With the continuous improvement of the medical industry’s requirements for the professional capabilities of nursing talents,traditional nursing teaching models can hardly meet the needs of complex nursing work in neu...With the continuous improvement of the medical industry’s requirements for the professional capabilities of nursing talents,traditional nursing teaching models can hardly meet the needs of complex nursing work in neurology.This paper focuses on nursing education for neurology nursing students and explores the construction of the“one-on-one”teaching model,aiming to achieve a paradigm shift in nursing education.By analyzing the current status of neurology nursing education,this paper identifies the problems in traditional teaching models.Combining the advantages of the“one-on-one”teaching model,it elaborates on the construction path of this model from aspects such as the selection and training of teaching instructors,the design of teaching content,the innovation of teaching methods,and the improvement of the teaching evaluation system.The research shows that the“one-on-one”teaching model can significantly enhance nursing students’mastery of professional knowledge,clinical operation skills,communication skills,and emergency response capabilities,as well as strengthen their professional identity and sense of responsibility.It provides an effective way to cultivate high-quality nursing talents who can meet the needs of neurology nursing work and promotes the innovative development of nursing education.展开更多
This paper explores the paradigm reconstruction of interpreting pedagogy driven by generative AI technology.With the breakthroughs of AI technologies such as ChatGPT in natural language processing,traditional interpre...This paper explores the paradigm reconstruction of interpreting pedagogy driven by generative AI technology.With the breakthroughs of AI technologies such as ChatGPT in natural language processing,traditional interpreting education faces dual challenges of technological substitution and pedagogical transformation.Based on Kuhn’s paradigm theory,the study analyzes the limitations of three traditional interpreting teaching paradigms,language-centric,knowledge-based,and skill-acquisition-oriented,and proposes a novel“teacher-AI-learner”triadic collaborative paradigm.Through reconstructing teaching subjects,environments,and curriculum systems,the integration of real-time translation tools and intelligent terminology databases facilitates the transition from static skill training to dynamic human-machine collaboration.The research simultaneously highlights challenges in technological ethics and curriculum design transformation pressures,emphasizing the necessity to balance technological empowerment with humanistic education.展开更多
The integration of artificial intelligence(AI)is fundamentally reshaping the scientific research,giving rise to a new era of discovery and innovation.This paper explores this transformative shift,introducing an innova...The integration of artificial intelligence(AI)is fundamentally reshaping the scientific research,giving rise to a new era of discovery and innovation.This paper explores this transformative shift,introducing an innovative concept of the“AI-Driven Research Ecosystem”,a dynamic and collaborative research environment.Within this ecosystem,we focus on the unification of human-AI collaboration models and the emerging new research thinking paradigms.We analyze the multifaceted roles of AI within the research lifecycle,spanning from a passive tool to an active assistant and autonomous participants,and categorize these interactions into distinct human-AI collaboration models.Furthermore,we examine how the pervasive involvement of AI necessitates an evolution in human research thinking,emphasizing the significant roles of critical,creative,and computational thinking.Through a review of existing literature and illustrative case studies,this paper provides a comprehensive overview of the AI-driven research ecosystem,highlighting its potential for transforming scientific research.Our findings advance the current understanding of AI’s multiple roles in research and underscore its capacity to revolutionize both knowledge discovery and collaborative innovation,paving the way for a more integrated and impactful research paradigm.展开更多
This study examines the advent of agent interaction(AIx)as a transformative paradigm in humancomputer interaction(HCI),signifying a notable evolution beyond traditional graphical interfaces and touchscreen interaction...This study examines the advent of agent interaction(AIx)as a transformative paradigm in humancomputer interaction(HCI),signifying a notable evolution beyond traditional graphical interfaces and touchscreen interactions.Within the context of large models,AIx is characterized by its innovative interaction patterns and a plethora of application scenarios that hold great potential.The paper highlights the pivotal role of AIx in shaping the future landscape of the large model industry,emphasizing its adoption and necessity from a user's perspective.This study underscores the pivotal role of AIx in dictating the future trajectory of a large model industry by emphasizing the importance of its adoption and necessity from a user-centric perspective.The fundamental drivers of AIx include the introduction of novel capabilities,replication of capabilities(both anthropomorphic and superhuman),migration of