Purpose: Regadenoson (REG) is currently becoming the stress agent of choice in patients undergoing pharmacologic single photon emission computed tomography (SPECT). However, in patients with left bundle branch block (...Purpose: Regadenoson (REG) is currently becoming the stress agent of choice in patients undergoing pharmacologic single photon emission computed tomography (SPECT). However, in patients with left bundle branch block (LBBB) and ventricular paced rhythm (VPR), hesitation exists amongst clinicians to use REG-SPECT due to the concern that the increased heart rate could cause false positive SPECT results. We sought to evaluate the comparability of A-SPECT and REG-SPECT in patients with LBBB and VPR. Methods: Retrospective study of 30 patients who served as their own controls. All 30 patients who underwent REG-SPECT (Grp 1) were compared to their prior A-SPECT (Grp 2) done within two years prior to REG-SPECT. Heart rate (HR) and blood pressure (BP) parameters, ECG, stress perfusion and gated variables, SPECT ischemia, and side-effects were evaluated. Statistical significance was set at P < 0.05. Results: Grp 1 and Grp 2 were comparable in hemodynamic parameters with increase in HR and decrease in systolic and diastolic BP with administration of adenosine and REG stress agents. However, there were no significant differences found in hemodynamic parameters and II degree AV block between the groups. All normal A-SPECT were found to be normal with REG-SPECT. No differences could be found between the two groups among SPECT parameters. Muscle pain was significantly higher in REG (10.0% vs. 0.0%, P = 0.083) and so was the use of aminophylline (16.7% vs. 0.0%, P = 0.025) to relieve the side-effect. Conclusion: REG-SPECT can be administered in patients with LBBB and VPR patients based on favorable and comparable hemodynamic responses and arrhythmia occurrences to A-SPECT. REG-SPECT can also be used for adequate interpretation of presence or absence of SPECT ischemia particularly in the LAD territory without any concern for false positive perfusion defects.展开更多
The PQRST segment which include the major information in a heart beatis detected and used as the input pattern to cluster by ART2 model. The parametersof pacemaker which consist of pulse, QRS characteristics, clusteri...The PQRST segment which include the major information in a heart beatis detected and used as the input pattern to cluster by ART2 model. The parametersof pacemaker which consist of pulse, QRS characteristics, clustering results andprogrammed parameters are combined in analyzing paced ECG (PECG) synthetically.展开更多
Depression/anxiety is commonly present in paced patients and is associated with increased cardiovascular morbidity and mortality. The high prevalence of depression/anxiety in paced patients supports a strategy of incr...Depression/anxiety is commonly present in paced patients and is associated with increased cardiovascular morbidity and mortality. The high prevalence of depression/anxiety in paced patients supports a strategy of increased awareness and treatment for depression/anxiety in paced patients. Health-related quality of life （HRQoL） is being increasingly considered as an expected out-come of therapeutic interventions and rehabilitation programs in clinical cardi- ology including patients before and after pacemaker（PM） implantation. This multispeciahy consensus document reviews the evidence linking depression/anxiety with arrhythmia and cardiac pacing; HRQoL and cardiac pacing, at the same time, provides recommendations for healthcare providers for the treatment of depression/anxiety. （S Chin J Cardiol 2009; 10（4） ： 190 -195）展开更多
Purpose The purpose of the study was to investigate the acute effect of a beginner martial art class and aerobic exercise on executive function(EF)in college-aged young adults.There is overwhelming evidence that demon...Purpose The purpose of the study was to investigate the acute effect of a beginner martial art class and aerobic exercise on executive function(EF)in college-aged young adults.There is overwhelming evidence that demonstrates acute as well as long-term aerobic exercise improves EF.Nevertheless,there is limited research comparing externally paced exercise(EPE)to self-paced exercise(SPE)such as walking on improving EF.EPE requires greater cortical demand than SPE to execute a motor plan.Methods Eight men and eight women,aged 24.2±2.8 years,participated in a Repeated Measures Crossover Design.Pre-and post-testing of EF with the Stroop and Tower of London(ToL)and stress level were measured after each of the two 1-h conditions:the SPE consisted of a walk(aerobic exercise)and the EPE was a beginner martial art class.Results There were significant main effects for the martial art class for the Stroop’s mean reaction time for congruent trials(P=0.01)with a large-effect size.The mean reaction time for incongruent trials was significant(P=0.05)with a medium-effect size.The ToL’s mean solution time(P=0.003)and mean execution time(P=0.002)were also significant with large-effect sizes.Stress levels were not significantly improved following either condition.Conclusion The martial art class significantly improved all the major domains of EF,while aerobic exercise of a similar intensity did not demonstrate any measured significant changes.The physiological benefits of physical exercise are well documented;however,the cognitive enhancing capability of EPE should also be appreciated given the results of this study.展开更多
