium-sized single-rotor helicopter,and the obtained results have been compared with theoretical analysis outcomes.Furthermore,this paper examines the characteristics of blade motion parameters during flight and discusses the challenges and potential solutions for measuring rotor motion parameters during helicopter flight using the proposed method.
文摘Cystic lesions of the anterior mediastinum in children suggest a well-known group of benign lesions that are comparatively frequent.Thymic cysts(TCs)are mostly positioned in the anterior mediastinum and some patients in the neck.Benign TCs classified as congenital intra-thoracic mesothelial cysts are commonly asymptomatic and have slight clinical significance.Multilocular TC,which can mimic another anterior mediastinal cystic tumor and is seen in adults,is more clinically important.It is a sporadic mediastinal lesion thought to arise in the course of acquired inflammation.Congenital mediastinal cysts represent 3%-6%of all mediastinal tumors and 10%-18%of radiologically reported mediastinal masses.Mediastinal TCs are uncommon and it is hard to know their true incidence.About 60%of cases with mediastinal TCs are asymptomatic,and the remainder of patients complains of nonspecific symptoms(e.g.,chest pain,dyspnea,or cough).The literature suggests that most cysts are benign,but an indefinite percentage may have a neoplastic process and result in significant compressive symptoms over time.Clinical symptoms of TCs vary depending on the location.In addition,frequent symptoms at the appearance of enlarged benign thymic and mediastinal cysts generally contain compressive symptoms(e.g.,respiratory distress,thymic pain,and symptoms related to Horner syndrome,hoarseness,dysphonia,dyspnea,orthopnea,wheezing,and fever).Many TCs have cystic density and a neat border and are simple to diagnose with radiological imaging.However,some TCs are hard to identify before surgery and may be misidentified as thymomas depending on their site and computed tomography results.Excision by thoracotomy,median sternotomy,or video-assisted techniques is essential for conclusive diagnosis,management,and abolition of relapse of anterior mediastinal masses and TCs.Histopathologic examination may be required after surgery.Considering the extent of the mass and the preliminary inability to make a definitive diagnosis,en bloc excision of the cyst was thought to be preferred to circumvent likely complications(e.g.,perforation,spillage of the contents,or incomplete excision).
文摘The Standard Model of particle physics assumes that fundamental fermions are point particles with zero radius, no spatial dimensions, and infinite matter density. This alternative model treats the nine charged fundamental fermions (three leptons and nine quarks) as spheres with non-zero holographic radius. Holographic analysis (based on quantum mechanics, general relativity, thermodynamics, and Shannon information theory) specifies electron mass by five fundamental constants: Planck’s constant ℏ, gravitational constant G, fine structure constant α, cosmological constant Λ, and vacuum energy fraction ΩΛ. Protons and neutrons are composite systems of up and down quarks. Describing forces between quark constituents confined within nucleons as inverse square attractive forces, this alternative model identifies composition factors Cpand Cnto relate proton and neutron masses to electron mass and thus to fundamental constants. An appendix summarizes holographic analyses characterizing astronomical masses at the opposite end of the mass scale for objects in the universe.
基金Natural Science Foundation of Shandong Province,Grant/Award Number:ZR202103010903Doctoral Fund of Shandong Jianzhu University,Grant/Award Number:X21101Z。
文摘To guarantee safe and efficient tunneling of a tunnel boring machine(TBM),rapid and accurate judgment of the rock mass condition is essential.Based on fuzzy C-means clustering,this paper proposes a grouped machine learning method for predicting rock mass parameters.An elaborate data set on field rock mass is collected,which also matches field TBM tunneling.Meanwhile,target stratum samples are divided into several clusters by fuzzy C-means clustering,and multiple submodels are trained by samples in different clusters with the input of pretreated TBM tunneling data and the output of rock mass parameter data.Each testing sample or newly encountered tunneling condition can be predicted by multiple submodels with the weight of the membership degree of the sample to each cluster.The proposed method has been realized by 100 training samples and verified by 30 testing samples collected from the C1 part of the Pearl Delta water resources allocation project.The average percentage error of uniaxial compressive strength and joint frequency(Jf)of the 30 testing samples predicted by the pure back propagation(BP)neural network is 13.62%and 12.38%,while that predicted by the BP neural network combined with fuzzy C-means is 7.66%and6.40%,respectively.In addition,by combining fuzzy C-means clustering,the prediction accuracies of support vector regression and random forest are also improved to different degrees,which demonstrates that fuzzy C-means clustering is helpful for improving the prediction accuracy of machine learning and thus has good applicability.Accordingly,the proposed method is valuable for predicting rock mass parameters during TBM tunneling.