capabilities,aggregation of intelligence,and multiplication of capabilities.These elements are essential for propelling innovation,expanding the frontiers of capability,and realizing the exponential superposition of capabilities,thereby mitigating labor redundancy and addressing a spectrum of human needs.Furthermore,this study provides an in-depth analysis of the structural components and operational mechanisms of agents supported by large models.Such advancements significantly enhance the capacity of agents to tackle complex problems and provide intelligent services,thereby facilitating a more intuitive,adaptive,and personalized engagement between humans and machines.The study further delineates four principal categories of interaction patterns that encompass eight distinct modalities of interaction,corresponding to twenty-one specific scenarios,including applications in smart home systems,health assistance,and elderly care.This emphasizes the significance of this new paradigm in advancing HCI,fostering technological advancements,and redefining user experiences.However,it also acknowledges the challenges and ethical considerations that accompany this paradigm shift,recognizing the need for a balanced approach to harness the full potential of AIx in modern society.展开更多
Digital-intelligent technologies represent the advanced direction of new quality productive forces and are becoming a driving force for the digital transformation and high-quality development of the cultural industry....Digital-intelligent technologies represent the advanced direction of new quality productive forces and are becoming a driving force for the digital transformation and high-quality development of the cultural industry.Empowered by new quality productive forces,the digital cultural industry has demonstrated diverse characteristics,including the innovation of cultural production subjects,the intelligentization of production tools,the digitization of production objects,the systematization of production methods,and the diversification of production factors.Leveraging technologies such as AIGC,virtual-physical integration,and DAOs based on Web 3.0,the digital cultural industry has established an innovative paradigm,fostering a new method of AIGC production in the digital cultural industry,a new business format of virtual-physical integration,and a new collaborative ecosystem characterized by co-creation,co-building,and co-governance.Meanwhile,the innovative paradigm of the digital cultural industry also faces a series of new challenges,such as the adaptability issues with AIGC algorithm models,creative bottlenecks,and content quality control problems.Additionally,there are obstacles like the immaturity of international development channels for new business formats,the lack of cultural connotations in creative products,and the lag of the digital-intelligent governance of the industry ecosystem behind digital practices.In light of this,there is an urgent need to establish an optimization mechanism for the high-quality development of digital cultural industries driven by new quality productive forces.This includes optimizing the content production mechanism for AIGC-led high-quality innovation in the digital cultural industry;improving the leapfrog development mechanism for new digital cultural business formats through global-regional collaboration;and enhancing the accurate,high-quality governance mechanism for the digital cultural industry that is aligned with the goals of Chinese modernization.展开更多
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
Head and neck cutaneous squamous cell carcinoma(HNCSCC)remains underexplored compared to oropharyngeal squamous cell carcinoma,particularly in relation to human papillomavirus(HPV)and molecular markers such as p16 and...Head and neck cutaneous squamous cell carcinoma(HNCSCC)remains underexplored compared to oropharyngeal squamous cell carcinoma,particularly in relation to human papillomavirus(HPV)and molecular markers such as p16 and p53.While p16 is a well-established surrogate for HPV in oropharyngeal cancer,our review highlights its unreliable role in HNCSCC,where positivity is instead associated with recurrence and metastasis.Similarly,p53 illustrates a dual role-wild-type as a genomic safeguard,mutated as an oncogenic driver-complicating prognostication.Methodological considerations,including the limitations of immunohistochemistry for HPV detection,underscore the need for multi-method and molecular validation in future studies.Ultraviolet radiation is posited as a key modifier of p16 function,decoupling expression from tumor suppression.To contextualize these findings,we draw parallels to glioblastoma(GBM),where subclonal evolution,p53 dysfunction,and intratumoral heterogeneity drive relapse despite aggressive multimodal therapies.GBM exemplifies how bulk-level biomarker generalizations often obscure dynamic cellular ecosystems,reinforcing the necessity of single-cell and spatial approaches.Multi-omics integration-encompassing genome,transcriptome,proteome,and tumor microenvironment mapping-coupled with single-cell RNA sequencing and spatial transcriptomics,offers a path forward for resolving subclonal dynamics in both HNCSCC and GBM.These technologies provide the resolution needed to track tumor-immunestromal co-evolution,identify therapy-resistant clones,and anticipate recurrence.We argue for a N-of-1,patient-and cell-centric paradigm that reframes biomarkers not as