Background: Our paper aimed to investigate whether there was a correlation among the pulse oximetry, cerebral oximetry (CO) and MetHb (methemoglobin) values of a patient with congenital methemoglobinemia who underwent...Background: Our paper aimed to investigate whether there was a correlation among the pulse oximetry, cerebral oximetry (CO) and MetHb (methemoglobin) values of a patient with congenital methemoglobinemia who underwent a laparoscopic cholecystectomy operation. Case: The 35-year-old male patient with a weight of 70 kg, body massindex (BMI) of 21, American Society of Anesthesia status-2(ASA-2) category who was planned for laparoscopic cholecystectomy operation was identified to have been diagnosed with congenital methemoglobinemia as per his medical history was methemoglobin levels ranged between 12% and 20% according to the periodical measurements taken for the past 3 years. The patient received standard monitoring during anesthesia and device monitoring with a cerebral oximeter (Invos 5100C somatic/cerebral oximeter, Covidien) and a CO-oximetry (Rad ?87 “Rainbow”, Masimo Inc., Irvine, CA) device to continuously follow up his MetHb values was also added. During the intra-operative follow-up, the patient’s methemoglobin level rose to 16%, his peripheral oxygen saturation levels decreased to 86% and his cerebral oximetry values were identified to have also decreased;therefore, methylene blue (MB) was intravenously administered to the patient. The patient continued to be followed up in the post-operative period and he did not develop any complications. Discussion: Appropriate treatment and monitoring enabled the prevention of potential complications. We believe that monitoring with NIRS and MASIMO CO-oximetry device will enable physicians to perform a safe follow-up and treatment in the intraoperative and postoperative follow-up of methemoglobinemia patients.展开更多
Saturation of peripheral oxygen （SpO2） is one of the most important parameters of vital signs. Pulse oximeter based on near-infrared spectroscopy is commonly used as a non-invasive method to measure SpO2 yl. Current...Saturation of peripheral oxygen （SpO2） is one of the most important parameters of vital signs. Pulse oximeter based on near-infrared spectroscopy is commonly used as a non-invasive method to measure SpO2 yl. Currently, medical device manufacturers as well as metrology measurement agencies in China usually use pulse oximeter simulator as the commonly accepted functional calibration equipment for pulse oximeters. So far, no experimental protocol or devices can be used to test the accuracy and reliability of a pulse oximeter simulator. Therefore, a set of new metrology apparatus with the name of calibration device for pulse oximeter simulator have been designed in order to make a traceable system for the calibration or verification of pulse oximeter simulators. The principles and some research methods of this calibration device for pulse oximeter simulator will be discussed in this paper. Besides that, many experiments have been applied in order to guarantee the accuracy as well as traceability of this set of device.展开更多
As a key monitoring device in modern medical systems,the projective oximeter plays an important role in clinical diagnosis and health monitoring with its non-invasiveness,high accuracy and convenience.In this paper,th...As a key monitoring device in modern medical systems,the projective oximeter plays an important role in clinical diagnosis and health monitoring with its non-invasiveness,high accuracy and convenience.In this paper,the working principle of the projective oximeter is firstly described systematically,including its basic measurement principle based on the difference in the absorption of different wavelengths of light by hemoglobin and oxyhemoglobin,the measurement method of optoelectronic sensing and signal processing,as well as the technical characteristics such as high accuracy,fast response and portability.Subsequently,through comparative experiments and data analysis,this study comprehensively evaluated the performance of the projective oximeter,including its measurement accuracy and stability under different environmental conditions,as well as its wide applicability to the population.It was found that the performance of the projective oximeter was stable in different populations and complex environments,showing good applicability and reliability.However,to address the shortcomings of the oximeter in terms of measurement stability,user experience,and functionality expansion,this paper proposes corresponding improvements,such as the adoption of advanced temperature and humidity compensation algorithms to improve stability,the optimization of the user interface and portability design to enhance user experience,and the integration of multimodal physiological monitoring technology and the construction of a telemedicine and healthcare platform to expand the functionality of the application.These improvement suggestions aim to provide theoretical support and practical guidance for the future development of projective oximeter and further promote its wide application and development in the field of healthcare.展开更多