Solar flare prediction is an important subject in the field of space weather.Deep learning technology has greatly promoted the development of this subject.In this study,we propose a novel solar flare forecasting model...Solar flare prediction is an important subject in the field of space weather.Deep learning technology has greatly promoted the development of this subject.In this study,we propose a novel solar flare forecasting model integrating Deep Residual Network(ResNet)and Support Vector Machine(SVM)for both≥C-class(C,M,and X classes)and≥M-class(M and X classes)flares.We collected samples of magnetograms from May 1,2010 to September 13,2018 from Space-weather Helioseismic and Magnetic Imager(HMI)Active Region Patches and then used a cross-validation method to obtain seven independent data sets.We then utilized five metrics to evaluate our fusion model,based on intermediate-output extracted by ResNet and SVM using the Gaussian kernel function.Our results show that the primary metric true skill statistics(TSS)achieves a value of 0.708±0.027 for≥C-class prediction,and of 0.758±0.042 for≥M-class prediction;these values indicate that our approach performs significantly better than those of previous studies.The metrics of our fusion model’s performance on the seven datasets indicate that the model is quite stable and robust,suggesting that fusion models that integrate an excellent baseline network with SVM can achieve improved performance in solar flare prediction.Besides,we also discuss the performance impact of architectural innovation in our fusion model.展开更多
Pacing-induced cardiomyopathy (PICM) resultsf rom the detrimental effect of frequent right ventricular pacing.^([1]) The diagnosis relies on a combination of pacing-associated ventricular dyschrony manifested with ECG...Pacing-induced cardiomyopathy (PICM) resultsf rom the detrimental effect of frequent right ventricular pacing.^([1]) The diagnosis relies on a combination of pacing-associated ventricular dyschrony manifested with ECG wide LBBB-pattern QRS duration and clinical assessment, imaging studies. Conduction system pacing (CSP), such as His bundle pacing (HBP)and left bundle branch pacing (LBBP), may help to prevent PICM,^([2]) but the criteria for optimal patient selection remain inadequately defined.展开更多
Objectives:People living with myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS)may face unique barriers to physical activity.Active video games may overcome these barriers and increase physical activity.The p...Objectives:People living with myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS)may face unique barriers to physical activity.Active video games may overcome these barriers and increase physical activity.The primary aim of this pilot study was to determine the feasibility and acceptability of active video games to increase physical activity levels of people with ME/CFS.Methods:A mixed method design was employed.Adults living with ME/CFS were randomised to a six-month intervention of(1)pacing,(2)pacing and conventional physical activity,or(3)pacing and active video gaming.Feasibility and acceptability were determined through semi-structured interviews.Health-related outcomes(e.g.,physical activity,blood samples,quality of life,and functioning)were also collected.Results:Fifteen people were assigned an intervention group with 12 completing.Three themes were identified from post-intervention interviews(1)positivity led to overall acceptability,(2)flexibility enabled participant autonomy,and(3)knowledge was gained about the self.No changes were seen in physical activity levels.An active video gaming intervention is acceptable but not feasible for people living with ME/CFS.Conclusions:Taken together,results suggest that physical activity can be managed safely by some people living with ME/CFS.Trial registration ACTRN12616000285459.展开更多
As humanity advances at a rapid pace,both material wealth and spiritual fulfillment continue to grow and enrich our lives.“The remarkable year of 2025 marks a pinnacle in AI advancement,a quantum leap in robotics app...As humanity advances at a rapid pace,both material wealth and spiritual fulfillment continue to grow and enrich our lives.“The remarkable year of 2025 marks a pinnacle in AI advancement,a quantum leap in robotics applications,and groundbreaking progress in cosmic exploration.Even Nezha II(a Chinese animated blockbuster) brilliantly integrates technology,space,culture,and AI into its narrative.Yet,none of these developments can escape humanity's enduring obsession with facial aesthetics.As civilizations flourish across all dimensions,the beauty economy emerges as a formidable industrial force,driving mankind's relentless pursuit of a better life and a more beautiful future.”展开更多