static surrogates but as dynamic readouts of cancer evolution across time and tissue contexts.Conceptually,we propose kinetic and microenvironmental frameworks(e.g.,“load-and-lock”barriers;dormancy and immunesynapse stabilization)as hypothesis-generating avenues to stall clonal handoffs and improve outcome prediction.Together,these perspectives argue for revised biomarker frameworks in HNCSCC and ethically inclusive,mechanism-anchored studies that bridge discovery with individualized care.By bridging insights from HNCSCC with the lessons of GBM,this review underscores the need for ethically inclusive,mechanistically informed frameworks that integrate subclonal evolution,biomarker re-interpretation,and precision-personalized hybrid models.Such an approach will be essential for advancing from one-size-fits-all strategies to individualized lifetime cancer care.展开更多
Interpreting the Universal Declaration of Human Rights from political,juridical and philosophical perspectives is es-sential for promoting the guiding principles of the Declaration,build-ing consensus on human rights,...Interpreting the Universal Declaration of Human Rights from political,juridical and philosophical perspectives is es-sential for promoting the guiding principles of the Declaration,build-ing consensus on human rights,and advancing human rights practice in the new historical context.To conduct an academic,systematic in-terpretation of the Declaration that conforms to the trends of the times and answers the fundamental questions of the world,it is necessary to find a new research paradigm.The common values of humanity,namely peace,development,equity,justice,democracy and freedom,put forward by Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,provide the most explanatory and penetrating scientific paradigm for reaching the issue.This paper an-alyzes and reflects on the views,value foundation and principled(con-tractual)consensus of human rights in the Declaration,and narrates and foresees the far-reaching significance of the three global initia-tives(namely,the Global Development Initiative,the Global Security Initiative,and the Global Civilization Initiative)with the common val-ues of humanity as the soul in advancing the modernization of global human rights governance and building a new form of human rights civilization.展开更多
The conflation of linguistic competencies with ideological and political educational paradigms presents unique opportunities and challenges for English language teaching(ELT)in our increasingly interconnected world.Th...The conflation of linguistic competencies with ideological and political educational paradigms presents unique opportunities and challenges for English language teaching(ELT)in our increasingly interconnected world.This research seeks to address the role of cross-cultural critical thinking within the landscape of English pedagogy,framed by the imperatives of ideological and political education.Employing a multi-method approach,including thematic content analysis and action research,the study proposes a pedagogical model designed to integrate transcultural discourse and ideologically reflective practices into the conventional ELT curriculum.This paper argues for a reimagined approach to teaching English that encourages students to engage with diverse cultural perspectives and develop a nuanced understanding of global issues.展开更多
As educational reforms intensify and societal emphasis shifts towards empowerment,the traditional discourse paradigm of management and control in educational supervision faces growing challenges.This paper explores th...As educational reforms intensify and societal emphasis shifts towards empowerment,the traditional discourse paradigm of management and control in educational supervision faces growing challenges.This paper explores the transformation of this discourse paradigm through the lens of empowerment,analyzing its distinct characteristics,potential pathways,and effective strategies.This paper begins by reviewing the concept of empowerment and examining the current research landscape surrounding the discourse paradigm in educational supervision.Subsequently,we conduct a comparative analysis of the“control”and“empowerment”paradigms,highlighting their essential differences.This analysis illuminates the key characteristics of an empowerment-oriented approach to educational supervision,particularly its emphasis on dialogue,collaboration,participation,and,crucially,empowerment itself.Ultimately,this research advocates for a shift in educational supervision towards an empowerment-oriented discourse system.This entails a multi-pronged approach:transforming ingrained beliefs,embracing renewed pedagogical concepts,fostering methodological innovation,and optimizing existing mechanisms and strategies within educational supervision.These changes are proposed to facilitate the more effective alignment of educational supervision with the pursuit of high-quality education.展开更多
