By modifying the salicylic-acid moiety with electron-withdrawing or –donating groups, three new terbium complexes（LⅠ·Tb, LⅡ·Tb, L·（Ⅲ）Tb） based on tripodal carboxylate ligands were synthesized. D...By modifying the salicylic-acid moiety with electron-withdrawing or –donating groups, three new terbium complexes（LⅠ·Tb, LⅡ·Tb, L·（Ⅲ）Tb） based on tripodal carboxylate ligands were synthesized. Due to different pull-push electronic effects of ligands, the fluorescence intensities of these terbium complexes significantly varied, that is： LⅡ·Tb 〉L（Ⅲ）·Tb〉 LⅠ·Tb. Meanwhile, the characteristic peaks at 492 nm（5D4→7F6） and 547 nm（5 D4→7F5） showed ＂Off–On–Off＂ fluorescence response to various p H conditions,which indicated that all of them can be used as the highly sensitive pH fluorescent probes. Notably, using LⅡ·Tb with the best fluorescence performance as a probe, some patients＇ urine samples can be easily monitored through the response triggered by pH value. Therefore, LⅡ·Tb has the potential to auxiliarily diagnose some diseases in clinical practice through p H detection of routine urine test.展开更多
Two kinds of fluorescent nano-probes（pH-A and pH-B） with different diameters for the determination of H＋concentration, based on photo-induced electron transfer mechanism, were synthesized through click reaction. In...Two kinds of fluorescent nano-probes（pH-A and pH-B） with different diameters for the determination of H＋concentration, based on photo-induced electron transfer mechanism, were synthesized through click reaction. In which 1,8-naphthalimide was employed as the fluorophore and N,N-dimethylethylenediamine as the receptor. The effects of particle size and linker length on the photophysical properties of the probe were studied. The results revealed that the nano-probes were more sensitive toward pH with increasing particle size. The fluorescence intensity at 529 nm（I529） of the nano-probe p H-A of 120 nm exhibited good linear relationship with solution＇s pH in the range of 6–8. The probe p H-A displayed excellent selectivity and competition toward proton over other possible coexisted ions, and it could be applied to detect pH in realistic samples（river water, urine）.展开更多
Flexible optical sensing systems have evolved into a promising frontier for personalized health monitoring,leveraging their non-invasive operation and continuous data acquisition.Nevertheless,current optical solutions...Flexible optical sensing systems have evolved into a promising frontier for personalized health monitoring,leveraging their non-invasive operation and continuous data acquisition.Nevertheless,current optical solutions remain constrained by limitations in detection sensitivity and specificity,hindering their reliability in dynamic clinical environments.Herein,we propose a design of flexible semiinterpenetrating network hydrogel lasing textiles for multifunctional sensing,including relative humidity and acid pH detection.By integrating the humidity-responsive swelling and carboxyl protonation-mediated optical loss modulation of hydrogels with whispering-gallery-mode microcavity lasers,we achieve a dual-parameter flexible optical sensing based on wavelength shift and spectral linewidth modulation,enabling a 227 pm/%RH sensitivity of humidity detection and 125 pm/pH sensitivity of acid pH monitoring,with limit of detection of 0.71%RH and 0.55 pH,respectively.This work is expected to establish new pathways for non-invasive health monitoring in flexible systems.展开更多
Methylene blue(MB)is an FDA(Food and Drug Administration)-approved contrast agent with donor−acceptor(D−A)structure integrated with carbonyl-containing nitrogen-heterocycles.MB can be converted into MBH(protonated MB)...Methylene blue(MB)is an FDA(Food and Drug Administration)-approved contrast agent with donor−acceptor(D−A)structure integrated with carbonyl-containing nitrogen-heterocycles.MB can be converted into MBH(protonated MB)by protonation,which not only induces the fluorescence emission redshifted from the first near-infrared window(NIR-I,650−950 nm)to the second near-infrared window(NIR-II,1000−1700 nm)but also achieves ACQ-to-AIE conversion.MB has been successfully demonstrated in hyperacidemia imaging with an extremely low pH value(<1).展开更多