BACKGROUND Radial artery obstruction is the most common complication of coronary angiography performed via transradial access.Patent hemostasis can significantly reduce the risk of radial artery occlusion.Previous stu...BACKGROUND Radial artery obstruction is the most common complication of coronary angiography performed via transradial access.Patent hemostasis can significantly reduce the risk of radial artery occlusion.Previous studies utilized sophisticated methods to evaluate radial artery patency.Simplified and easily applicable methods for successful patent hemostasis are currently lacking.AIM To determine which method(pulse oximeter vs the traditional radial artery palpation)is better to achieve patent hemostasis.METHODS This prospective,single center study included 299 consecutive patients who underwent coronary angiography or percutaneous coronary intervention between November 2017 and July 2019.Patients less than 18 years old,with a history of radial artery disease,or no palpable artery pulse were excluded from the study.Patients were randomly assigned to two groups.In the first group,radial artery flow was assessed by palpation of the artery during hemostasis(traditional method).In the second group,radial artery patency was estimated with the use of a pulse oximeter.Two different compression devices were used for hemostasis(air chamber and pressure valve).The primary study endpoint was the achievement of successful patent hemostasis.RESULTS The two groups(pulse oximeter vs artery palpation)had no significant differences in age,sex,body mass index,risk factors,or comorbidities except for supraventricular arrhythmias.The percentage of patients with successful patent hemostasis was significantly higher in the pulse oximeter group(82.2%vs 68.1%,P=0.005).A lower percentage of patients with spasm was recorded in the pulse oximeter group(9.9%vs 19.0%,P=0.024).The incidence of local complications,edema,bleeding,hematoma,vagotonia,or pain did not differ between the two groups.In the multivariate analysis,the use of a pulse oximeter(OR:2.35,95%CI:1.34-4.13,P=0.003)and advanced age(OR:1.04,95%CI:1.01-1.07,P=0.006),were independently associated with an increased probability of successful patent hemostasis.The type of hemostatic device did not affect patent hemostasis(P=0.450).CONCLUSION Patent hemostasis with the use of pulse oximeter is a simple,efficient,and safe method that is worthy of further investigation.Larger randomized studies are required to consider its clinical implications.展开更多
BACKGROUND Achenbach’s syndrome is a rare condition,and the etiology is unknown.It is most commonly seen in the volar plate of the hand distal interphalangeal joint.Patients diagnosed with Achenbach’s syndrome in ca...BACKGROUND Achenbach’s syndrome is a rare condition,and the etiology is unknown.It is most commonly seen in the volar plate of the hand distal interphalangeal joint.Patients diagnosed with Achenbach’s syndrome in cardiovascular surgery clinic were retrospectively compared with the literature.AIM To investigate the symptoms,findings,sociodemographic conditions,and laboratory data of patients diagnosed with Achenbach’s syndrome.METHODS The study is a retrospective review of 24 patients diagnosed with Achenbach’s syndrome at Afyonkarahisar State Hospital between March 2015 and November 2016,at Sivas Numune Hospital between November 2016 and November 2017,and at Cumhuriyet University Cardiovascular Surgery Department between November 2017 and November 2018.In the study,demographic characteristics of the patients,signs and symptoms of the disease,and laboratory data were analyzed retrospectively.RESULTS The cohort consisted of 83.33%female patients and 16.67%male patients.The disease was most commonly located in the index finger of the right hand.All of the patients complained of bruising and pain.No pathologic findings were present in the laboratory results.According to these results,it can be concluded that Achenbach syndrome is most commonly seen in the right index finger of middle-aged female patients.CONCLUSION Further research is needed to clarify Achenbach’s syndrome and to develop a diagnosis and treatment algorithm.As the awareness of this syndrome increases,large amounts of data will be obtained.According to current knowledge,Achenbach’s syndrome is not among the known causes of mortality or morbidity.However,it is unknown whether it is seen in brain or other vital organs.展开更多