This article explores the key role of intelligent computing in driving the paradigm shift of scientific discovery.The article first outlines the five paradigms of scientific discovery,from empirical observation to the...This article explores the key role of intelligent computing in driving the paradigm shift of scientific discovery.The article first outlines the five paradigms of scientific discovery,from empirical observation to theoretical models,then to computational simulation and data intensive science,and finally introduces intelligent computing as the core of the fifth paradigm.Intelligent computing enhances the ability to understand,predict,and automate scientific discoveries of complex systems through technologies such as deep learning and machine learning.The article further analyzes the applications of intelligent computing in fields such as bioinformatics,astronomy,climate science,materials science,and medical image analysis,demonstrating its practical utility in solving scientific problems and promoting knowledge development.Finally,the article predicts that intelligent computing will play a more critical role in future scientific research,promoting interdisciplinary integration,open science,and collaboration,providing new solutions for solving complex problems.展开更多
The farming-pastoral zone of northern China plays a dual role in ecological conditions and production and occupies an important position in the national economy. In this paper, the methodology of system engineering is...The farming-pastoral zone of northern China plays a dual role in ecological conditions and production and occupies an important position in the national economy. In this paper, the methodology of system engineering is introduced to construct and optimize an eco-productive paradigm system for the typical areas of the farming-pastoral zone. The system was constructed in the following steps: (1) design the framework of the paradigm system based on the data of physical site characteristics, biocommunities, production and economy, social culture and historical changes; (2) analyze the vegetation patterns, the interactions between vegetation and environmental factors (natural, social, economic, etc.) and the contributions of vegetation to the area, including the synthesis of the existing researches; and (3) provide the spatial arrangements of ecosystems and planning of each area, raise a comprehensive indicators of evaluation, evaluate the feasibility and soundness, and determine the optimum eco-productive paradigms for policy-makers which were land-use patterns within the threshold of ecological conservation. Three primitive paradigms of Maowusu (Mu Us) Ssandy Land, Loess Plateau and Huailai Basin in the farming-pastoral zone of northern China were proposed according to this paradigm system.展开更多
Crossing is a fundamental paradigm for target selection in human-computer interaction systems.This paradigm was first introduced to virtual reality(VR)interactions by Tu et al.,who investigated its performance in comp...Crossing is a fundamental paradigm for target selection in human-computer interaction systems.This paradigm was first introduced to virtual reality(VR)interactions by Tu et al.,who investigated its performance in comparison to pointing,and concluded that crossing is generally no less effective than pointing and has unique advantages.However,owing to the characteristics of VR interactions,there are still many factors to consider when applying crossing to a VR environment.Thus,this review summarizes the main techniques for object selection in VR and crossing-related studies.Then,factors that may affect crossing interactions are analyzed from the perspectives of the input space and visual space.The aim of this study is to provide a reference for future studies on target selection based on the crossing paradigm in virtual reality.展开更多
With the development of English as an international language,English speakers are widely spread in the world.The English learning fashion has been greatly changed since the culture background of English as a langauge ...With the development of English as an international language,English speakers are widely spread in the world.The English learning fashion has been greatly changed since the culture background of English as a langauge has shifted to a mixed cultures instead of just British and American. But the standard varieties of British and American English have been accepted as the only generally accepted forms of standard English in China.The language learning fashion in China is about to undertake a big paradigm shift.This paper is an analysis of the English learning pattern shift in Chinese setting and therefore suggests a practical activities to apply this concept in English learning classes.展开更多
In this article,some new developments in the field of applied linguistics are summarized.In addition,it is illustrated that researchers’epistemology determines their methodology.And their research conclusions are als...In this article,some new developments in the field of applied linguistics are summarized.In addition,it is illustrated that researchers’epistemology determines their methodology.And their research conclusions are also led by their epistemology.It is proposed that a critical,bio-social paradigm be taken in the field of applied linguistics.展开更多
This study examines how writer stance is projected in citation from a comparative perspective.The dataset consisted of 120 qualitative and quantitative research articles(RAs)that were authored by Anglophone and Chines...This study examines how writer stance is projected in citation from a comparative perspective.The dataset consisted of 120 qualitative and quantitative research articles(RAs)that were authored by Anglophone and Chinese applied linguists.ANO?VA tests revealed marked cross-language and cross-paradigmatic differences in stance-based dialogic engagement.展开更多