Here,we demonstrate the assembly of a new stable lanthanide-based metal-organic framework(MOF),Eu(HDPB)(phen)(1)(HDPB=(1,1’:3’,1’’-terphenyl)-3,3’’,5,5’’-tetracarboxylic acid,phen=1,10-phenanthroline),with a t...Here,we demonstrate the assembly of a new stable lanthanide-based metal-organic framework(MOF),Eu(HDPB)(phen)(1)(HDPB=(1,1’:3’,1’’-terphenyl)-3,3’’,5,5’’-tetracarboxylic acid,phen=1,10-phenanthroline),with a three-dimensional framework under solvothermal conditions.1 showed strong red fluorescence emission at room temperature and could be used as a selective and sensitive chemical sensor for pH and folic acid(FA)detection.Moreover,1 could also be applied as a fluorescent material for the visible identification of fingerprints.Then,using 1 as a filler,two mixed-matrix membranes(MMMs),1@poly(ε-caprolactone)(PCL)and 1@poly(vinylidene difluoride)(PVDF),have been fabricated.Notably,owing to the hydrophobic protection provided by the polymer matrix of the MOF particles,these two MMMs also exhibited fluorescence emission comparable to that of 1 and could be used for FA sensing with good selectivity and remarkable recyclability.More importantly,this is the first time that Eu-MOF-based MMMs have been employed in FA detection.The fabrication of MOF-based MMMs not only provides a facile method for sensing biomarkers,but it also enhances the recyclability of sensors.展开更多
A new 2D Eu-BTB framework(1) with stratified gridding structure of about 14.6×16.9was synthesized and characterized.Compound 1 displays excellent water stability with the pH 2–12. The luminescent investigations ...A new 2D Eu-BTB framework(1) with stratified gridding structure of about 14.6×16.9was synthesized and characterized.Compound 1 displays excellent water stability with the pH 2–12. The luminescent investigations suggest that 1 could represent a chemical sensor of PO43. with high sensitivity and selectivity. Importantly, 1 as a sensor of PO_4^(3-) can be reused at least five times.On the other hand, the catalytic investigations of 1 were carried out, indicating that 1 could be demonstrated as a recyclable catalyst for CO_2 conversion with epoxides.展开更多
基金supported by the National Natural Science Foundation of China (Nos. 21572091 and 21472075)the Fundamental Research Funds for the Central Universities (No. lzujbky-2016-51) by Ministry of Education of China
文摘By modifying the salicylic-acid moiety with electron-withdrawing or –donating groups, three new terbium complexes（LⅠ·Tb, LⅡ·Tb, L·（Ⅲ）Tb） based on tripodal carboxylate ligands were synthesized. Due to different pull-push electronic effects of ligands, the fluorescence intensities of these terbium complexes significantly varied, that is： LⅡ·Tb 〉L（Ⅲ）·Tb〉 LⅠ·Tb. Meanwhile, the characteristic peaks at 492 nm（5D4→7F6） and 547 nm（5 D4→7F5） showed ＂Off–On–Off＂ fluorescence response to various p H conditions,which indicated that all of them can be used as the highly sensitive pH fluorescent probes. Notably, using LⅡ·Tb with the best fluorescence performance as a probe, some patients＇ urine samples can be easily monitored through the response triggered by pH value. Therefore, LⅡ·Tb has the potential to auxiliarily diagnose some diseases in clinical practice through p H detection of routine urine test.
基金financial support from the National Natural Science Foundation of China (No. 21576085)
文摘Two kinds of fluorescent nano-probes（pH-A and pH-B） with different diameters for the determination of H＋concentration, based on photo-induced electron transfer mechanism, were synthesized through click reaction. In which 1,8-naphthalimide was employed as the fluorophore and N,N-dimethylethylenediamine as the receptor. The effects of particle size and linker length on the photophysical properties of the probe were studied. The results revealed that the nano-probes were more sensitive toward pH with increasing particle size. The fluorescence intensity at 529 nm（I529） of the nano-probe p H-A of 120 nm exhibited good linear relationship with solution＇s pH in the range of 6–8. The probe p H-A displayed excellent selectivity and competition toward proton over other possible coexisted ions, and it could be applied to detect pH in realistic samples（river water, urine）.
基金the Beijing Natural Science Foundation(No.Z180015)the National Natural Science Foundation of China(NSFC)(No.52203252)for financial support.