A medical device is an instrument that includes components,parts,or accessories to diagnose or treat patients.Since the complexity of medical devices has increased in recent years,functional safety and basic safety ar...A medical device is an instrument that includes components,parts,or accessories to diagnose or treat patients.Since the complexity of medical devices has increased in recent years,functional safety and basic safety are required to ensure the overall device safety.Functional safety is part of the overall safety that relates to the equipment under control(EUC)and to the EUC control system that depends on the correct functionality of the electrical/electronic/programmable electronic(E/E/PE)safety-related systems.This study proposes approach methods to functional safety of medical devices for which it is important to correctly identify the safety functions and the safety integrity level(SIL).The relationship between the functional safety and essential performance is identified focusing on the safety function.The essential performance of E/E/PE systems is defined as the safety function of the functional safety.The target SIL of the essential performance is determined according to the potential risk levels,based on the classification rules of medical devices.This approach is applied to the pulse oximeter as a case study.The target SIL for the functionality of the power-failure alarm condition is determined to be SIL1.The target SILs of other functions are determined as SIL2.展开更多
Photoelectric pulse oximeters are widely favored for their non-invasive and continuous monitoring of pulse rate and blood oxygen saturation,which are vital indicators of physiological health.However,traditional pulse ...Photoelectric pulse oximeters are widely favored for their non-invasive and continuous monitoring of pulse rate and blood oxygen saturation,which are vital indicators of physiological health.However,traditional pulse oximeters are frequently hindered by several limitations,such as high-power consumption,instability,and reduced precision.Herein,a WSe_(2)/Si p-n heterojunction photodiode was in-situ fabricated for self-powered high-precision pulse rate and blood oxygen saturation monitoring.Our device demonstrated the excellent broadband photoresponse performance from 265 to 980 nm,covering the biological window,including a high responsivity of 740 mA/W,a fast response time of 7.8/7.1μs and a low detection limit of 25 nW/cm^(2).Leveraging these prominent photoelectrical properties,the WSe_(2)/Si photodiode demonstrates high accuracy and reliability in detecting the physiological signals of heart rate and blood oxygen saturation through a triple-wavelength measurement method,with an error margin of less than 1%,thereby validating its accuracy and reliability for non-invasive health monitoring applications.These achievements provide a new approach for developing low-power,high-sensitivity optoelectronic pulse oximeters.展开更多
文摘Background: Our paper aimed to investigate whether there was a correlation among the pulse oximetry, cerebral oximetry (CO) and MetHb (methemoglobin) values of a patient with congenital methemoglobinemia who underwent a laparoscopic cholecystectomy operation. Case: The 35-year-old male patient with a weight of 70 kg, body massindex (BMI) of 21, American Society of Anesthesia status-2(ASA-2) category who was planned for laparoscopic cholecystectomy operation was identified to have been diagnosed with congenital methemoglobinemia as per his medical history was methemoglobin levels ranged between 12% and 20% according to the periodical measurements taken for the past 3 years. The patient received standard monitoring during anesthesia and device monitoring with a cerebral oximeter (Invos 5100C somatic/cerebral oximeter, Covidien) and a CO-oximetry (Rad ?87 “Rainbow”, Masimo Inc., Irvine, CA) device to continuously follow up his MetHb values was also added. During the intra-operative follow-up, the patient’s methemoglobin level rose to 16%, his peripheral oxygen saturation levels decreased to 86% and his cerebral oximetry values were identified to have also decreased;therefore, methylene blue (MB) was intravenously administered to the patient. The patient continued to be followed up in the post-operative period and he did not develop any complications. Discussion: Appropriate treatment and monitoring enabled the prevention of potential complications. We believe that monitoring with NIRS and MASIMO CO-oximetry device will enable physicians to perform a safe follow-up and treatment in the intraoperative and postoperative follow-up of methemoglobinemia patients.
