Let G be a primitive group. It is proved that there exits some prime p such that every p-central automorphism of G is inner. As an application, it is proved that every Coleman automorphism of the holomorph of G is inn...Let G be a primitive group. It is proved that there exits some prime p such that every p-central automorphism of G is inner. As an application, it is proved that every Coleman automorphism of the holomorph of G is inner. In particular, the normalizer property holds for such groups in question. Additionally, other related results are obtained as well.展开更多
目的:基于"上调MDR(multiple drug resistance)基因、诱导P-糖蛋白(P-gp,P-glycoprotein)外向转运解除中枢抑制药物中毒"的机制研究,对临床中毒多发的中枢抑制药物建立P-gp底物谱,明确适合该解救治疗方案的药物(毒物)。方法:...目的:基于"上调MDR(multiple drug resistance)基因、诱导P-糖蛋白(P-gp,P-glycoprotein)外向转运解除中枢抑制药物中毒"的机制研究,对临床中毒多发的中枢抑制药物建立P-gp底物谱,明确适合该解救治疗方案的药物(毒物)。方法:采用三磷酸腺苷酶(adenosine triphosphate,ATP)酶活性测试法确定待测中枢抑制药物是否为P-gp的底物。结果:舒必利、齐拉西酮、佐匹克隆、氯米帕明、西酞普兰及吗氯贝胺均为P-gp底物。舒必利、齐拉西酮与西酞普兰为非浓度依赖的ATP酶抑制剂,佐匹克隆、氯米帕明与吗氯贝胺浓度依赖的ATP酶双向调节子。结论:该研究结果将为新的中枢药物中毒解救方案的临床应用提供参考和依据。展开更多
基金Supported by the National Natural Science Foundation of China(Grant No.71571108)Projects of International(Regional)Cooperation and Exchanges of NSFC(Grant Nos.71611530712+4 种基金 61661136002)Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20133706110002)Natural Science Foundation of Shandong Province(Grant No.ZR2015GZ007)Project Funded by China Postdoctoral Science Foundation(Grant No.2016M590613)the Specialized Fund for the Postdoctoral Innovative Research Program of Shandong Province(Grant No.201602035)
文摘Let G be a primitive group. It is proved that there exits some prime p such that every p-central automorphism of G is inner. As an application, it is proved that every Coleman automorphism of the holomorph of G is inner. In particular, the normalizer property holds for such groups in question. Additionally, other related results are obtained as well.
文摘目的:基于"上调MDR(multiple drug resistance)基因、诱导P-糖蛋白(P-gp,P-glycoprotein)外向转运解除中枢抑制药物中毒"的机制研究,对临床中毒多发的中枢抑制药物建立P-gp底物谱,明确适合该解救治疗方案的药物(毒物)。方法:采用三磷酸腺苷酶(adenosine triphosphate,ATP)酶活性测试法确定待测中枢抑制药物是否为P-gp的底物。结果:舒必利、齐拉西酮、佐匹克隆、氯米帕明、西酞普兰及吗氯贝胺均为P-gp底物。舒必利、齐拉西酮与西酞普兰为非浓度依赖的ATP酶抑制剂,佐匹克隆、氯米帕明与吗氯贝胺浓度依赖的ATP酶双向调节子。结论:该研究结果将为新的中枢药物中毒解救方案的临床应用提供参考和依据。
基金Key Project Process Mechanism and Prediction of Geological Hazards (2001CB711005-1-3) and State Key Basic Research Project Mechanism and Prediction of Continental Earthquakes (G1998040702). sponsored by the Ministry of Science and Techno