文摘Flexible optical sensing systems have evolved into a promising frontier for personalized health monitoring,leveraging their non-invasive operation and continuous data acquisition.Nevertheless,current optical solutions remain constrained by limitations in detection sensitivity and specificity,hindering their reliability in dynamic clinical environments.Herein,we propose a design of flexible semiinterpenetrating network hydrogel lasing textiles for multifunctional sensing,including relative humidity and acid pH detection.By integrating the humidity-responsive swelling and carboxyl protonation-mediated optical loss modulation of hydrogels with whispering-gallery-mode microcavity lasers,we achieve a dual-parameter flexible optical sensing based on wavelength shift and spectral linewidth modulation,enabling a 227 pm/%RH sensitivity of humidity detection and 125 pm/pH sensitivity of acid pH monitoring,with limit of detection of 0.71%RH and 0.55 pH,respectively.This work is expected to establish new pathways for non-invasive health monitoring in flexible systems.
基金supported by National Key R&D Programs(China)(2021YFA0910001,2023YFA0915400)Guangdong Provincial Key Area R&D Program(2020B111-1540001)+7 种基金Shenzhen Basic Research(key project)(China)(JCYJ20210324120011030,JCYJ20210324115804013,and JCYJ20200109114616534)the Shenzhen Science and Technology Program(KQTD20210811090115019)the Major Instrumentation Development Program of the Chinese Academy of Sciences(Project Number:ZDKYYQ20220008)Shenzhen-Macao Technology Plan(SGDX202011030928-0301)Technological Cooperation Projects(China)(2020-A0505100047)Guangdong Basic and Applied Basic Research Fund Project(China)(2021A1515110699)Zhuhai Innovation and Entrepreneurship Team Project(ZH011104-05180056PWC)All animal experiments were performed under the protocols approved by the Animal Care and Use Committee(Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences)(Serial number:SIAT-IACUC-210701-YYS-GP-A1974).
文摘Methylene blue(MB)is an FDA(Food and Drug Administration)-approved contrast agent with donor−acceptor(D−A)structure integrated with carbonyl-containing nitrogen-heterocycles.MB can be converted into MBH(protonated MB)by protonation,which not only induces the fluorescence emission redshifted from the first near-infrared window(NIR-I,650−950 nm)to the second near-infrared window(NIR-II,1000−1700 nm)but also achieves ACQ-to-AIE conversion.MB has been successfully demonstrated in hyperacidemia imaging with an extremely low pH value(<1).
基金the National Science Foundation of China(No.52075218,51775232).
文摘Here,we demonstrate the assembly of a new stable lanthanide-based metal-organic framework(MOF),Eu(HDPB)(phen)(1)(HDPB=(1,1’:3’,1’’-terphenyl)-3,3’’,5,5’’-tetracarboxylic acid,phen=1,10-phenanthroline),with a three-dimensional framework under solvothermal conditions.1 showed strong red fluorescence emission at room temperature and could be used as a selective and sensitive chemical sensor for pH and folic acid(FA)detection.Moreover,1 could also be applied as a fluorescent material for the visible identification of fingerprints.Then,using 1 as a filler,two mixed-matrix membranes(MMMs),1@poly(ε-caprolactone)(PCL)and 1@poly(vinylidene difluoride)(PVDF),have been fabricated.Notably,owing to the hydrophobic protection provided by the polymer matrix of the MOF particles,these two MMMs also exhibited fluorescence emission comparable to that of 1 and could be used for FA sensing with good selectivity and remarkable recyclability.More importantly,this is the first time that Eu-MOF-based MMMs have been employed in FA detection.The fabrication of MOF-based MMMs not only provides a facile method for sensing biomarkers,but it also enhances the recyclability of sensors.
基金supported by the National Natural Science Foundation of China (21571123, 21571107, 21421001)the Natural Science Foundation of Tianjin (15JCZDJC37700)+1 种基金111 Project (B12015)MOE Innovation Team (IRT13022, IRT-13R30) of China
文摘A new 2D Eu-BTB framework(1) with stratified gridding structure of about 14.6×16.9was synthesized and characterized.Compound 1 displays excellent water stability with the pH 2–12. The luminescent investigations suggest that 1 could represent a chemical sensor of PO43. with high sensitivity and selectivity. Importantly, 1 as a sensor of PO_4^(3-) can be reused at least five times.On the other hand, the catalytic investigations of 1 were carried out, indicating that 1 could be demonstrated as a recyclable catalyst for CO_2 conversion with epoxides.
