Sepsis is a life-threatening condition caused by a dysregulated host response to infection,with its high mortality closely linked to excessive neutrophil activation and the release of neutrophil extracellular traps(NE...Sepsis is a life-threatening condition caused by a dysregulated host response to infection,with its high mortality closely linked to excessive neutrophil activation and the release of neutrophil extracellular traps(NETs).While NETs play a critical role in antimicrobial immunity,their overproduction can lead to tissue damage and multiple organ dysfunction,exacerbating the pathological progression of sepsis.This study focuses on the role of palmitoyltransferase ZDHHC18 in sepsis,proposing that it may regulate the formation of neutrophil NETs through palmitoylation,thereby promoting the onset of sepsis.Currently,there is no research,domestically or internationally,on the role of ZDHHC18 in NETs during sepsis.Therefore,exploring potential therapeutic strategies—such as inhibiting ZDHHC18 to mitigate the pathological effects of sepsis—could provide new insights for treating sepsis-related inflammatory diseases.展开更多
文摘Sepsis is a life-threatening condition caused by a dysregulated host response to infection,with its high mortality closely linked to excessive neutrophil activation and the release of neutrophil extracellular traps(NETs).While NETs play a critical role in antimicrobial immunity,their overproduction can lead to tissue damage and multiple organ dysfunction,exacerbating the pathological progression of sepsis.This study focuses on the role of palmitoyltransferase ZDHHC18 in sepsis,proposing that it may regulate the formation of neutrophil NETs through palmitoylation,thereby promoting the onset of sepsis.Currently,there is no research,domestically or internationally,on the role of ZDHHC18 in NETs during sepsis.Therefore,exploring potential therapeutic strategies—such as inhibiting ZDHHC18 to mitigate the pathological effects of sepsis—could provide new insights for treating sepsis-related inflammatory diseases.