文摘Saturation of peripheral oxygen （SpO2） is one of the most important parameters of vital signs. Pulse oximeter based on near-infrared spectroscopy is commonly used as a non-invasive method to measure SpO2 yl. Currently, medical device manufacturers as well as metrology measurement agencies in China usually use pulse oximeter simulator as the commonly accepted functional calibration equipment for pulse oximeters. So far, no experimental protocol or devices can be used to test the accuracy and reliability of a pulse oximeter simulator. Therefore, a set of new metrology apparatus with the name of calibration device for pulse oximeter simulator have been designed in order to make a traceable system for the calibration or verification of pulse oximeter simulators. The principles and some research methods of this calibration device for pulse oximeter simulator will be discussed in this paper. Besides that, many experiments have been applied in order to guarantee the accuracy as well as traceability of this set of device.
文摘As a key monitoring device in modern medical systems,the projective oximeter plays an important role in clinical diagnosis and health monitoring with its non-invasiveness,high accuracy and convenience.In this paper,the working principle of the projective oximeter is firstly described systematically,including its basic measurement principle based on the difference in the absorption of different wavelengths of light by hemoglobin and oxyhemoglobin,the measurement method of optoelectronic sensing and signal processing,as well as the technical characteristics such as high accuracy,fast response and portability.Subsequently,through comparative experiments and data analysis,this study comprehensively evaluated the performance of the projective oximeter,including its measurement accuracy and stability under different environmental conditions,as well as its wide applicability to the population.It was found that the performance of the projective oximeter was stable in different populations and complex environments,showing good applicability and reliability.However,to address the shortcomings of the oximeter in terms of measurement stability,user experience,and functionality expansion,this paper proposes corresponding improvements,such as the adoption of advanced temperature and humidity compensation algorithms to improve stability,the optimization of the user interface and portability design to enhance user experience,and the integration of multimodal physiological monitoring technology and the construction of a telemedicine and healthcare platform to expand the functionality of the application.These improvement suggestions aim to provide theoretical support and practical guidance for the future development of projective oximeter and further promote its wide application and development in the field of healthcare.
文摘BACKGROUND Radial artery obstruction is the most common complication of coronary angiography performed via transradial access.Patent hemostasis can significantly reduce the risk of radial artery occlusion.Previous studies utilized sophisticated methods to evaluate radial artery patency.Simplified and easily applicable methods for successful patent hemostasis are currently lacking.AIM To determine which method(pulse oximeter vs the traditional radial artery palpation)is better to achieve patent hemostasis.METHODS This prospective,single center study included 299 consecutive patients who underwent coronary angiography or percutaneous coronary intervention between November 2017 and July 2019.Patients less than 18 years old,with a history of radial artery disease,or no palpable artery pulse were excluded from the study.Patients were randomly assigned to two groups.In the first group,radial artery flow was assessed by palpation of the artery during hemostasis(traditional method).In the second group,radial artery patency was estimated with the use of a pulse oximeter.Two different compression devices were used for hemostasis(air chamber and pressure valve).The primary study endpoint was the achievement of successful patent hemostasis.RESULTS The two groups(pulse oximeter vs artery palpation)had no significant differences in age,sex,body mass index,risk factors,or comorbidities except for supraventricular arrhythmias.The percentage of patients with successful patent hemostasis was significantly higher in the pulse oximeter group(82.2%vs 68.1%,P=0.005).A lower percentage of patients with spasm was recorded in the pulse oximeter group(9.9%vs 19.0%,P=0.024).The incidence of local complications,edema,bleeding,hematoma,vagotonia,or pain did not differ between the two groups.In the multivariate analysis,the use of a pulse oximeter(OR:2.35,95%CI:1.34-4.13,P=0.003)and advanced age(OR:1.04,95%CI:1.01-1.07,P=0.006),were independently associated with an increased probability of successful patent hemostasis.The type of hemostatic device did not affect patent hemostasis(P=0.450).CONCLUSION Patent hemostasis with the use of pulse oximeter is a simple,efficient,and safe method that is worthy of further investigation.Larger randomized studies are required to consider its clinical implications.
