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EFFECTS OF A SYNTHETIC POLYPEPTIDE ENCODED BY THE p14-6,A cDNA CLONE WITH ANTIONCOGENE ACTIVITY, ON MALIGNANT TRANSFORMED DT CELLS
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作者 刘定干 陈珍珍 李载平 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1992年第1期4-8,共5页
A synthetic polypeptide, pt27, which is encoded by a cDNA clone with antloncogene activity, p14-6, is found to be able to reduce remarkably the soft agar colony formation ability of part of DT cells and to raise their... A synthetic polypeptide, pt27, which is encoded by a cDNA clone with antloncogene activity, p14-6, is found to be able to reduce remarkably the soft agar colony formation ability of part of DT cells and to raise their resistance to the ouabaln toxtcity. This shows that the pt27 peptide can affect the DT cells In a manner similar to the p14- 6 done and provides evidence that the reverting action of the p14-6 to DT cells may be exerted by the expression of its cDNA. 展开更多
关键词 DT EFFECTS OF A SYNTHETIC pOLYpEpTIDE ENCODED BY THE p14-6 A cDNA CLONE WITH ANTIONCOGENE ACTIVITY pt
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生物化学
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《中国医学文摘(基础医学)》 CSCD 1991年第6期333-335,共3页
抗癌基因或肿瘤抑制基因是一类能抑制肿瘤细胞恶性表型的细胞基因。从回复突变株R_(14)中回收到5个cDNA克隆,其中一个P14-6对DT细胞具有抗癌基因功能,转染DT后可使其恶性表型发生部分逆转。P14-6含有约0.4kb的cDNA插入片段。作者对400... 抗癌基因或肿瘤抑制基因是一类能抑制肿瘤细胞恶性表型的细胞基因。从回复突变株R_(14)中回收到5个cDNA克隆,其中一个P14-6对DT细胞具有抗癌基因功能,转染DT后可使其恶性表型发生部分逆转。P14-6含有约0.4kb的cDNA插入片段。作者对400碱基对进行DNA序列分析,经计算机处理在EMBL和GENEPRO数据库中没有检索到和它同源的基因。 展开更多
关键词 CDNA克隆 p14-6 抗癌基因 肿瘤抑制基因
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