This article discusses the importance of theory and paradigm to a researcher. It starts from introducing and analyzing thedefinition of the two terms, by using the theories in the field of intercultural communication ...This article discusses the importance of theory and paradigm to a researcher. It starts from introducing and analyzing thedefinition of the two terms, by using the theories in the field of intercultural communication as examples. To a good researcher, heneeds not only clarifying the paradigm his research is positioned, but also integrating the theories in his paradigm.展开更多
文摘With the continuous improvement of the medical industry’s requirements for the professional capabilities of nursing talents,traditional nursing teaching models can hardly meet the needs of complex nursing work in neurology.This paper focuses on nursing education for neurology nursing students and explores the construction of the“one-on-one”teaching model,aiming to achieve a paradigm shift in nursing education.By analyzing the current status of neurology nursing education,this paper identifies the problems in traditional teaching models.Combining the advantages of the“one-on-one”teaching model,it elaborates on the construction path of this model from aspects such as the selection and training of teaching instructors,the design of teaching content,the innovation of teaching methods,and the improvement of the teaching evaluation system.The research shows that the“one-on-one”teaching model can significantly enhance nursing students’mastery of professional knowledge,clinical operation skills,communication skills,and emergency response capabilities,as well as strengthen their professional identity and sense of responsibility.It provides an effective way to cultivate high-quality nursing talents who can meet the needs of neurology nursing work and promotes the innovative development of nursing education.
基金2025 General Project of Humanities and Social Sciences Research in Henan Higher Education Institutions,“Research on the Dynamic Mechanisms and Paths of Innovative Development of Undergraduate Translation Programs Empowered by New Productive Forces”(Project No.:2025-ZDJH-885)2024 College-Level Undergraduate Teaching Reform Project of the School of Foreign Languages,Henan University of Technology,“Research on Implementation Paths of New Models for Interpreter Training Based on AI Large Models”(Project No.:2024YJWYJG06)+1 种基金2025 First-Class Undergraduate Program Construction Special Project of the School of Foreign Languages,Henan University of Technology,titled“Research on Development Paths for Innovative Development of Undergraduate Translation Programs Empowered by New Productive Forces”(Project No.:2025WYZYJS30)2025 Educational Reform Project of the School of International Education,Henan University of Technology,“A Study on the Language Competence Development Model for International Talents Based on the Al Large Model-Taking IELTS Reading and Writing Teaching Practice as an Example”(Project No.:GJXY202533)。
文摘This paper explores the paradigm reconstruction of interpreting pedagogy driven by generative AI technology.With the breakthroughs of AI technologies such as ChatGPT in natural language processing,traditional interpreting education faces dual challenges of technological substitution and pedagogical transformation.Based on Kuhn’s paradigm theory,the study analyzes the limitations of three traditional interpreting teaching paradigms,language-centric,knowledge-based,and skill-acquisition-oriented,and proposes a novel“teacher-AI-learner”triadic collaborative paradigm.Through reconstructing teaching subjects,environments,and curriculum systems,the integration of real-time translation tools and intelligent terminology databases facilitates the transition from static skill training to dynamic human-machine collaboration.The research simultaneously highlights challenges in technological ethics and curriculum design transformation pressures,emphasizing the necessity to balance technological empowerment with humanistic education.
基金funded by the General Program of the National Natural Science Foundation of China grant number 62277022.
文摘The integration of artificial intelligence(AI)is fundamentally reshaping the scientific research,giving rise to a new era of discovery and innovation.This paper explores this transformative shift,introducing an innovative concept of the“AI-Driven Research Ecosystem”,a dynamic and collaborative research environment.Within this ecosystem,we focus on the unification of human-AI collaboration models and the emerging new research thinking paradigms.We analyze the multifaceted roles of AI within the research lifecycle,spanning from a passive tool to an active assistant and autonomous participants,and categorize these interactions into distinct human-AI collaboration models.Furthermore,we examine how the pervasive involvement of AI necessitates an evolution in human research thinking,emphasizing the significant roles of critical,creative,and computational thinking.Through a review of existing literature and illustrative case studies,this paper provides a comprehensive overview of the AI-driven research ecosystem,highlighting its potential for transforming scientific research.Our findings advance the current understanding of AI’s multiple roles in research and underscore its capacity to revolutionize both knowledge discovery and collaborative innovation,paving the way for a more integrated and impactful research paradigm.