Background:The perception of effort is a key determinant of endurance performance and a barrier to physical activity in inactive populations.From a neurophysiological viewpoint,effort perception is thought to arise fr...Background:The perception of effort is a key determinant of endurance performance and a barrier to physical activity in inactive populations.From a neurophysiological viewpoint,effort perception is thought to arise from the brain processing of an efference copy of the motor command in sensory areas.However,recent research suggests that feedback from muscle spindles plays a significant role in this perception.In this study,tendon vibration protocols were employed to attenuate sensory feedback during subsequent cycling exercises.The aim was to assess whether vibration would increase cycling power output,muscle activation,and heart rate at fixed perceived effort intensities.Methods:Fifteen healthy young participants completed 2 experimental visits(vibration and sham).In each visit,participants performed two 3-min cycling bouts,1 at a moderate perceived effort intensity and 1 at a strong perceived effort intensity,before(pre)and after(post)an actual or a sham vibration protocol.Vibration was applied bilaterally on the patellar and Achilles tendons for 10 min.Power output,heart rate,and vastus lateralis electromyography(VL EMG)were recorded and averaged for each bout.Absolute values as well as relative change(%)between pre and post conditions were compared across sham and vibration conditions.Results:At moderate perceived effort,power output,heart rate,and VL EMG increased post-vibration compared to pre-vibration(p<0.05),while no difference was observed in the sham condition.At strong perceived effort,power output and VL EMG decreased post-sham(p<0.05)but remained unchanged post-vibration.Moreover,the relative change between pre and post conditions was significantly higher in the vibration conditions compared to the sham condition for all variables.Conclusion:This study shows that tendon vibration reduces effort perception during subsequent cycling bouts.This effect is likely a consequence of vibration-induced reduction in muscle spindle reafferent signaling to the brain,but this mechanism remains to be further elucidated.From an applied perspective,these findings highlight tendon vibration as a promising tool for enhancing physical activity engagement.展开更多
Congenitally corrected transposition of the great arteries(CCTGA)is a rare congenital heart disease characterized by atrioventricular,ventriculoarterial,and conduction system discordance,commonly accompanied by atriov...Congenitally corrected transposition of the great arteries(CCTGA)is a rare congenital heart disease characterized by atrioventricular,ventriculoarterial,and conduction system discordance,commonly accompanied by atrioventricular block(AVB).Pacing in patients with CCTGA and AVB(both pediatric and adult)poses challenges in strategy selection,procedural complexity,and clinical decision-making due to limited evidence.Conventional morphological left ventricular pacing is widely adopted but may induce ventricular dyssynchrony,heart failure,and tricuspid valve dysfunction.While cardiac resynchronization therapy serves as an upgrade for pacing-induced cardiomyopathy and heart failure,its application may be limited by coronary sinus anatomical variations and uncertain clinical outcomes.His bundle pacing is rarely reported due to the variation of the His bundle and high pacing threshold.The superficial,wide,multi-branched left bundle branch favors left bundle branch pacing,though delayed systemic right ventricle(sRV)activation may cause ventricular dyssynchrony and impair sRV function.Right bundle branch pacing offers a novel alternative for pacing therapy.Conduction system pacing-optimized cardiac resynchronization therapy is preferred in those with evidence of intrinsic ventricular conduction dysfunction.This narrative review synthesizes current evidence on pacing strategies for CCTGA with AVB,integrating anatomical and pathophysiological insights to evaluate physiological pacing strategies,while highlighting critical knowledge gaps to guide future research.展开更多
Cardiac resynchronization therapy(CRT)reduces heart failure(HF)hospitaliz-ations and all-cause mortality in patients with HF with reduced ejection fraction with left bundle branch(LBB)block.Biventricular pacing(BVP)is...Cardiac resynchronization therapy(CRT)reduces heart failure(HF)hospitaliz-ations and all-cause mortality in patients with HF with reduced ejection fraction with left bundle branch(LBB)block.Biventricular pacing(BVP)is considered the gold standard for achieving CRT;however,approximately 30%–40%of patients do not respond to BVP-CRT.Recent studies have demonstrated that LBB pacing(LBBP)produces remarkable results in CRT.In this meta-analysis,LBBP-CRT showed better outcomes than conventional BVP-CRT,including greater QRS duration reduction and left ventricular ejection fraction improvement,along with consistently lower pacing thresholds on follow-up.Additionally,there was a grea-ter reduction in New York Heart Association class and brain natriuretic peptide levels.This study contributes to the growing body of encouraging data on LBBP-CRT from recent years.With ongoing technological advancements and increasing operator expertise,the day may not be far when LBBP-CRT becomes the standard of care rather than the exception.展开更多
