Botulinum neurotoxin(Bo NT) is the most potent neurotoxin,causing neuroparalysis.The toxin can induce skeletal muscle paralysis,and even respiratory failure and death in severe cases,by blocking the release of acetylc...Botulinum neurotoxin(Bo NT) is the most potent neurotoxin,causing neuroparalysis.The toxin can induce skeletal muscle paralysis,and even respiratory failure and death in severe cases,by blocking the release of acetylcholine(Ach) from the presynaptic membrane and its transmission to the peripheral nerves.Eight serotypes(A–G and FA) exist,in which A/B/E/F affect humans and animals,C/D affect livestock,and G remains unreported.Bo NT/FA(or Bo NT/H) shares genetic homology with A1/F5,but its classification remains debated.^([1,2]) Here,we report a Bo NT/E poisoning case confirmed by immuno-endopeptidasemass spectrometry(immuno-endopep-MS).展开更多
文摘Botulinum neurotoxin(Bo NT) is the most potent neurotoxin,causing neuroparalysis.The toxin can induce skeletal muscle paralysis,and even respiratory failure and death in severe cases,by blocking the release of acetylcholine(Ach) from the presynaptic membrane and its transmission to the peripheral nerves.Eight serotypes(A–G and FA) exist,in which A/B/E/F affect humans and animals,C/D affect livestock,and G remains unreported.Bo NT/FA(or Bo NT/H) shares genetic homology with A1/F5,but its classification remains debated.^([1,2]) Here,we report a Bo NT/E poisoning case confirmed by immuno-endopeptidasemass spectrometry(immuno-endopep-MS).