文摘This study examines the advent of agent interaction(AIx)as a transformative paradigm in humancomputer interaction(HCI),signifying a notable evolution beyond traditional graphical interfaces and touchscreen interactions.Within the context of large models,AIx is characterized by its innovative interaction patterns and a plethora of application scenarios that hold great potential.The paper highlights the pivotal role of AIx in shaping the future landscape of the large model industry,emphasizing its adoption and necessity from a user's perspective.This study underscores the pivotal role of AIx in dictating the future trajectory of a large model industry by emphasizing the importance of its adoption and necessity from a user-centric perspective.The fundamental drivers of AIx include the introduction of novel capabilities,replication of capabilities(both anthropomorphic and superhuman),migration of capabilities,aggregation of intelligence,and multiplication of capabilities.These elements are essential for propelling innovation,expanding the frontiers of capability,and realizing the exponential superposition of capabilities,thereby mitigating labor redundancy and addressing a spectrum of human needs.Furthermore,this study provides an in-depth analysis of the structural components and operational mechanisms of agents supported by large models.Such advancements significantly enhance the capacity of agents to tackle complex problems and provide intelligent services,thereby facilitating a more intuitive,adaptive,and personalized engagement between humans and machines.The study further delineates four principal categories of interaction patterns that encompass eight distinct modalities of interaction,corresponding to twenty-one specific scenarios,including applications in smart home systems,health assistance,and elderly care.This emphasizes the significance of this new paradigm in advancing HCI,fostering technological advancements,and redefining user experiences.However,it also acknowledges the challenges and ethical considerations that accompany this paradigm shift,recognizing the need for a balanced approach to harness the full potential of AIx in modern society.
基金funded by Research on Policy Design and Implementation Path for High-Quality Development of Digital Cultural Industry(23&ZD087),a major project of the National Social Science Foundation of China.
文摘Digital-intelligent technologies represent the advanced direction of new quality productive forces and are becoming a driving force for the digital transformation and high-quality development of the cultural industry.Empowered by new quality productive forces,the digital cultural industry has demonstrated diverse characteristics,including the innovation of cultural production subjects,the intelligentization of production tools,the digitization of production objects,the systematization of production methods,and the diversification of production factors.Leveraging technologies such as AIGC,virtual-physical integration,and DAOs based on Web 3.0,the digital cultural industry has established an innovative paradigm,fostering a new method of AIGC production in the digital cultural industry,a new business format of virtual-physical integration,and a new collaborative ecosystem characterized by co-creation,co-building,and co-governance.Meanwhile,the innovative paradigm of the digital cultural industry also faces a series of new challenges,such as the adaptability issues with AIGC algorithm models,creative bottlenecks,and content quality control problems.Additionally,there are obstacles like the immaturity of international development channels for new business formats,the lack of cultural connotations in creative products,and the lag of the digital-intelligent governance of the industry ecosystem behind digital practices.In light of this,there is an urgent need to establish an optimization mechanism for the high-quality development of digital cultural industries driven by new quality productive forces.This includes optimizing the content production mechanism for AIGC-led high-quality innovation in the digital cultural industry;improving the leapfrog development mechanism for new digital cultural business formats through global-regional collaboration;and enhancing the accurate,high-quality governance mechanism for the digital cultural industry that is aligned with the goals of Chinese modernization.