文摘Purpose: Regadenoson (REG) is currently becoming the stress agent of choice in patients undergoing pharmacologic single photon emission computed tomography (SPECT). However, in patients with left bundle branch block (LBBB) and ventricular paced rhythm (VPR), hesitation exists amongst clinicians to use REG-SPECT due to the concern that the increased heart rate could cause false positive SPECT results. We sought to evaluate the comparability of A-SPECT and REG-SPECT in patients with LBBB and VPR. Methods: Retrospective study of 30 patients who served as their own controls. All 30 patients who underwent REG-SPECT (Grp 1) were compared to their prior A-SPECT (Grp 2) done within two years prior to REG-SPECT. Heart rate (HR) and blood pressure (BP) parameters, ECG, stress perfusion and gated variables, SPECT ischemia, and side-effects were evaluated. Statistical significance was set at P < 0.05. Results: Grp 1 and Grp 2 were comparable in hemodynamic parameters with increase in HR and decrease in systolic and diastolic BP with administration of adenosine and REG stress agents. However, there were no significant differences found in hemodynamic parameters and II degree AV block between the groups. All normal A-SPECT were found to be normal with REG-SPECT. No differences could be found between the two groups among SPECT parameters. Muscle pain was significantly higher in REG (10.0% vs. 0.0%, P = 0.083) and so was the use of aminophylline (16.7% vs. 0.0%, P = 0.025) to relieve the side-effect. Conclusion: REG-SPECT can be administered in patients with LBBB and VPR patients based on favorable and comparable hemodynamic responses and arrhythmia occurrences to A-SPECT. REG-SPECT can also be used for adequate interpretation of presence or absence of SPECT ischemia particularly in the LAD territory without any concern for false positive perfusion defects.
文摘The PQRST segment which include the major information in a heart beatis detected and used as the input pattern to cluster by ART2 model. The parametersof pacemaker which consist of pulse, QRS characteristics, clustering results andprogrammed parameters are combined in analyzing paced ECG (PECG) synthetically.
文摘Depression/anxiety is commonly present in paced patients and is associated with increased cardiovascular morbidity and mortality. The high prevalence of depression/anxiety in paced patients supports a strategy of increased awareness and treatment for depression/anxiety in paced patients. Health-related quality of life （HRQoL） is being increasingly considered as an expected out-come of therapeutic interventions and rehabilitation programs in clinical cardi- ology including patients before and after pacemaker（PM） implantation. This multispeciahy consensus document reviews the evidence linking depression/anxiety with arrhythmia and cardiac pacing; HRQoL and cardiac pacing, at the same time, provides recommendations for healthcare providers for the treatment of depression/anxiety. （S Chin J Cardiol 2009; 10（4） ： 190 -195）
文摘Purpose The purpose of the study was to investigate the acute effect of a beginner martial art class and aerobic exercise on executive function(EF)in college-aged young adults.There is overwhelming evidence that demonstrates acute as well as long-term aerobic exercise improves EF.Nevertheless,there is limited research comparing externally paced exercise(EPE)to self-paced exercise(SPE)such as walking on improving EF.EPE requires greater cortical demand than SPE to execute a motor plan.Methods Eight men and eight women,aged 24.2±2.8 years,participated in a Repeated Measures Crossover Design.Pre-and post-testing of EF with the Stroop and Tower of London(ToL)and stress level were measured after each of the two 1-h conditions:the SPE consisted of a walk(aerobic exercise)and the EPE was a beginner martial art class.Results There were significant main effects for the martial art class for the Stroop’s mean reaction time for congruent trials(P=0.01)with a large-effect size.The mean reaction time for incongruent trials was significant(P=0.05)with a medium-effect size.The ToL’s mean solution time(P=0.003)and mean execution time(P=0.002)were also significant with large-effect sizes.Stress levels were not significantly improved following either condition.Conclusion The martial art class significantly improved all the major domains of EF,while aerobic exercise of a similar intensity did not demonstrate any measured significant changes.The physiological benefits of physical exercise are well documented;however,the cognitive enhancing capability of EPE should also be appreciated given the results of this study.