文摘In complex systems,there is a kind of parameters having only a minor impact on the outputs in most cases,but their accurate values are still critical for the operation of systems.In this paper,the authors focus on the identification of these weak influence parameters in the complex systems and propose a identification model based on the parameter recursion.As an application,three parameters of the steam generator are identified,that is,the valve opening,the valve CV value,and the reference water level,in which the valve opening and the reference water level are weak influence parameters under most operating conditions.Numerical simulation results show that,in comparison with the multi-layer perceptron(MLP),the identification error rate is decreased.Actually,the average identification error rate for the valve opening decreases by 0.96%,for the valve CV decreases by 0.002%,and for the reference water level decreases by 12%after one recursion.After two recursions,the average identification error rate for the valve opening decreases by 11.07%,for the valve CV decreases by 2.601%,and for the reference water level decreases by 95.79%.This method can help to improve the control of the steam generator.
基金supported by the National Natural Science Foundation of China(Nos.52304108,52274148)China University of Mining and Technology-Beijing Undergraduate Innovation Training Program(No.202515011).
文摘Joints are widely distributed structural defects in rock masses,and their geometric characteristics play a decisive role in the overall stability of rocks under complex stress conditions.To clarify the influence of joint geometry on the mechanical behavior of jointed rock under such conditions,this study investigated the mechanical properties and failure mechanisms of composite jointed rock specimens with varying joint roughness and joint dip angles.Three typical failure modes under triaxial loading were identified,and a mechanical analysis model incorporating joint roughness and dip angle was established.The failure mechanism was revealed,and a discrete element model was developed to analyze the micro-damage evolution process of the specimens.The results show that the mechanical parameters of the specimens exhibit pronounced anisotropy.Both the elastic modulus and peak strength reach their minimum values at a joint dip angle of 60°.Increasing joint roughness significantly reduces the degree of anisotropy and enhances the energy storage capacity of the specimens.A strong linear relationship is observed between the elastic strain energy and the peak deviatoric stress,confirming the applicability of the linear energy storage law in composite jointed rocks.Discrete element simulations revealed the evolution path and dominant types of microcracks between the joint and matrix.The joint dip angle governs the transition of dominant crack types from tensile to shear and then back to tensile.Increased joint roughness significantly suppresses damage localization along the joint and results in an approximately 20%increase in the proportion of shear microcracks within the matrix.These findings clarify the regulatory role of joint geometrical parameters in the damage evolution process.
基金Supported by the National Natural Science Foundation of China(11971458,11471310)。
文摘In this paper,we propose a neural network approach to learn the parameters of a class of stochastic Lotka-Volterra systems.Approximations of the mean and covariance matrix of the observational variables are obtained from the Euler-Maruyama discretization of the underlying stochastic differential equations(SDEs),based on which the loss function is built.The stochastic gradient descent method is applied in the neural network training.Numerical experiments demonstrate the effectiveness of our method.
基金Shaanxi Province Qin Chuangyuan“Scientist+Engineer”Team Construction Project(2022KXJ-071)2022 Qin Chuangyuan Achievement Transformation Incubation Capacity Improvement Project(2022JH-ZHFHTS-0012)+1 种基金Shaanxi Province Key Research and Development Plan-“Two Chains”Integration Key Project-Qin Chuangyuan General Window Industrial Cluster Project(2023QCY-LL-02)Xixian New Area Science and Technology Plan(2022-YXYJ-003,2022-XXCY-010)。
文摘To overcome the shortage of complex equipment,large volume,and high energy consumption in space capsule manufacturing,a novel sliding pressure Joule heat fuse additive manufacturing technique with reduced volume and low energy consumption was proposed.But the unreasonable process parameters may lead to the inferior consistency of the forming quality of single-channel multilayer in Joule heat additive manufacturing process,and it is difficult to reach the condition for forming thinwalled parts.Orthogonal experiments were designed to fabricate single-channel multilayer samples with varying numbers of layers,and their forming quality was evaluated.The influence of printing current,forming speed,and contact pressure on the forming quality of the single-channel multilayer was analyzed.The optimal process parameters were obtained and the quality characterization of the experiment results was conducted.Results show that the printing current has the most significant influence on the forming quality of the single-channel multilayer.Under the optimal process parameters,the forming section is well fused and the surface is continuously smooth.The surface roughness of a single-channel 3-layer sample is 0.16μm,and the average Vickers hardness of cross section fusion zone is 317 HV,which lays a foundation for the subsequent use of Joule heat additive manufacturing technique to form thinwall parts.