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
文摘Head and neck cutaneous squamous cell carcinoma(HNCSCC)remains underexplored compared to oropharyngeal squamous cell carcinoma,particularly in relation to human papillomavirus(HPV)and molecular markers such as p16 and p53.While p16 is a well-established surrogate for HPV in oropharyngeal cancer,our review highlights its unreliable role in HNCSCC,where positivity is instead associated with recurrence and metastasis.Similarly,p53 illustrates a dual role-wild-type as a genomic safeguard,mutated as an oncogenic driver-complicating prognostication.Methodological considerations,including the limitations of immunohistochemistry for HPV detection,underscore the need for multi-method and molecular validation in future studies.Ultraviolet radiation is posited as a key modifier of p16 function,decoupling expression from tumor suppression.To contextualize these findings,we draw parallels to glioblastoma(GBM),where subclonal evolution,p53 dysfunction,and intratumoral heterogeneity drive relapse despite aggressive multimodal therapies.GBM exemplifies how bulk-level biomarker generalizations often obscure dynamic cellular ecosystems,reinforcing the necessity of single-cell and spatial approaches.Multi-omics integration-encompassing genome,transcriptome,proteome,and tumor microenvironment mapping-coupled with single-cell RNA sequencing and spatial transcriptomics,offers a path forward for resolving subclonal dynamics in both HNCSCC and GBM.These technologies provide the resolution needed to track tumor-immunestromal co-evolution,identify therapy-resistant clones,and anticipate recurrence.We argue for a N-of-1,patient-and cell-centric paradigm that reframes biomarkers not as static surrogates but as dynamic readouts of cancer evolution across time and tissue contexts.Conceptually,we propose kinetic and microenvironmental frameworks(e.g.,“load-and-lock”barriers;dormancy and immunesynapse stabilization)as hypothesis-generating avenues to stall clonal handoffs and improve outcome prediction.Together,these perspectives argue for revised biomarker frameworks in HNCSCC and ethically inclusive,mechanism-anchored studies that bridge discovery with individualized care.By bridging insights from HNCSCC with the lessons of GBM,this review underscores the need for ethically inclusive,mechanistically informed frameworks that integrate subclonal evolution,biomarker re-interpretation,and precision-personalized hybrid models.Such an approach will be essential for advancing from one-size-fits-all strategies to individualized lifetime cancer care.
基金the major special project of the Ministry of Education for Philosophy and Social Science Research,“Research on the Basic Theory and Core Essence of Xi Jinping Thought on the Rule of Law”(Project Approv-al Number 2022JZDZ001).
文摘Interpreting the Universal Declaration of Human Rights from political,juridical and philosophical perspectives is es-sential for promoting the guiding principles of the Declaration,build-ing consensus on human rights,and advancing human rights practice in the new historical context.To conduct an academic,systematic in-terpretation of the Declaration that conforms to the trends of the times and answers the fundamental questions of the world,it is necessary to find a new research paradigm.The common values of humanity,namely peace,development,equity,justice,democracy and freedom,put forward by Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,provide the most explanatory and penetrating scientific paradigm for reaching the issue.This paper an-alyzes and reflects on the views,value foundation and principled(con-tractual)consensus of human rights in the Declaration,and narrates and foresees the far-reaching significance of the three global initia-tives(namely,the Global Development Initiative,the Global Security Initiative,and the Global Civilization Initiative)with the common val-ues of humanity as the soul in advancing the modernization of global human rights governance and building a new form of human rights civilization.
文摘The conflation of linguistic competencies with ideological and political educational paradigms presents unique opportunities and challenges for English language teaching(ELT)in our increasingly interconnected world.This research seeks to address the role of cross-cultural critical thinking within the landscape of English pedagogy,framed by the imperatives of ideological and political education.Employing a multi-method approach,including thematic content analysis and action research,the study proposes a pedagogical model designed to integrate transcultural discourse and ideologically reflective practices into the conventional ELT curriculum.This paper argues for a reimagined approach to teaching English that encourages students to engage with diverse cultural perspectives and develop a nuanced understanding of global issues.
文摘As educational reforms intensify and societal emphasis shifts towards empowerment,the traditional discourse paradigm of management and control in educational supervision faces growing challenges.This paper explores the transformation of this discourse paradigm through the lens of empowerment,analyzing its distinct characteristics,potential pathways,and effective strategies.This paper begins by reviewing the concept of empowerment and examining the current research landscape surrounding the discourse paradigm in educational supervision.Subsequently,we conduct a comparative analysis of the“control”and“empowerment”paradigms,highlighting their essential differences.This analysis illuminates the key characteristics of an empowerment-oriented approach to educational supervision,particularly its emphasis on dialogue,collaboration,participation,and,crucially,empowerment itself.Ultimately,this research advocates for a shift in educational supervision towards an empowerment-oriented discourse system.This entails a multi-pronged approach:transforming ingrained beliefs,embracing renewed pedagogical concepts,fostering methodological innovation,and optimizing existing mechanisms and strategies within educational supervision.These changes are proposed to facilitate the more effective alignment of educational supervision with the pursuit of high-quality education.
