针对正常基因和异常基因在样本中的占比差异较大、变异断点位置难以准确确定的问题,提出了一种基于OCSVM(one-class support vector machine)的多策略融合拷贝数变异检测算法。算法融合读对深度、分裂读段和双端映射三种策略,建立多信...针对正常基因和异常基因在样本中的占比差异较大、变异断点位置难以准确确定的问题,提出了一种基于OCSVM(one-class support vector machine)的多策略融合拷贝数变异检测算法。算法融合读对深度、分裂读段和双端映射三种策略,建立多信号通道,并使用OCSVM模型解决正常基因和异常基因占比差异较大的影响以提高算法的拷贝数变异检测性能;对串联重复区域、穿插重复区域和缺失区域进行了分析探索,利用分裂读段信号实现变异点位置的精确定位,并确定变异类型。在240个模拟数据集和4个真实数据集上进行测试,并与其它几种算法进行比较。实验结果表明,该算法可以显著提高拷贝数变异检测的灵敏度、精度、F1评分以及重叠密度评分,同时减小了检测结果的边界偏差。展开更多
As an important productive ability, writing is superiorly regarded nowadays. Many students are still unable to achieve the writing goals as required. Some feasible and effective writing strategies are recommended in t...As an important productive ability, writing is superiorly regarded nowadays. Many students are still unable to achieve the writing goals as required. Some feasible and effective writing strategies are recommended in the paper, which can help students in a beneficial way.展开更多
对关节臂式坐标测量机数据采集系统的几个关键点进行了分析设计,其中包括数据同步锁存、对径读数、坐标实时显示.通过可编程逻辑器件(CPLD)与单片机的结合,完成了光栅信号的滤波、4细分、辨向及可逆计数等功能.实验证明,该设计能够准确...对关节臂式坐标测量机数据采集系统的几个关键点进行了分析设计,其中包括数据同步锁存、对径读数、坐标实时显示.通过可编程逻辑器件(CPLD)与单片机的结合,完成了光栅信号的滤波、4细分、辨向及可逆计数等功能.实验证明,该设计能够准确完成测量机的数据采集.Abstract：Several key pints of articulated arm - cmm data acquisition system are analyzed and designed, including data synchronous latches, pair-radius readings, and coordinates real-time display. The combination of CPLD and AVR microcontroller completes the functions of grating signal faltering, 4 subdivided, discerning direction and reversible counting, and so on. According to the experiment , the data collection of the machine can be complete accurately.展开更多
文摘针对正常基因和异常基因在样本中的占比差异较大、变异断点位置难以准确确定的问题,提出了一种基于OCSVM(one-class support vector machine)的多策略融合拷贝数变异检测算法。算法融合读对深度、分裂读段和双端映射三种策略,建立多信号通道,并使用OCSVM模型解决正常基因和异常基因占比差异较大的影响以提高算法的拷贝数变异检测性能;对串联重复区域、穿插重复区域和缺失区域进行了分析探索,利用分裂读段信号实现变异点位置的精确定位,并确定变异类型。在240个模拟数据集和4个真实数据集上进行测试,并与其它几种算法进行比较。实验结果表明,该算法可以显著提高拷贝数变异检测的灵敏度、精度、F1评分以及重叠密度评分,同时减小了检测结果的边界偏差。
文摘As an important productive ability, writing is superiorly regarded nowadays. Many students are still unable to achieve the writing goals as required. Some feasible and effective writing strategies are recommended in the paper, which can help students in a beneficial way.
文摘对关节臂式坐标测量机数据采集系统的几个关键点进行了分析设计,其中包括数据同步锁存、对径读数、坐标实时显示.通过可编程逻辑器件(CPLD)与单片机的结合,完成了光栅信号的滤波、4细分、辨向及可逆计数等功能.实验证明,该设计能够准确完成测量机的数据采集.Abstract：Several key pints of articulated arm - cmm data acquisition system are analyzed and designed, including data synchronous latches, pair-radius readings, and coordinates real-time display. The combination of CPLD and AVR microcontroller completes the functions of grating signal faltering, 4 subdivided, discerning direction and reversible counting, and so on. According to the experiment , the data collection of the machine can be complete accurately.