基金supported by the National Key R&D Program of China (Grant No.2022YFF0503700)the National Natural Science Foundation of China (42074196, 41925018)
文摘Solar flare prediction is an important subject in the field of space weather.Deep learning technology has greatly promoted the development of this subject.In this study,we propose a novel solar flare forecasting model integrating Deep Residual Network(ResNet)and Support Vector Machine(SVM)for both≥C-class(C,M,and X classes)and≥M-class(M and X classes)flares.We collected samples of magnetograms from May 1,2010 to September 13,2018 from Space-weather Helioseismic and Magnetic Imager(HMI)Active Region Patches and then used a cross-validation method to obtain seven independent data sets.We then utilized five metrics to evaluate our fusion model,based on intermediate-output extracted by ResNet and SVM using the Gaussian kernel function.Our results show that the primary metric true skill statistics(TSS)achieves a value of 0.708±0.027 for≥C-class prediction,and of 0.758±0.042 for≥M-class prediction;these values indicate that our approach performs significantly better than those of previous studies.The metrics of our fusion model’s performance on the seven datasets indicate that the model is quite stable and robust,suggesting that fusion models that integrate an excellent baseline network with SVM can achieve improved performance in solar flare prediction.Besides,we also discuss the performance impact of architectural innovation in our fusion model.
文摘Pacing-induced cardiomyopathy (PICM) resultsf rom the detrimental effect of frequent right ventricular pacing.^([1]) The diagnosis relies on a combination of pacing-associated ventricular dyschrony manifested with ECG wide LBBB-pattern QRS duration and clinical assessment, imaging studies. Conduction system pacing (CSP), such as His bundle pacing (HBP)and left bundle branch pacing (LBBP), may help to prevent PICM,^([2]) but the criteria for optimal patient selection remain inadequately defined.
基金funded by the Mason Foundation National Medical Program(MAS2015F053).
文摘Objectives:People living with myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS)may face unique barriers to physical activity.Active video games may overcome these barriers and increase physical activity.The primary aim of this pilot study was to determine the feasibility and acceptability of active video games to increase physical activity levels of people with ME/CFS.Methods:A mixed method design was employed.Adults living with ME/CFS were randomised to a six-month intervention of(1)pacing,(2)pacing and conventional physical activity,or(3)pacing and active video gaming.Feasibility and acceptability were determined through semi-structured interviews.Health-related outcomes(e.g.,physical activity,blood samples,quality of life,and functioning)were also collected.Results:Fifteen people were assigned an intervention group with 12 completing.Three themes were identified from post-intervention interviews(1)positivity led to overall acceptability,(2)flexibility enabled participant autonomy,and(3)knowledge was gained about the self.No changes were seen in physical activity levels.An active video gaming intervention is acceptable but not feasible for people living with ME/CFS.Conclusions:Taken together,results suggest that physical activity can be managed safely by some people living with ME/CFS.Trial registration ACTRN12616000285459.
文摘As humanity advances at a rapid pace,both material wealth and spiritual fulfillment continue to grow and enrich our lives.“The remarkable year of 2025 marks a pinnacle in AI advancement,a quantum leap in robotics applications,and groundbreaking progress in cosmic exploration.Even Nezha II(a Chinese animated blockbuster) brilliantly integrates technology,space,culture,and AI into its narrative.Yet,none of these developments can escape humanity's enduring obsession with facial aesthetics.As civilizations flourish across all dimensions,the beauty economy emerges as a formidable industrial force,driving mankind's relentless pursuit of a better life and a more beautiful future.”