文摘This article explores the key role of intelligent computing in driving the paradigm shift of scientific discovery.The article first outlines the five paradigms of scientific discovery,from empirical observation to theoretical models,then to computational simulation and data intensive science,and finally introduces intelligent computing as the core of the fifth paradigm.Intelligent computing enhances the ability to understand,predict,and automate scientific discoveries of complex systems through technologies such as deep learning and machine learning.The article further analyzes the applications of intelligent computing in fields such as bioinformatics,astronomy,climate science,materials science,and medical image analysis,demonstrating its practical utility in solving scientific problems and promoting knowledge development.Finally,the article predicts that intelligent computing will play a more critical role in future scientific research,promoting interdisciplinary integration,open science,and collaboration,providing new solutions for solving complex problems.
文摘The farming-pastoral zone of northern China plays a dual role in ecological conditions and production and occupies an important position in the national economy. In this paper, the methodology of system engineering is introduced to construct and optimize an eco-productive paradigm system for the typical areas of the farming-pastoral zone. The system was constructed in the following steps: (1) design the framework of the paradigm system based on the data of physical site characteristics, biocommunities, production and economy, social culture and historical changes; (2) analyze the vegetation patterns, the interactions between vegetation and environmental factors (natural, social, economic, etc.) and the contributions of vegetation to the area, including the synthesis of the existing researches; and (3) provide the spatial arrangements of ecosystems and planning of each area, raise a comprehensive indicators of evaluation, evaluate the feasibility and soundness, and determine the optimum eco-productive paradigms for policy-makers which were land-use patterns within the threshold of ecological conservation. Three primitive paradigms of Maowusu (Mu Us) Ssandy Land, Loess Plateau and Huailai Basin in the farming-pastoral zone of northern China were proposed according to this paradigm system.
基金Foundation of Jiangsu Province Science&Technology Department(BE2017104)Natural Science Foundation of China(61602236)+2 种基金Science Foundation of Jiangsu Province(BK20160801)China Postdoctoral Science Foundation(2016M591843)and Postdoctoral Science Foundation of Jiangsu Province(1501053B).
文摘Crossing is a fundamental paradigm for target selection in human-computer interaction systems.This paradigm was first introduced to virtual reality(VR)interactions by Tu et al.,who investigated its performance in comparison to pointing,and concluded that crossing is generally no less effective than pointing and has unique advantages.However,owing to the characteristics of VR interactions,there are still many factors to consider when applying crossing to a VR environment.Thus,this review summarizes the main techniques for object selection in VR and crossing-related studies.Then,factors that may affect crossing interactions are analyzed from the perspectives of the input space and visual space.The aim of this study is to provide a reference for future studies on target selection based on the crossing paradigm in virtual reality.
文摘With the development of English as an international language,English speakers are widely spread in the world.The English learning fashion has been greatly changed since the culture background of English as a langauge has shifted to a mixed cultures instead of just British and American. But the standard varieties of British and American English have been accepted as the only generally accepted forms of standard English in China.The language learning fashion in China is about to undertake a big paradigm shift.This paper is an analysis of the English learning pattern shift in Chinese setting and therefore suggests a practical activities to apply this concept in English learning classes.
文摘In this article,some new developments in the field of applied linguistics are summarized.In addition,it is illustrated that researchers’epistemology determines their methodology.And their research conclusions are also led by their epistemology.It is proposed that a critical,bio-social paradigm be taken in the field of applied linguistics.
文摘This study examines how writer stance is projected in citation from a comparative perspective.The dataset consisted of 120 qualitative and quantitative research articles(RAs)that were authored by Anglophone and Chinese applied linguists.ANO?VA tests revealed marked cross-language and cross-paradigmatic differences in stance-based dialogic engagement.
文摘This article discusses the importance of theory and paradigm to a researcher. It starts from introducing and analyzing thedefinition of the two terms, by using the theories in the field of intercultural communication as examples. To a good researcher, heneeds not only clarifying the paradigm his research is positioned, but also integrating the theories in his paradigm.