文摘BACKGROUND Achenbach’s syndrome is a rare condition,and the etiology is unknown.It is most commonly seen in the volar plate of the hand distal interphalangeal joint.Patients diagnosed with Achenbach’s syndrome in cardiovascular surgery clinic were retrospectively compared with the literature.AIM To investigate the symptoms,findings,sociodemographic conditions,and laboratory data of patients diagnosed with Achenbach’s syndrome.METHODS The study is a retrospective review of 24 patients diagnosed with Achenbach’s syndrome at Afyonkarahisar State Hospital between March 2015 and November 2016,at Sivas Numune Hospital between November 2016 and November 2017,and at Cumhuriyet University Cardiovascular Surgery Department between November 2017 and November 2018.In the study,demographic characteristics of the patients,signs and symptoms of the disease,and laboratory data were analyzed retrospectively.RESULTS The cohort consisted of 83.33%female patients and 16.67%male patients.The disease was most commonly located in the index finger of the right hand.All of the patients complained of bruising and pain.No pathologic findings were present in the laboratory results.According to these results,it can be concluded that Achenbach syndrome is most commonly seen in the right index finger of middle-aged female patients.CONCLUSION Further research is needed to clarify Achenbach’s syndrome and to develop a diagnosis and treatment algorithm.As the awareness of this syndrome increases,large amounts of data will be obtained.According to current knowledge,Achenbach’s syndrome is not among the known causes of mortality or morbidity.However,it is unknown whether it is seen in brain or other vital organs.
文摘A medical device is an instrument that includes components,parts,or accessories to diagnose or treat patients.Since the complexity of medical devices has increased in recent years,functional safety and basic safety are required to ensure the overall device safety.Functional safety is part of the overall safety that relates to the equipment under control(EUC)and to the EUC control system that depends on the correct functionality of the electrical/electronic/programmable electronic(E/E/PE)safety-related systems.This study proposes approach methods to functional safety of medical devices for which it is important to correctly identify the safety functions and the safety integrity level(SIL).The relationship between the functional safety and essential performance is identified focusing on the safety function.The essential performance of E/E/PE systems is defined as the safety function of the functional safety.The target SIL of the essential performance is determined according to the potential risk levels,based on the classification rules of medical devices.This approach is applied to the pulse oximeter as a case study.The target SIL for the functionality of the power-failure alarm condition is determined to be SIL1.The target SILs of other functions are determined as SIL2.
基金financially supported by the National Natural Science Foundation of China(Nos.U22A20138 and 62374149)the Natural Science Foundation of Henan Province(No.252300421059)Henan Province Undergraduate Colleges and Universities Young Key Teachers Development Program(No.2023GGJS007).
文摘Photoelectric pulse oximeters are widely favored for their non-invasive and continuous monitoring of pulse rate and blood oxygen saturation,which are vital indicators of physiological health.However,traditional pulse oximeters are frequently hindered by several limitations,such as high-power consumption,instability,and reduced precision.Herein,a WSe_(2)/Si p-n heterojunction photodiode was in-situ fabricated for self-powered high-precision pulse rate and blood oxygen saturation monitoring.Our device demonstrated the excellent broadband photoresponse performance from 265 to 980 nm,covering the biological window,including a high responsivity of 740 mA/W,a fast response time of 7.8/7.1μs and a low detection limit of 25 nW/cm^(2).Leveraging these prominent photoelectrical properties,the WSe_(2)/Si photodiode demonstrates high accuracy and reliability in detecting the physiological signals of heart rate and blood oxygen saturation through a triple-wavelength measurement method,with an error margin of less than 1%,thereby validating its accuracy and reliability for non-invasive health monitoring applications.These achievements provide a new approach for developing low-power,high-sensitivity optoelectronic pulse oximeters.