基金supported by the French National Research Agency(Agence Nationale de la Recherche,ANR,Grant No.ANR-23-CE37-0014)for the Effort_(LESS)Project.
文摘Background:The perception of effort is a key determinant of endurance performance and a barrier to physical activity in inactive populations.From a neurophysiological viewpoint,effort perception is thought to arise from the brain processing of an efference copy of the motor command in sensory areas.However,recent research suggests that feedback from muscle spindles plays a significant role in this perception.In this study,tendon vibration protocols were employed to attenuate sensory feedback during subsequent cycling exercises.The aim was to assess whether vibration would increase cycling power output,muscle activation,and heart rate at fixed perceived effort intensities.Methods:Fifteen healthy young participants completed 2 experimental visits(vibration and sham).In each visit,participants performed two 3-min cycling bouts,1 at a moderate perceived effort intensity and 1 at a strong perceived effort intensity,before(pre)and after(post)an actual or a sham vibration protocol.Vibration was applied bilaterally on the patellar and Achilles tendons for 10 min.Power output,heart rate,and vastus lateralis electromyography(VL EMG)were recorded and averaged for each bout.Absolute values as well as relative change(%)between pre and post conditions were compared across sham and vibration conditions.Results:At moderate perceived effort,power output,heart rate,and VL EMG increased post-vibration compared to pre-vibration(p<0.05),while no difference was observed in the sham condition.At strong perceived effort,power output and VL EMG decreased post-sham(p<0.05)but remained unchanged post-vibration.Moreover,the relative change between pre and post conditions was significantly higher in the vibration conditions compared to the sham condition for all variables.Conclusion:This study shows that tendon vibration reduces effort perception during subsequent cycling bouts.This effect is likely a consequence of vibration-induced reduction in muscle spindle reafferent signaling to the brain,but this mechanism remains to be further elucidated.From an applied perspective,these findings highlight tendon vibration as a promising tool for enhancing physical activity engagement.
文摘Congenitally corrected transposition of the great arteries(CCTGA)is a rare congenital heart disease characterized by atrioventricular,ventriculoarterial,and conduction system discordance,commonly accompanied by atrioventricular block(AVB).Pacing in patients with CCTGA and AVB(both pediatric and adult)poses challenges in strategy selection,procedural complexity,and clinical decision-making due to limited evidence.Conventional morphological left ventricular pacing is widely adopted but may induce ventricular dyssynchrony,heart failure,and tricuspid valve dysfunction.While cardiac resynchronization therapy serves as an upgrade for pacing-induced cardiomyopathy and heart failure,its application may be limited by coronary sinus anatomical variations and uncertain clinical outcomes.His bundle pacing is rarely reported due to the variation of the His bundle and high pacing threshold.The superficial,wide,multi-branched left bundle branch favors left bundle branch pacing,though delayed systemic right ventricle(sRV)activation may cause ventricular dyssynchrony and impair sRV function.Right bundle branch pacing offers a novel alternative for pacing therapy.Conduction system pacing-optimized cardiac resynchronization therapy is preferred in those with evidence of intrinsic ventricular conduction dysfunction.This narrative review synthesizes current evidence on pacing strategies for CCTGA with AVB,integrating anatomical and pathophysiological insights to evaluate physiological pacing strategies,while highlighting critical knowledge gaps to guide future research.
文摘Cardiac resynchronization therapy(CRT)reduces heart failure(HF)hospitaliz-ations and all-cause mortality in patients with HF with reduced ejection fraction with left bundle branch(LBB)block.Biventricular pacing(BVP)is considered the gold standard for achieving CRT;however,approximately 30%–40%of patients do not respond to BVP-CRT.Recent studies have demonstrated that LBB pacing(LBBP)produces remarkable results in CRT.In this meta-analysis,LBBP-CRT showed better outcomes than conventional BVP-CRT,including greater QRS duration reduction and left ventricular ejection fraction improvement,along with consistently lower pacing thresholds on follow-up.Additionally,there was a grea-ter reduction in New York Heart Association class and brain natriuretic peptide levels.This study contributes to the growing body of encouraging data on LBBP-CRT from recent years.With ongoing technological advancements and increasing operator expertise,the day may not be far when LBBP-CRT becomes the standard of care rather than the exception.