文摘BACKGROUND Sagittal spinopelvic alignment(SSA)is essential for preserving a stable and effective upright posture and locomotion.Although alterations in the SSA are recognised to induce compensatory modifications in the pelvis,hips,and knees,the inverse relationship concerning knee pathology undergoing total knee arthroplasty(TKA)has been examined by a limited number of studies,yielding inconclusive results.AIM To generate evidence of the effect of TKA on the SSA from existing literature.METHODS Databases like PubMed,EMBASE,and Scopus were used to identify articles related to the“knee spine syndrome”phenomenon using a combination of subject terms and keywords such as“spinopelvic parameters”,“sagittal spinal balance”,and“total knee arthroplasty”were used with appropriate Boolean operators.Studies measuring the SSA following TKA were included,and research was conducted as per preferred reporting items for systematic review and metaanalysis guidelines.RESULTS A total of 475 participants had undergone TKA,and six studies measuring SSA were analysed.Following TKA,pelvic tilt was the only parameter that showed significant changes,while lumbar lordosis(LL),pelvic incidence,and sacral slope were non-significant,as evident from the forest plots.CONCLUSION The body's sagittal alignment is a complex balance between pelvic,spine,and lower extremity parameters.TKA,while having the potential to correct the flexion contracture,can also correct it.Still,the primary SSA for spinal pathology,i.e.,LL,may not be corrected in patients with co-existent spinal degenerative disease.
文摘The study of the morphometric parameters of the three most abundant species in the lower course of the Kouilou River (Chrysichthys auratus, Liza falcipinnis and Pellonula vorax) was carried out. The standard length of Chrysichthys auratus varies between 43.57 and 210 mm, for an average of 96.70 ± 28.63 mm;the weight varies between 2.92 and 140.83 mg, an average of 73.03 ± 21.62 mg. The condition coefficient is equal to 4.42 ± 1.52. Liza falcipinnis has a standard length which varies between 59.9 mm and 158.08 mm for an average of 88.15 ± 29.74 mm;its weight varies between 4.77 and 76.21 mg, an average of 18.61 ± 11.82 mg. The condition coefficient is equal to 2.47 ± 1.57. Pellonula vorax has a standard length which varies between 60.33 mm and 117.72 mm;for an average of 80.48 ± 17.75 mm;the weight varies between 3.61 and 25.17 mg, an average of 9.03 ± 3.61 mg. The condition coefficient is equal to 2.17 ± 0.57. These three species have a minor allometric growth.
文摘The current investigation focuses on intertwined relationships of ecology and aquaculture for the benefit of farmers involved in fish farming practices.The study evaluated glucosinolate reduction in black,brown,and white mustard meals as fish feed ingredients for Indian Major Carps.Fish were fed with 10%mustard meal-supplemented diets in three forms:Raw(R),Anti-nutritional Rich(AR),and Anti-nutritional Lowered(AL),alongside a control group using floating feed.The three-month indoor experiment(September-November 2023)was conducted in FRP tanks with triplicate treatments.Blood analysis revealed compromised health in AR-fed carps,with reduced hemoglobin levels in rohu,catla and mrigal and elevated total leukocyte counts indicating inflammation in all the three carps studied here.Liver function was impaired in AR-fed fish,shown by increased alanine transaminase levels,highest in rohu followed by mrigal and catla.Histopathological examination of AR-fed carps liver tissue revealed necrotic spots,deformed hepatocytes,and significant vacuolation.In contrast,AL-fed fish demonstrated improved health parameters through Complete Blood Count analysis,liver function tests,and histo-pathological observations,suggesting successful reduction of anti-nutritional factors in the processed mustard meals.In near future,replacement of unprocessed seed meal with processed seed meal will lead to economic gains in fish farming.
